5WY2
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3HC7
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3HDF
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3HDE
| Crystal structure of full-length endolysin R21 from phage 21 | 分子名称: | Lysozyme | 著者 | Sun, Q, Arockiasamy, A, McKee, E, Caronna, E, Sacchettini, J.C. | 登録日 | 2009-05-07 | 公開日 | 2009-11-03 | 最終更新日 | 2017-11-01 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Regulation of a muralytic enzyme by dynamic membrane topology. Nat.Struct.Mol.Biol., 16, 2009
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4GMX
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4HB4
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4HAZ
| Crystal structure of CRM1 inhibitor Leptomycin B in complex with CRM1(R543S,K548E,K579Q)-Ran-RanBP1 | 分子名称: | CHLORIDE ION, Exportin-1, GTP-binding nuclear protein Ran, ... | 著者 | Sun, Q, Chook, Y.M. | 登録日 | 2012-09-27 | 公開日 | 2013-01-09 | 最終更新日 | 2017-07-26 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Nuclear export inhibition through covalent conjugation and hydrolysis of Leptomycin B by CRM1. Proc.Natl.Acad.Sci.USA, 110, 2013
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4HB3
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4HAY
| Crystal structure of CRM1 inhibitor Leptomycin B in complex with CRM1(K548E,K579Q)-Ran-RanBP1 | 分子名称: | 1,2-ETHANEDIOL, CHLORIDE ION, Exportin-1, ... | 著者 | Sun, Q, Chook, Y.M. | 登録日 | 2012-09-27 | 公開日 | 2013-01-09 | 最終更新日 | 2017-07-26 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Nuclear export inhibition through covalent conjugation and hydrolysis of Leptomycin B by CRM1. Proc.Natl.Acad.Sci.USA, 110, 2013
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4HAT
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4HB0
| Crystal structure of CRM1 inhibitor Leptomycin B in complex with CRM1(K541Q,K542Q,R543S,K545Q,K548Q,K579Q)-Ran-RanBP1 | 分子名称: | CHLORIDE ION, Exportin-1, GTP-binding nuclear protein Ran, ... | 著者 | Sun, Q, Chook, Y.M. | 登録日 | 2012-09-27 | 公開日 | 2013-01-09 | 最終更新日 | 2017-07-26 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Nuclear export inhibition through covalent conjugation and hydrolysis of Leptomycin B by CRM1. Proc.Natl.Acad.Sci.USA, 110, 2013
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4GPT
| Crystal structure of KPT251 in complex with CRM1-Ran-RanBP1 | 分子名称: | 1,2-ETHANEDIOL, 2-(2-{3-[3,5-bis(trifluoromethyl)phenyl]-1H-1,2,4-triazol-1-yl}ethyl)-1,3,4-oxadiazole, CHLORIDE ION, ... | 著者 | Sun, Q, Chook, Y.M. | 登録日 | 2012-08-21 | 公開日 | 2012-09-05 | 最終更新日 | 2013-01-23 | 実験手法 | X-RAY DIFFRACTION (2.22 Å) | 主引用文献 | Antileukemic activity of nuclear export inhibitors that spare normal hematopoietic cells. Leukemia, 27, 2013
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4HAX
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4HAV
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4HB2
| Crystal structure of CRM1-Ran-RanBP1 | 分子名称: | 1,2-ETHANEDIOL, CHLORIDE ION, Exportin-1, ... | 著者 | Sun, Q, Chook, Y.M. | 登録日 | 2012-09-27 | 公開日 | 2013-01-09 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Nuclear export inhibition through covalent conjugation and hydrolysis of Leptomycin B by CRM1. Proc.Natl.Acad.Sci.USA, 110, 2013
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4HAU
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4HAW
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3PLF
| Reverse Binding Mode of MetRD peptide complexed with c-Cbl TKB domain | 分子名称: | CALCIUM ION, CHLORIDE ION, E3 ubiquitin-protein ligase CBL, ... | 著者 | Sun, Q, Sivaraman, J. | 登録日 | 2010-11-15 | 公開日 | 2010-12-01 | 最終更新日 | 2023-12-06 | 実験手法 | X-RAY DIFFRACTION (1.92 Å) | 主引用文献 | An adjacent arginine, and the phosphorylated tyrosine in the c-Met receptor target sequence, dictates the orientation of c-Cbl binding Febs Lett., 585, 2011
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6A3A
| MVM NES mutant Nm2 in complex with CRM1-Ran-RanBP1 | 分子名称: | 1,2-ETHANEDIOL, Exportin-1, GLYCEROL, ... | 著者 | Sun, Q, Li, Y. | 登録日 | 2018-06-15 | 公開日 | 2019-06-19 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Cancer Therapy with Nanoparticle-Medicated Intracellular Expression of Peptide CRM1-Inhibitor. Int J Nanomedicine, 16, 2021
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6A3E
| MVM NES mutant Nm15 in complex with CRM1-Ran-RanBP1 | 分子名称: | Exportin-1, GTP-binding nuclear protein Ran, GUANOSINE-5'-TRIPHOSPHATE, ... | 著者 | Sun, Q, Li, Y. | 登録日 | 2018-06-15 | 公開日 | 2019-06-19 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Cancer Therapy with Nanoparticle-Medicated Intracellular Expression of Peptide CRM1-Inhibitor. Int J Nanomedicine, 16, 2021
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6A3C
| MVM NES mutant Nm12 in complex with CRM1-Ran-RanBP1 | 分子名称: | 1,2-ETHANEDIOL, CHLORIDE ION, Exportin-1, ... | 著者 | Sun, Q, Li, Y. | 登録日 | 2018-06-15 | 公開日 | 2019-06-19 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | 主引用文献 | Cancer Therapy with Nanoparticle-Medicated Intracellular Expression of Peptide CRM1-Inhibitor. Int J Nanomedicine, 16, 2021
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6A38
| MVM NS2 NES in complex with CRM1-Ran-RanBP1 | 分子名称: | 1,2-ETHANEDIOL, Exportin-1, GLYCEROL, ... | 著者 | Sun, Q, Li, Y. | 登録日 | 2018-06-15 | 公開日 | 2019-06-19 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.69 Å) | 主引用文献 | Cancer Therapy with Nanoparticle-Medicated Intracellular Expression of Peptide CRM1-Inhibitor. Int J Nanomedicine, 16, 2021
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5WFO
| Ligand-bound Ras:SOS:Ras complex | 分子名称: | 6-chloranyl-~{N}-(4-fluorophenyl)-1,2,3,4-tetrahydroacridin-9-amine, GTPase HRas, MAGNESIUM ION, ... | 著者 | Sun, Q, Phan, J, Burns, M.C, Fesik, S.W. | 登録日 | 2017-07-12 | 公開日 | 2018-05-23 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.99 Å) | 主引用文献 | High-throughput screening identifies small molecules that bind to the RAS:SOS:RAS complex and perturb RAS signaling. Anal. Biochem., 548, 2018
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6A3B
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5WFP
| Ligand-bound Ras:SOS:Ras complex | 分子名称: | 6-chloranyl-~{N}-(3-chloranyl-4-fluoranyl-phenyl)-1,2,3,4-tetrahydroacridin-9-amine, GTPase HRas, MAGNESIUM ION, ... | 著者 | Sun, Q, Phan, J, Burns, M.C, Fesik, S.W. | 登録日 | 2017-07-12 | 公開日 | 2018-05-23 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.08 Å) | 主引用文献 | High-throughput screening identifies small molecules that bind to the RAS:SOS:RAS complex and perturb RAS signaling. Anal. Biochem., 548, 2018
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