7Q8T
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![BU of 7q8t by Molmil](/molmil-images/mine/7q8t) | Crystal structure of NAMPT bound to ligand TSY535(compound 9a) | Descriptor: | Nicotinamide phosphoribosyltransferase, SULFATE ION, [(2~{R},3~{S},4~{R},5~{S})-3,4-bis(oxidanyl)-5-[4-[[[4-(phenylsulfonyl)phenyl]carbamoylamino]methyl]phenyl]oxolan-2-yl]methyl dihydrogen phosphate | Authors: | Kraemer, A, Tang, S, Butterworth, S, Knapp, S, Structural Genomics Consortium (SGC) | Deposit date: | 2021-11-11 | Release date: | 2021-11-24 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | Chemistry-led investigations into the mode of action of NAMPT activators, resulting in the discovery of non-pyridyl class NAMPT activators. Acta Pharm Sin B, 13, 2023
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7OEX
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![BU of 7oex by Molmil](/molmil-images/mine/7oex) | |
8H3M
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![BU of 8h3m by Molmil](/molmil-images/mine/8h3m) | Conformation 1 of SARS-CoV-2 Omicron BA.1 Variant Spike protein complexed with MO1 Fab | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, MO1 heavy chain, Spike glycoprotein | Authors: | Ishimaru, H, Nishimura, M, Sutandhio, S, Shigematsu, H, Kato, K, Hasegawa, N, Mori, Y. | Deposit date: | 2022-10-09 | Release date: | 2023-05-10 | Last modified: | 2023-08-02 | Method: | ELECTRON MICROSCOPY (2.48 Å) | Cite: | Identification and Analysis of Monoclonal Antibodies with Neutralizing Activity against Diverse SARS-CoV-2 Variants. J.Virol., 97, 2023
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8H3N
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![BU of 8h3n by Molmil](/molmil-images/mine/8h3n) | Conformation 2 of SARS-CoV-2 Omicron BA.1 Variant Spike protein complexed with MO1 Fab | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, MO1 heavy-chain, MO1 light chain, ... | Authors: | Ishimaru, H, Nishimura, M, Sutandhio, S, Shigematsu, H, Kato, K, Hasegawa, N, Mori, Y. | Deposit date: | 2022-10-09 | Release date: | 2023-05-10 | Last modified: | 2023-08-02 | Method: | ELECTRON MICROSCOPY (2.73 Å) | Cite: | Identification and Analysis of Monoclonal Antibodies with Neutralizing Activity against Diverse SARS-CoV-2 Variants. J.Virol., 97, 2023
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5NUQ
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![BU of 5nuq by Molmil](/molmil-images/mine/5nuq) | Structural basis for maintenance of bacterial outer membrane lipid asymmetry | Descriptor: | (HYDROXYETHYLOXY)TRI(ETHYLOXY)OCTANE, Outer membrane protein F, Probable phospholipid-binding lipoprotein mlaA | Authors: | Abellon-Ruiz, J, Kaptan, S.S, Basle, A, Claudi, B, Bumann, D, Kleinekathofer, U, van den Berg, B. | Deposit date: | 2017-05-01 | Release date: | 2017-10-25 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Structural basis for maintenance of bacterial outer membrane lipid asymmetry. Nat Microbiol, 2, 2017
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8J7W
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![BU of 8j7w by Molmil](/molmil-images/mine/8j7w) | Cryo-EM structure of hZnT7-Fab complex in zinc state 2, determined in heterogeneous conformations- one subunit in an inward-facing zinc-bound and the other in an outward-facing zinc-bound conformation | Descriptor: | Heavy chain of YN7114-08 Fab, Light chain of YN7114-08 Fab, ZINC ION, ... | Authors: | Han, B.B, Inaba, K, Watanabe, S. | Deposit date: | 2023-04-28 | Release date: | 2023-09-20 | Method: | ELECTRON MICROSCOPY (2.92 Å) | Cite: | Cryo-EM structures of human zinc transporter ZnT7 reveal the mechanism of Zn 2+ uptake into the Golgi apparatus. Nat Commun, 14, 2023
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8J7X
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![BU of 8j7x by Molmil](/molmil-images/mine/8j7x) | Cryo-EM structure of hZnT7DeltaHis-loop-Fab complex in zinc-unbound state, determined in outward-facing conformation | Descriptor: | Heavy chain of YN7114-08 Fab, Light chain of YN7114-08 Fab, Zinc transporter 7 | Authors: | Han, B.B, Inaba, K, Watanabe, S. | Deposit date: | 2023-04-28 | Release date: | 2023-09-20 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Cryo-EM structures of human zinc transporter ZnT7 reveal the mechanism of Zn 2+ uptake into the Golgi apparatus. Nat Commun, 14, 2023
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8J7V
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![BU of 8j7v by Molmil](/molmil-images/mine/8j7v) | Cryo-EM structure of hZnT7-Fab complex in zinc-unbound state, determined in heterogeneous conformations- one subunit in an inward-facing and the other in an outward-facing conformation | Descriptor: | Heavy chain of YN7114-08 Fab, Light chain of YN7114-08 Fab, Zinc transporter 7 | Authors: | Han, B.B, Inaba, K, Watanabe, S. | Deposit date: | 2023-04-28 | Release date: | 2023-09-20 | Method: | ELECTRON MICROSCOPY (2.79 Å) | Cite: | Cryo-EM structures of human zinc transporter ZnT7 reveal the mechanism of Zn 2+ uptake into the Golgi apparatus. Nat Commun, 14, 2023
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8J7U
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![BU of 8j7u by Molmil](/molmil-images/mine/8j7u) | Cryo-EM structure of hZnT7-Fab complex in zinc-bound state, determined in outward-facing conformation | Descriptor: | Heavy chain of YN7114-08 Fab, Light chain of YN7114-08 Fab, ZINC ION, ... | Authors: | Han, B.B, Inaba, K, Watanabe, S. | Deposit date: | 2023-04-28 | Release date: | 2023-09-20 | Method: | ELECTRON MICROSCOPY (3.12 Å) | Cite: | Cryo-EM structures of human zinc transporter ZnT7 reveal the mechanism of Zn 2+ uptake into the Golgi apparatus. Nat Commun, 14, 2023
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8J80
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![BU of 8j80 by Molmil](/molmil-images/mine/8j80) | Cryo-EM structure of hZnT7-Fab complex in zinc state 1, determined in heterogeneous conformations- one subunit in an inward-facing zinc-bound and the other in an outward-facing zinc-unbound conformation | Descriptor: | Heavy chain of YN7114-08 Fab, Light chain of YN7114-08 Fab, ZINC ION, ... | Authors: | Han, B.B, Inaba, K, Watanabe, S. | Deposit date: | 2023-04-28 | Release date: | 2023-09-20 | Method: | ELECTRON MICROSCOPY (2.68 Å) | Cite: | Cryo-EM structures of human zinc transporter ZnT7 reveal the mechanism of Zn 2+ uptake into the Golgi apparatus. Nat Commun, 14, 2023
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8J7T
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![BU of 8j7t by Molmil](/molmil-images/mine/8j7t) | Cryo-EM structure of hZnT7-Fab complex in zinc-unbound state, determined in outward-facing conformation | Descriptor: | Heavy chain of YN7114-08 Fab, Light chain of YN7114-08 Fab, Zinc transporter 7 | Authors: | Han, B.B, Inaba, K, Watanabe, S. | Deposit date: | 2023-04-28 | Release date: | 2023-09-20 | Method: | ELECTRON MICROSCOPY (2.2 Å) | Cite: | Cryo-EM structures of human zinc transporter ZnT7 reveal the mechanism of Zn 2+ uptake into the Golgi apparatus. Nat Commun, 14, 2023
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8J7Y
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![BU of 8j7y by Molmil](/molmil-images/mine/8j7y) | Cryo-EM structure of hZnT7DeltaHis-loop-Fab complex in zinc-bound state, determined in outward-facing conformation | Descriptor: | Heavy chain of YN7114-08 Fab, Light chain of YN7114-08 Fab, ZINC ION, ... | Authors: | Han, B.B, Inaba, K, Watanabe, S. | Deposit date: | 2023-04-28 | Release date: | 2023-09-20 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Cryo-EM structures of human zinc transporter ZnT7 reveal the mechanism of Zn 2+ uptake into the Golgi apparatus. Nat Commun, 14, 2023
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8K7P
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![BU of 8k7p by Molmil](/molmil-images/mine/8k7p) | Staphylococcus aureus lipase -PSA complex | Descriptor: | ACETIC ACID, CALCIUM ION, CHLORIDE ION, ... | Authors: | Kitadokoro, J, Kamitani, S, Kitadokoro, K. | Deposit date: | 2023-07-27 | Release date: | 2024-06-05 | Last modified: | 2024-06-19 | Method: | X-RAY DIFFRACTION (2.19 Å) | Cite: | Crystal structure of Staphylococcus aureus lipase complex with unsaturated petroselinic acid. Febs Open Bio, 14, 2024
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8K7Q
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![BU of 8k7q by Molmil](/molmil-images/mine/8k7q) | Staphylococcus aureus lipase S116A inactive mutant-PSA complex | Descriptor: | ACETIC ACID, CALCIUM ION, CHLORIDE ION, ... | Authors: | Kitadokoro, J, Kamitani, S, Kitadokoro, K. | Deposit date: | 2023-07-27 | Release date: | 2024-06-05 | Last modified: | 2024-06-19 | Method: | X-RAY DIFFRACTION (2.02 Å) | Cite: | Crystal structure of Staphylococcus aureus lipase complex with unsaturated petroselinic acid. Febs Open Bio, 14, 2024
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5YXY
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![BU of 5yxy by Molmil](/molmil-images/mine/5yxy) | Crystal structure of the HyhL-HypA complex (form I) | Descriptor: | Cytosolic NiFe-hydrogenase, alpha subunit, Probable hydrogenase nickel incorporation protein HypA, ... | Authors: | Kwon, S, Watanabe, S, Nishitani, Y, Miki, K. | Deposit date: | 2017-12-07 | Release date: | 2018-06-20 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (3.299 Å) | Cite: | Crystal structures of a [NiFe] hydrogenase large subunit HyhL in an immature state in complex with a Ni chaperone HypA. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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5YY0
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![BU of 5yy0 by Molmil](/molmil-images/mine/5yy0) | Crystal structure of the HyhL-HypA complex (form II) | Descriptor: | Cytosolic NiFe-hydrogenase, alpha subunit, Probable hydrogenase nickel incorporation protein HypA, ... | Authors: | Kwon, S, Watanabe, S, Nishitani, Y, Miki, K. | Deposit date: | 2017-12-07 | Release date: | 2018-06-20 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (3.243 Å) | Cite: | Crystal structures of a [NiFe] hydrogenase large subunit HyhL in an immature state in complex with a Ni chaperone HypA. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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1Y67
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![BU of 1y67 by Molmil](/molmil-images/mine/1y67) | |
3JCX
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![BU of 3jcx by Molmil](/molmil-images/mine/3jcx) | Canine Parvovirus complexed with Fab E | Descriptor: | Capsid protein 2, Fab E heavy chain, Fab E light chain | Authors: | Organtini, L.J, Iketani, S, Huang, K, Ashley, R.E, Makhov, A.M, Conway, J.F, Parrish, C.R, Hafenstein, S. | Deposit date: | 2016-03-21 | Release date: | 2016-07-20 | Last modified: | 2018-07-18 | Method: | ELECTRON MICROSCOPY (4.1 Å) | Cite: | Near-Atomic Resolution Structure of a Highly Neutralizing Fab Bound to Canine Parvovirus. J.Virol., 90, 2016
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5MTF
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![BU of 5mtf by Molmil](/molmil-images/mine/5mtf) | A modular route to novel potent and selective inhibitors of rhomboid intramembrane proteases | Descriptor: | CHLORIDE ION, Rhomboid protease GlpG, inhibitor, ... | Authors: | Ticha, A, Stanchev, S, Vinothkumar, K.R, Mikles, D.C, Pachl, P, Svehlova, K, Nguyen, M.T.N, Verhelst, S.H.L, Johnson, D, Bachovchin, D, Lepsik, M, Majer, P, Strisovsky, K. | Deposit date: | 2017-01-09 | Release date: | 2017-11-15 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.79 Å) | Cite: | General and Modular Strategy for Designing Potent, Selective, and Pharmacologically Compliant Inhibitors of Rhomboid Proteases. Cell Chem Biol, 24, 2017
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6GG8
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![BU of 6gg8 by Molmil](/molmil-images/mine/6gg8) | Mineralocorticoid receptor in complex with (s)-13 | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, Mineralocorticoid receptor, Nuclear receptor coactivator 1, ... | Authors: | Edman, K, Aagaard, A, Tangefjord, S. | Deposit date: | 2018-05-03 | Release date: | 2019-01-09 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Identification of Mineralocorticoid Receptor Modulators with Low Impact on Electrolyte Homeostasis but Maintained Organ Protection. J.Med.Chem., 62, 2019
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6GGG
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![BU of 6ggg by Molmil](/molmil-images/mine/6ggg) | Mineralocorticoid receptor in complex with (s)-13 | Descriptor: | 2-[(3~{S})-7-fluoranyl-6-(2-methylpropyl)-4-[(3-oxidanylidene-4~{H}-1,4-benzoxazin-6-yl)carbonyl]-2,3-dihydro-1,4-benzoxazin-3-yl]-~{N}-methyl-ethanamide, CHLORIDE ION, Mineralocorticoid receptor, ... | Authors: | Edman, K, Aagaard, A, Tangefjord, S. | Deposit date: | 2018-05-03 | Release date: | 2019-01-09 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.71 Å) | Cite: | Identification of Mineralocorticoid Receptor Modulators with Low Impact on Electrolyte Homeostasis but Maintained Organ Protection. J.Med.Chem., 62, 2019
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6GEV
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![BU of 6gev by Molmil](/molmil-images/mine/6gev) | Mineralocorticoid receptor in complex with (s)-13 | Descriptor: | 6-[[(3~{S})-7-fluoranyl-3-(2-methylpropyl)-2,3-dihydro-1,4-benzoxazin-4-yl]carbonyl]-4~{H}-1,4-benzoxazin-3-one, GLYCEROL, Mineralocorticoid receptor, ... | Authors: | Edman, K, Aagaard, A, Tangefjord, S. | Deposit date: | 2018-04-27 | Release date: | 2019-01-09 | Last modified: | 2024-05-15 | Method: | X-RAY DIFFRACTION (1.54 Å) | Cite: | Identification of Mineralocorticoid Receptor Modulators with Low Impact on Electrolyte Homeostasis but Maintained Organ Protection. J.Med.Chem., 62, 2019
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8GZV
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![BU of 8gzv by Molmil](/molmil-images/mine/8gzv) | Klebsiella pneumoniae FtsZ complexed with monobody (P212121) | Descriptor: | Cell division protein FtsZ, GUANOSINE-5'-DIPHOSPHATE, Monobody | Authors: | Matsumura, H, Yoshizawa, T, Fujita, J, Tanaka, S, Amesaka, H. | Deposit date: | 2022-09-27 | Release date: | 2023-07-19 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structures of a FtsZ single protofilament and a double-helical tube in complex with a monobody. Nat Commun, 14, 2023
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8GZX
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![BU of 8gzx by Molmil](/molmil-images/mine/8gzx) | Escherichia coli FtsZ complexed with monobody (P212121) | Descriptor: | Cell division protein FtsZ, GUANOSINE-5'-DIPHOSPHATE, Monobody | Authors: | Matsumura, H, Yoshizawa, T, Fujita, J, Tanaka, S, Amesaka, H. | Deposit date: | 2022-09-27 | Release date: | 2023-07-19 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.84 Å) | Cite: | Structures of a FtsZ single protofilament and a double-helical tube in complex with a monobody. Nat Commun, 14, 2023
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8GZW
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![BU of 8gzw by Molmil](/molmil-images/mine/8gzw) | Klebsiella pneumoniae FtsZ complexed with monobody (P21) | Descriptor: | Cell division protein FtsZ, GUANOSINE-5'-DIPHOSPHATE, Monobody | Authors: | Matsumura, H, Yoshizawa, T, Fujita, J, Tanaka, S, Amesaka, H. | Deposit date: | 2022-09-27 | Release date: | 2023-07-19 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structures of a FtsZ single protofilament and a double-helical tube in complex with a monobody. Nat Commun, 14, 2023
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