6OVY
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7BMJ
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![BU of 7bmj by Molmil](/molmil-images/mine/7bmj) | Aspartyl/Asparaginyl beta-hydroxylase (AspH) oxygenase and TPR domains in complex with manganese, 5-fluoropyridine-2,4-dicarboxylic acid, and factor X substrate peptide fragment (39mer-4Ser) | Descriptor: | 5-fluoranylpyridine-2,4-dicarboxylic acid, Aspartyl/asparaginyl beta-hydroxylase, Coagulation factor X, ... | Authors: | Nakashima, Y, Brewitz, L, Schofield, C.J. | Deposit date: | 2021-01-20 | Release date: | 2021-06-02 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Fluorinated derivatives of pyridine-2,4-dicarboxylate are potent inhibitors of human 2-oxoglutarate dependent oxygenases J Fluor Chem, 247, 2021
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6OVR
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4ZID
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![BU of 4zid by Molmil](/molmil-images/mine/4zid) | Dimeric Hydrogenobacter thermophilus cytochrome c552 obtained from Escherichia coli | Descriptor: | Cytochrome c-552, HEME C | Authors: | Hayashi, Y, Yamanaka, M, Nagao, S, Komori, H, Higuchi, Y, Hirota, S. | Deposit date: | 2015-04-28 | Release date: | 2016-02-10 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Domain swapping oligomerization of thermostable c-type cytochrome in E. coli cells Sci Rep, 6, 2016
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5KC1
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![BU of 5kc1 by Molmil](/molmil-images/mine/5kc1) | Structure of the C-terminal dimerization domain of Atg38 | Descriptor: | 1,2-ETHANEDIOL, AMMONIUM ION, Autophagy-related protein 38, ... | Authors: | Ohashi, Y, Soler, N, Garcia-Ortegon, M, Zhang, L, Perisic, O, Masson, G.R, Johnson, C.M, Williams, R.J. | Deposit date: | 2016-06-04 | Release date: | 2016-10-05 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Characterization of Atg38 and NRBF2, a fifth subunit of the autophagic Vps34/PIK3C3 complex. Autophagy, 12, 2016
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8WD4
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![BU of 8wd4 by Molmil](/molmil-images/mine/8wd4) | EGFR(L858R/T790/C797S) in complex with compound 5j | Descriptor: | CHLORIDE ION, Epidermal growth factor receptor, ~{N}-[3,3-bis(fluoranyl)propyl]-4-[[(2~{S})-butan-2-yl]amino]-6-[[2-(1-cyclopropylsulfonylpyrazol-4-yl)pyrimidin-4-yl]amino]pyridine-3-carboxamide | Authors: | Nishikawa, Y. | Deposit date: | 2023-09-14 | Release date: | 2023-12-20 | Last modified: | 2024-01-03 | Method: | X-RAY DIFFRACTION (2.55 Å) | Cite: | Synthesis, activity, and their relationships of 2,4-diaminonicotinamide derivatives as EGFR inhibitors targeting C797S mutation. Bioorg.Med.Chem.Lett., 98, 2023
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3KDN
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![BU of 3kdn by Molmil](/molmil-images/mine/3kdn) | Crystal structure of Type III Rubisco SP4 mutant complexed with 2-CABP | Descriptor: | 2-CARBOXYARABINITOL-1,5-DIPHOSPHATE, MAGNESIUM ION, Ribulose bisphosphate carboxylase | Authors: | Nishitani, Y, Fujihashi, M, Doi, T, Yoshida, S, Atomi, H, Imanaka, T, Miki, K. | Deposit date: | 2009-10-23 | Release date: | 2010-10-06 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.09 Å) | Cite: | Structure-based catalytic optimization of a type III Rubisco from a hyperthermophile J.Biol.Chem., 285, 2010
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3KDO
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![BU of 3kdo by Molmil](/molmil-images/mine/3kdo) | Crystal structure of Type III Rubisco SP6 mutant complexed with 2-CABP | Descriptor: | 2-CARBOXYARABINITOL-1,5-DIPHOSPHATE, MAGNESIUM ION, Ribulose bisphosphate carboxylase | Authors: | Nishitani, Y, Fujihashi, M, Doi, T, Yoshida, S, Atomi, H, Imanaka, T, Miki, K. | Deposit date: | 2009-10-23 | Release date: | 2010-10-06 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.36 Å) | Cite: | Structure-based catalytic optimization of a type III Rubisco from a hyperthermophile J.Biol.Chem., 285, 2010
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3O26
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5ZQU
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![BU of 5zqu by Molmil](/molmil-images/mine/5zqu) | Crystal structure of tetrameric RXRalpha-LBD complexed with partial agonist CBt-PMN | Descriptor: | 1-(3,5,5,8,8-pentamethyl-6,7-dihydronaphthalen-2-yl)benzotriazole-5-carboxylic acid, BROMIDE ION, Retinoic acid receptor RXR-alpha | Authors: | Miyashita, Y, Numoto, N, Arulmozhiraja, S, Nakano, S, Matsuo, N, Shimizu, K, Kakuta, H, Ito, S, Ikura, T, Ito, N, Tokiwa, H. | Deposit date: | 2018-04-20 | Release date: | 2019-02-27 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.60038781 Å) | Cite: | Dual conformation of the ligand induces the partial agonistic activity of retinoid X receptor alpha (RXR alpha ). FEBS Lett., 593, 2019
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6IOS
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![BU of 6ios by Molmil](/molmil-images/mine/6ios) | The ligand binding domain of Mlp24 with proline | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ACETATE ION, CALCIUM ION, ... | Authors: | Takahashi, Y, Sumita, K, Nishiyama, S, Kawagishi, I, Imada, K. | Deposit date: | 2018-10-31 | Release date: | 2019-03-06 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | Calcium Ions Modulate Amino Acid Sensing of the Chemoreceptor Mlp24 ofVibrio cholerae. J. Bacteriol., 201, 2019
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6IOV
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![BU of 6iov by Molmil](/molmil-images/mine/6iov) | The ligand binding domain of Mlp37 with arginine | Descriptor: | ARGININE, Methyl-accepting chemotaxis (MCP) signaling domain protein | Authors: | Takahashi, Y, Sumita, K, Nishiyama, S, Kawagishi, I, Imada, K. | Deposit date: | 2018-10-31 | Release date: | 2019-11-06 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.351 Å) | Cite: | Structural basis of the binding affinity of chemoreceptors Mlp24p and Mlp37p for various amino acids. Biochem.Biophys.Res.Commun., 523, 2020
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6IOQ
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![BU of 6ioq by Molmil](/molmil-images/mine/6ioq) | The ligand binding domain of Mlp24 with glycine | Descriptor: | CALCIUM ION, GLYCINE, Methyl-accepting chemotaxis protein | Authors: | Takahashi, Y, Sumita, K, Nishiyama, S, Kawagishi, I, Imada, K. | Deposit date: | 2018-10-31 | Release date: | 2019-03-06 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (2.143 Å) | Cite: | Calcium Ions Modulate Amino Acid Sensing of the Chemoreceptor Mlp24 ofVibrio cholerae. J. Bacteriol., 201, 2019
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6IOU
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![BU of 6iou by Molmil](/molmil-images/mine/6iou) | The ligand binding domain of Mlp24 with serine | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CALCIUM ION, Methyl-accepting chemotaxis protein, ... | Authors: | Takahashi, Y, Sumita, K, Nishiyama, S, Kawagishi, I, Imada, K. | Deposit date: | 2018-10-31 | Release date: | 2019-03-06 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Calcium Ions Modulate Amino Acid Sensing of the Chemoreceptor Mlp24 ofVibrio cholerae. J. Bacteriol., 201, 2019
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6IOR
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![BU of 6ior by Molmil](/molmil-images/mine/6ior) | The ligand binding domain of Mlp24 with asparagine | Descriptor: | ASPARAGINE, CALCIUM ION, Methyl-accepting chemotaxis protein | Authors: | Takahashi, Y, Sumita, K, Nishiyama, S, Kawagishi, I, Imada, K. | Deposit date: | 2018-10-31 | Release date: | 2019-03-20 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Calcium Ions Modulate Amino Acid Sensing of the Chemoreceptor Mlp24 ofVibrio cholerae. J. Bacteriol., 201, 2019
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6IOT
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![BU of 6iot by Molmil](/molmil-images/mine/6iot) | The ligand binding domain of Mlp24 with arginine | Descriptor: | ARGININE, CALCIUM ION, Methyl-accepting chemotaxis protein | Authors: | Takahashi, Y, Sumita, K, Nishiyama, S, Kawagishi, I, Imada, K. | Deposit date: | 2018-10-31 | Release date: | 2019-03-20 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Calcium Ions Modulate Amino Acid Sensing of the Chemoreceptor Mlp24 ofVibrio cholerae. J. Bacteriol., 201, 2019
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8H8N
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![BU of 8h8n by Molmil](/molmil-images/mine/8h8n) | Crystal structure of apo-R52Y/E56Y/R59Y/E63Y-rHLFr | Descriptor: | 1,2-ETHANEDIOL, CADMIUM ION, CHLORIDE ION, ... | Authors: | Hishikawa, Y, Noya, H, Maity, B, Abe, S, Ueno, T. | Deposit date: | 2022-10-23 | Release date: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Elucidating Conformational Dynamics and Thermostability of Designed Aromatic Clusters by Using Protein Cages. Chemistry, 29, 2023
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8H8L
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![BU of 8h8l by Molmil](/molmil-images/mine/8h8l) | Crystal structure of apo-R52F/E56F/R59F/E63F-rHLFr | Descriptor: | 1,2-ETHANEDIOL, CADMIUM ION, CHLORIDE ION, ... | Authors: | Hishikawa, Y, Noya, H, Maity, B, Abe, S, Ueno, T. | Deposit date: | 2022-10-23 | Release date: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Elucidating Conformational Dynamics and Thermostability of Designed Aromatic Clusters by Using Protein Cages. Chemistry, 29, 2023
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8H8M
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![BU of 8h8m by Molmil](/molmil-images/mine/8h8m) | Crystal structure of apo-E53F/E57F/E60F/E64F-rHLFr | Descriptor: | 1,2-ETHANEDIOL, CADMIUM ION, CHLORIDE ION, ... | Authors: | Hishikawa, Y, Noya, H, Maity, B, Abe, S, Ueno, T. | Deposit date: | 2022-10-23 | Release date: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Elucidating Conformational Dynamics and Thermostability of Designed Aromatic Clusters by Using Protein Cages. Chemistry, 29, 2023
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8H8O
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![BU of 8h8o by Molmil](/molmil-images/mine/8h8o) | Crystal structure of apo-R52W/E56W/R59W/E63W-rHLFr | Descriptor: | 1,2-ETHANEDIOL, CADMIUM ION, CHLORIDE ION, ... | Authors: | Hishikawa, Y, Noya, H, Maity, B, Abe, S, Ueno, T. | Deposit date: | 2022-10-23 | Release date: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Elucidating Conformational Dynamics and Thermostability of Designed Aromatic Clusters by Using Protein Cages. Chemistry, 29, 2023
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6AJN
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![BU of 6ajn by Molmil](/molmil-images/mine/6ajn) | Crystal structure of AtaTR bound with AcCoA | Descriptor: | ACETYL COENZYME *A, DUF1778 domain-containing protein, N-acetyltransferase | Authors: | Yashiro, Y, Yamashita, S, Tomita, K. | Deposit date: | 2018-08-28 | Release date: | 2019-01-02 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (3.302 Å) | Cite: | Crystal Structure of the Enterohemorrhagic Escherichia coli AtaT-AtaR Toxin-Antitoxin Complex. Structure, 27, 2019
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6AJM
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![BU of 6ajm by Molmil](/molmil-images/mine/6ajm) | Crystal structure of apo AtaTR | Descriptor: | DUF1778 domain-containing protein, N-acetyltransferase, TRIETHYLENE GLYCOL | Authors: | Yashiro, Y, Yamashita, S, Tomita, K. | Deposit date: | 2018-08-28 | Release date: | 2019-01-02 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.604 Å) | Cite: | Crystal Structure of the Enterohemorrhagic Escherichia coli AtaT-AtaR Toxin-Antitoxin Complex. Structure, 27, 2019
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8II0
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![BU of 8ii0 by Molmil](/molmil-images/mine/8ii0) | FACTOR INHIBITING HIF-1 ALPHA in complex with (5-(3-(3-chlorophenyl)isoxazol-5-yl)-3-hydroxypicolinoyl)glycine | Descriptor: | 2-[[5-[3-(3-chlorophenyl)-1,2-oxazol-5-yl]-3-oxidanyl-pyridin-2-yl]carbonylamino]ethanoic acid, GLYCEROL, Hypoxia-inducible factor 1-alpha inhibitor, ... | Authors: | Nakashima, Y, Corner, T, Zhang, X, Schofield, C.J. | Deposit date: | 2023-02-24 | Release date: | 2024-02-28 | Last modified: | 2024-07-10 | Method: | X-RAY DIFFRACTION (2.04 Å) | Cite: | A Small-Molecule Inhibitor of Factor Inhibiting HIF Binding to a Tyrosine-flip Pocket for the Treatment of Obesity. Angew.Chem.Int.Ed.Engl., 2024
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8IHZ
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![BU of 8ihz by Molmil](/molmil-images/mine/8ihz) | FACTOR INHIBITING HIF-1 ALPHA in complex with (5-(1-(3-(4-chlorophenyl)propyl)-1H-1,2,3-triazol-4-yl)-3-hydroxypicolinoyl)glycine | Descriptor: | 2-[[5-[1-[3-(4-chlorophenyl)propyl]-1,2,3-triazol-4-yl]-3-oxidanyl-pyridin-2-yl]carbonylamino]ethanoic acid, Hypoxia-inducible factor 1-alpha inhibitor, SULFATE ION, ... | Authors: | Nakashima, Y, Corner, T, Zhang, X, Schofield, C.J. | Deposit date: | 2023-02-24 | Release date: | 2024-02-28 | Last modified: | 2024-07-10 | Method: | X-RAY DIFFRACTION (2.22 Å) | Cite: | A Small-Molecule Inhibitor of Factor Inhibiting HIF Binding to a Tyrosine-flip Pocket for the Treatment of Obesity. Angew.Chem.Int.Ed.Engl., 2024
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5DIC
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