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PDB: 17 件
6P7J
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BU of 6p7j by Molmil
Crystal structure of Latency Associated Peptide unbound to TGF-beta1
分子名称: Transforming growth factor beta-1 proprotein
著者Stachowski, T.R, Snell, M.E, Snell, E.H.
登録日2019-06-05
公開日2020-03-11
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (3.501 Å)
主引用文献Structural insights into conformational switching in latency-associated peptide between transforming growth factor beta-1 bound and unbound states
Iucrj, 7, 2020
6VE1
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BU of 6ve1 by Molmil
Crystal structure of endo-beta-N-acetylglucosaminidase H at high pH
分子名称: Endo-beta-N-acetylglucosaminidase H, MAGNESIUM ION
著者Stachowski, T.R, Snell, M.E, Snell, E.S.
登録日2019-12-28
公開日2020-11-25
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献SAXS studies of X-ray induced disulfide bond damage: Engineering high-resolution insight from a low-resolution technique.
Plos One, 15, 2020
7ULL
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BU of 7ull by Molmil
Human Grp94 N-terminal domain in complex with 42C
分子名称: DIMETHYL SULFOXIDE, Endoplasmin, GLYCEROL, ...
著者Stachowski, T.R, Nithianantham, S, Vanarotti, M, Fischer, M.
登録日2022-04-05
公開日2023-04-12
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2.31 Å)
主引用文献Pan-HSP90 ligand binding reveals isoform-specific differences in plasticity and water networks.
Protein Sci., 32, 2023
7ULK
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BU of 7ulk by Molmil
Human TRAP1 NM in complex with 42C
分子名称: CALCIUM ION, Heat shock protein 75 kDa, mitochondrial, ...
著者Stachowski, T.R, Nithianantham, S, Vanarotti, M, Fischer, M.
登録日2022-04-05
公開日2023-04-12
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2.34 Å)
主引用文献Pan-HSP90 ligand binding reveals isoform-specific differences in plasticity and water networks.
Protein Sci., 32, 2023
7ULJ
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BU of 7ulj by Molmil
Hsp90b N-terminal domain in complex with 42C
分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, GLYCEROL, Heat shock protein HSP 90-beta, ...
著者Stachowski, T.R, Nithianantham, S, Vanarotti, M, Fischer, M.
登録日2022-04-05
公開日2023-04-12
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (1.82 Å)
主引用文献Pan-HSP90 ligand binding reveals isoform-specific differences in plasticity and water networks.
Protein Sci., 32, 2023
7RN2
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BU of 7rn2 by Molmil
Crystal structure of the first bromodomain of human BRD4 in complex with SJ001010551-2
分子名称: 1,2-ETHANEDIOL, 2-[(6S,10S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl]-N-[(pyridin-2-yl)methyl]acetamide, Bromodomain-containing protein 4
著者Stachowski, T.R, Fischer, M.
登録日2021-07-28
公開日2022-08-03
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.05 Å)
主引用文献From PROTAC to inhibitor: Structure-guided discovery of potent and orally bioavailable BET inhibitors.
Eur.J.Med.Chem., 251, 2023
7RMD
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BU of 7rmd by Molmil
Crystal structure of the first bromodomain of human BRD4 in complex with SJ001011461-1
分子名称: 1,2-ETHANEDIOL, 2-[(6S,10R)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl]-N-(1,3,4-thiadiazol-2-yl)acetamide, Bromodomain-containing protein 4
著者Stachowski, T.R, Fischer, M.
登録日2021-07-27
公開日2022-08-03
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.18 Å)
主引用文献From PROTAC to inhibitor: Structure-guided discovery of potent and orally bioavailable BET inhibitors.
Eur.J.Med.Chem., 251, 2023
7S8Z
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BU of 7s8z by Molmil
Room-temperature apo Human Hsp90a-NTD
分子名称: Heat shock protein HSP 90-alpha
著者Stachowski, T.R, Vanarotti, M, Lopez, K, Fischer, M.
登録日2021-09-20
公開日2022-08-03
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.64 Å)
主引用文献Water Networks Repopulate Protein-Ligand Interfaces with Temperature.
Angew.Chem.Int.Ed.Engl., 61, 2022
7S9G
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BU of 7s9g by Molmil
Room-temperature Human Hsp90a-NTD bound to BIIB021
分子名称: 6-chloro-9-[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]-9H-purin-2-amine, Heat shock protein HSP 90-alpha, MAGNESIUM ION
著者Stachowski, T.R, Vanarotti, M, Fischer, M.
登録日2021-09-21
公開日2022-08-03
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.79 Å)
主引用文献Water Networks Repopulate Protein-Ligand Interfaces with Temperature.
Angew.Chem.Int.Ed.Engl., 61, 2022
7S9F
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BU of 7s9f by Molmil
Cryogenic Human Hsp90a-NTD bound to BIIB021
分子名称: 6-chloro-9-[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]-9H-purin-2-amine, Heat shock protein HSP 90-alpha, MAGNESIUM ION
著者Stachowski, T.R, Vanarotti, M, Seetharaman, J, Fischer, M.
登録日2021-09-20
公開日2022-08-03
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Water Networks Repopulate Protein-Ligand Interfaces with Temperature.
Angew.Chem.Int.Ed.Engl., 61, 2022
7S95
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BU of 7s95 by Molmil
Room-temperature Human Hsp90a-NTD bound to adenine
分子名称: ADENINE, Heat shock protein HSP 90-alpha
著者Stachowski, T.R, Vanarotti, M, Lopez, K, Fischer, M.
登録日2021-09-20
公開日2022-08-03
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (1.71 Å)
主引用文献Water Networks Repopulate Protein-Ligand Interfaces with Temperature.
Angew.Chem.Int.Ed.Engl., 61, 2022
7S9I
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BU of 7s9i by Molmil
Room-temperature Human Hsp90a-NTD bound to EC144
分子名称: 5-{2-amino-4-chloro-7-[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]-7H-pyrrolo[2,3-d]pyrimidin-5-yl}-2-methylpent-4-yn-2 -ol, Heat shock protein HSP 90-alpha
著者Stachowski, T.R, Vanarotti, M, Fischer, M.
登録日2021-09-21
公開日2022-08-03
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Water Networks Repopulate Protein-Ligand Interfaces with Temperature.
Angew.Chem.Int.Ed.Engl., 61, 2022
7S98
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BU of 7s98 by Molmil
Cryogenic Human Hsp90a-NTD bound to N6M
分子名称: Heat shock protein HSP 90-alpha, N-METHYL-9H-PURIN-6-AMINE
著者Stachowski, T.R, Vanarotti, M, Lopez, K, Fischer, M.
登録日2021-09-20
公開日2022-08-03
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Water Networks Repopulate Protein-Ligand Interfaces with Temperature.
Angew.Chem.Int.Ed.Engl., 61, 2022
7S9H
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BU of 7s9h by Molmil
Cryogenic Human Hsp90a-NTD bound to EC144
分子名称: 5-{2-amino-4-chloro-7-[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]-7H-pyrrolo[2,3-d]pyrimidin-5-yl}-2-methylpent-4-yn-2 -ol, Heat shock protein HSP 90-alpha, MAGNESIUM ION
著者Stachowski, T.R, Vanarotti, M, Seetharaman, J, Fischer, M.
登録日2021-09-21
公開日2022-08-03
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.45 Å)
主引用文献Water Networks Repopulate Protein-Ligand Interfaces with Temperature.
Angew.Chem.Int.Ed.Engl., 61, 2022
7S90
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BU of 7s90 by Molmil
Cryogenic Human Hsp90a-NTD bound to adenine
分子名称: ADENINE, Heat shock protein HSP 90-alpha
著者Stachowski, T.R, Vanarotti, M, Lopez, K, Fischer, M.
登録日2021-09-20
公開日2022-08-03
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (1.79 Å)
主引用文献Water Networks Repopulate Protein-Ligand Interfaces with Temperature.
Angew.Chem.Int.Ed.Engl., 61, 2022
7S8Y
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BU of 7s8y by Molmil
Cryogenic apo Human Hsp90a-NTD
分子名称: Heat shock protein HSP 90-alpha
著者Stachowski, T.R, Vanarotti, M, Lopez, K, Fischer, M.
登録日2021-09-20
公開日2022-08-03
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.59 Å)
主引用文献Water Networks Repopulate Protein-Ligand Interfaces with Temperature.
Angew.Chem.Int.Ed.Engl., 61, 2022
7S99
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BU of 7s99 by Molmil
Room-temperature Human Hsp90a-NTD bound to N6M
分子名称: Heat shock protein HSP 90-alpha, N-METHYL-9H-PURIN-6-AMINE
著者Stachowski, T.R, Vanarotti, M, Lopez, K, Fischer, M.
登録日2021-09-20
公開日2022-08-03
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.52 Å)
主引用文献Water Networks Repopulate Protein-Ligand Interfaces with Temperature.
Angew.Chem.Int.Ed.Engl., 61, 2022

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件を2024-07-24に公開中

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