4LI5

EGFR-K IN COMPLEX WITH N-[3-[[5-chloro-4-(1H-indol-3-yl)pyrimidin-2-yl]amino]-4-methoxy-phenyl] Prop-2-enamide

Summary for 4LI5

• Entry DOI: 10.2210/pdb4li5/pdb
• Descriptor: Epidermal growth factor receptor, N-(3-{[5-chloro-4-(1H-indol-3-yl)pyrimidin-2-yl]amino}-4-methoxyphenyl)propanamide, SODIUM ION, ... (4 entities in total)
• Functional Keywords: egf receptor kinase, inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (human)
• Cellular location: Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted: P00533
• Total number of polymer chains: 1
• Total formula weight: 37839.15

Authors

Debreczeni, J.E.,Seiffert, G.B.,Kiefersauer, R.,Augustin, M.,Nagel, S.,Ward, R.,Anderton, M.,Ashton, S.,Bethel, P.,Box, M.,Butterworth, S.,Colclough, N.,Chroley, C.,Chuaqui, C.,Cross, D.,Eberlein, C.,Finlay, R.,Hill, G.,Grist, M.,Klinowska, T.,Lane, C.,Martin, S.,Orme, J.,Smith, P.,Wang, F.,Waring, M. (deposition date: 2013-07-02, release date: 2013-08-28, Last modification date: 2024-02-28)

• Primary citation: Ward, R.A.,Anderton, M.J.,Ashton, S.,Bethel, P.A.,Box, M.,Butterworth, S.,Colclough, N.,Chorley, C.G.,Chuaqui, C.,Cross, D.A.,Dakin, L.A.,Debreczeni, J.E.,Eberlein, C.,Finlay, M.R.,Hill, G.B.,Grist, M.,Klinowska, T.C.,Lane, C.,Martin, S.,Orme, J.P.,Smith, P.,Wang, F.,Waring, M.J.; Structure- and Reactivity-Based Development of Covalent Inhibitors of the Activating and Gatekeeper Mutant Forms of the Epidermal Growth Factor Receptor (EGFR).; J.Med.Chem., 56:7025-7048, 2013; PubMed: 23930994; DOI: 10.1021/jm400822z

Experimental method

X-RAY DIFFRACTION (2.64 Å)