7S9I

Room-temperature Human Hsp90a-NTD bound to EC144

Summary for 7S9I

Entry DOI	10.2210/pdb7s9i/pdb
Descriptor	Heat shock protein HSP 90-alpha, 5-{2-amino-4-chloro-7-[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]-7H-pyrrolo[2,3-d]pyrimidin-5-yl}-2-methylpent-4-yn-2 -ol (3 entities in total)
Functional Keywords	heat shock, chaperone, signaling, hydrolase
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	27153.82
Authors	Stachowski, T.R.,Vanarotti, M.,Fischer, M. (deposition date: 2021-09-21, release date: 2022-08-03, Last modification date: 2023-10-18)
Primary citation	Stachowski, T.R.,Vanarotti, M.,Seetharaman, J.,Lopez, K.,Fischer, M. Water Networks Repopulate Protein-Ligand Interfaces with Temperature. Angew.Chem.Int.Ed.Engl., 61:e202112919-e202112919, 2022 Cited by PubMed: 35648650 DOI: 10.1002/anie.202112919 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.75 Å)

Structure validation