5SYR
| Crystal Structure of ATPase delta1-79 Spa47 R350A | 分子名称: | Probable ATP synthase SpaL/MxiB, SULFATE ION | 著者 | Morales, Y, Johnson, S.J, Burgess, J.L, Burgess, R.A, Dickenson, N.E. | 登録日 | 2016-08-11 | 公開日 | 2016-11-02 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Structural and Biochemical Characterization of Spa47 Provides Mechanistic Insight into Type III Secretion System ATPase Activation and Shigella Virulence Regulation. J. Biol. Chem., 291, 2016
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6B2E
| Structure of full length human AMPK (a2b2g1) in complex with a small molecule activator SC4. | 分子名称: | 5'-AMP-activated protein kinase catalytic subunit alpha-2, 5'-AMP-activated protein kinase subunit beta-2, 5'-AMP-activated protein kinase subunit gamma-1, ... | 著者 | Ngoei, K.R.W, Langendorf, C.G, Ling, N.X.Y, Hoque, A, Johnson, S, Camerino, M.C, Walker, S.R, Bozikis, Y.E, Dite, T.A, Ovens, A.J, Smiles, W.J, Jacobs, R, Huang, H, Parker, M.W, Scott, J.W, Rider, M.H, Kemp, B.E, Foitzik, R.C, Baell, J.B, Oakhill, J.S. | 登録日 | 2017-09-19 | 公開日 | 2018-04-25 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (3.8 Å) | 主引用文献 | Structural Determinants for Small-Molecule Activation of Skeletal Muscle AMPK alpha 2 beta 2 gamma 1 by the Glucose Importagog SC4. Cell Chem Biol, 25, 2018
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6BEM
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8THU
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5SWJ
| Crystal Structure of ATPase delta1-79 Spa47 | 分子名称: | Probable ATP synthase SpaL/MxiB, SULFATE ION | 著者 | Morales, Y, Johnson, S.J, Burgess, J.L, Burgess, R.A, Dickenson, N.E. | 登録日 | 2016-08-08 | 公開日 | 2016-11-02 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.401 Å) | 主引用文献 | Structural and Biochemical Characterization of Spa47 Provides Mechanistic Insight into Type III Secretion System ATPase Activation and Shigella Virulence Regulation. J. Biol. Chem., 291, 2016
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5SWL
| Crystal Structure of ATPase delta1-79 Spa47 E188A | 分子名称: | Probable ATP synthase SpaL/MxiB, SULFATE ION | 著者 | Morales, Y, Johnson, S.J, Burgess, J.L, Burgess, R.A, Dickenson, N.E. | 登録日 | 2016-08-08 | 公開日 | 2016-11-02 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Structural and Biochemical Characterization of Spa47 Provides Mechanistic Insight into Type III Secretion System ATPase Activation and Shigella Virulence Regulation. J. Biol. Chem., 291, 2016
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5W6C
| UCA Fab (unbound) from 6649 Lineage | 分子名称: | UCA Fab heavy chain, UCA Fab light chain | 著者 | Raymond, D.D, Harrison, S.C. | 登録日 | 2017-06-16 | 公開日 | 2017-12-13 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.634 Å) | 主引用文献 | Conserved epitope on influenza-virus hemagglutinin head defined by a vaccine-induced antibody. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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5SYP
| Crystal Structure of ATPase delta1-79 Spa47 K165A | 分子名称: | Probable ATP synthase SpaL/MxiB, SULFATE ION | 著者 | Morales, Y, Johnson, S.J, Burgess, J.L, Burgess, R.A, Dickenson, N.E. | 登録日 | 2016-08-11 | 公開日 | 2016-11-02 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | 主引用文献 | Structural and Biochemical Characterization of Spa47 Provides Mechanistic Insight into Type III Secretion System ATPase Activation and Shigella Virulence Regulation. J. Biol. Chem., 291, 2016
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4GXK
| R283K DNA polymerase beta ternary complex with a templating 8OG and incoming dATP analog | 分子名称: | 2'-deoxy-5'-O-[(S)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]methyl}phosphoryl]adenosine, DNA (5'-D(*CP*CP*GP*AP*CP*(8OG)P*TP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*A)-3'), ... | 著者 | Freudenthal, B.D, Beard, W.A, Wilson, S.H. | 登録日 | 2012-09-04 | 公開日 | 2013-01-16 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (1.998 Å) | 主引用文献 | DNA polymerase minor groove interactions modulate mutagenic bypass of a templating 8-oxoguanine lesion. Nucleic Acids Res., 41, 2013
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2YFW
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4GXJ
| R283K DNA polymerase beta ternary complex with a templating 8OG and incoming dCTP analog | 分子名称: | 2'-deoxy-5'-O-[(S)-{difluoro[(S)-hydroxy(phosphonooxy)phosphoryl]methyl}(hydroxy)phosphoryl]cytidine, DNA (5'-D(*CP*CP*GP*AP*CP*(8OG)P*TP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*A)-3'), ... | 著者 | Freudenthal, B.D, Beard, W.A, Wilson, S.H. | 登録日 | 2012-09-04 | 公開日 | 2013-01-16 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | DNA polymerase minor groove interactions modulate mutagenic bypass of a templating 8-oxoguanine lesion. Nucleic Acids Res., 41, 2013
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6B1U
| Structure of full-length human AMPK (a2b1g1) in complex with a small molecule activator SC4 | 分子名称: | 5'-AMP-activated protein kinase catalytic subunit alpha-2, 5'-AMP-activated protein kinase subunit beta-1, 5'-AMP-activated protein kinase subunit gamma-1, ... | 著者 | Ngoei, K.R.W, Langendorf, C.G, Ling, N.X.Y, Hoque, A, Johnson, S, Camerino, M.C, Walker, S.R, Bozikis, Y.E, Dite, T.A, Ovens, A.J, Smiles, W.J, Jacobs, R, Huang, H, Parker, M.W, Scott, J.W, Rider, M.H, Kemp, B.E, Foitzik, R.C, Baell, J.B, Oakhill, J.S. | 登録日 | 2017-09-19 | 公開日 | 2018-04-25 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.77 Å) | 主引用文献 | Structural Determinants for Small-Molecule Activation of Skeletal Muscle AMPK alpha 2 beta 2 gamma 1 by the Glucose Importagog SC4. Cell Chem Biol, 25, 2018
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8G0P
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4F5Q
| Closed ternary complex of R283K DNA polymerase beta | 分子名称: | 2'-deoxy-5'-O-[(S)-{difluoro[(S)-hydroxy(phosphonooxy)phosphoryl]methyl}(hydroxy)phosphoryl]cytidine, DNA (5'-D(*CP*CP*GP*AP*CP*GP*GP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), DNA (5'-D(P*GP*CP*TP*GP*AP*TP*GP*CP*GP*C)-3'), ... | 著者 | Freudenthal, B.D, Beard, W.A, Wilson, S.H. | 登録日 | 2012-05-13 | 公開日 | 2012-12-12 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | 主引用文献 | Structures of dNTP Intermediate States during DNA Polymerase Active Site Assembly. Structure, 20, 2012
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2UWN
| Crystal structure of Human Complement Factor H, SCR domains 6-8 (H402 risk variant), in complex with ligand. | 分子名称: | 1,3,4,6-tetra-O-sulfo-beta-D-fructofuranose-(2-1)-2,3,4,6-tetra-O-sulfonato-alpha-D-glucopyranose, ACETATE ION, CHLORIDE ION, ... | 著者 | Prosser, B.E, Johnson, S, Roversi, P, Herbert, A.P, Blaum, B.S, Tyrrell, J, Jowitt, T.A, Clark, S.J, Terelli, E, Uhrin, D, Barlow, P.N, Sim, R.B, Day, A.J, Lea, S.M. | 登録日 | 2007-03-22 | 公開日 | 2007-10-02 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | 主引用文献 | Structural Basis for Complement Factor H Linked Age-Related Macular Degeneration. J.Exp.Med., 204, 2007
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4JHS
| Crystal structure of a C-terminal two domain fragment of human beta-2-glycoprotein 1 | 分子名称: | Beta-2-glycoprotein 1, SULFATE ION | 著者 | Bonanno, J.B, Toro, R, Gizzi, A, Chan, M.K, Garrett-Thomson, S.C, Patel, H, Lim, S, Matikainen, B, Celikgil, A, Garforth, S, Hillerich, B, Seidel, R, Rand, J.H, Almo, S.C, New York Structural Genomics Research Consortium (NYSGRC), Atoms-to-Animals: The Immune Function Network (IFN) | 登録日 | 2013-03-05 | 公開日 | 2013-04-24 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Crystal structure of a C-terminal two domain fragment of human beta-2-glycoprotein 1 To be Published
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3DZC
| 2.35 Angstrom resolution structure of WecB (VC0917), a UDP-N-acetylglucosamine 2-epimerase from Vibrio cholerae. | 分子名称: | CALCIUM ION, CHLORIDE ION, UDP-N-acetylglucosamine 2-epimerase | 著者 | Minasov, G, Shuvalova, L, Dubrovska, I, Winsor, J, Papazisi, L, Kwon, K, Hasseman, J, Peterson, S.N, Anderson, W.F, Center for Structural Genomics of Infectious Diseases (CSGID) | 登録日 | 2008-07-29 | 公開日 | 2008-08-12 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | 主引用文献 | 2.35 Angstrom resolution structure of WecB (VC0917), a UDP-N-acetylglucosamine 2-epimerase from Vibrio cholerae. TO BE PUBLISHED
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4CSJ
| The discovery of potent selective glucocorticoid receptor modulators, suitable for inhalation | 分子名称: | 1,2-ETHANEDIOL, GLUCOCORTICOID RECEPTOR, N-[(2S)-1-[[1-(4-fluorophenyl)indazol-4-yl]amino]propan-2-yl]-2,4,6-trimethyl-benzenesulfonamide, ... | 著者 | Edman, K, Ahlgren, R, Bengtsson, M, Bladh, H, Backstrom, S, Dahmen, J, Henriksson, K, Hillertz, P, Hulikal, V, Jerre, A, Kinchin, L, Kase, C, Lepisto, M, Mile, I, Nilsson, S, Smailagic, A, Taylor, J, Tjornebo, A, Wissler, L, Hansson, T. | 登録日 | 2014-03-07 | 公開日 | 2014-05-07 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | The Discovery of Potent and Selective Non-Steroidal Glucocorticoid Receptor Modulators, Suitable for Inhalation. Bioorg.Med.Chem.Lett., 24, 2014
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5ALC
| Ticagrelor antidote candidate Fab 72 in complex with ticagrelor | 分子名称: | ANTI-TICAGRELOR FAB 72, HEAVY CHAIN, LIGHT CHAIN, ... | 著者 | Buchanan, A, Newton, P, Pehrsson, S, Inghardt, T, Antonsson, T, Svensson, P, Sjogren, T, Oster, L, Janefeldt, A, Sandinge, A, Keyes, F, Austin, M, Spooner, J, Penney, M, Howells, G, Vaughan, T, Nylander, S. | 登録日 | 2015-03-07 | 公開日 | 2015-04-01 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Structural and Functional Characterisation of a Specific Antidote for Ticagrelor. Blood, 125, 2015
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2V6L
| Molecular Model of a Type III Secretion System Needle | 分子名称: | MXIH | 著者 | Deane, J.E, Roversi, P, Cordes, F.S, Johnson, S, Kenjale, R, Daniell, S, Booy, F, Picking, W.L, Picking, W.D, Blocker, A.J, Lea, S.M. | 登録日 | 2007-07-19 | 公開日 | 2007-07-31 | 最終更新日 | 2024-05-08 | 実験手法 | ELECTRON MICROSCOPY (16 Å) | 主引用文献 | Molecular model of a type III secretion system needle: Implications for host-cell sensing. Proc. Natl. Acad. Sci. U.S.A., 103, 2006
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2V8E
| Crystal structure of Human Complement Factor H, SCR domains 6-8 (H402 risk variant), in complex with ligand. | 分子名称: | 1,3,4,6-tetra-O-sulfo-beta-D-fructofuranose-(2-1)-2,3,4,6-tetra-O-sulfonato-alpha-D-glucopyranose, CHLORIDE ION, COMPLEMENT FACTOR H, ... | 著者 | Prosser, B.E, Johnson, S, Roversi, P, Herbert, A.P, Blaum, B.S, Tyrrell, J, Jowitt, T.A, Clark, S.J, Tarelli, E, Uhrin, D, Barlow, P.N, Sim, R.B, Day, A.J, Lea, S.M. | 登録日 | 2007-08-07 | 公開日 | 2007-10-02 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Structural Basis for Complement Factor H Linked Age-Related Macular Degeneration. J.Exp.Med., 204, 2007
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4F5O
| Open ternary complex of R283K DNA polymerase beta with a one metal bound dCTP analog | 分子名称: | 2'-deoxy-5'-O-[(S)-{difluoro[(S)-hydroxy(phosphonooxy)phosphoryl]methyl}(hydroxy)phosphoryl]cytidine, DNA (5'-D(*CP*CP*GP*AP*CP*(8OG)P*TP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*A)-3'), ... | 著者 | Freudenthal, B.D, Beard, W.A, Wilson, S.H. | 登録日 | 2012-05-13 | 公開日 | 2012-12-12 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Structures of dNTP Intermediate States during DNA Polymerase Active Site Assembly. Structure, 20, 2012
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2CA5
| MxiH needle protein of Shigella Flexneri (monomeric form, residues 1- 78) | 分子名称: | GLYCEROL, ISOPROPYL ALCOHOL, MXIH, ... | 著者 | Deane, J.E, Roversi, P, Cordes, F.S, Johnson, S, Kenjale, R, Picking, W.L, Picking, W.D, Blocker, A.J, Lea, S.M. | 登録日 | 2005-12-16 | 公開日 | 2006-08-07 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Molecular Model of a Type III Secretion System Needle: Implications for Host-Cell Sensing Proc.Natl.Acad.Sci.USA, 103, 2006
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1TVA
| HUMAN DNA POLYMERASE BETA COMPLEXED WITH NICKED DNA CONTAINING A MISMATCHED TEMPLATE THYMIDINE AND INCOMING CYTIDINE | 分子名称: | 5'-D(*CP*CP*GP*AP*CP*TP*GP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3', 5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*CP*C)-3', 5'-D(P*GP*TP*CP*GP*G)-3', ... | 著者 | Krahn, J.M, Beard, W.A, Wilson, S.H. | 登録日 | 2004-06-29 | 公開日 | 2004-11-23 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Structural insights into DNA polymerase Beta deterrents for misincorporation support an induced-fit mechanism for fidelity Structure, 12, 2004
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2P66
| Human DNA Polymerase beta complexed with tetrahydrofuran (abasic site) containing DNA | 分子名称: | DNA (5'-D(*CP*CP*GP*AP*CP*AP*GP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*CP*C)-3'), DNA (5'-D(P*(3DR)P*GP*TP*CP*GP*G)-3'), ... | 著者 | Prasad, R, Batra, V.K, Yang, X.-P, Krahn, J.M, Pedersen, L.C, Beard, W.A, Wilson, S.H. | 登録日 | 2007-03-16 | 公開日 | 2007-04-10 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Structural insight into the DNA Polymerase beta deoxyribose phosphate lyase mechanism DNA REPAIR, 4, 2005
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