5W2F
| Crystal Structure of the C-terminal Domain of Human eIF2D at 1.4 A resolution | 分子名称: | Eukaryotic translation initiation factor 2D, FORMIC ACID | 著者 | Vaidya, A.T, Lomakin, I.B, Joseph, N.N, Dmitriev, S.E, Steitz, T.A. | 登録日 | 2017-06-06 | 公開日 | 2017-08-02 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | Crystal Structure of the C-terminal Domain of Human eIF2D and Its Implications on Eukaryotic Translation Initiation. J. Mol. Biol., 429, 2017
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4V7Y
| Structure of the Thermus thermophilus 70S ribosome complexed with azithromycin. | 分子名称: | 16S rRNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... | 著者 | Bulkley, D.P, Innis, C.A, Blaha, G, Steitz, T.A. | 登録日 | 2010-08-18 | 公開日 | 2014-07-09 | 最終更新日 | 2014-12-10 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Revisiting the structures of several antibiotics bound to the bacterial ribosome. Proc.Natl.Acad.Sci.USA, 107, 2010
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4V7X
| Structure of the Thermus thermophilus ribosome complexed with erythromycin. | 分子名称: | 16S rRNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... | 著者 | Bulkley, D.P, Innis, C.A, Blaha, G, Steitz, T.A. | 登録日 | 2010-08-17 | 公開日 | 2014-07-09 | 最終更新日 | 2014-12-10 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Revisiting the structures of several antibiotics bound to the bacterial ribosome. Proc.Natl.Acad.Sci.USA, 107, 2010
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5TBZ
| E. Coli RNA Polymerase complexed with NusG | 分子名称: | DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... | 著者 | Liu, B, Steitz, T.A. | 登録日 | 2016-09-13 | 公開日 | 2016-12-07 | 最終更新日 | 2019-12-25 | 実験手法 | X-RAY DIFFRACTION (7 Å) | 主引用文献 | Structural insights into NusG regulating transcription elongation. Nucleic Acids Res., 45, 2017
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3J4J
| Model of full-length T. thermophilus Translation Initiation Factor 2 refined against its cryo-EM density from a 30S Initiation Complex map | 分子名称: | Translation initiation factor IF-2 | 著者 | Simonetti, A, Marzi, S, Billas, I.M.L, Tsai, A, Fabbretti, A, Myasnikov, A, Roblin, P, Vaiana, A.C, Hazemann, I, Eiler, D, Steitz, T.A, Puglisi, J.D, Gualerzi, C.O, Klaholz, B.P. | 登録日 | 2013-08-26 | 公開日 | 2013-09-25 | 最終更新日 | 2024-02-21 | 実験手法 | ELECTRON MICROSCOPY (11.5 Å) | 主引用文献 | Involvement of protein IF2 N domain in ribosomal subunit joining revealed from architecture and function of the full-length initiation factor. Proc.Natl.Acad.Sci.USA, 110, 2013
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3P22
| Crystal structure of the ENE, a viral RNA stability element, in complex with A9 RNA | 分子名称: | Core ENE hairpin from KSHV PAN RNA, oligo(A)9 RNA | 著者 | Mitton-Fry, R.M, DeGregorio, S.J, Wang, J, Steitz, T.A, Steitz, J.A. | 登録日 | 2010-10-01 | 公開日 | 2010-12-08 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.501 Å) | 主引用文献 | Poly(A) tail recognition by a viral RNA element through assembly of a triple helix. Science, 330, 2010
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4V8H
| Crystal structure of HPF bound to the 70S ribosome. | 分子名称: | 16S Ribosomal RNA, 23S Ribosomal RNA, 30S Ribosomal Protein S10, ... | 著者 | Polikanov, Y.S, Blaha, G.M, Steitz, T.A. | 登録日 | 2011-12-11 | 公開日 | 2014-07-09 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | 主引用文献 | How Hibernation Factors RMF, HPF, and YfiA Turn Off Protein Synthesis. Science, 336, 2012
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4V9S
| Crystal structure of antibiotic GE82832 bound to 70S ribosome | 分子名称: | 16S Ribosomal RNA, 23S Ribosomal RNA, 30S Ribosomal Protein S10, ... | 著者 | Bulkley, D.P, Brandi, L, Polikanov, Y.S, Fabbretti, A, O'Connor, M, Gualerzi, C.O, Steitz, T.A. | 登録日 | 2013-12-05 | 公開日 | 2014-07-09 | 最終更新日 | 2018-06-27 | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | 主引用文献 | The antibiotics dityromycin and GE82832 bind protein S12 and block EF-G-catalyzed translocation. Cell Rep, 6, 2014
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4V8I
| Crystal structure of YfiA bound to the 70S ribosome. | 分子名称: | 16S Ribosomal RNA, 23S Ribosomal RNA, 30S Ribosomal Protein S10, ... | 著者 | Polikanov, Y.S, Blaha, G.M, Steitz, T.A. | 登録日 | 2011-12-12 | 公開日 | 2014-07-09 | 最終更新日 | 2014-12-10 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | How hibernation factors RMF, HPF, and YfiA turn off protein synthesis. Science, 336, 2012
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4V8A
| The structure of thermorubin in complex with the 70S ribosome from Thermus thermophilus. | 分子名称: | 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... | 著者 | Bulkley, D, Johnson, F.A, Steitz, T.A. | 登録日 | 2011-12-05 | 公開日 | 2014-07-09 | 最終更新日 | 2014-12-10 | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | 主引用文献 | The antibiotic thermorubin inhibits protein synthesis by binding to inter-subunit bridge b2a of the ribosome. J.Mol.Biol., 416, 2012
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4V95
| Crystal structure of YAEJ bound to the 70S ribosome | 分子名称: | 16S Ribosomal RNA, 23S Ribosomal RNA, 30S Ribosomal Protein S10, ... | 著者 | Gagnon, M.G, Seetharaman, S.V, Bulkley, D.P, Steitz, T.A. | 登録日 | 2012-01-27 | 公開日 | 2014-07-09 | 最終更新日 | 2018-07-11 | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | 主引用文献 | Structural basis for the rescue of stalled ribosomes: structure of YaeJ bound to the ribosome. Science, 335, 2012
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4V5H
| E.Coli 70s Ribosome Stalled During Translation Of Tnac Leader Peptide. | 分子名称: | 16S RIBOSOMAL RNA, 23S RIBOSOMAL RNA, 30S RIBOSOMAL PROTEIN S10, ... | 著者 | Seidelt, B, Innis, C.A, Wilson, D.N, Gartmann, M, Armache, J, Villa, E, Trabuco, L.G, Becker, T, Mielke, T, Schulten, K, Steitz, T.A, Beckmann, R. | 登録日 | 2009-10-26 | 公開日 | 2014-07-09 | 最終更新日 | 2024-05-08 | 実験手法 | ELECTRON MICROSCOPY (5.8 Å) | 主引用文献 | Structural insight into nascent polypeptide chain-mediated translational stalling. Science, 326, 2009
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4IQJ
| Structure of PolIIIalpha-Tauc-DNA complex suggests an atomic model of the replisome | 分子名称: | DNA (5'-D(*TP*TP*TP*TP*TP*TP*TP*GP*TP*GP*GP*CP*AP*CP*TP*GP*GP*CP*CP*GP*TP*CP*GP*TP*TP*TP*CP*G)-3'), DNA (5'-D(P*CP*GP*AP*AP*AP*CP*GP*AP*CP*GP*GP*CP*CP*AP*GP*TP*GP*CP*CP*A)-3'), DNA (5'-D(P*CP*GP*AP*AP*AP*CP*GP*AP*CP*GP*GP*CP*CP*AP*GP*TP*GP*CP*CP*AP*(DOC))-3'), ... | 著者 | Liu, B, Lin, J, Steitz, T. | 登録日 | 2013-01-11 | 公開日 | 2013-03-13 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | 主引用文献 | Structure of PolIIIalpha-Tauc-DNA complex suggests an atomic model of the replisome Structure, 21, 2013
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6MS4
| Crystal structure of the DENR-MCT-1 complex | 分子名称: | Density-regulated protein, GLYCEROL, Malignant T-cell-amplified sequence 1, ... | 著者 | Lomakin, I.B, Steitz, T.A, Dmitriev, S.E. | 登録日 | 2018-10-16 | 公開日 | 2019-01-02 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.001 Å) | 主引用文献 | Crystal structure of the DENR-MCT-1 complex revealed zinc-binding site essential for heterodimer formation. Proc. Natl. Acad. Sci. U.S.A., 116, 2019
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4W2I
| Crystal structure of the Thermus thermophilus 70S ribosome in complex with negamycin, mRNA and three deacylated tRNAs in the A, P and E sites | 分子名称: | 16S Ribosomal RNA, 23S Ribosomal RNA, 30S Ribosomal Protein S10, ... | 著者 | Polikanov, Y.S, Szal, T, Jiang, F, Gupta, P, Matsuda, R, Shiozuka, M, Steitz, T.A, Vazquez-Laslop, N, Mankin, A.S. | 登録日 | 2014-09-12 | 公開日 | 2014-10-15 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Negamycin Interferes with Decoding and Translocation by Simultaneous Interaction with rRNA and tRNA. Mol.Cell, 56, 2014
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2KZZ
| KLENOW FRAGMENT WITH NORMAL SUBSTRATE AND ZINC ONLY | 分子名称: | DNA (5'-D(*GP*CP*TP*T*AP*CP*G)-3'), PROTEIN (DNA POLYMERASE I), ZINC ION | 著者 | Brautigam, C.A, Sun, S, Piccirilli, J.A, Steitz, T.A. | 登録日 | 1998-07-07 | 公開日 | 1999-12-14 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | 主引用文献 | Structures of normal single-stranded DNA and deoxyribo-3'-S-phosphorothiolates bound to the 3'-5' exonucleolytic active site of DNA polymerase I from Escherichia coli. Biochemistry, 38, 1999
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430D
| STRUCTURE OF SARCIN/RICIN LOOP FROM RAT 28S RRNA | 分子名称: | MAGNESIUM ION, SARCIN/RICIN LOOP FROM RAT 28S R-RNA | 著者 | Correll, C.C, Munishkin, A, Chan, Y.L, Ren, Z, Wool, I.G, Steitz, T.A. | 登録日 | 1998-10-04 | 公開日 | 1998-10-07 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Crystal structure of the ribosomal RNA domain essential for binding elongation factors. Proc.Natl.Acad.Sci.USA, 95, 1998
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354D
| Structure of loop E FROM E. coli 5S RRNA | 分子名称: | MAGNESIUM ION, RNA (5'-R(*CP*CP*GP*AP*UP*GP*GP*UP*AP*GP*UP*G)-3'), RNA-DNA (5'-R(*GP*CP*GP*AP*GP*AP*GP*UP*AP*)-D(*DGP(S)*)-R(*GP*C)-3') | 著者 | Correll, C.C, Freeborn, B, Moore, P.B, Steitz, T.A. | 登録日 | 1997-10-01 | 公開日 | 1997-11-26 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Metals, motifs, and recognition in the crystal structure of a 5S rRNA domain. Cell(Cambridge,Mass.), 91, 1997
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5DOX
| Crystal structure of the Thermus thermophilus 70S ribosome in complex with Hygromycin-A at 3.1A resolution | 分子名称: | 16S Ribosomal RNA, 23S Ribosomal RNA, 30S ribosomal protein S10, ... | 著者 | Polikanov, Y.S, Starosta, A.L, Juette, M.F, Altman, R.B, Terry, D.S, Lu, W, Burnett, B.J, Dinos, G, Reynolds, K, Blanchard, S.C, Steitz, T.A, Wilson, D.N. | 登録日 | 2015-09-11 | 公開日 | 2015-12-30 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | 主引用文献 | Distinct tRNA Accommodation Intermediates Observed on the Ribosome with the Antibiotics Hygromycin A and A201A. Mol.Cell, 58, 2015
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5DOY
| Crystal structure of the Thermus thermophilus 70S ribosome in complex with antibiotic Hygromycin A, mRNA and three tRNAs in the A, P and E sites at 2.6A resolution | 分子名称: | 16S Ribosomal RNA, 23S Ribosomal RNA, 30S Ribosomal Protein S10, ... | 著者 | Polikanov, Y.S, Starosta, A.L, Juette, M.F, Altman, R.B, Terry, D.S, Lu, W, Burnett, B.J, Dinos, G, Reynolds, K, Blanchard, S.C, Steitz, T.A, Wilson, D.N. | 登録日 | 2015-09-11 | 公開日 | 2015-12-30 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Distinct tRNA Accommodation Intermediates Observed on the Ribosome with the Antibiotics Hygromycin A and A201A. Mol.Cell, 58, 2015
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4V7W
| Structure of the Thermus thermophilus ribosome complexed with chloramphenicol. | 分子名称: | 16S rRNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... | 著者 | Bulkley, D.P, Innis, C.A, Blaha, G, Steitz, T.A. | 登録日 | 2010-08-16 | 公開日 | 2014-07-09 | 最終更新日 | 2014-12-10 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Revisiting the structures of several antibiotics bound to the bacterial ribosome. Proc.Natl.Acad.Sci.USA, 107, 2010
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2KFZ
| KLENOW FRAGMENT WITH BRIDGING-SULFUR SUBSTRATE AND ZINC ONLY | 分子名称: | 5'-D(*GP*CP*TP*TP*AP*(US1)P*G)-3', KLENOW FRAGMENT OF DNA POLYMERASE I, MAGNESIUM ION, ... | 著者 | Brautigam, C.A, Sun, S, Piccirilli, J.A, Steitz, T.A. | 登録日 | 1998-07-02 | 公開日 | 1998-11-11 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.03 Å) | 主引用文献 | Structures of normal single-stranded DNA and deoxyribo-3'-S-phosphorothiolates bound to the 3'-5' exonucleolytic active site of DNA polymerase I from Escherichia coli. Biochemistry, 38, 1999
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2KZM
| KLENOW FRAGMENT WITH NORMAL SUBSTRATE AND ZINC AND MANGANESE | 分子名称: | DNA (5'-D(*GP*CP*TP*TP*A*CP*GP*C)-3'), MANGANESE (II) ION, PROTEIN (DNA POLYMERASE I), ... | 著者 | Brautigam, C.A, Sun, S, Piccirilli, J.A, Steitz, T.A. | 登録日 | 1998-07-03 | 公開日 | 1999-02-16 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Structures of normal single-stranded DNA and deoxyribo-3'-S-phosphorothiolates bound to the 3'-5' exonucleolytic active site of DNA polymerase I from Escherichia coli. Biochemistry, 38, 1999
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2KFN
| KLENOW FRAGMENT WITH BRIDGING-SULFUR SUBSTRATE AND MANGANESE | 分子名称: | 5'-D(*GP*CP*TP*TP*AP*(US1)P*G)-3', KLENOW FRAGMENT OF DNA POLYMERASE I, MAGNESIUM ION, ... | 著者 | Brautigam, C.A, Sun, S, Piccirilli, J.A, Steitz, T.A. | 登録日 | 1998-07-01 | 公開日 | 1998-11-11 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.03 Å) | 主引用文献 | Structures of normal single-stranded DNA and deoxyribo-3'-S-phosphorothiolates bound to the 3'-5' exonucleolytic active site of DNA polymerase I from Escherichia coli. Biochemistry, 38, 1999
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6DUG
| Crystal structure of HIV-1 reverse transcriptase K101P mutant in complex with non-nucleoside inhibitor 25a | 分子名称: | 1,2-ETHANEDIOL, 4-({4-[(4-{4-[(E)-2-cyanoethenyl]-2,6-dimethylphenoxy}thieno[3,2-d]pyrimidin-2-yl)amino]piperidin-1-yl}methyl)benzene-1-sulfonamide, DIMETHYL SULFOXIDE, ... | 著者 | Yang, Y, Nguyen, L.A, Smithline, Z.B, Steitz, T.A. | 登録日 | 2018-06-20 | 公開日 | 2018-08-01 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.225 Å) | 主引用文献 | Structural basis for potent and broad inhibition of HIV-1 RT by thiophene[3,2-d]pyrimidine non-nucleoside inhibitors. Elife, 7, 2018
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