6XJN
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2II0
| Crystal Structure of catalytic domain of Son of sevenless (Rem-Cdc25) in the absence of Ras | Descriptor: | Son of sevenless homolog 1 | Authors: | Freedman, T.S, Sondermann, H, Friedland, G.D, Kortemme, T, Bar-Sagi, D, Marqusee, S, Kuriyan, J. | Deposit date: | 2006-09-27 | Release date: | 2006-10-31 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.02 Å) | Cite: | A Ras-induced conformational switch in the Ras activator Son of sevenless. Proc.Natl.Acad.Sci.Usa, 103, 2006
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5EXP
| AAA+ domain of FleQ from Pseudomonas aeruginosa | Descriptor: | 1,2-ETHANEDIOL, SULFATE ION, Transcriptional regulator FleQ | Authors: | Navarro, M.V.A.S, Sondermann, H, Matsuyama, B.Y. | Deposit date: | 2015-11-24 | Release date: | 2016-01-13 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Mechanistic insights into c-di-GMP-dependent control of the biofilm regulator FleQ from Pseudomonas aeruginosa. Proc.Natl.Acad.Sci.USA, 113, 2016
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5EUH
| Crystal structure of the c-di-GMP-bound GGDEF domain of P. fluorescens GcbC | Descriptor: | 9,9'-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one), Putative GGDEF domain membrane protein, SULFATE ION | Authors: | Giglio, K.M, Cooley, R.B, Sondermann, H. | Deposit date: | 2015-11-18 | Release date: | 2015-12-30 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.989 Å) | Cite: | Contribution of Physical Interactions to Signaling Specificity between a Diguanylate Cyclase and Its Effector. Mbio, 6, 2015
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1NVV
| Structural evidence for feedback activation by RasGTP of the Ras-specific nucleotide exchange factor SOS | Descriptor: | MAGNESIUM ION, PHOSPHATE ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ... | Authors: | Margarit, S.M, Sondermann, H, Hall, B.E, Nagar, B, Hoelz, A, Pirruccello, M, Bar-Sagi, D, Kuriyan, J. | Deposit date: | 2003-02-04 | Release date: | 2003-04-01 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (2.18 Å) | Cite: | Structural evidence for feedback activation by RasGTP of the
Ras-specific nucleotide exchange factor SOS Cell(Cambridge,Mass.), 112, 2003
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1NVW
| Structural evidence for feedback activation by RasGTP of the Ras-specific nucleotide exchange factor SOS | Descriptor: | MAGNESIUM ION, PHOSPHATE ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ... | Authors: | Margarit, S.M, Sondermann, H, Hall, B.E, Nagar, B, Hoelz, A, Pirruccello, M, Bar-Sagi, D, Kuriyan, J. | Deposit date: | 2003-02-04 | Release date: | 2003-04-01 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Structural evidence for feedback activation by RasGTP of the Ras-specific nucleotide exchange factor SOS Cell(Cambridge,Mass.), 112, 2003
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1NVU
| Structural evidence for feedback activation by RasGTP of the Ras-specific nucleotide exchange factor SOS | Descriptor: | GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, PHOSPHATE ION, ... | Authors: | Margarit, S.M, Sondermann, H, Hall, B.E, Nagar, B, Hoelz, A, Pirruccello, M, Bar-Sagi, D, Kuriyan, J. | Deposit date: | 2003-02-04 | Release date: | 2003-04-01 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structural evidence for feedback activation by RasGTP of the Ras-specific nucleotide exchange factor SOS Cell(Cambridge,Mass.), 112, 2003
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4IDP
| human atlastin-1 1-446, N440T, GppNHp | Descriptor: | Atlastin-1, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER | Authors: | Byrnes, L.J, Singh, A, Szeto, K, Benvin, N.M, O'Donnell, J.P, Zipfel, W.R, Sondermann, H. | Deposit date: | 2012-12-12 | Release date: | 2013-01-09 | Last modified: | 2023-12-06 | Method: | X-RAY DIFFRACTION (2.587 Å) | Cite: | Structural basis for conformational switching and GTP loading of the large G protein atlastin. Embo J., 32, 2013
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4IDQ
| human atlastin-1 1-446, N440T, GDPAlF4- | Descriptor: | Atlastin-1, GUANOSINE-5'-DIPHOSPHATE, HEXAETHYLENE GLYCOL, ... | Authors: | Byrnes, L.J, Singh, A, Szeto, K, Benvin, N.M, O'Donnell, J.P, Zipfel, W.R, Sondermann, H. | Deposit date: | 2012-12-12 | Release date: | 2013-01-09 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.295 Å) | Cite: | Structural basis for conformational switching and GTP loading of the large G protein atlastin. Embo J., 32, 2013
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1NVX
| Structural evidence for feedback activation by RasGTP of the Ras-specific nucleotide exchange factor SOS | Descriptor: | GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, PHOSPHATE ION, ... | Authors: | Margarit, S.M, Sondermann, H, Hall, B.E, Nagar, B, Hoelz, A, Pirruccello, M, Bar-Sagi, D, Kuriyan, J. | Deposit date: | 2003-02-04 | Release date: | 2003-04-01 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Structural evidence for feedback activation by RasGTP of the Ras-specific nucleotide exchange factor SOS Cell(Cambridge,Mass.), 112, 2003
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4IDO
| human atlastin-1 1-446, C-his6, GDPAlF4- | Descriptor: | Atlastin-1, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... | Authors: | Byrnes, L.J, Singh, A, Szeto, K, Benvin, N.M, O'Donnell, J.P, Zipfel, W.R, Sondermann, H. | Deposit date: | 2012-12-12 | Release date: | 2013-01-09 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.091 Å) | Cite: | Structural basis for conformational switching and GTP loading of the large G protein atlastin. Embo J., 32, 2013
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4IDN
| Human atlastin-1 1-446, C-his6, GppNHp | Descriptor: | Atlastin-1, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER | Authors: | Byrnes, L.J, Singh, A, Szeto, K, Benvin, N.M, O'Donnell, J.P, Zipfel, W.R, Sondermann, H. | Deposit date: | 2012-12-12 | Release date: | 2013-01-09 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.252 Å) | Cite: | Structural basis for conformational switching and GTP loading of the large G protein atlastin. Embo J., 32, 2013
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6B9F
| Human ATL1 mutant - F151S bound to GDPAlF4- | Descriptor: | Atlastin-1, GLYCEROL, GUANOSINE-5'-DIPHOSPHATE, ... | Authors: | O'Donnell, J.P, Sondermann, H. | Deposit date: | 2017-10-10 | Release date: | 2017-12-06 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | A hereditary spastic paraplegia-associated atlastin variant exhibits defective allosteric coupling in the catalytic core. J. Biol. Chem., 293, 2018
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6B9G
| human ATL1 GTPase domain bound to GDP | Descriptor: | Atlastin-1, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION | Authors: | O'Donnell, J.P, Sondermann, H. | Deposit date: | 2017-10-10 | Release date: | 2017-12-06 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | A hereditary spastic paraplegia-associated atlastin variant exhibits defective allosteric coupling in the catalytic core. J. Biol. Chem., 293, 2018
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1OEB
| Mona/Gads SH3C domain | Descriptor: | CADMIUM ION, GRB2-RELATED ADAPTOR PROTEIN 2, LYMPHOCYTE CYTOSOLIC PROTEIN 2 | Authors: | Harkiolaki, M, Lewitzky, M, Gilbert, R.J.C, Jones, E.Y, Bourette, R.P, Mouchiroud, G, Sondermann, H, Moarefi, I, Feller, S.M. | Deposit date: | 2003-03-24 | Release date: | 2003-04-02 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.76 Å) | Cite: | Structural Basis for SH3 Domain-Mediated High-Affinity Binding between Mona/Gads and Slp-76 Embo J., 22, 2003
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6B9E
| Human ATL1 mutant - R77A / F151S bound to GDP | Descriptor: | Atlastin-1, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... | Authors: | O'Donnell, J.P, Sondermann, H. | Deposit date: | 2017-10-10 | Release date: | 2017-12-06 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.99 Å) | Cite: | A hereditary spastic paraplegia-associated atlastin variant exhibits defective allosteric coupling in the catalytic core. J. Biol. Chem., 293, 2018
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6B9D
| Human ATL1 mutant - R77A bound to GDP | Descriptor: | Atlastin-1, GLYCEROL, GUANOSINE-5'-DIPHOSPHATE, ... | Authors: | O'Donnell, J.P, Sondermann, H. | Deposit date: | 2017-10-10 | Release date: | 2017-12-06 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | A hereditary spastic paraplegia-associated atlastin variant exhibits defective allosteric coupling in the catalytic core. J. Biol. Chem., 293, 2018
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5EXT
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5EXS
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5EXX
| AAA+ ATPase FleQ from Pseudomonas aeruginosa bound to c-di-GMP | Descriptor: | 9,9'-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one), SULFATE ION, Transcriptional regulator FleQ | Authors: | Navarro, M.V.A.S, Sondermann, H, Krasteva, P.V. | Deposit date: | 2015-11-24 | Release date: | 2016-02-10 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (3.311 Å) | Cite: | Mechanistic insights into c-di-GMP-dependent control of the biofilm regulator FleQ from Pseudomonas aeruginosa. Proc.Natl.Acad.Sci.USA, 113, 2016
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6N6J
| Human REXO2 bound to pAA | Descriptor: | 1,2-ETHANEDIOL, GLYCEROL, MALONATE ION, ... | Authors: | Lormand, J.D, Sondermann, H. | Deposit date: | 2018-11-26 | Release date: | 2019-06-12 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.317 Å) | Cite: | A dedicated diribonucleotidase resolves a key bottleneck for the terminal step of RNA degradation. Elife, 8, 2019
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4J40
| Crystal structure of the dual-domain GGDEF-EAL module of FimX from Pseudomonas aeruginosa | Descriptor: | FimX | Authors: | Navarro, M.V, De, N, Bae, N, Wang, Q, Sondermann, H. | Deposit date: | 2013-02-06 | Release date: | 2013-02-20 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.99 Å) | Cite: | Structural analysis of the GGDEF-EAL domain-containing c-di-GMP receptor FimX. Structure, 17, 2009
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6N6I
| Human REXO2 bound to pGG | Descriptor: | 1,2-ETHANEDIOL, GLYCEROL, MALONATE ION, ... | Authors: | Lormand, J.D, Sondermann, H. | Deposit date: | 2018-11-26 | Release date: | 2019-06-12 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.431 Å) | Cite: | A dedicated diribonucleotidase resolves a key bottleneck for the terminal step of RNA degradation. Elife, 8, 2019
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6N6K
| Human REXO2 bound to pAG | Descriptor: | MALONATE ION, RNA (5'-R(P*AP*G)-3'), RNA exonuclease 2 homolog,Small fragment nuclease, ... | Authors: | Lormand, J.D, Sondermann, H. | Deposit date: | 2018-11-26 | Release date: | 2019-06-12 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.418 Å) | Cite: | A dedicated diribonucleotidase resolves a key bottleneck for the terminal step of RNA degradation. Elife, 8, 2019
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1YVL
| Structure of Unphosphorylated STAT1 | Descriptor: | 5-residue peptide, GOLD ION, Signal transducer and activator of transcription 1-alpha/beta | Authors: | Mao, X, Ren, Z, Parker, G.N, Sondermann, H, Pastorello, M.A, Wang, W, McMurray, J.S, Demeler, B, Darnell Jr, J.E, Chen, X. | Deposit date: | 2005-02-16 | Release date: | 2005-03-22 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Structural bases of unphosphorylated STAT1 association and receptor binding. Mol.Cell, 17, 2005
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