6QZQ
 
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6QZT
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7PQ6
 | | Crystal Structure of the Ring Nuclease 0811 mutant-S12A from Sulfolobus islandicus (Sis0811) | | 分子名称: | CRISPR-associated protein, APE2256 family | | 著者 | Molina, R, Jensen, A.L.G, Marchena-Hurtado, J, Lopez-Mendez, B, Stella, S, Montoya, G. | | 登録日 | 2021-09-16 | | 公開日 | 2021-11-24 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2.67 Å) | | 主引用文献 | Structural basis of cyclic oligoadenylate degradation by ancillary Type III CRISPR-Cas ring nucleases.
Nucleic Acids Res., 49, 2021
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7PQ3
 | | Crystal Structure of the Ring Nuclease 0811 from Sulfolobus islandicus (Sis0811) in complex with its post-catalytic reaction product | | 分子名称: | 3'-O-[(R)-{[(2S,3aS,4S,6S,6aS)-6-(6-amino-9H-purin-9-yl)-2-hydroxy-2-oxotetrahydro-2H-2lambda~5~-furo[3,4-d][1,3,2]dioxaphosphol-4-yl]methoxy}(hydroxy)phosphoryl]adenosine, CRISPR-associated protein, APE2256 family | | 著者 | Molina, R, Jensen, A.L.G, Marchena-Hurtado, J, Lopez-Mendez, B, Stella, S, Montoya, G. | | 登録日 | 2021-09-16 | | 公開日 | 2021-11-24 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2.85 Å) | | 主引用文献 | Structural basis of cyclic oligoadenylate degradation by ancillary Type III CRISPR-Cas ring nucleases.
Nucleic Acids Res., 49, 2021
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7PQ2
 | | Crystal Structure of the Ring Nuclease 0811 from Sulfolobus islandicus (Sis0811) in its apo form | | 分子名称: | CRISPR-associated protein, APE2256 family, CRISPR Ring Nuclease | | 著者 | Molina, R, Jensen, A.L.G, Marchena-Hurtado, J, Lopez-Mendez, B, Stella, S, Montoya, G. | | 登録日 | 2021-09-16 | | 公開日 | 2021-11-24 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2.38 Å) | | 主引用文献 | Structural basis of cyclic oligoadenylate degradation by ancillary Type III CRISPR-Cas ring nucleases.
Nucleic Acids Res., 49, 2021
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7PQA
 | | Crystal Structure of the Ring Nuclease 0811 mutant-S12G/K169G from Sulfolobus islandicus (Sis0811) | | 分子名称: | CRISPR-associated protein, APE2256 family | | 著者 | Molina, R, Jensen, A.L.G, Marchena-Hurtado, J, Lopez-Mendez, B, Stella, S, Montoya, G. | | 登録日 | 2021-09-16 | | 公開日 | 2021-12-01 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2.04 Å) | | 主引用文献 | Structural basis of cyclic oligoadenylate degradation by ancillary Type III CRISPR-Cas ring nucleases.
Nucleic Acids Res., 49, 2021
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4UNA
 | | THE CRYSTAL STRUCTURE OF I-DMOI IN COMPLEX WITH ITS TARGET DNA AT 2 DAYS INCUBATION IN 5MM MN (STATE 4) | | 分子名称: | 25MER, 5'-D(*CP*CP*GP*GP*CP*AP*AP*GP*GP*C)-3', 5'-D(*CP*GP*CP*GP*CP*CP*GP*GP*AP*AP*CP*TP*TP*AP*C)-3', ... | | 著者 | Molina, R, Stella, S, Redondo, P, Gomez, H, Marcaida, M.J, Orozco, M, Prieto, J, Montoya, G. | | 登録日 | 2014-05-26 | | 公開日 | 2014-12-17 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Visualizing Phosphodiester-Bond Hydrolysis by an Endonuclease.
Nat.Struct.Mol.Biol., 22, 2015
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4UNB
 | | THE CRYSTAL STRUCTURE OF I-DMOI IN COMPLEX WITH ITS TARGET DNA AT 6 DAYS INCUBATION IN 5MM MN (STATE 5) | | 分子名称: | 5'-D(*CP*CP*GP*GP*CP*AP*AP*GP*GP*C)-3', 5'-D(*CP*GP*CP*GP*CP*CP*GP*GP*AP*AP*CP*TP*TP*AP*C)-3', 5'-D(*GP*CP*CP*TP*TP*GP*CP*CP*GP*GP*GP*TP*AP*A)-3', ... | | 著者 | Molina, R, Stella, S, Redondo, P, Gomez, H, Marcaida, M.J, Orozco, M, Prieto, J, Montoya, G. | | 登録日 | 2014-05-26 | | 公開日 | 2014-12-17 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (2.55 Å) | | 主引用文献 | Visualizing Phosphodiester-Bond Hydrolysis by an Endonuclease.
Nat.Struct.Mol.Biol., 22, 2015
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4UNC
 | | THE CRYSTAL STRUCTURE OF I-DMOI IN COMPLEX WITH ITS TARGET DNA AT 8 DAYS INCUBATION IN 5MM MN (STATE 6) | | 分子名称: | 5'-D(*CP*CP*GP*GP*CP*AP*AP*GP*GP*C)-3', 5'-D(*CP*GP*CP*GP*CP*CP*GP*GP*AP*AP*CP*TP*TP*AP*C)-3', 5'-D(*GP*CP*CP*TP*TP*GP*CP*CP*GP*GP*GP*TP*AP*A)-3', ... | | 著者 | Molina, R, Stella, S, Redondo, P, Gomez, H, Marcaida, M.J, Orozco, M, Prieto, J, Montoya, G. | | 登録日 | 2014-05-26 | | 公開日 | 2014-12-17 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Visualizing Phosphodiester-Bond Hydrolysis by an Endonuclease.
Nat.Struct.Mol.Biol., 22, 2015
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4UN8
 | | THE CRYSTAL STRUCTURE OF I-DMOI IN COMPLEX WITH ITS TARGET DNA AT 1H INCUBATION IN 5MM MN (STATE 2) | | 分子名称: | 25MER, HOMING ENDONUCLEASE I-DMOI, MANGANESE (II) ION | | 著者 | Molina, R, Stella, S, Redondo, P, Gomez, H, Marcaida, M.J, Orozco, M, Prieto, J, Montoya, G. | | 登録日 | 2014-05-26 | | 公開日 | 2014-12-17 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Visualizing Phosphodiester-Bond Hydrolysis by an Endonuclease.
Nat.Struct.Mol.Biol., 22, 2015
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4UN7
 | | THE CRYSTAL STRUCTURE OF I-DMOI IN COMPLEX WITH ITS TARGET DNA BEFORE INCUBATION IN 5MM MN (STATE 1) | | 分子名称: | 25MER, HOMING ENDONUCLEASE I-DMOI, ZINC ION | | 著者 | Molina, R, Stella, S, Redondo, P, Gomez, H, Marcaida, M.J, Orozco, M, Prieto, J, Montoya, G. | | 登録日 | 2014-05-26 | | 公開日 | 2014-12-03 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Visualizing Phosphodiester-Bond Hydrolysis by an Endonuclease.
Nat.Struct.Mol.Biol., 22, 2015
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4UN9
 | | THE CRYSTAL STRUCTURE OF I-DMOI IN COMPLEX WITH ITS TARGET DNA AT 8H INCUBATION IN 5MM MN (STATE 3) | | 分子名称: | 25MER, HOMING ENDONUCLEASE I-DMOI, MANGANESE (II) ION | | 著者 | Molina, R, Stella, S, Redondo, P, Gomez, H, Marcaida, M.J, Orozco, M, Prieto, J, Montoya, G. | | 登録日 | 2014-05-26 | | 公開日 | 2015-01-14 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (2.734 Å) | | 主引用文献 | Visualizing Phosphodiester-Bond Hydrolysis by an Endonuclease.
Nat.Struct.Mol.Biol., 22, 2015
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6S6B
 | | Type III-B Cmr-beta Cryo-EM structure of the Apo state | | 分子名称: | CRISPR-associated RAMP protein, Cmr4 family, Cmr6 family, ... | | 著者 | Sofos, N, Montoya, G, Stella, S. | | 登録日 | 2019-07-02 | | 公開日 | 2020-07-08 | | 最終更新日 | 2020-09-16 | | 実験手法 | ELECTRON MICROSCOPY (2.75 Å) | | 主引用文献 | Structures of the Cmr-beta Complex Reveal the Regulation of the Immunity Mechanism of Type III-B CRISPR-Cas.
Mol.Cell, 79, 2020
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6S8B
 | | Cryo-EM structure of the Type III-B Cmr-beta bound to cognate target RNA and AMPPnP, state 1 | | 分子名称: | CRISPR-associated RAMP protein, Cmr4 family, Cmr6 family, ... | | 著者 | Sofos, N, Montoya, G, Stella, S. | | 登録日 | 2019-07-09 | | 公開日 | 2020-07-08 | | 最終更新日 | 2020-09-16 | | 実験手法 | ELECTRON MICROSCOPY (2.41 Å) | | 主引用文献 | Structures of the Cmr-beta Complex Reveal the Regulation of the Immunity Mechanism of Type III-B CRISPR-Cas.
Mol.Cell, 79, 2020
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6S91
 | | Cryo-EM structure of the Type III-B Cmr-beta bound to cognate target RNA and AMPPnP, state 2 | | 分子名称: | CRISPR-associated RAMP protein, Cmr4 family, Cmr6 family, ... | | 著者 | Sofos, N, Montoya, G, Stella, S. | | 登録日 | 2019-07-11 | | 公開日 | 2020-07-08 | | 最終更新日 | 2020-09-16 | | 実験手法 | ELECTRON MICROSCOPY (2.68 Å) | | 主引用文献 | Structures of the Cmr-beta Complex Reveal the Regulation of the Immunity Mechanism of Type III-B CRISPR-Cas.
Mol.Cell, 79, 2020
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6SIC
 | | Cryo-EM structure of the Type III-B Cmr-beta bound to cognate target RNA | | 分子名称: | CRISPR-associated RAMP protein, Cmr1 family, Cmr4 family, ... | | 著者 | Sofos, N, Montoya, G, Stella, S. | | 登録日 | 2019-08-09 | | 公開日 | 2020-07-08 | | 最終更新日 | 2020-09-16 | | 実験手法 | ELECTRON MICROSCOPY (3.52 Å) | | 主引用文献 | Structures of the Cmr-beta Complex Reveal the Regulation of the Immunity Mechanism of Type III-B CRISPR-Cas.
Mol.Cell, 79, 2020
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6S8E
 | | Cryo-EM structure of the type III-B Cmr-beta complex bound to non-cognate target RNA | | 分子名称: | CRISPR-associated RAMP protein, Cmr4 family, Cmr6 family, ... | | 著者 | Sofos, N, Montoya, G, Stella, S. | | 登録日 | 2019-07-09 | | 公開日 | 2020-07-08 | | 最終更新日 | 2020-09-16 | | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | | 主引用文献 | Structures of the Cmr-beta Complex Reveal the Regulation of the Immunity Mechanism of Type III-B CRISPR-Cas.
Mol.Cell, 79, 2020
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6SH8
 | | Cryo-EM structure of the Type III-B Cmr-beta bound to cognate target RNA and AMPPnP, state 2, in the presence of ssDNA | | 分子名称: | CRISPR-associated RAMP protein, Cmr4 family, Cmr6 family, ... | | 著者 | Sofos, N, Montoya, G, Stella, S. | | 登録日 | 2019-08-06 | | 公開日 | 2020-07-08 | | 最終更新日 | 2020-09-16 | | 実験手法 | ELECTRON MICROSCOPY (3.14 Å) | | 主引用文献 | Structures of the Cmr-beta Complex Reveal the Regulation of the Immunity Mechanism of Type III-B CRISPR-Cas.
Mol.Cell, 79, 2020
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6SHB
 | | Cryo-EM structure of the Type III-B Cmr-beta bound to cognate target RNA and AMPPnP, state 1, in the presence of ssDNA | | 分子名称: | CRISPR-associated RAMP protein, Cmr4 family, Cmr6 family, ... | | 著者 | Sofos, N, Montoya, G, Stella, S. | | 登録日 | 2019-08-06 | | 公開日 | 2020-07-08 | | 最終更新日 | 2020-09-16 | | 実験手法 | ELECTRON MICROSCOPY (3.07 Å) | | 主引用文献 | Structures of the Cmr-beta Complex Reveal the Regulation of the Immunity Mechanism of Type III-B CRISPR-Cas.
Mol.Cell, 79, 2020
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6GTE
 | | Transient state structure of CRISPR-Cpf1 (Cas12a) I3 conformation | | 分子名称: | CRISPR-associated endonuclease Cas12a, DNA (5'-D(P*AP*TP*GP*AP*CP*TP*TP*CP*TP*CP*TP*AP*AP*CP*AP*AP*GP*CP*TP*CP*G)-3'), DNA (5'-D(P*CP*GP*AP*GP*CP*TP*CP*GP*TP*TP*AP*GP*AP*GP*AP*AP*G)-3'), ... | | 著者 | Montoya, G, Mesa, P, Stella, S. | | 登録日 | 2018-06-18 | | 公開日 | 2018-12-19 | | 最終更新日 | 2024-05-15 | | 実験手法 | ELECTRON MICROSCOPY (4.07 Å) | | 主引用文献 | Conformational Activation Promotes CRISPR-Cas12a Catalysis and Resetting of the Endonuclease Activity.
Cell, 175, 2018
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6GTG
 | | Transition state structure of Cpf1(Cas12a) I4 conformation | | 分子名称: | CRISPR-associated endonuclease Cas12a, DNA (32-MER), DNA (5'-D(P*CP*GP*AP*GP*CP*TP*CP*GP*TP*TP*AP*GP*AP*GP*AP*AP*GP*T)-3'), ... | | 著者 | Mesa, P, Montoya, G, Stella, S. | | 登録日 | 2018-06-18 | | 公開日 | 2018-12-19 | | 最終更新日 | 2024-05-15 | | 実験手法 | ELECTRON MICROSCOPY (3.27 Å) | | 主引用文献 | Conformational Activation Promotes CRISPR-Cas12a Catalysis and Resetting of the Endonuclease Activity.
Cell, 175, 2018
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6GTF
 | | Transient state structure of CRISPR-Cpf1 (Cas12a) I5 conformation | | 分子名称: | CRISPR-associated endonuclease Cas12a, DNA (5'-D(P*AP*TP*GP*AP*CP*TP*TP*CP*TP*CP*TP*AP*AP*CP*AP*AP*GP*CP*TP*CP*G)-3'), DNA (5'-D(P*CP*GP*AP*GP*CP*TP*CP*GP*TP*TP*AP*GP*AP*GP*AP*A)-3'), ... | | 著者 | Montoya, G, Mesa, P, Stella, S. | | 登録日 | 2018-06-18 | | 公開日 | 2018-12-19 | | 最終更新日 | 2024-05-15 | | 実験手法 | ELECTRON MICROSCOPY (3.63 Å) | | 主引用文献 | Conformational Activation Promotes CRISPR-Cas12a Catalysis and Resetting of the Endonuclease Activity.
Cell, 175, 2018
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4AAB
 | | Crystal structure of the mutant D75N I-CreI in complex with its wild- type target (The four central bases, 2NN region, are composed by GTAC from 5' to 3') | | 分子名称: | 10MER DNA 5'-D(*GP*AP*CP*GP*TP*TP*TP*TP*GP*AP)-3', 14MER DNA 5'-D(*TP*CP*AP*AP*AP*AP*CP*GP*TP*CP*GP*TP*AP*CP)-3', DNA ENDONUCLEASE I-CREI, ... | | 著者 | Molina, R, Redondo, P, Stella, S, Marenchino, M, D'Abramo, M, Gervasio, F.L, Epinat, J.C, Valton, J, Grizot, S, Duchateau, P, Prieto, J, Montoya, G. | | 登録日 | 2011-12-01 | | 公開日 | 2012-05-02 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Non-Specific Protein-DNA Interactions Control I-Crei Target Binding and Cleavage.
Nucleic Acids Res., 40, 2012
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4D6O
 | | THE CRYSTAL STRUCTURE OF I-DMOI IN COMPLEX WITH ITS TARGET DNA AT 1H INCUBATION IN 5MM MG (STATE 2) | | 分子名称: | 25MER, ACETATE ION, HOMING ENDONUCLEASE I-DMOI, ... | | 著者 | Molina, R, Stella, S, Redondo, P, Gomez, H, Marcaida, M.J, Orozco, M, Prieto, J, Montoya, G. | | 登録日 | 2014-11-13 | | 公開日 | 2014-12-17 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Visualizing Phosphodiester-Bond Hydrolysis by an Endonuclease.
Nat.Struct.Mol.Biol., 22, 2015
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4D6N
 | | THE CRYSTAL STRUCTURE OF I-DMOI IN COMPLEX WITH ITS TARGET DNA AT 10 DAYS INCUBATION IN 5MM MG (STATE 7) | | 分子名称: | 5'-D(*DCP*CP*GP*GP*CP*AP*AP*GP*GP*CP)-3', 5'-D(*DCP*GP*CP*GP*CP*CP*GP*GP*AP*AP*CP*TP*TP*DAP*C)-3', 5'-D(*DGP*CP*CP*TP*TP*GP*CP*CP*GP*GP*GP*TP*AP*DAP)-3', ... | | 著者 | Molina, R, Stella, S, Redondo, P, Gomez, H, Marcaida, M.J, Orozco, M, Prieto, J, Montoya, G. | | 登録日 | 2014-11-13 | | 公開日 | 2014-12-17 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | | 主引用文献 | Visualizing Phosphodiester-Bond Hydrolysis by an Endonuclease.
Nat.Struct.Mol.Biol., 22, 2015
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