7AVZ
| MerTK kinase domain in complex with a bisaminopyrimidine inhibitor | 分子名称: | (R)-N2-(4-(cyclopropylmethoxy)-3,5-difluorophenyl)-5-(3-methylpiperazin-1-yl)-N4-(tetrahydro-2H-pyran-4-yl)pyrimidine-2,4-diamine, Tyrosine-protein kinase Mer | 著者 | Pflug, A, Nissink, J.W.M, Blackett, C, Goldberg, K, Hennessy, E.J, Hardaker, E, McCoull, W, McMurray, L, Collingwood, O, Overman, R, Preston, M, Rawlins, P, Rivers, E, Schimpl, M, Smith, P, Underwood, E, Truman, C, Warwicker, J, Winter, J, Woodcock, S. | 登録日 | 2020-11-06 | 公開日 | 2021-03-03 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (2.04 Å) | 主引用文献 | Generating Selective Leads for Mer Kinase Inhibitors-Example of a Comprehensive Lead-Generation Strategy. J.Med.Chem., 64, 2021
|
|
7AW1
| MerTK kinase domain in complex with a type 2 inhibitor | 分子名称: | N-(6-(4-(3-(4-((5,6-dihydroimidazo[1,2-a]pyrazin-7(8H)-yl)methyl)-3-(trifluoromethyl)phenyl)ureido)phenoxy)pyrimidin-4-yl)cyclopropanecarboxamide, Tyrosine-protein kinase Mer | 著者 | Schimpl, M, Nissink, J.W.M, Blackett, C, Goldberg, K, Hennessy, E.J, Hardaker, E, McCoull, W, McMurray, L, Collingwood, O, Overman, R, Pflug, A, Preston, M, Rawlins, P, Rivers, E, Smith, P, Underwood, E, Truman, C, Warwicker, J, Winter, J, Woodcock, S. | 登録日 | 2020-11-06 | 公開日 | 2021-03-03 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (1.98 Å) | 主引用文献 | Generating Selective Leads for Mer Kinase Inhibitors-Example of a Comprehensive Lead-Generation Strategy. J.Med.Chem., 64, 2021
|
|
7AW3
| MerTK kinase domain with type 1 inhibitor from a DNA-encoded library | 分子名称: | 2-(1-((5-chloro-1H-pyrrolo[2,3-b]pyridine-3-carboxamido)methyl)-2-azabicyclo[2.1.1]hexan-2-yl)-N-methyl-4-(trifluoromethyl)thiazole-5-carboxamide, Tyrosine-protein kinase Mer | 著者 | Schimpl, M, Nissink, J.W.M, Blackett, C, Goldberg, K, Hennessy, E.J, Hardaker, E, McCoull, W, McMurray, L, Collingwood, O, Overman, R, Pflug, A, Preston, M, Rawlins, P, Rivers, E, Smith, P, Underwood, E, Truman, C, Warwicker, J, Winter, J, Woodcock, S. | 登録日 | 2020-11-06 | 公開日 | 2021-03-03 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (1.99 Å) | 主引用文献 | Generating Selective Leads for Mer Kinase Inhibitors-Example of a Comprehensive Lead-Generation Strategy. J.Med.Chem., 64, 2021
|
|
4QM6
| Structure of bacterial polynucleotide kinase bound to GTP and RNA | 分子名称: | GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Metallophosphoesterase, ... | 著者 | Das, U, Wang, L.K, Smith, P, Shuman, S. | 登録日 | 2014-06-15 | 公開日 | 2014-10-08 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Structures of bacterial polynucleotide kinase in a michaelis complex with nucleoside triphosphate (NTP)-Mg2+ and 5'-OH RNA and a mixed substrate-product complex with NTP-Mg2+ and a 5'-phosphorylated oligonucleotide. J.Bacteriol., 196, 2014
|
|
4QM7
| Structure of bacterial polynucleotide kinase bound to GTP and pDNA | 分子名称: | DNA, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | 著者 | Das, U, Wang, L.K, Smith, P, Shuman, S. | 登録日 | 2014-06-15 | 公開日 | 2014-10-08 | 最終更新日 | 2015-02-18 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Structures of bacterial polynucleotide kinase in a michaelis complex with nucleoside triphosphate (NTP)-Mg2+ and 5'-OH RNA and a mixed substrate-product complex with NTP-Mg2+ and a 5'-phosphorylated oligonucleotide. J.Bacteriol., 196, 2014
|
|
4O88
| Crystal structure of a C-tagged Nuclease | 分子名称: | CHLORIDE ION, N-tagged Nuclease, SULFATE ION | 著者 | Chakravarty, A.K, Smith, P, Shuman, S. | 登録日 | 2013-12-26 | 公開日 | 2014-10-15 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Structure, mechanism, and specificity of a eukaryal tRNA restriction enzyme involved in self-nonself discrimination. Cell Rep, 7, 2014
|
|
7LS1
| 80S ribosome from mouse bound to eEF2 (Class II) | 分子名称: | 28S rRNA, 40S ribosomal protein S10, 40S ribosomal protein S11, ... | 著者 | Loerch, S, Smith, P.R, Kunder, N, Stanowick, A.D, Lou, T.-F, Campbell, Z.T. | 登録日 | 2021-02-17 | 公開日 | 2021-11-03 | 最終更新日 | 2021-12-08 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Functionally distinct roles for eEF2K in the control of ribosome availability and p-body abundance. Nat Commun, 12, 2021
|
|
7LS2
| 80S ribosome from mouse bound to eEF2 (Class I) | 分子名称: | 18S rRNA, 28S rRNA, 40S ribosomal protein S10, ... | 著者 | Loerch, S, Smith, P.R, Kunder, N, Stanowick, A.D, Lou, T.-F, Campbell, Z.T. | 登録日 | 2021-02-17 | 公開日 | 2021-11-03 | 最終更新日 | 2021-12-08 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Functionally distinct roles for eEF2K in the control of ribosome availability and p-body abundance. Nat Commun, 12, 2021
|
|
4LQD
| The crystal structures of the Brucella protein TcpB and the TLR adaptor protein TIRAP show structural differences in microbial TIR mimicry | 分子名称: | GLYCEROL, Toll/interleukin-1 receptor domain-containing adapter protein | 著者 | Snyder, G.A, Smith, P, Jiang, J, Xiao, T.S. | 登録日 | 2013-07-17 | 公開日 | 2013-12-04 | 最終更新日 | 2014-04-09 | 実験手法 | X-RAY DIFFRACTION (2.451 Å) | 主引用文献 | Crystal structures of the Toll/Interleukin-1 receptor (TIR) domains from the Brucella protein TcpB and host adaptor TIRAP reveal mechanisms of molecular mimicry. J.Biol.Chem., 289, 2014
|
|
4GP6
| Polynucleotide kinase | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Metallophosphoesterase | 著者 | Wang, L.K, Das, U, Smith, P, Shuman, S. | 登録日 | 2012-08-20 | 公開日 | 2012-11-14 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Structure and mechanism of the polynucleotide kinase component of the bacterial Pnkp-Hen1 RNA repair system. Rna, 18, 2012
|
|
4GP7
| Polynucleotide kinase | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, CITRIC ACID, MAGNESIUM ION, ... | 著者 | Wang, L.K, Das, U, Smith, P, Shuman, S. | 登録日 | 2012-08-20 | 公開日 | 2012-11-14 | 最終更新日 | 2017-11-15 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Structure and mechanism of the polynucleotide kinase component of the bacterial Pnkp-Hen1 RNA repair system. Rna, 18, 2012
|
|
4LQC
| The crystal structures of the Brucella protein TcpB and the TLR adaptor protein TIRAP show structural differences in microbial TIR mimicry. | 分子名称: | TcpB | 著者 | Snyder, G.A, Smith, P, Fresquez, T, Cirl, C, Jiang, J, Snyder, N, Luchetti, T, Miethke, T, Xiao, T.S. | 登録日 | 2013-07-17 | 公開日 | 2013-12-04 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Crystal structures of the Toll/Interleukin-1 receptor (TIR) domains from the Brucella protein TcpB and host adaptor TIRAP reveal mechanisms of molecular mimicry. J.Biol.Chem., 289, 2014
|
|
3VD8
| Crystal structure of human AIM2 PYD domain with MBP fusion | 分子名称: | 1,2-ETHANEDIOL, Maltose-binding periplasmic protein, Interferon-inducible protein AIM2, ... | 著者 | Jin, T.C, Perry, A, Smith, P, Xiao, T.S. | 登録日 | 2012-01-04 | 公開日 | 2013-01-16 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.0685 Å) | 主引用文献 | Structure of the Absent in Melanoma 2 (AIM2) Pyrin Domain Provides Insights into the Mechanisms of AIM2 Autoinhibition and Inflammasome Assembly. J.Biol.Chem., 288, 2013
|
|
4IRL
| X-ray structure of the CARD domain of zebrafish GBP-NLRP1 like protein | 分子名称: | 1,2-ETHANEDIOL, ACETATE ION, DI(HYDROXYETHYL)ETHER, ... | 著者 | Jin, T, Huang, M, Smith, P, Xiao, T. | 登録日 | 2013-01-15 | 公開日 | 2013-08-07 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.47 Å) | 主引用文献 | Structure of the caspase-recruitment domain from a zebrafish guanylate-binding protein. Acta Crystallogr.,Sect.F, 69, 2013
|
|
4J6O
| Crystal Structure of the Phosphatase Domain of C. thermocellum (Bacterial) PnkP | 分子名称: | CITRIC ACID, GLYCEROL, MANGANESE (II) ION, ... | 著者 | Wang, L, Smith, P, Shuman, S. | 登録日 | 2013-02-11 | 公開日 | 2013-04-10 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Structure and mechanism of the 2',3' phosphatase component of the bacterial Pnkp-Hen1 RNA repair system. Nucleic Acids Res., 41, 2013
|
|
4JT2
| Structure of Clostridium thermocellum polynucleotide kinase bound to CTP | 分子名称: | CYTIDINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Metallophosphoesterase | 著者 | Das, U, Wang, L.K, Smith, P, Shuman, S. | 登録日 | 2013-03-22 | 公開日 | 2013-08-28 | 最終更新日 | 2013-12-18 | 実験手法 | X-RAY DIFFRACTION (2.49 Å) | 主引用文献 | Structural and biochemical analysis of the phosphate donor specificity of the polynucleotide kinase component of the bacterial pnkphen1 RNA repair system. Biochemistry, 52, 2013
|
|
4JT4
| Structure of Clostridium thermocellum polynucleotide kinase bound to dATP | 分子名称: | 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, MAGNESIUM ION, Metallophosphoesterase, ... | 著者 | Das, U, Wang, L.K, Smith, P, Shuman, S. | 登録日 | 2013-03-22 | 公開日 | 2013-08-28 | 最終更新日 | 2013-12-18 | 実験手法 | X-RAY DIFFRACTION (2.01 Å) | 主引用文献 | Structural and biochemical analysis of the phosphate donor specificity of the polynucleotide kinase component of the bacterial pnkphen1 RNA repair system. Biochemistry, 52, 2013
|
|
4JSY
| Structure of Clostridium thermocellum polynucleotide kinase bound to GTP | 分子名称: | GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Metallophosphoesterase | 著者 | Das, U, Wang, L.K, Smith, P, Shuman, S. | 登録日 | 2013-03-22 | 公開日 | 2013-08-28 | 最終更新日 | 2013-12-18 | 実験手法 | X-RAY DIFFRACTION (2.14 Å) | 主引用文献 | Structural and biochemical analysis of the phosphate donor specificity of the polynucleotide kinase component of the bacterial pnkphen1 RNA repair system. Biochemistry, 52, 2013
|
|
4JST
| Structure of Clostridium thermocellum polynucleotide kinase bound to UTP | 分子名称: | MAGNESIUM ION, Metallophosphoesterase, SODIUM ION, ... | 著者 | Das, U, Wang, L.K, Smith, P, Shuman, S. | 登録日 | 2013-03-22 | 公開日 | 2013-08-28 | 最終更新日 | 2013-12-18 | 実験手法 | X-RAY DIFFRACTION (2.03 Å) | 主引用文献 | Structural and biochemical analysis of the phosphate donor specificity of the polynucleotide kinase component of the bacterial pnkphen1 RNA repair system. Biochemistry, 52, 2013
|
|
4IKM
| X-ray structure of CARD8 CARD domain | 分子名称: | 1,2-ETHANEDIOL, IODIDE ION, Maltose-binding periplasmic protein, ... | 著者 | Jin, T, Huang, M, Smith, P, Jiang, J, Xiao, T. | 登録日 | 2012-12-26 | 公開日 | 2013-05-08 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.4606 Å) | 主引用文献 | The structure of the CARD8 caspase-recruitment domain suggests its association with the FIIND domain and procaspases through adjacent surfaces. Acta Crystallogr.,Sect.F, 69, 2013
|
|
4LI5
| EGFR-K IN COMPLEX WITH N-[3-[[5-chloro-4-(1H-indol-3-yl)pyrimidin-2-yl]amino]-4-methoxy-phenyl] Prop-2-enamide | 分子名称: | Epidermal growth factor receptor, N-(3-{[5-chloro-4-(1H-indol-3-yl)pyrimidin-2-yl]amino}-4-methoxyphenyl)propanamide, SODIUM ION | 著者 | Debreczeni, J.E, Seiffert, G.B, Kiefersauer, R, Augustin, M, Nagel, S, Ward, R, Anderton, M, Ashton, S, Bethel, P, Box, M, Butterworth, S, Colclough, N, Chroley, C, Chuaqui, C, Cross, D, Eberlein, C, Finlay, R, Hill, G, Grist, M, Klinowska, T, Lane, C, Martin, S, Orme, J, Smith, P, Wang, F, Waring, M. | 登録日 | 2013-07-02 | 公開日 | 2013-08-28 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.64 Å) | 主引用文献 | Structure- and Reactivity-Based Development of Covalent Inhibitors of the Activating and Gatekeeper Mutant Forms of the Epidermal Growth Factor Receptor (EGFR). J.Med.Chem., 56, 2013
|
|
1NKV
| X-RAY STRUCTURE OF YJHP FROM E.COLI NORTHEAST STRUCTURAL GENOMICS RESEARCH CONSORTIUM (NESG) TARGET ER13 | 分子名称: | HYPOTHETICAL PROTEIN yjhP | 著者 | Kuzin, A, Manor, P, Benach, J, Smith, P, Rost, B, Xiao, R, Montelione, G, Hunt, J, Northeast Structural Genomics Consortium (NESG) | 登録日 | 2003-01-03 | 公開日 | 2003-01-28 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | X-RAY STRUCTURE OF YJHP FROM E.COLI NORTHEAST STRUCTURAL GENOMICS RESEARCH CONSORTIUM (NESG) TARGET ER13 To be published
|
|
4MDE
| Structure of bacterial polynucleotide kinase product complex bound to GDP and DNA | 分子名称: | DNA (5'-D(P*CP*CP*TP*GP*T)-3'), GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... | 著者 | Shuman, S, Das, U, Wang, L.K, Smith, P, Jacewicz, A. | 登録日 | 2013-08-22 | 公開日 | 2013-11-06 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Structures of bacterial polynucleotide kinase in a Michaelis complex with GTP*Mg2+ and 5'-OH oligonucleotide and a product complex with GDP*Mg2+ and 5'-PO4 oligonucleotide reveal a mechanism of general acid-base catalysis and the determinants of phosphoacceptor recognition. Nucleic Acids Res., 42, 2014
|
|
1L3I
| MT0146, THE PRECORRIN-6Y METHYLTRANSFERASE (CBIT) HOMOLOG FROM M. THERMOAUTOTROPHICUM, ADOHCY BINARY COMPLEX | 分子名称: | Precorrin-6y methyltransferase/putative decarboxylase, S-ADENOSYL-L-HOMOCYSTEINE | 著者 | Keller, J.P, Smith, P.M, Benach, J, Christendat, D, deTitta, G, Hunt, J.F. | 登録日 | 2002-02-27 | 公開日 | 2002-11-27 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | The Crystal Structure of Mt0146/CbiT Suggests that the Putative Precorrin-8W Decarboxylase is a Methyltransferase Structure, 10, 2002
|
|
4MDF
| Structure of bacterial polynucleotide kinase Michaelis complex bound to GTP and DNA | 分子名称: | CITRIC ACID, DNA (5'-D(*CP*CP*TP*GP*T)-3'), GUANOSINE-5'-TRIPHOSPHATE, ... | 著者 | Shuman, S, Das, U, Wang, L.K, Smith, P, Jacewicz, A. | 登録日 | 2013-08-22 | 公開日 | 2013-11-06 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.727 Å) | 主引用文献 | Structures of bacterial polynucleotide kinase in a Michaelis complex with GTP*Mg2+ and 5'-OH oligonucleotide and a product complex with GDP*Mg2+ and 5'-PO4 oligonucleotide reveal a mechanism of general acid-base catalysis and the determinants of phosphoacceptor recognition. Nucleic Acids Res., 42, 2014
|
|