5KL7
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![BU of 5kl7 by Molmil](/molmil-images/mine/5kl7) | Wilms Tumor Protein (WT1) ZnF2-4Q369R in complex with carboxylated DNA | Descriptor: | 1,2-ETHANEDIOL, DNA (5'-D(*AP*GP*CP*GP*TP*GP*GP*GP*(1CC)P*GP*T)-3'), DNA (5'-D(*TP*AP*(5CM)P*GP*CP*CP*CP*AP*CP*GP*C)-3'), ... | Authors: | Hashimoto, H, Cheng, X. | Deposit date: | 2016-06-23 | Release date: | 2016-09-14 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.579 Å) | Cite: | Denys-Drash syndrome associated WT1 glutamine 369 mutants have altered sequence-preferences and altered responses to epigenetic modifications. Nucleic Acids Res., 44, 2016
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8HN3
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![BU of 8hn3 by Molmil](/molmil-images/mine/8hn3) | Soluble domain of cytochrome c-556 from Chlorobaculum tepidum | Descriptor: | ACETATE ION, Cytochrome c-556, GLYCEROL, ... | Authors: | Kishimoto, H, Azai, C, Yamamoto, T, Mutoh, R, Nakaniwa, T, Tanaka, H, Kurisu, G, Oh-oka, H. | Deposit date: | 2022-12-07 | Release date: | 2023-07-05 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | Soluble domains of cytochrome c-556 and Rieske iron-sulfur protein from Chlorobaculum tepidum: Crystal structures and interaction analysis. Curr Res Struct Biol, 5, 2023
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6DNZ
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![BU of 6dnz by Molmil](/molmil-images/mine/6dnz) | Trypanosoma brucei PRMT1 enzyme-prozyme heterotetrameric complex with AdoHcy | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Arginine N-methyltransferase, putative, ... | Authors: | Hashimoto, H, Kafkova, L, Jordan, K, Read, L.K, Debler, E.W. | Deposit date: | 2018-06-08 | Release date: | 2019-06-12 | Last modified: | 2020-02-12 | Method: | X-RAY DIFFRACTION (2.384 Å) | Cite: | Structural Basis of Protein Arginine Methyltransferase Activation by a Catalytically Dead Homolog (Prozyme). J.Mol.Biol., 432, 2020
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8HN2
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![BU of 8hn2 by Molmil](/molmil-images/mine/8hn2) | Selenomethionine-labelled soluble domain of Rieske iron-sulfur protein from chlorobaculum tepidum | Descriptor: | Cytochrome b6-f complex iron-sulfur subunit, FE2/S2 (INORGANIC) CLUSTER | Authors: | Kishimoto, H, Mutoh, R, Tanaka, H, Kurisu, G, Oh-oka, H. | Deposit date: | 2022-12-07 | Release date: | 2023-07-05 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Soluble domains of cytochrome c-556 and Rieske iron-sulfur protein from Chlorobaculum tepidum: Crystal structures and interaction analysis. Curr Res Struct Biol, 5, 2023
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5ZHX
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![BU of 5zhx by Molmil](/molmil-images/mine/5zhx) | |
8XGR
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![BU of 8xgr by Molmil](/molmil-images/mine/8xgr) | ETB-eGt complex bound to endothelin-1 | Descriptor: | Camelid antibody VHH fragment, Endothelin receptor type B, Endothelin-1, ... | Authors: | Oshima, H.S, Sano, F.K, Akasaka, H, Iwama, A, Shihoya, W, Nureki, O. | Deposit date: | 2023-12-15 | Release date: | 2024-04-03 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Optimizing cryo-EM structural analysis of G i -coupling receptors via engineered G t and Nb35 application. Biochem.Biophys.Res.Commun., 693, 2024
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5T00
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![BU of 5t00 by Molmil](/molmil-images/mine/5t00) | Human CTCF ZnF3-7 and methylated DNA complex | Descriptor: | DNA (5'-GCCAGCAGGGGG(5CM)GCTA-3'), DNA (5'-TAG(5CM)GCCCCCTGCTGGC-3'), Transcriptional repressor CTCF, ... | Authors: | Hashimoto, H, Wang, D, Cheng, X. | Deposit date: | 2016-08-15 | Release date: | 2017-05-24 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.19 Å) | Cite: | Structural Basis for the Versatile and Methylation-Dependent Binding of CTCF to DNA. Mol. Cell, 66, 2017
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5T0U
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![BU of 5t0u by Molmil](/molmil-images/mine/5t0u) | CTCF ZnF2-7 and DNA complex structure | Descriptor: | DNA (5'-D(*CP*CP*TP*CP*AP*CP*TP*AP*GP*CP*GP*CP*CP*CP*CP*CP*TP*GP*CP*TP*GP*GP*C)-3'), DNA (5'-D(*GP*CP*CP*AP*GP*CP*AP*GP*GP*GP*GP*GP*CP*GP*CP*TP*AP*GP*TP*GP*AP*GP*G)-3'), Transcriptional repressor CTCF, ... | Authors: | Hashimoto, H, Wang, D, Cheng, X. | Deposit date: | 2016-08-16 | Release date: | 2017-05-24 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (3.199 Å) | Cite: | Structural Basis for the Versatile and Methylation-Dependent Binding of CTCF to DNA. Mol. Cell, 66, 2017
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2RSO
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3ALR
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![BU of 3alr by Molmil](/molmil-images/mine/3alr) | Crystal structure of Nanos | Descriptor: | Nanos protein, ZINC ION | Authors: | Hashimoto, H, Hara, K, Hishiki, A, Kawaguchi, S, Shichijo, N, Nakamura, K, Unzai, S, Tamaru, Y, Shimizu, T, Sato, M. | Deposit date: | 2010-08-06 | Release date: | 2011-02-02 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Crystal structure of zinc-finger domain of Nanos and its functional implications Embo Rep., 11, 2010
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3G5S
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![BU of 3g5s by Molmil](/molmil-images/mine/3g5s) | Crystal structure of Thermus thermophilus TrmFO in complex with glutathione | Descriptor: | 1,2-ETHANEDIOL, FLAVIN-ADENINE DINUCLEOTIDE, GLUTATHIONE, ... | Authors: | Nishimasu, H, Ishitani, R, Hori, H, Nureki, O. | Deposit date: | 2009-02-05 | Release date: | 2009-05-19 | Last modified: | 2011-12-14 | Method: | X-RAY DIFFRACTION (1.05 Å) | Cite: | Atomic structure of a folate/FAD-dependent tRNA T54 methyltransferase Proc.Natl.Acad.Sci.USA, 106, 2009
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5XGC
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![BU of 5xgc by Molmil](/molmil-images/mine/5xgc) | Crystal structure of SmgGDS-558 | Descriptor: | Rap1 GTPase-GDP dissociation stimulator 1 | Authors: | Shimizu, H, Toma-Fukai, S, Shimizu, T. | Deposit date: | 2017-04-13 | Release date: | 2017-06-28 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structure-based analysis of the guanine nucleotide exchange factor SmgGDS reveals armadillo-repeat motifs and key regions for activity and GTPase binding J. Biol. Chem., 292, 2017
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3G5R
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![BU of 3g5r by Molmil](/molmil-images/mine/3g5r) | Crystal structure of Thermus thermophilus TrmFO in complex with tetrahydrofolate | Descriptor: | (6S)-5,6,7,8-TETRAHYDROFOLATE, 1,2-ETHANEDIOL, CALCIUM ION, ... | Authors: | Nishimasu, H, Ishitani, R, Hori, H, Nureki, O. | Deposit date: | 2009-02-05 | Release date: | 2009-05-19 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Atomic structure of a folate/FAD-dependent tRNA T54 methyltransferase Proc.Natl.Acad.Sci.USA, 106, 2009
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4LT5
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![BU of 4lt5 by Molmil](/molmil-images/mine/4lt5) | Structure of a Naegleria Tet-like dioxygenase in complex with 5-methylcytosine DNA | Descriptor: | 1,2-ETHANEDIOL, DNA, MANGANESE (II) ION, ... | Authors: | Hashimoto, H, Pais, J.E, Zhang, X, Saleh, L, Fu, Z.Q, Dai, N, Correa, I.R, Roberts, R.J, Zheng, Y, Cheng, X. | Deposit date: | 2013-07-23 | Release date: | 2013-12-18 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.893 Å) | Cite: | Structure of a Naegleria Tet-like dioxygenase in complex with 5-methylcytosine DNA. Nature, 506, 2014
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5KE7
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![BU of 5ke7 by Molmil](/molmil-images/mine/5ke7) | mouse Klf4 ZnF1-3 and TpG/MpA sequence DNA complex structure | Descriptor: | 1,2-ETHANEDIOL, DNA (5'-D(*GP*AP*GP*GP*TP*GP*TP*GP*GP*C)-3'), DNA (5'-D(*GP*CP*CP*AP*(5CM)P*AP*CP*CP*TP*C)-3'), ... | Authors: | Hashimoto, H, Cheng, X. | Deposit date: | 2016-06-09 | Release date: | 2016-09-14 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.06 Å) | Cite: | Distinctive Klf4 mutants determine preference for DNA methylation status. Nucleic Acids Res., 44, 2016
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5K5I
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![BU of 5k5i by Molmil](/molmil-images/mine/5k5i) | |
5KE6
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![BU of 5ke6 by Molmil](/molmil-images/mine/5ke6) | mouse Klf4 ZnF1-3 and TpG/CpA sequence DNA complex structure | Descriptor: | DNA (5'-D(*GP*AP*GP*GP*TP*GP*TP*GP*GP*C)-3'), DNA (5'-D(*GP*CP*CP*AP*CP*AP*CP*CP*TP*C)-3'), Krueppel-like factor 4, ... | Authors: | Hashimoto, H, Cheng, X. | Deposit date: | 2016-06-09 | Release date: | 2016-09-14 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.99 Å) | Cite: | Distinctive Klf4 mutants determine preference for DNA methylation status. Nucleic Acids Res., 44, 2016
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5KEB
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3W69
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![BU of 3w69 by Molmil](/molmil-images/mine/3w69) | Crystal structure of human mdm2 with a dihydroimidazothiazole inhibitor | Descriptor: | (5R,6S)-2-[((2S,5R)-2-{[(3R)-4-acetyl-3-methylpiperazin-1-yl]carbonyl}-5-ethylpyrrolidin-1-yl)carbonyl]-5,6-bis(4-chlorophenyl)-3-isopropyl-6-methyl-5,6-dihydroimidazo[2,1-b][1,3]thiazole, E3 ubiquitin-protein ligase Mdm2, SULFATE ION | Authors: | Shimizu, H, Katakura, S, Miyazaki, M, Naito, H, Sugimoto, Y, Kawato, H, Okayama, T, Soga, T. | Deposit date: | 2013-02-12 | Release date: | 2013-06-05 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Synthesis and evaluation of novel orally active p53-MDM2 interaction inhibitors Bioorg.Med.Chem., 21, 2013
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4GEM
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![BU of 4gem by Molmil](/molmil-images/mine/4gem) | Crystal structure of Zucchini (K171A) | Descriptor: | 1,2-ETHANEDIOL, Mitochondrial cardiolipin hydrolase, ZINC ION | Authors: | Nishimasu, H, Fukuhara, S, Ishitani, R, Nureki, O. | Deposit date: | 2012-08-02 | Release date: | 2012-10-17 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.206 Å) | Cite: | Structure and function of Zucchini endoribonuclease in piRNA biogenesis Nature, 491, 2012
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6AI6
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![BU of 6ai6 by Molmil](/molmil-images/mine/6ai6) | Crystal structure of SpCas9-NG | Descriptor: | 1,2-ETHANEDIOL, CRISPR-associated endonuclease Cas9/Csn1, DNA (28-MER), ... | Authors: | Nishimasu, H, Hirano, S, Ishitani, R, Nureki, O. | Deposit date: | 2018-08-21 | Release date: | 2018-10-31 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Engineered CRISPR-Cas9 nuclease with expanded targeting space Science, 361, 2018
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2RO0
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![BU of 2ro0 by Molmil](/molmil-images/mine/2ro0) | Solution structure of the knotted tudor domain of the yeast histone acetyltransferase, Esa1 | Descriptor: | Histone acetyltransferase ESA1 | Authors: | Shimojo, H, Sano, N, Moriwaki, Y, Okuda, M, Horikoshi, M, Nishimura, Y. | Deposit date: | 2008-03-01 | Release date: | 2008-04-29 | Last modified: | 2024-05-29 | Method: | SOLUTION NMR | Cite: | Novel structural and functional mode of a knot essential for RNA binding activity of the Esa1 presumed chromodomain J.Mol.Biol., 378, 2008
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2RNZ
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![BU of 2rnz by Molmil](/molmil-images/mine/2rnz) | Solution structure of the presumed chromodomain of the yeast histone acetyltransferase, Esa1 | Descriptor: | Histone acetyltransferase ESA1 | Authors: | Shimojo, H, Sano, N, Moriwaki, Y, Okuda, M, Horikoshi, M, Nishimura, Y. | Deposit date: | 2008-03-01 | Release date: | 2008-04-29 | Last modified: | 2024-05-29 | Method: | SOLUTION NMR | Cite: | Novel structural and functional mode of a knot essential for RNA binding activity of the Esa1 presumed chromodomain J.Mol.Biol., 378, 2008
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2RSN
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![BU of 2rsn by Molmil](/molmil-images/mine/2rsn) | |
1EHG
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![BU of 1ehg by Molmil](/molmil-images/mine/1ehg) | |