7YTC
 
 | | Cryo-EM structure of human FcmR bound to IgM-Fc/J | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Fas apoptotic inhibitory molecule 3, Immunoglobulin J chain, ... | | 著者 | Li, Y, Shen, H, Xiao, J. | | 登録日 | 2022-08-14 | | 公開日 | 2023-02-01 | | 最終更新日 | 2023-05-03 | | 実験手法 | ELECTRON MICROSCOPY (3.39 Å) | | 主引用文献 | Immunoglobulin M perception by Fc mu R.
Nature, 615, 2023
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7YTE
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3PCU
 | | Crystal structure of human retinoic X receptor alpha ligand-binding domain complexed with LX0278 and SRC1 peptide | | 分子名称: | 2-[(2S)-6-(2-methylbut-3-en-2-yl)-7-oxo-2,3-dihydro-7H-furo[3,2-g]chromen-2-yl]propan-2-yl acetate, Nuclear receptor coactivator 2, Retinoic acid receptor RXR-alpha | | 著者 | Zhang, H, Zhang, Y, Shen, H, Chen, J, Li, C, Chen, L, Hu, L, Jiang, H, Shen, X. | | 登録日 | 2010-10-22 | | 公開日 | 2011-11-16 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | (+)-Rutamarin as a Dual Inducer of Both GLUT4 Translocation and Expression Efficiently Ameliorates Glucose Homeostasis in Insulin-Resistant Mice.
Plos One, 7, 2012
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6E9T
 | | DHF58 filament | | 分子名称: | DHF58 filament | | 著者 | Lynch, E.M, Shen, H, Fallas, J.A, Kollman, J.M, Baker, D. | | 登録日 | 2018-08-01 | | 公開日 | 2018-11-21 | | 最終更新日 | 2024-03-13 | | 実験手法 | ELECTRON MICROSCOPY (5.4 Å) | | 主引用文献 | De novo design of self-assembling helical protein filaments.
Science, 362, 2018
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6E9Y
 | | DHF38 filament | | 分子名称: | DHF38 filament | | 著者 | Lynch, E.M, Shen, H, Fallas, J.A, Kollman, J.M, Baker, D. | | 登録日 | 2018-08-01 | | 公開日 | 2018-11-21 | | 最終更新日 | 2024-03-13 | | 実験手法 | ELECTRON MICROSCOPY (4.3 Å) | | 主引用文献 | De novo design of self-assembling helical protein filaments.
Science, 362, 2018
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6E9X
 | | DHF91 filament | | 分子名称: | DHF91 filament | | 著者 | Lynch, E.M, Shen, H, Fallas, J.A, Kollman, J.M, Baker, D. | | 登録日 | 2018-08-01 | | 公開日 | 2018-11-21 | | 最終更新日 | 2024-03-13 | | 実験手法 | ELECTRON MICROSCOPY (7.8 Å) | | 主引用文献 | De novo design of self-assembling helical protein filaments.
Science, 362, 2018
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8K66
 | | Cryo-EM structure of Oryza sativa HKT2;1 at 2.5 angstrom | | 分子名称: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, CHOLESTEROL, CHOLESTEROL HEMISUCCINATE, ... | | 著者 | Wang, X, Shen, X, Qu, Y, Wang, C, Shen, H. | | 登録日 | 2023-07-25 | | 公開日 | 2024-04-03 | | 最終更新日 | 2024-05-08 | | 実験手法 | ELECTRON MICROSCOPY (2.53 Å) | | 主引用文献 | Structural insights into ion selectivity and transport mechanisms of Oryza sativa HKT2;1 and HKT2;2/1 transporters.
Nat.Plants, 10, 2024
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8K69
 | | Cryo-EM structure of Oryza sativa HKT2;2/1 at 2.3 angstrom | | 分子名称: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, CHOLESTEROL, CHOLESTEROL HEMISUCCINATE, ... | | 著者 | Wang, X, Shen, X, Qu, Y, Wang, C, Shen, H. | | 登録日 | 2023-07-25 | | 公開日 | 2024-04-03 | | 最終更新日 | 2024-05-08 | | 実験手法 | ELECTRON MICROSCOPY (2.33 Å) | | 主引用文献 | Structural insights into ion selectivity and transport mechanisms of Oryza sativa HKT2;1 and HKT2;2/1 transporters.
Nat.Plants, 10, 2024
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7X9Y
 | | Cryo-EM structure of the apo CCR3-Gi complex | | 分子名称: | C-C chemokine receptor type 3, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | 著者 | Shao, Z, Tan, Y, Shen, Q, Yao, B, Hou, L, Qin, J, Xu, P, Mao, C, Chen, L, Zhang, H, Shen, D, Zhang, C, Li, W, Du, X, Li, F, Chen, Z, Jiang, Y, Xu, H.E, Ying, S, Ma, H, Zhang, Y, Shen, H. | | 登録日 | 2022-03-16 | | 公開日 | 2022-08-24 | | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | | 主引用文献 | Molecular insights into ligand recognition and activation of chemokine receptors CCR2 and CCR3.
Cell Discov, 8, 2022
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7XA3
 | | Cryo-EM structure of the CCL2 bound CCR2-Gi complex | | 分子名称: | C-C motif chemokine 2, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | 著者 | Shao, Z, Tan, Y, Shen, Q, Yao, B, Hou, L, Qin, J, Xu, P, Mao, C, Chen, L, Zhang, H, Shen, D, Zhang, C, Li, W, Du, X, Li, F, Chen, Z, Jiang, Y, Xu, H.E, Ying, S, Ma, H, Zhang, Y, Shen, H. | | 登録日 | 2022-03-17 | | 公開日 | 2022-08-24 | | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | | 主引用文献 | Molecular insights into ligand recognition and activation of chemokine receptors CCR2 and CCR3.
Cell Discov, 8, 2022
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7VL8
 | | Cryo-EM structure of the Apo CCR1-Gi complex | | 分子名称: | C-C chemokine receptor type 1, CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | 著者 | Shao, Z, Shen, Q, Mao, C, Yao, B, Chen, L, Zhang, H, Shen, D, Zhang, C, Li, W, Du, X, Li, F, Ma, H, Chen, Z, Xu, H.E, Ying, S, Zhang, Y, Shen, H. | | 登録日 | 2021-10-02 | | 公開日 | 2022-03-23 | | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | | 主引用文献 | Identification and mechanism of G protein-biased ligands for chemokine receptor CCR1.
Nat.Chem.Biol., 18, 2022
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7VL9
 | | Cryo-EM structure of the CCL15(26-92) bound CCR1-Gi complex | | 分子名称: | C-C chemokine receptor type 1, CCL15(26-92), CHOLESTEROL, ... | | 著者 | Shao, Z, Shen, Q, Mao, C, Yao, B, Chen, L, Zhang, H, Shen, D, Zhang, C, Li, W, Du, X, Li, F, Ma, H, Chen, Z, Xu, H.E, Ying, S, Zhang, Y, Shen, H. | | 登録日 | 2021-10-02 | | 公開日 | 2022-03-23 | | 実験手法 | ELECTRON MICROSCOPY (2.6 Å) | | 主引用文献 | Identification and mechanism of G protein-biased ligands for chemokine receptor CCR1.
Nat.Chem.Biol., 18, 2022
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7VLA
 | | Cryo-EM structure of the CCL15(27-92) bound CCR1-Gi complex | | 分子名称: | C-C chemokine receptor type 1, CCL15(27-92), CHOLESTEROL, ... | | 著者 | Shao, Z, Shen, Q, Mao, C, Yao, B, Chen, L, Zhang, H, Shen, D, Zhang, C, Li, W, Du, X, Li, F, Ma, H, Chen, Z, Xu, H.E, Ying, S, Zhang, Y, Shen, H. | | 登録日 | 2021-10-02 | | 公開日 | 2022-03-23 | | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | | 主引用文献 | Identification and mechanism of G protein-biased ligands for chemokine receptor CCR1.
Nat.Chem.Biol., 18, 2022
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8UBG
 | | DpHF19 filament | | 分子名称: | DpHF19,Green fluorescent protein (Fragment) | | 著者 | Lynch, E.M, Shen, H, Kollman, J.M, Baker, D. | | 登録日 | 2023-09-22 | | 公開日 | 2024-04-10 | | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | | 主引用文献 | De novo design of pH-responsive self-assembling helical protein filaments.
Nat Nanotechnol, 2024
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8UB3
 | | DpHF7 filament | | 分子名称: | DpHF7 filament | | 著者 | Lynch, E.M, Farrell, D, Shen, H, Kollman, J.M, DiMaio, F, Baker, D. | | 登録日 | 2023-09-22 | | 公開日 | 2024-04-10 | | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | | 主引用文献 | De novo design of pH-responsive self-assembling helical protein filaments.
Nat Nanotechnol, 2024
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8UAO
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1IL5
 | | STRUCTURE OF RICIN A CHAIN BOUND WITH INHIBITOR 2,5-DIAMINO-4,6-DIHYDROXYPYRIMIDINE (DDP) | | 分子名称: | 2,4-DIAMINO-4,6-DIHYDROXYPYRIMIDINE, RICIN A CHAIN | | 著者 | Miller, D.J, Ravikumar, K, Shen, H, Suh, J.-K, Kerwin, S.M, Robertus, J.D. | | 登録日 | 2001-05-07 | | 公開日 | 2002-01-16 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Structure-based design and characterization of novel platforms for ricin and shiga toxin inhibition.
J.Med.Chem., 45, 2002
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1IL3
 | | STRUCTURE OF RICIN A CHAIN BOUND WITH INHIBITOR 7-DEAZAGUANINE | | 分子名称: | 7-DEAZAGUANINE, RICIN A CHAIN | | 著者 | Miller, D.J, Ravikumar, K, Shen, H, Suh, J.-K, Kerwin, S.M, Robertus, J.D. | | 登録日 | 2001-05-07 | | 公開日 | 2002-01-16 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Structure-based design and characterization of novel platforms for ricin and shiga toxin inhibition.
J.Med.Chem., 45, 2002
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1IL9
 | | STRUCTURE OF RICIN A CHAIN BOUND WITH INHIBITOR 8-METHYL-9-OXOGUANINE | | 分子名称: | 5-AMINO-2-METHYL-6H-OXAZOLO[5,4-D]PYRIMIDIN-7-ONE, RICIN A CHAIN | | 著者 | Miller, D.J, Ravikumar, K, Shen, H, Suh, J.-K, Kerwin, S.M, Robertus, J.D. | | 登録日 | 2001-05-07 | | 公開日 | 2002-01-16 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | | 主引用文献 | Structure-based design and characterization of novel platforms for ricin and shiga toxin inhibition.
J.Med.Chem., 45, 2002
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1IL4
 | | STRUCTURE OF RICIN A CHAIN BOUND WITH INHIBITOR 9-DEAZAGUANINE | | 分子名称: | 9-DEAZAGUANINE, RICIN A CHAIN | | 著者 | Miller, D.J, Ravikumar, K, Shen, H, Suh, J.-K, Kerwin, S.M, Robertus, J.D. | | 登録日 | 2001-05-07 | | 公開日 | 2002-01-16 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Structure-based design and characterization of novel platforms for ricin and shiga toxin inhibition.
J.Med.Chem., 45, 2002
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3FKS
 | | Yeast F1 ATPase in the absence of bound nucleotides | | 分子名称: | ATP synthase subunit alpha, mitochondrial, ATP synthase subunit beta, ... | | 著者 | Kabaleeswaran, V, Symersky, J, Shen, H, Walker, J.E, Leslie, A.G.W, Mueller, D.M. | | 登録日 | 2008-12-17 | | 公開日 | 2009-03-03 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (3.587 Å) | | 主引用文献 | Asymmetric structure of the yeast f1 ATPase in the absence of bound nucleotides.
J.Biol.Chem., 284, 2009
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8K14
 | | X-ray crystal structure of 18a in BRD4(1) | | 分子名称: | 4-[8-methoxy-2-methyl-1-(1-phenylethyl)imidazo[4,5-c]quinolin-7-yl]-3,5-dimethyl-1,2-oxazole, Bromodomain-containing protein 4 | | 著者 | Xu, H, Shen, H, Zhang, Y, Xu, Y, Li, R. | | 登録日 | 2023-07-10 | | 公開日 | 2024-03-27 | | 実験手法 | X-RAY DIFFRACTION (1.28 Å) | | 主引用文献 | Discovery of (R)-4-(8-methoxy-2-methyl-1-(1-phenylethy)-1H-imidazo[4,5-c]quinnolin-7-yl)-3,5-dimethylisoxazole as a potent and selective BET inhibitor for treatment of acute myeloid leukemia (AML) guided by FEP calculation.
Eur.J.Med.Chem., 263, 2024
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5ZL4
 | | Crystal structure of DFA-IIIase from Arthrobacter chlorophenolicus A6 wihout its lid in complex with GF2 | | 分子名称: | DFA-IIIase, beta-D-fructofuranose-(2-1)-beta-D-fructofuranose-(2-1)-alpha-D-glucopyranose | | 著者 | Yu, S.H, Shen, H, Li, X, Mu, W.M. | | 登録日 | 2018-03-26 | | 公開日 | 2018-12-19 | | 最終更新日 | 2024-03-27 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | Structural and functional basis of difructose anhydride III hydrolase, which sequentially converts inulin using the same catalytic residue
Acs Catalysis, 8, 2018
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5ZL5
 | | Crystal structure of DFA-IIIase mutant C387A from Arthrobacter chlorophenolicus A6 | | 分子名称: | DFA-IIIase C387A mutant, GLYCEROL | | 著者 | Yu, S.H, Shen, H, Li, X, Mu, W.M. | | 登録日 | 2018-03-26 | | 公開日 | 2018-12-19 | | 最終更新日 | 2024-03-27 | | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | | 主引用文献 | Structural and functional basis of difructose anhydride III hydrolase, which sequentially converts inulin using the same catalytic residue
Acs Catalysis, 8, 2018
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5ZKW
 | | Crystal structure of DFA-IIIase from Arthrobacter chlorophenolicus A6 in complex with GF2 | | 分子名称: | DFA-IIIase, alpha-D-glucopyranose-(1-2)-beta-D-fructofuranose-(2-1)-beta-D-fructofuranose | | 著者 | Yu, S.H, Shen, H, Li, X, Mu, W.M. | | 登録日 | 2018-03-26 | | 公開日 | 2018-12-19 | | 最終更新日 | 2024-03-27 | | 実験手法 | X-RAY DIFFRACTION (1.86 Å) | | 主引用文献 | Structural and functional basis of difructose anhydride III hydrolase, which sequentially converts inulin using the same catalytic residue
Acs Catalysis, 8, 2018
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