4IDJ
 
 | | S.Aureus a-hemolysin monomer in complex with Fab | | 分子名称: | Alpha-hemolysin, Fab Heavy chain, Fab Light chain, ... | | 著者 | Strop, P. | | 登録日 | 2012-12-12 | | 公開日 | 2013-06-26 | | 最終更新日 | 2021-05-26 | | 実験手法 | X-RAY DIFFRACTION (3.36 Å) | | 主引用文献 | Mechanism of Action and In Vivo Efficacy of a Human-Derived Antibody against Staphylococcus aureus alpha-Hemolysin.
J.Mol.Biol., 425, 2013
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1QCV
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3SQO
 | | PCSK9 J16 Fab complex | | 分子名称: | J16 Heavy chain, J16 Light chain, PCSK9 prodomain, ... | | 著者 | Strop, P. | | 登録日 | 2011-07-05 | | 公開日 | 2012-05-16 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Proprotein convertase substilisin/kexin type 9 antagonism reduces low-density lipoprotein cholesterol in statin-treated hypercholesterolemic nonhuman primates.
J.Pharmacol.Exp.Ther., 340, 2012
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3HN8
 | | Crystal structure of synaptotagmin | | 分子名称: | CALCIUM ION, Synaptotagmin-3, ZINC ION | | 著者 | Strop, P, Vrljic, M, Ernst, J, Brunger, A.T. | | 登録日 | 2009-05-30 | | 公開日 | 2010-02-23 | | 最終更新日 | 2017-11-01 | | 実験手法 | X-RAY DIFFRACTION (3.5 Å) | | 主引用文献 | Molecular mechanism of the synaptotagmin-SNARE interaction in Ca2+-triggered vesicle fusion.
Nat.Struct.Mol.Biol., 17, 2010
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5EPM
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4DZ8
 | | human IgG1 Fc fragment Heterodimer | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Ig gamma-1 chain C region | | 著者 | Strop, P. | | 登録日 | 2012-02-29 | | 公開日 | 2012-08-01 | | 最終更新日 | 2020-07-29 | | 実験手法 | X-RAY DIFFRACTION (1.91 Å) | | 主引用文献 | Generating Bispecific Human IgG1 and IgG2 Antibodies from Any Antibody Pair.
J.Mol.Biol., 420, 2012
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1XFD
 | | Structure of a human A-type Potassium Channel Accelerating factor DPPX, a member of the dipeptidyl aminopeptidase family | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Dipeptidyl aminopeptidase-like protein 6, alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-alpha-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Strop, P, Bankovich, A.J, Hansen, K.C, Garcia, K.C, Brunger, A.T. | | 登録日 | 2004-09-14 | | 公開日 | 2004-10-26 | | 最終更新日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | Structure of a human A-type potassium channel interacting protein DPPX, a member of the dipeptidyl aminopeptidase family
J.Mol.Biol., 343, 2004
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2Q3Z
 | | Transglutaminase 2 undergoes large conformational change upon activation | | 分子名称: | Polypeptide, SULFATE ION, Transglutaminase 2 | | 著者 | Strop, P, Pinkas, D.M, Brunger, A.T, Khosla, C. | | 登録日 | 2007-05-30 | | 公開日 | 2007-10-23 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Transglutaminase 2 undergoes a large conformational change upon activation
Plos Biol., 5, 2007
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3B5N
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1G5P
 | | NITROGENASE IRON PROTEIN FROM AZOTOBACTER VINELANDII | | 分子名称: | IRON/SULFUR CLUSTER, NITROGENASE IRON PROTEIN | | 著者 | Strop, P, Takahara, P.M, Chiu, H.J, Angove, H.C, Burgess, B.K, Rees, D.C. | | 登録日 | 2000-11-01 | | 公開日 | 2001-01-31 | | 最終更新日 | 2023-08-09 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Crystal structure of the all-ferrous [4Fe-4S]0 form of the nitrogenase iron protein from Azotobacter vinelandii.
Biochemistry, 40, 2001
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1G1M
 | | ALL-FERROUS NITROGENASE IRON PROTEIN FROM AZOTOBACTER VINELANDII | | 分子名称: | IRON/SULFUR CLUSTER, NITROGENASE IRON PROTEIN | | 著者 | Strop, P, Takahara, P.M, Chiu, H.-J, Angove, H.C, Burgess, B.K, Rees, D.C. | | 登録日 | 2000-10-12 | | 公開日 | 2001-01-31 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | | 主引用文献 | Crystal structure of the all-ferrous [4Fe-4S]0 form of the nitrogenase iron protein from Azotobacter vinelandii.
Biochemistry, 40, 2001
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1G5C
 | | CRYSTAL STRUCTURE OF THE 'CAB' TYPE BETA CLASS CARBONIC ANHYDRASE FROM METHANOBACTERIUM THERMOAUTOTROPHICUM | | 分子名称: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, BETA-CARBONIC ANHYDRASE, CALCIUM ION, ... | | 著者 | Strop, P, Smith, K.S, Iverson, T.M, Ferry, J.G, Rees, D.C. | | 登録日 | 2000-10-31 | | 公開日 | 2001-04-04 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Crystal structure of the "cab"-type beta class carbonic anhydrase from the archaeon Methanobacterium thermoautotrophicum.
J.Biol.Chem., 276, 2001
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1AIQ
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1EM7
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1AJM
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7SU1
 | | Crystal structure of an acidic pH-selective Ipilimumab variant Ipi.106 in complex with CTLA-4 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Cytotoxic T-lymphocyte protein 4, Fab heavy chain, ... | | 著者 | Lee, P.S, Chau, B, Strop, P. | | 登録日 | 2021-11-15 | | 公開日 | 2022-03-02 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.53 Å) | | 主引用文献 | Improved therapeutic index of an acidic pH-selective antibody.
Mabs, 14, 2022
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7SU0
 | | Crystal structure of an acidic pH-selective Ipilimumab variant Ipi.105 in complex with CTLA-4 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CITRATE ANION, Cytotoxic T-lymphocyte protein 4, ... | | 著者 | Lee, P.S, Chau, B, Strop, P. | | 登録日 | 2021-11-15 | | 公開日 | 2022-03-02 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.41 Å) | | 主引用文献 | Improved therapeutic index of an acidic pH-selective antibody.
Mabs, 14, 2022
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7UM3
 | | Crystal structure of a Fab in complex with a peptide derived from the LAG-3 D1 domain loop insertion | | 分子名称: | D1 domain loop peptide from Lymphocyte activation gene 3 protein, Fab heavy chain, Fab light chain | | 著者 | Zorn, J.A, Lee, P.S, Rajpal, A, Strop, P. | | 登録日 | 2022-04-06 | | 公開日 | 2022-09-07 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.3983 Å) | | 主引用文献 | Preclinical Characterization of Relatlimab, a Human LAG-3-Blocking Antibody, Alone or in Combination with Nivolumab.
Cancer Immunol Res, 10, 2022
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2OAU
 | | Mechanosensitive Channel of Small Conductance (MscS) | | 分子名称: | Small-conductance mechanosensitive channel | | 著者 | Rees, D.C, Bass, R.B, Steinbacher, S, Strop, P, Barclay, M.T. | | 登録日 | 2006-12-17 | | 公開日 | 2007-01-09 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (3.7 Å) | | 主引用文献 | Structures of the Prokaryotic Mechanosensitive Channels MscL and MscS
CURRENT TOPICS IN MEMBRANES, 58, 2007
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7KQL
 | | Anti-Tim3 antibody Fab complex | | 分子名称: | GLYCEROL, Hepatitis A virus cellular receptor 2, Tim3.18 Fab heavy chain, ... | | 著者 | Deng, X.A, West, S.M, Strop, P. | | 登録日 | 2020-11-16 | | 公開日 | 2022-02-09 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (1.49 Å) | | 主引用文献 | Tim-3 mediates T cell trogocytosis to limit antitumor immunity.
J.Clin.Invest., 132, 2022
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6UQC
 | | Mouse IgG2a Bispecific Fc | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Wang, F, Tsai, J.C, Davis, J.H, West, S.M, Strop, P. | | 登録日 | 2019-10-18 | | 公開日 | 2020-01-01 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (1.87 Å) | | 主引用文献 | Design and characterization of mouse IgG1 and IgG2a bispecific antibodies for use in syngeneic models.
Mabs, 12, 2019
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2FO5
 | | Crystal structure of recombinant barley cysteine endoprotease B isoform 2 (EP-B2) in complex with leupeptin | | 分子名称: | ACE-LEU-LEU-argininal (leupeptin), Cysteine proteinase EP-B 2, SULFATE ION | | 著者 | Bethune, M.T, Strop, P, Brunger, A.T, Khosla, C. | | 登録日 | 2006-01-12 | | 公開日 | 2006-07-18 | | 最終更新日 | 2017-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Heterologous Expression, Purification, Refolding, and Structural-Functional Characterization of EP-B2, a Self-Activating Barley Cysteine Endoprotease.
Chem.Biol., 13, 2006
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2OAR
 | | Mechanosensitive Channel of Large Conductance (MscL) | | 分子名称: | GOLD ION, Large-conductance mechanosensitive channel | | 著者 | Rees, D.C, Chang, G, Spencer, R.H, Lee, A.T, Steinbacher, S, Strop, P. | | 登録日 | 2006-12-17 | | 公開日 | 2007-01-09 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (3.5 Å) | | 主引用文献 | Structures of the Prokaryotic Mechanosensitive Channels MscL and MscS
Current Topics in Membranes, 58, 2007
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7KHD
 | | Human GITR-GITRL complex | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Tumor necrosis factor ligand superfamily member 18, Tumor necrosis factor receptor superfamily member 18 | | 著者 | Wang, F, Chau, B, West, S.M, Strop, P. | | 登録日 | 2020-10-21 | | 公開日 | 2021-03-03 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.956102 Å) | | 主引用文献 | Structures of mouse and human GITR-GITRL complexes reveal unique TNF superfamily interactions.
Nat Commun, 12, 2021
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7KHX
 | | Mouse GITR-GITRL complex | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Tumor necrosis factor ligand superfamily member 18, ... | | 著者 | Wang, F, Chau, B, West, S.M, Strop, P. | | 登録日 | 2020-10-22 | | 公開日 | 2021-03-03 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (3.20569849 Å) | | 主引用文献 | Structures of mouse and human GITR-GITRL complexes reveal unique TNF superfamily interactions.
Nat Commun, 12, 2021
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