6XOZ
Structure of human PYCR1 complexed with L-tetrahydro-2-furoic acid
Summary for 6XOZ
| Entry DOI | 10.2210/pdb6xoz/pdb |
| Descriptor | Pyrroline-5-carboxylate reductase 1, mitochondrial, TETRAHYDROFURAN-2-CARBOXYLIC ACID, CHLORIDE ION, ... (4 entities in total) |
| Functional Keywords | amino-acid biosynthesis, oxidoreductase, proline biosynthesis |
| Biological source | Homo sapiens (Human) |
| Total number of polymer chains | 5 |
| Total formula weight | 170831.81 |
| Authors | Tanner, J.J.,Christensen, E.M. (deposition date: 2020-07-07, release date: 2020-11-04, Last modification date: 2023-10-18) |
| Primary citation | Christensen, E.M.,Bogner, A.N.,Vandekeere, A.,Tam, G.S.,Patel, S.M.,Becker, D.F.,Fendt, S.M.,Tanner, J.J. In crystallo screening for proline analog inhibitors of the proline cycle enzyme PYCR1. J.Biol.Chem., 295:18316-18327, 2020 Cited by PubMed: 33109600DOI: 10.1074/jbc.RA120.016106 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.35 Å) |
Structure validation
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