5UEH

Structure of GSTO1 covalently conjugated to quinolinic acid fluorosulfate

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004364	molecular_function	glutathione transferase activity
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006749	biological_process	glutathione metabolic process
A	0010880	biological_process	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
A	0010881	biological_process	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
A	0014810	biological_process	positive regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion
A	0016491	molecular_function	oxidoreductase activity
A	0016740	molecular_function	transferase activity
A	0019852	biological_process	L-ascorbic acid metabolic process
A	0042178	biological_process	xenobiotic catabolic process
A	0045174	molecular_function	glutathione dehydrogenase (ascorbate) activity
A	0050610	molecular_function	methylarsonate reductase activity
A	0051280	biological_process	negative regulation of release of sequestered calcium ion into cytosol
A	0051281	biological_process	positive regulation of release of sequestered calcium ion into cytosol
A	0070062	cellular_component	extracellular exosome
A	0071243	biological_process	cellular response to arsenic-containing substance
A	0098869	biological_process	cellular oxidant detoxification

Functional Information from PDB Data

site_id	AC1
Number of Residues	10
Details	binding site for residue 85P A 301

Chain	Residue
A	MET29
A	HOH563
A	PHE31
A	LEU56
A	VAL127
A	ILE131
A	ARG183
A	ALA186
A	PHE225
A	TYR229

---

site_id	AC2
Number of Residues	8
Details	binding site for residue SO4 A 302

Chain	Residue
A	ARG39
A	HIS49
A	VAL51
A	LEU215
A	HOH421
A	HOH510
A	HOH515
A	HOH532

---

site_id	AC3
Number of Residues	8
Details	binding site for residue SO4 A 303

Chain	Residue
A	ARG30
A	LYS136
A	HOH421
A	HOH459
A	HOH473
A	HOH490
A	HOH498
A	HOH515

---

site_id	AC4
Number of Residues	7
Details	binding site for residue SO4 A 304

Chain	Residue
A	GLU21
A	GLY22
A	SER78
A	GLN79
A	HOH407
A	HOH409
A	HOH435

---

site_id	AC5
Number of Residues	2
Details	binding site for residue SO4 A 305

Chain	Residue
A	ARG48
A	LYS200

---

site_id	AC6
Number of Residues	2
Details	binding site for residue SO4 A 306

Chain	Residue
A	SER129
A	ARG132

---

site_id	AC7
Number of Residues	5
Details	binding site for residue GOL A 307

Chain	Residue
A	TYR84
A	CYS112
A	HOH402
A	HOH416
A	HOH518

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	79
Details	Domain: {"description":"GST N-terminal"}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	124
Details	Domain: {"description":"GST C-terminal"}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	Active site: {"description":"Nucleophile","evidences":[{"source":"PubMed","id":"10783391","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PubMed","id":"10783391","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21106529","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---