3E50
 
 | | Crystal structure of human insulin degrading enzyme in complex with transforming growth factor-alpha | | Descriptor: | Insulin-degrading enzyme, Protransforming growth factor alpha, ZINC ION | | Authors: | Guo, Q, Manolopoulou, M, Tang, W.-J. | | Deposit date: | 2008-08-12 | | Release date: | 2009-08-18 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Molecular Basis for the Recognition and Cleavages of IGF-II, TGF-alpha, and Amylin by Human Insulin-Degrading Enzyme.
J.Mol.Biol., 395, 2010
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3KBX
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3N56
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3N57
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8EZL
 | | Pfs25 in complex with transmission-reducing antibody AS01-50 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 25 kDa ookinete surface antigen, Transmission-reducing antibody AS01-50, ... | | Authors: | Shukla, N, Tang, W.K, Tolia, N.H. | | Deposit date: | 2022-11-01 | | Release date: | 2023-08-16 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | A human antibody epitope map of the malaria vaccine antigen Pfs25.
Npj Vaccines, 8, 2023
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8EZM
 | | Pfs25 in complex with transmission-reducing antibody AS01-63 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 25 kDa ookinete surface antigen, SULFATE ION, ... | | Authors: | Shukla, N, Tang, W.K, Tolia, N.H. | | Deposit date: | 2022-11-01 | | Release date: | 2023-08-16 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | A human antibody epitope map of the malaria vaccine antigen Pfs25.
Npj Vaccines, 8, 2023
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8EZK
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3CWW
 | | Crystal Structure of IDE-bradykinin complex | | Descriptor: | 1,4-DIETHYLENE DIOXIDE, ACETATE ION, Insulin-degrading enzyme, ... | | Authors: | Malito, E, Tang, W.J. | | Deposit date: | 2008-04-23 | | Release date: | 2008-11-25 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (1.96 Å) | | Cite: | Molecular Bases for the Recognition of Short Peptide Substrates and Cysteine-Directed Modifications of Human Insulin-Degrading Enzyme
Biochemistry, 47, 2008
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8D56
 | | One RBD-up state of SARS-CoV-2 BA.2 variant spike protein | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Zhang, J, Tang, W.C, Gao, H.L, Shi, W, Peng, H.Q, Volloch, S.R, Xiao, T.S, Chen, B. | | Deposit date: | 2022-06-04 | | Release date: | 2023-06-07 | | Last modified: | 2023-07-26 | | Method: | ELECTRON MICROSCOPY (3 Å) | | Cite: | Structural and functional characteristics of the SARS-CoV-2 Omicron subvariant BA.2 spike protein.
Nat.Struct.Mol.Biol., 30, 2023
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8D55
 | | Closed state of SARS-CoV-2 BA.2 variant spike protein | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Zhang, J, Tang, W.C, Gao, H.L, Shi, W, Peng, H.Q, Volloch, S.R, Xiao, T.S, Chen, B. | | Deposit date: | 2022-06-04 | | Release date: | 2023-06-07 | | Last modified: | 2023-07-26 | | Method: | ELECTRON MICROSCOPY (2.8 Å) | | Cite: | Structural and functional characteristics of the SARS-CoV-2 Omicron subvariant BA.2 spike protein.
Nat.Struct.Mol.Biol., 30, 2023
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8D5A
 | | Middle state of SARS-CoV-2 BA.2 variant spike protein | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Zhang, J, Tang, W.C, Gao, H.L, Shi, W, Peng, H.Q, Volloch, S.R, Xiao, T.S, Chen, B. | | Deposit date: | 2022-06-04 | | Release date: | 2023-06-07 | | Last modified: | 2023-07-26 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | Structural and functional characteristics of the SARS-CoV-2 Omicron subvariant BA.2 spike protein.
Nat.Struct.Mol.Biol., 30, 2023
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5L2U
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8GYC
 | | Annexin A5 protein dimer mutant | | Descriptor: | Annexin A5, CALCIUM ION | | Authors: | Hua, Z.C, Tang, W. | | Deposit date: | 2022-09-22 | | Release date: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | structure dissection of the membrane aggregation mechanism induced by Annexin A5 mutation
To Be Published
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6VHJ
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4RE9
 | | Crystal structure of human insulin degrading enzyme (IDE) in complex with compound 71290 | | Descriptor: | 1,2-ETHANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, 4-fluoro-N-({1-[(2R)-4-(hydroxyamino)-1-(naphthalen-2-yl)-4-oxobutan-2-yl]-1H-1,2,3-triazol-5-yl}methyl)benzamide, ... | | Authors: | Liang, W.G, Deprez, R, Deprez, B, Tang, W.J. | | Deposit date: | 2014-09-22 | | Release date: | 2015-09-30 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (2.908 Å) | | Cite: | Catalytic site inhibition of insulin-degrading enzyme by a small molecule induces glucose intolerance in mice.
Nat Commun, 6, 2015
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4RA8
 | | Structure analysis of the Mip1a P8A mutant | | Descriptor: | C-C motif chemokine 3 | | Authors: | Liang, W.G, Ren, M, Guo, Q, Tang, W.J. | | Deposit date: | 2014-09-09 | | Release date: | 2014-09-24 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Structures of human CCL18, CCL3, and CCL4 reveal molecular determinants for quaternary structures and sensitivity to insulin-degrading enzyme.
J.Mol.Biol., 427, 2015
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4RAL
 | | Crystal structure of insulin degrading enzyme in complex with macrophage inflammatory protein 1 beta | | Descriptor: | C-C motif chemokine 4, Insulin-degrading enzyme, ZINC ION | | Authors: | Liang, W.G, Ren, M, Guo, Q, Tang, W.J. | | Deposit date: | 2014-09-10 | | Release date: | 2015-05-13 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (3.148 Å) | | Cite: | Structures of human CCL18, CCL3, and CCL4 reveal molecular determinants for quaternary structures and sensitivity to insulin-degrading enzyme.
J.Mol.Biol., 427, 2015
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4RPU
 | | Crystal Structure of Human Presequence Protease in Complex with Inhibitor MitoBloCK-60 | | Descriptor: | ACETATE ION, CALCIUM ION, GLYCEROL, ... | | Authors: | Mo, S.M, Liang, W.G, King, J.V, Wijaya, J, Koehler, C.M, Tang, W.J. | | Deposit date: | 2014-10-31 | | Release date: | 2015-12-09 | | Method: | X-RAY DIFFRACTION (2.265 Å) | | Cite: | Crystal Structure of Human Presequence Protease in Complex with Inhibitor MitoBloCK-60
TO BE PUBLISHED
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6VGT
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6VE9
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2YSO
 | | Solution structure of the C2H2 type zinc finger (region 656-688) of human Zinc finger protein 95 homolog | | Descriptor: | ZINC ION, Zinc finger protein 95 homolog | | Authors: | Takahashi, M, Kuwasako, K, Tsuda, K, Tanabe, W, Harada, T, Watanabe, S, Tochio, N, Muto, Y, Kigawa, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | Deposit date: | 2007-04-03 | | Release date: | 2007-10-09 | | Last modified: | 2024-05-29 | | Method: | SOLUTION NMR | | Cite: | Solution structure of the C2H2 type zinc finger (region 656-688) of human Zinc finger protein 95 homolog
To be Published
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2YSP
 | | Solution structure of the C2H2 type zinc finger (region 507-539) of human Zinc finger protein 224 | | Descriptor: | ZINC ION, Zinc finger protein 224 | | Authors: | Takahashi, M, Kuwasako, K, Tsuda, K, Tanabe, W, Harada, T, Watanabe, S, Tochio, N, Muto, Y, Kigawa, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | Deposit date: | 2007-04-03 | | Release date: | 2007-10-09 | | Last modified: | 2024-05-29 | | Method: | SOLUTION NMR | | Cite: | Solution structure of the C2H2 type zinc finger (region 507-539)of human Zinc finger protein 224
To be Published
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8DFI
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5KLI
 | | Rhodobacter sphaeroides bc1 with stigmatellin and antimycin | | Descriptor: | (1R)-2-{[(R)-(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(DODECANOYLOXY)METHYL]ETHYL (9Z)-OCTADEC-9-ENOATE, (2R,3S,6S,7R,8R)-3-{[3-(FORMYLAMINO)-2-HYDROXYBENZOYL]AMINO}-8-HEXYL-2,6-DIMETHYL-4,9-DIOXO-1,5-DIOXONAN-7-YL (2S)-2-METHYLBUTANOATE, Cytochrome b, ... | | Authors: | Xia, D, Esser, L, Zhou, F, Tang, W.K, Yu, C.A. | | Deposit date: | 2016-06-24 | | Release date: | 2016-10-12 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (2.996 Å) | | Cite: | Hydrogen Bonding to the Substrate Is Not Required for Rieske Iron-Sulfur Protein Docking to the Quinol Oxidation Site of Complex III.
J.Biol.Chem., 291, 2016
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5KLV
 | | Structure of bos taurus cytochrome bc1 with fenamidone inhibited | | Descriptor: | (2R)-3-{[(S)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-2-(tetradecanoyloxy)propyl octadecanoate, (5S)-5-methyl-2-(methylsulfanyl)-5-phenyl-3-(phenylamino)-3,5-dihydro-4H-imidazol-4-one, 1,2-DIHEXANOYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE, ... | | Authors: | Xia, D, Esser, L, Zhou, F, Zhou, Y, Xiao, Y, Tang, W.K, Yu, C.A, Qin, Z. | | Deposit date: | 2016-06-25 | | Release date: | 2016-10-12 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (2.652 Å) | | Cite: | Hydrogen Bonding to the Substrate Is Not Required for Rieske Iron-Sulfur Protein Docking to the Quinol Oxidation Site of Complex III.
J.Biol.Chem., 291, 2016
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