5UEH

Structure of GSTO1 covalently conjugated to quinolinic acid fluorosulfate

Summary for 5UEH

Entry DOI	10.2210/pdb5ueh/pdb
Descriptor	Glutathione S-transferase omega-1, 2-(4-chlorophenyl)-6-[(fluorosulfonyl)oxy]quinoline-4-carboxylic acid, SULFATE ION, ... (5 entities in total)
Functional Keywords	arylfluorosulfate, gst, covalent inhibitor, transferase-oxidoreductase complex, transferase/oxidoreductase
Biological source	Homo sapiens (Human)
Cellular location	Cytoplasm, cytosol : P78417
Total number of polymer chains	1
Total formula weight	28641.10
Authors	Mortenson, D.E.,Wilson, I.A.,Kelly, J.W. (deposition date: 2017-01-02, release date: 2018-01-17, Last modification date: 2023-10-04)
Primary citation	Mortenson, D.E.,Brighty, G.J.,Plate, L.,Bare, G.,Chen, W.,Li, S.,Wang, H.,Cravatt, B.F.,Forli, S.,Powers, E.T.,Sharpless, K.B.,Wilson, I.A.,Kelly, J.W. "Inverse Drug Discovery" Strategy To Identify Proteins That Are Targeted by Latent Electrophiles As Exemplified by Aryl Fluorosulfates. J. Am. Chem. Soc., 140:200-210, 2018 Cited by PubMed: 29265822 DOI: 10.1021/jacs.7b08366 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation