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PDB: 2044 件

5UEH
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Structure of GSTO1 covalently conjugated to quinolinic acid fluorosulfate
分子名称: 2-(4-chlorophenyl)-6-[(fluorosulfonyl)oxy]quinoline-4-carboxylic acid, GLYCEROL, Glutathione S-transferase omega-1, ...
著者Mortenson, D.E, Wilson, I.A, Kelly, J.W.
登録日2017-01-02
公開日2018-01-17
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献"Inverse Drug Discovery" Strategy To Identify Proteins That Are Targeted by Latent Electrophiles As Exemplified by Aryl Fluorosulfates.
J. Am. Chem. Soc., 140, 2018
5UI4
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Structure of NME1 covalently conjugated to imidazole fluorosulfate
分子名称: 4-[4-(3-methoxyphenyl)-1-(prop-2-yn-1-yl)-1H-imidazol-5-yl]phenyl sulfurofluoridate, Nucleoside diphosphate kinase A
著者Mortenson, D.E, Brighty, G.J, Wilson, I.A, Kelly, J.W.
登録日2017-01-12
公開日2018-01-17
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.75 Å)
主引用文献"Inverse Drug Discovery" Strategy To Identify Proteins That Are Targeted by Latent Electrophiles As Exemplified by Aryl Fluorosulfates.
J. Am. Chem. Soc., 140, 2018
4V0I
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Water Network Determines Selectivity for a Series of Pyrimidone Indoline Amide PI3KBeta Inhibitors over PI3K-Delta
分子名称: 2-[2-(2-METHYL-2,3-DIHYDRO-INDOL-1-YL)-2-OXO-ETHYL]-6-MORPHOLIN-4-YL-3H-PYRIMIDIN-4-ONE, PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
著者Robinson, D, Bertrand, T, Carry, J.C, Halley, F, Karlsson, A, Mathieu, M, Minoux, H, Perrin, M.A, Robert, B, Schio, L, Sherman, W.
登録日2014-09-16
公開日2015-09-30
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2.54 Å)
主引用文献Differential Water Thermodynamics Determine Pi3K-Beta/Delta Selectivity for Solvent-Exposed Ligand Modifications.
J.Chem.Inf.Model., 56, 2016
1ADD
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A PRE-TRANSITION STATE MIMIC OF AN ENZYME: X-RAY STRUCTURE OF ADENOSINE DEAMINASE WITH BOUND 1-DEAZA-ADENOSINE AND ZINC-ACTIVATED WATER
分子名称: 1-DEAZA-ADENOSINE, ADENOSINE DEAMINASE, ZINC ION
著者Wilson, D.K, Quiocho, F.A.
登録日1992-12-22
公開日1994-01-31
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献A pre-transition-state mimic of an enzyme: X-ray structure of adenosine deaminase with bound 1-deazaadenosine and zinc-activated water.
Biochemistry, 32, 1993
3CZM
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T. Gondii bradyzoite-specific LDH (LDH2) in complex with NAD and OXQ
分子名称: 4-HYDROXY-1,2,5-OXADIAZOLE-3-CARBOXYLIC ACID, L-lactate dehydrogenase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE
著者Wilson, D.K, Susko, M.S.
登録日2008-04-29
公開日2009-06-02
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献T. Gondii bradyzoite-specific LDH (LDH2) in complex with NAD and OXQ
To be Published
1FKW
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MURINE ADENOSINE DEAMINASE (D295E)
分子名称: ADENOSINE DEAMINASE, PURINE RIBOSIDE, ZINC ION
著者Wilson, D.K, Quiocho, F.A.
登録日1996-02-29
公開日1996-08-01
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Probing the functional role of two conserved active site aspartates in mouse adenosine deaminase.
Biochemistry, 35, 1996
1FKX
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MURINE ADENOSINE DEAMINASE (D296A)
分子名称: 6-HYDROXY-1,6-DIHYDRO PURINE NUCLEOSIDE, ADENOSINE DEAMINASE, ZINC ION
著者Wilson, D.K, Quiocho, F.A.
登録日1996-02-29
公開日1996-08-01
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Probing the functional role of two conserved active site aspartates in mouse adenosine deaminase.
Biochemistry, 35, 1996
1UIP
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ADENOSINE DEAMINASE (HIS 238 GLU MUTANT)
分子名称: ADENOSINE DEAMINASE, PURINE RIBOSIDE, ZINC ION
著者Wilson, D.K, Quiocho, F.A.
登録日1996-08-30
公開日1997-06-24
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Site-directed mutagenesis of histidine 238 in mouse adenosine deaminase: substitution of histidine 238 does not impede hydroxylate formation.
Biochemistry, 35, 1996
1L9L
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GRANULYSIN FROM HUMAN CYTOLYTIC T LYMPHOCYTES
分子名称: 3[N-MORPHOLINO]PROPANE SULFONIC ACID, ETHANOL, Granulysin, ...
著者Anderson, D.H, Sawaya, M.R, Cascio, D, Ernst, W, Krensky, A, Modlin, R, Eisenberg, D.
登録日2002-03-25
公開日2002-11-06
最終更新日2017-09-13
実験手法X-RAY DIFFRACTION (0.92 Å)
主引用文献Granulysin Crystal Structure and a Structure-Derived Lytic Mechanism
J.Mol.Biol., 325, 2002
1UIO
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ADENOSINE DEAMINASE (HIS 238 ALA MUTANT)
分子名称: 6-HYDROXY-7,8-DIHYDRO PURINE NUCLEOSIDE, ADENOSINE DEAMINASE, ZINC ION
著者Wilson, D.K, Quiocho, F.A.
登録日1996-08-30
公開日1997-06-24
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Site-directed mutagenesis of histidine 238 in mouse adenosine deaminase: substitution of histidine 238 does not impede hydroxylate formation.
Biochemistry, 35, 1996
1ADS
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AN UNLIKELY SUGAR SUBSTRATE SITE IN THE 1.65 ANGSTROMS STRUCTURE OF THE HUMAN ALDOSE REDUCTASE HOLOENZYME IMPLICATED IN DIABETIC COMPLICATIONS
分子名称: ALDOSE REDUCTASE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
著者Wilson, D.K, Quiocho, F.A.
登録日1992-07-08
公開日1993-10-31
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (1.65 Å)
主引用文献An unlikely sugar substrate site in the 1.65 A structure of the human aldose reductase holoenzyme implicated in diabetic complications.
Science, 257, 1992
5UXI
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Protein 4 with aldehyde deformylating oxygenase activity from Nostoc puntiforme
分子名称: Aldehyde decarbonylase, DECYLAMINE-N,N-DIMETHYL-N-OXIDE
著者Wilson, D.K, Mak, W.S, Siegel, J.B.
登録日2017-02-22
公開日2018-02-28
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Protein 4 with aldehyde deformylating oxygenase activity from Nostoc puntiforme
To Be Published
7DUW
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Cryo-EM structure of the multiple peptide resistance factor (MprF) loaded with two lysyl-phosphatidylglycerol molecules
分子名称: (1S)-2-{[{[(2R)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL STEARATE, (2~{R},3~{S},4~{S},5~{S},6~{S})-2-(hydroxymethyl)-6-[(2~{R},3~{S},4~{R},5~{R},6~{R})-2-(hydroxymethyl)-6-[2-[[(2~{R},3~{S},4~{R},5~{R},6~{S})-6-(hydroxymethyl)-5-[(2~{S},3~{R},4~{S},5~{S},6~{R})-6-(hydroxymethyl)-3,4,5-tris(oxidanyl)oxan-2-yl]oxy-3,4-bis(oxidanyl)oxan-2-yl]oxymethyl]-4-[(1~{R},2~{R},4~{S},5'~{R},6~{R},7~{R},8~{R},9~{S},12~{S},13~{R},16~{S})-5',7,9,13-tetramethylspiro[5-oxapentacyclo[10.8.0.0^{2,9}.0^{4,8}.0^{13,18}]icos-18-ene-6,2'-oxane]-16-yl]oxy-butoxy]-4,5-bis(oxidanyl)oxan-3-yl]oxy-oxane-3,4,5-triol, 1,2-DIPALMITOYL-PHOSPHATIDYL-GLYCEROLE, ...
著者Song, D.F, Jiao, H.Z, Liu, Z.F.
登録日2021-01-12
公開日2021-04-21
最終更新日2024-06-05
実験手法ELECTRON MICROSCOPY (2.96 Å)
主引用文献Phospholipid translocation captured in a bifunctional membrane protein MprF.
Nat Commun, 12, 2021
5UX2
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Protein 19 with aldehyde deformylating oxidase activity from Synechococcus
分子名称: Aldehyde decarbonylase, FE (III) ION, PROPANOIC ACID
著者Wilson, D.K, Mak, W.S, Siegel, J.B.
登録日2017-02-21
公開日2018-02-28
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.99 Å)
主引用文献Protein 19 with aldehyde deformylating oxidase activity from Synechococcus
To Be Published
1FRB
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FR-1 PROTEIN/NADPH/ZOPOLRESTAT COMPLEX
分子名称: 3,4-DIHYDRO-4-OXO-3-((5-TRIFLUOROMETHYL-2-BENZOTHIAZOLYL)METHYL)-1-PHTHALAZINE ACETIC ACID, FR-1 PROTEIN, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
著者Wilson, D.K, Quiocho, F.A.
登録日1995-08-08
公開日1996-10-14
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献1.7 A structure of FR-1, a fibroblast growth factor-induced member of the aldo-keto reductase family, complexed with coenzyme and inhibitor.
Biochemistry, 34, 1995
3DLL
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The oxazolidinone antibiotics perturb the ribosomal peptidyl-transferase center and effect tRNA positioning
分子名称: 50S ribosomal protein L11, 50S ribosomal protein L13, 50S ribosomal protein L14, ...
著者Wilson, D.N, Schluenzen, F, Harms, J.M, Starosta, A.L, Connell, S.R, Fucini, P.
登録日2008-06-27
公開日2008-09-16
最終更新日2024-10-30
実験手法X-RAY DIFFRACTION (3.5 Å)
主引用文献The oxazolidinone antibiotics perturb the ribosomal peptidyl-transferase center and effect tRNA positioning
Proc.Natl.Acad.Sci.Usa, 105, 2008
5UXG
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Protein 84 with aldehyde deformylating oxygenase activity from Sulfolobus tokodaii (monoclinic)
分子名称: PHOSPHATE ION, aldehyde deformylating oxygenase
著者Wilson, D.K, Mak, W.S, Siegel, J.B.
登録日2017-02-22
公開日2018-02-28
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (1.72 Å)
主引用文献Protein 84 with aldehyde deformylating oxygenase activity from Sulfolobus tokodaii (monoclinic)
To Be Published
5V4T
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Protein 84 with aldehyde deformylating oxygenase activity from Sulfolobus tokodaii (orthorhombic form)
分子名称: 1,2-ETHANEDIOL, FE (III) ION, hypothetic aldehyde deformylating oxygenase
著者Wilson, D.K, Mak, W.S, Siegel, J.B.
登録日2017-03-10
公開日2018-03-14
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Protein 84 with aldehyde deformylating oxygenase activity from Sulfolobus tokodaii (orthorhombic form)
To Be Published
1YFQ
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High resolution S. cerevisiae Bub3 mitotic checkpoint protein
分子名称: ACETATE ION, CALCIUM ION, Cell cycle arrest protein BUB3
著者Wilson, D.K, Cerna, D, Chew, E.
登録日2005-01-03
公開日2005-01-11
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (1.1 Å)
主引用文献The 1.1-a structure of the spindle checkpoint protein bub3p reveals functional regions.
J.Biol.Chem., 280, 2005
5UWZ
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Protein 12 with aldehyde deformylating oxygenase activity from Gloeobacter violaceus
分子名称: 1,2-ETHANEDIOL, Aldehyde decarbonylase, STEARIC ACID
著者Wilson, D.K.
登録日2017-02-21
公開日2018-02-28
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (1.25 Å)
主引用文献Protein 12 with aldehyde deformylating oxygenase activity from Gloeobacter violaceus
To Be Published
7F3T
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Cryo-EM structure of human TMEM120A in the CoASH-bound state
分子名称: COENZYME A, Transmembrane protein 120A
著者Song, D.F, Rong, Y, Liu, Z.F.
登録日2021-06-17
公開日2021-06-30
最終更新日2024-06-12
実験手法ELECTRON MICROSCOPY (3.69 Å)
主引用文献TMEM120A contains a specific coenzyme A-binding site and might not mediate poking- or stretch-induced channel activities in cells.
Elife, 10, 2021
1Y69
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RRF domain I in complex with the 50S ribosomal subunit from Deinococcus radiodurans
分子名称: 23S ribosomal RNA, 50S ribosomal protein L16, 50S ribosomal protein L27, ...
著者Wilson, D.N, Schluenzen, F, Harms, J.M, Yoshida, T, Ohkubo, T, Albrecht, R, Buerger, J, Kobayashi, Y, Fucini, P.
登録日2004-12-04
公開日2005-03-01
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (3.33 Å)
主引用文献X-ray crystallography on ribosome recycling: mechanism of binding and action of RRF on the 50S ribosomal subunit
EMBO J., 24, 2005
5UX1
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Protein 43 with aldehyde deformylating oxygenase activity from Synechococcus
分子名称: FE (III) ION, tRNA-(MS(2)IO(6)A)-hydroxylase-like
著者Wilson, D.K, Mak, W.S, Siegel, J.B.
登録日2017-02-21
公開日2018-02-28
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Protein 43 with aldehyde deformylating oxygenase activity from Synechococcus
To Be Published
1MAR
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REFINED 1.8 ANGSTROMS STRUCTURE OF HUMAN ALDOSE REDUCTASE COMPLEXED WITH THE POTENT INHIBITOR ZOPOLRESTAT
分子名称: 3,4-DIHYDRO-4-OXO-3-((5-TRIFLUOROMETHYL-2-BENZOTHIAZOLYL)METHYL)-1-PHTHALAZINE ACETIC ACID, ALDOSE REDUCTASE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
著者Wilson, D.K, Quiocho, F.A.
登録日1993-07-20
公開日1995-07-20
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Refined 1.8 A structure of human aldose reductase complexed with the potent inhibitor zopolrestat.
Proc.Natl.Acad.Sci.USA, 90, 1993
1ABF
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SUBSTRATE SPECIFICITY AND AFFINITY OF A PROTEIN MODULATED BY BOUND WATER MOLECULES
分子名称: L-ARABINOSE-BINDING PROTEIN, alpha-D-fucopyranose, beta-D-fucopyranose
著者Wilson, D.K, Quiocho, F.A.
登録日1992-04-23
公開日1993-10-31
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Substrate specificity and affinity of a protein modulated by bound water molecules.
Nature, 340, 1989

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件を2024-10-30に公開中

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