5UEH
| Structure of GSTO1 covalently conjugated to quinolinic acid fluorosulfate | 分子名称: | 2-(4-chlorophenyl)-6-[(fluorosulfonyl)oxy]quinoline-4-carboxylic acid, GLYCEROL, Glutathione S-transferase omega-1, ... | 著者 | Mortenson, D.E, Wilson, I.A, Kelly, J.W. | 登録日 | 2017-01-02 | 公開日 | 2018-01-17 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | "Inverse Drug Discovery" Strategy To Identify Proteins That Are Targeted by Latent Electrophiles As Exemplified by Aryl Fluorosulfates. J. Am. Chem. Soc., 140, 2018
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5UI4
| Structure of NME1 covalently conjugated to imidazole fluorosulfate | 分子名称: | 4-[4-(3-methoxyphenyl)-1-(prop-2-yn-1-yl)-1H-imidazol-5-yl]phenyl sulfurofluoridate, Nucleoside diphosphate kinase A | 著者 | Mortenson, D.E, Brighty, G.J, Wilson, I.A, Kelly, J.W. | 登録日 | 2017-01-12 | 公開日 | 2018-01-17 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | 主引用文献 | "Inverse Drug Discovery" Strategy To Identify Proteins That Are Targeted by Latent Electrophiles As Exemplified by Aryl Fluorosulfates. J. Am. Chem. Soc., 140, 2018
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4V0I
| Water Network Determines Selectivity for a Series of Pyrimidone Indoline Amide PI3KBeta Inhibitors over PI3K-Delta | 分子名称: | 2-[2-(2-METHYL-2,3-DIHYDRO-INDOL-1-YL)-2-OXO-ETHYL]-6-MORPHOLIN-4-YL-3H-PYRIMIDIN-4-ONE, PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM | 著者 | Robinson, D, Bertrand, T, Carry, J.C, Halley, F, Karlsson, A, Mathieu, M, Minoux, H, Perrin, M.A, Robert, B, Schio, L, Sherman, W. | 登録日 | 2014-09-16 | 公開日 | 2015-09-30 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.54 Å) | 主引用文献 | Differential Water Thermodynamics Determine Pi3K-Beta/Delta Selectivity for Solvent-Exposed Ligand Modifications. J.Chem.Inf.Model., 56, 2016
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1ADD
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3CZM
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1FKW
| MURINE ADENOSINE DEAMINASE (D295E) | 分子名称: | ADENOSINE DEAMINASE, PURINE RIBOSIDE, ZINC ION | 著者 | Wilson, D.K, Quiocho, F.A. | 登録日 | 1996-02-29 | 公開日 | 1996-08-01 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Probing the functional role of two conserved active site aspartates in mouse adenosine deaminase. Biochemistry, 35, 1996
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1FKX
| MURINE ADENOSINE DEAMINASE (D296A) | 分子名称: | 6-HYDROXY-1,6-DIHYDRO PURINE NUCLEOSIDE, ADENOSINE DEAMINASE, ZINC ION | 著者 | Wilson, D.K, Quiocho, F.A. | 登録日 | 1996-02-29 | 公開日 | 1996-08-01 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Probing the functional role of two conserved active site aspartates in mouse adenosine deaminase. Biochemistry, 35, 1996
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1UIP
| ADENOSINE DEAMINASE (HIS 238 GLU MUTANT) | 分子名称: | ADENOSINE DEAMINASE, PURINE RIBOSIDE, ZINC ION | 著者 | Wilson, D.K, Quiocho, F.A. | 登録日 | 1996-08-30 | 公開日 | 1997-06-24 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Site-directed mutagenesis of histidine 238 in mouse adenosine deaminase: substitution of histidine 238 does not impede hydroxylate formation. Biochemistry, 35, 1996
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1L9L
| GRANULYSIN FROM HUMAN CYTOLYTIC T LYMPHOCYTES | 分子名称: | 3[N-MORPHOLINO]PROPANE SULFONIC ACID, ETHANOL, Granulysin, ... | 著者 | Anderson, D.H, Sawaya, M.R, Cascio, D, Ernst, W, Krensky, A, Modlin, R, Eisenberg, D. | 登録日 | 2002-03-25 | 公開日 | 2002-11-06 | 最終更新日 | 2017-09-13 | 実験手法 | X-RAY DIFFRACTION (0.92 Å) | 主引用文献 | Granulysin Crystal Structure and a Structure-Derived Lytic Mechanism J.Mol.Biol., 325, 2002
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1UIO
| ADENOSINE DEAMINASE (HIS 238 ALA MUTANT) | 分子名称: | 6-HYDROXY-7,8-DIHYDRO PURINE NUCLEOSIDE, ADENOSINE DEAMINASE, ZINC ION | 著者 | Wilson, D.K, Quiocho, F.A. | 登録日 | 1996-08-30 | 公開日 | 1997-06-24 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Site-directed mutagenesis of histidine 238 in mouse adenosine deaminase: substitution of histidine 238 does not impede hydroxylate formation. Biochemistry, 35, 1996
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1ADS
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5UXI
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7DUW
| Cryo-EM structure of the multiple peptide resistance factor (MprF) loaded with two lysyl-phosphatidylglycerol molecules | 分子名称: | (1S)-2-{[{[(2R)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL STEARATE, (2~{R},3~{S},4~{S},5~{S},6~{S})-2-(hydroxymethyl)-6-[(2~{R},3~{S},4~{R},5~{R},6~{R})-2-(hydroxymethyl)-6-[2-[[(2~{R},3~{S},4~{R},5~{R},6~{S})-6-(hydroxymethyl)-5-[(2~{S},3~{R},4~{S},5~{S},6~{R})-6-(hydroxymethyl)-3,4,5-tris(oxidanyl)oxan-2-yl]oxy-3,4-bis(oxidanyl)oxan-2-yl]oxymethyl]-4-[(1~{R},2~{R},4~{S},5'~{R},6~{R},7~{R},8~{R},9~{S},12~{S},13~{R},16~{S})-5',7,9,13-tetramethylspiro[5-oxapentacyclo[10.8.0.0^{2,9}.0^{4,8}.0^{13,18}]icos-18-ene-6,2'-oxane]-16-yl]oxy-butoxy]-4,5-bis(oxidanyl)oxan-3-yl]oxy-oxane-3,4,5-triol, 1,2-DIPALMITOYL-PHOSPHATIDYL-GLYCEROLE, ... | 著者 | Song, D.F, Jiao, H.Z, Liu, Z.F. | 登録日 | 2021-01-12 | 公開日 | 2021-04-21 | 最終更新日 | 2024-06-05 | 実験手法 | ELECTRON MICROSCOPY (2.96 Å) | 主引用文献 | Phospholipid translocation captured in a bifunctional membrane protein MprF. Nat Commun, 12, 2021
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5UX2
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1FRB
| FR-1 PROTEIN/NADPH/ZOPOLRESTAT COMPLEX | 分子名称: | 3,4-DIHYDRO-4-OXO-3-((5-TRIFLUOROMETHYL-2-BENZOTHIAZOLYL)METHYL)-1-PHTHALAZINE ACETIC ACID, FR-1 PROTEIN, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | 著者 | Wilson, D.K, Quiocho, F.A. | 登録日 | 1995-08-08 | 公開日 | 1996-10-14 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | 1.7 A structure of FR-1, a fibroblast growth factor-induced member of the aldo-keto reductase family, complexed with coenzyme and inhibitor. Biochemistry, 34, 1995
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3DLL
| The oxazolidinone antibiotics perturb the ribosomal peptidyl-transferase center and effect tRNA positioning | 分子名称: | 50S ribosomal protein L11, 50S ribosomal protein L13, 50S ribosomal protein L14, ... | 著者 | Wilson, D.N, Schluenzen, F, Harms, J.M, Starosta, A.L, Connell, S.R, Fucini, P. | 登録日 | 2008-06-27 | 公開日 | 2008-09-16 | 最終更新日 | 2024-10-30 | 実験手法 | X-RAY DIFFRACTION (3.5 Å) | 主引用文献 | The oxazolidinone antibiotics perturb the ribosomal peptidyl-transferase center and effect tRNA positioning Proc.Natl.Acad.Sci.Usa, 105, 2008
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5UXG
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5V4T
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1YFQ
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5UWZ
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7F3T
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1Y69
| RRF domain I in complex with the 50S ribosomal subunit from Deinococcus radiodurans | 分子名称: | 23S ribosomal RNA, 50S ribosomal protein L16, 50S ribosomal protein L27, ... | 著者 | Wilson, D.N, Schluenzen, F, Harms, J.M, Yoshida, T, Ohkubo, T, Albrecht, R, Buerger, J, Kobayashi, Y, Fucini, P. | 登録日 | 2004-12-04 | 公開日 | 2005-03-01 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (3.33 Å) | 主引用文献 | X-ray crystallography on ribosome recycling: mechanism of binding and action of RRF on the 50S ribosomal subunit EMBO J., 24, 2005
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5UX1
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1MAR
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1ABF
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