Loading
PDBj
English日本語简体中文繁體中文한국어
✖
ﾒﾆｭｰPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help
PDB: 803 件
7ST9
DownloadVisualize
BU of 7st9 by Molmil
Open state of Rad24-RFC:9-1-1 bound to a 5' ss/dsDNA junction
分子名称: ADENOSINE-5'-DIPHOSPHATE, Checkpoint protein RAD24, DNA (5'-D(P*CP*GP*CP*TP*CP*CP*TP*TP*CP*CP*TP*GP*AP*CP*TP*CP*GP*TP*CP*C)-3'), ...
著者Castaneda, J.C, Schrecker, M, Remus, D, Hite, R.K.
登録日2021-11-12
公開日2022-03-23
最終更新日2024-06-05
実験手法ELECTRON MICROSCOPY (2.2 Å)
主引用文献Mechanisms of loading and release of the 9-1-1 checkpoint clamp.
Nat.Struct.Mol.Biol., 29, 2022
6ZYA
DownloadVisualize
BU of 6zya by Molmil
Extended human uromodulin filament core at 3.5 A resolution
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Uromodulin, alpha-D-mannopyranose-(1-6)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose
著者Stanisich, J.J, Zyla, D, Afanasyev, P, Xu, J, Pilhofer, M, Boeringer, D, Glockshuber, R.
登録日2020-07-31
公開日2020-09-02
実験手法ELECTRON MICROSCOPY (3.5 Å)
主引用文献The cryo-EM structure of the human uromodulin filament core reveals a unique assembly mechanism.
Elife, 9, 2020
6ZS5
DownloadVisualize
BU of 6zs5 by Molmil
3.5 A cryo-EM structure of human uromodulin filament core
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Uromodulin, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose
著者Stanisich, J.J, Zyla, D, Afanasyev, P, Xu, J, Pilhofer, M, Boeringer, D, Glockshuber, R.
登録日2020-07-15
公開日2020-09-02
実験手法ELECTRON MICROSCOPY (3.5 Å)
主引用文献The cryo-EM structure of the human uromodulin filament core reveals a unique assembly mechanism.
Elife, 9, 2020
6TL6
DownloadVisualize
BU of 6tl6 by Molmil
Three dimensional structure of human carbonic anhydrase IX in complex with sulfonamide
分子名称: Carbonic anhydrase 9, GLYCEROL, ZINC ION, ...
著者Leitans, J, Tars, K.
登録日2019-12-01
公開日2020-12-16
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.15 Å)
主引用文献Isoform-Selective Enzyme Inhibitors by Exploring Pocket Size According to the Lock-and-Key Principle.
Biophys.J., 119, 2020
8Q19
DownloadVisualize
BU of 8q19 by Molmil
The Crystal Structure of Human Carbonic Anhydrase IX in Complex with Sulfonamide
分子名称: 2-but-2-ynyl-1,1,3-tris(oxidanylidene)-1,2-benzothiazole-6-sulfonamide, Carbonic anhydrase 9, GLYCEROL, ...
著者Leitans, J, Tars, K.
登録日2023-07-31
公開日2023-11-08
最終更新日2023-12-06
実験手法X-RAY DIFFRACTION (2.63 Å)
主引用文献Structural Basis of Saccharin Derivative Inhibition of Carbonic Anhydrase IX.
Chemmedchem, 18, 2023
8Q18
DownloadVisualize
BU of 8q18 by Molmil
The Crystal Structure of Human Carbonic Anhydrase IX in Complex with Sulfonamide
分子名称: 1,1,3-tris(oxidanylidene)-2-(2-phenylethyl)-1,2-benzothiazole-6-sulfonamide, Carbonic anhydrase 9, GLYCEROL, ...
著者Leitans, J, Tars, K.
登録日2023-07-31
公開日2023-11-08
最終更新日2023-12-06
実験手法X-RAY DIFFRACTION (2.13 Å)
主引用文献Structural Basis of Saccharin Derivative Inhibition of Carbonic Anhydrase IX.
Chemmedchem, 18, 2023
8Q1A
DownloadVisualize
BU of 8q1a by Molmil
The Crystal Structure of Human Carbonic Anhydrase IX in Complex with inhibitor
分子名称: 1,1,3-tris(oxidanylidene)-2-pentyl-1,2-benzothiazole-6-sulfonamide, Carbonic anhydrase 9, GLYCEROL, ...
著者Leitans, J, Tars, K.
登録日2023-07-31
公開日2023-11-08
最終更新日2023-12-06
実験手法X-RAY DIFFRACTION (2.35 Å)
主引用文献Structural Basis of Saccharin Derivative Inhibition of Carbonic Anhydrase IX.
Chemmedchem, 18, 2023
6TL5
DownloadVisualize
BU of 6tl5 by Molmil
Three dimensional structure of human carbonic anhydrase IX in complex with sulfonamide
分子名称: 3,5-diphenylbenzenesulfonamide, Carbonic anhydrase 9, ZINC ION
著者Leitans, J, Tars, K.
登録日2019-12-01
公開日2020-12-16
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.21 Å)
主引用文献Isoform-Selective Enzyme Inhibitors by Exploring Pocket Size According to the Lock-and-Key Principle.
Biophys.J., 119, 2020
8TDD
DownloadVisualize
BU of 8tdd by Molmil
Structure of PYCR1 complexed with NADH and 2-(furan-2-yl)acetic acid
分子名称: (furan-2-yl)acetic acid, 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, Pyrroline-5-carboxylate reductase 1, ...
著者Tanner, J.J, Meeks, K.R.
登録日2023-07-02
公開日2024-07-03
実験手法X-RAY DIFFRACTION (1.91 Å)
主引用文献Screening a knowledge-based library of low molecular weight compounds against the proline biosynthetic enzyme 1-pyrroline-5-carboxylate 1 (PYCR1)
Protein Sci., 33, 2024
8TD3
DownloadVisualize
BU of 8td3 by Molmil
Structure of PYCR1 complexed with NADH and (S)-Tetrahydro-2H-pyran-2-carboxylic acid
分子名称: (2S)-oxane-2-carboxylic acid, 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, DI(HYDROXYETHYL)ETHER, ...
著者Tanner, J.J, Meeks, K.R.
登録日2023-07-02
公開日2024-07-03
実験手法X-RAY DIFFRACTION (1.67 Å)
主引用文献Screening a knowledge-based library of low molecular weight compounds against the proline biosynthetic enzyme 1-pyrroline-5-carboxylate 1 (PYCR1)
Protein Sci., 33, 2024
8TD9
DownloadVisualize
BU of 8td9 by Molmil
Structure of PYCR1 complexed with NADH and L-pipecolic acid
分子名称: (2S)-piperidine-2-carboxylic acid, 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, Pyrroline-5-carboxylate reductase 1, ...
著者Tanner, J.J, Meeks, K.R.
登録日2023-07-02
公開日2024-07-03
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Screening a knowledge-based library of low molecular weight compounds against the proline biosynthetic enzyme 1-pyrroline-5-carboxylate 1 (PYCR1)
Protein Sci., 33, 2024
8TD2
DownloadVisualize
BU of 8td2 by Molmil
Structure of PYCR1 complexed with NADH and cyclobutane-1,1-dicarboxylic acid
分子名称: 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, Pyrroline-5-carboxylate reductase 1, mitochondrial, ...
著者Tanner, J.J, Meeks, K.R.
登録日2023-07-02
公開日2024-07-03
実験手法X-RAY DIFFRACTION (1.65 Å)
主引用文献Screening a knowledge-based library of low molecular weight compounds against the proline biosynthetic enzyme 1-pyrroline-5-carboxylate 1 (PYCR1)
Protein Sci., 33, 2024
8TD6
DownloadVisualize
BU of 8td6 by Molmil
Structure of PYCR1 complexed with NADH and 2-(Methylthio)acetic acid
分子名称: 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, Pyrroline-5-carboxylate reductase 1, mitochondrial, ...
著者Tanner, J.J, Meeks, K.R.
登録日2023-07-02
公開日2024-07-03
実験手法X-RAY DIFFRACTION (2.08 Å)
主引用文献Screening a knowledge-based library of low molecular weight compounds against the proline biosynthetic enzyme 1-pyrroline-5-carboxylate 1 (PYCR1)
Protein Sci., 33, 2024
8TDC
DownloadVisualize
BU of 8tdc by Molmil
Structure of PYCR1 complexed with NADH and 1,3-dithiane-2-carboxylic acid
分子名称: 1,3-dithiane-2-carboxylic acid, 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, Pyrroline-5-carboxylate reductase 1, ...
著者Tanner, J.J, Meeks, K.R.
登録日2023-07-02
公開日2024-07-03
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Screening a knowledge-based library of low molecular weight compounds against the proline biosynthetic enzyme 1-pyrroline-5-carboxylate 1 (PYCR1)
Protein Sci., 33, 2024
8TD4
DownloadVisualize
BU of 8td4 by Molmil
Structure of PYCR1 complexed with NADH and 1,3-Dithiolane-2-carboxylic acid
分子名称: 1,3-dithiolane-2-carboxylic acid, 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, Pyrroline-5-carboxylate reductase 1, ...
著者Tanner, J.J, Meeks, K.R.
登録日2023-07-02
公開日2024-07-03
実験手法X-RAY DIFFRACTION (1.76 Å)
主引用文献Screening a knowledge-based library of low molecular weight compounds against the proline biosynthetic enzyme 1-pyrroline-5-carboxylate 1 (PYCR1)
Protein Sci., 33, 2024
8TDB
DownloadVisualize
BU of 8tdb by Molmil
Structure of PYCR1 complexed with NADH and 1-hydroxyethane-1-sulfonate
分子名称: (1R)-1-hydroxyethane-1-sulfonic acid, 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, Pyrroline-5-carboxylate reductase 1, ...
著者Tanner, J.J, Meeks, K.R.
登録日2023-07-02
公開日2024-07-03
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Screening a knowledge-based library of low molecular weight compounds against the proline biosynthetic enzyme 1-pyrroline-5-carboxylate 1 (PYCR1)
Protein Sci., 33, 2024
8TD7
DownloadVisualize
BU of 8td7 by Molmil
Structure of PYCR1 complexed with 2S-hydroxy-3-methylbutyric acid
分子名称: (2S)-2-hydroxy-3-methylbutanoic acid, DI(HYDROXYETHYL)ETHER, Pyrroline-5-carboxylate reductase 1, ...
著者Tanner, J.J, Meeks, K.R.
登録日2023-07-02
公開日2024-07-03
実験手法X-RAY DIFFRACTION (1.61 Å)
主引用文献Screening a knowledge-based library of low molecular weight compounds against the proline biosynthetic enzyme 1-pyrroline-5-carboxylate 1 (PYCR1)
Protein Sci., 33, 2024
8TD5
DownloadVisualize
BU of 8td5 by Molmil
Structure of PYCR1 complexed with NADH and Tetrahydrothiophene-2-carboxylic acid
分子名称: (2R)-thiolane-2-carboxylic acid, 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, Pyrroline-5-carboxylate reductase 1, ...
著者Tanner, J.J, Meeks, K.R.
登録日2023-07-02
公開日2024-07-03
実験手法X-RAY DIFFRACTION (1.81 Å)
主引用文献Screening a knowledge-based library of low molecular weight compounds against the proline biosynthetic enzyme 1-pyrroline-5-carboxylate 1 (PYCR1)
Protein Sci., 33, 2024
8TD8
DownloadVisualize
BU of 8td8 by Molmil
Structure of PYCR1 complexed with NADH and 2S-Hydroxy-3,3-dimethylbutyric acid
分子名称: (2S)-2-hydroxy-3,3-dimethylbutanoic acid, 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, Pyrroline-5-carboxylate reductase 1, ...
著者Tanner, J.J, Meeks, K.R.
登録日2023-07-02
公開日2024-07-03
実験手法X-RAY DIFFRACTION (1.71 Å)
主引用文献Screening a knowledge-based library of low molecular weight compounds against the proline biosynthetic enzyme 1-pyrroline-5-carboxylate 1 (PYCR1)
Protein Sci., 33, 2024
7SQN
DownloadVisualize
BU of 7sqn by Molmil
Structure of the E. coli PutA proline dehydrogenase domain (residues 86-630) complexed with (2S)-oxetane-2-carboxylic acid
分子名称: (2S)-oxetane-2-carboxylic acid, Bifunctional protein PutA, FLAVIN-ADENINE DINUCLEOTIDE, ...
著者Tanner, J.J, Bogner, A.N.
登録日2021-11-05
公開日2022-01-19
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.25 Å)
主引用文献Structure-affinity relationships of reversible proline analog inhibitors targeting proline dehydrogenase.
Org.Biomol.Chem., 20, 2022
8W0K
DownloadVisualize
BU of 8w0k by Molmil
Minimal PutA proline dehydrogenase domain (design #2) complexed with 1-hydroxyethane-1-sulfonate
分子名称: (1R)-1-hydroxyethane-1-sulfonic acid, Bifunctional protein PutA fusion protein, FLAVIN-ADENINE DINUCLEOTIDE
著者Tanner, J.J, Meeks, K.R.
登録日2024-02-13
公開日2024-07-03
実験手法X-RAY DIFFRACTION (1.42 Å)
主引用文献Screening a knowledge-based library of low molecular weight compounds against the proline biosynthetic enzyme 1-pyrroline-5-carboxylate 1 (PYCR1)
Protein Sci., 33, 2024
8VRE
DownloadVisualize
BU of 8vre by Molmil
Structure of PYCR1 complexed with NADH and N-formyl-L-proline
分子名称: 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, 1-formyl-L-proline, Pyrroline-5-carboxylate reductase 1, ...
著者Tanner, J.J, Meeks, K.R.
登録日2024-01-21
公開日2024-07-03
実験手法X-RAY DIFFRACTION (1.83 Å)
主引用文献Screening a knowledge-based library of low molecular weight compounds against the proline biosynthetic enzyme 1-pyrroline-5-carboxylate 1 (PYCR1)
Protein Sci., 33, 2024
7POM
DownloadVisualize
BU of 7pom by Molmil
Three dimensional structure of human carbonic anhydrase IX in complex with sulfonamide
分子名称: Carbonic anhydrase 9, ZINC ION, methyl 2-chloranyl-4-cyclohexylsulfanyl-5-sulfamoyl-benzoate
著者Leitans, J, Tars, K.
登録日2021-09-09
公開日2022-01-12
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.98 Å)
主引用文献Methyl 2-Halo-4-Substituted-5-Sulfamoyl-Benzoates as High Affinity and Selective Inhibitors of Carbonic Anhydrase IX.
Int J Mol Sci, 23, 2021
6XOZ
DownloadVisualize
BU of 6xoz by Molmil
Structure of human PYCR1 complexed with L-tetrahydro-2-furoic acid
分子名称: CHLORIDE ION, Pyrroline-5-carboxylate reductase 1, mitochondrial, ...
著者Tanner, J.J, Christensen, E.M.
登録日2020-07-07
公開日2020-11-04
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.35 Å)
主引用文献In crystallo screening for proline analog inhibitors of the proline cycle enzyme PYCR1.
J.Biol.Chem., 295, 2020
6XP0
DownloadVisualize
BU of 6xp0 by Molmil
Structure of human PYCR1 complexed with N-formyl L-proline
分子名称: 1-formyl-L-proline, Pyrroline-5-carboxylate reductase 1, mitochondrial
著者Tanner, J.J, Christensen, E.M.
登録日2020-07-07
公開日2020-11-04
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献In crystallo screening for proline analog inhibitors of the proline cycle enzyme PYCR1.
J.Biol.Chem., 295, 2020

223790

件を2024-08-14に公開中

PDB statisticsPDBj update infoContact PDBjnumon