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PDB: 36 件
7WGI
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BU of 7wgi by Molmil
Crystal structure of AflSQS from Aspergillus flavus
分子名称: INDOLE, PHOSPHATE ION, Squalene synthase
著者Shang, N, Liu, W.D, Chen, C.C, Guo, R.T.
登録日2021-12-28
公開日2022-11-09
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献A Structural and Bioinformatics Investigation of a Fungal Squalene Synthase and Comparisons with Other Membrane Proteins.
Acs Omega, 7, 2022
7WGH
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BU of 7wgh by Molmil
Crystal structure of AflSQS from Aspergillus flavus in complex with FSPP
分子名称: PHOSPHATE ION, PYROPHOSPHATE 2-, S-[(2E,6E)-3,7,11-TRIMETHYLDODECA-2,6,10-TRIENYL] TRIHYDROGEN THIODIPHOSPHATE, ...
著者Shang, N, Liu, W.D, Chen, C.C, Guo, R.T.
登録日2021-12-28
公開日2022-11-09
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.36 Å)
主引用文献A Structural and Bioinformatics Investigation of a Fungal Squalene Synthase and Comparisons with Other Membrane Proteins.
Acs Omega, 7, 2022
3WCL
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BU of 3wcl by Molmil
The complex structure of HsSQS wtih ligand,BPH1344
分子名称: Squalene synthase, hydrogen [(1R)-2-(3-pentadecyl-1H-imidazol-3-ium-1-yl)-1-phosphonoethyl]phosphonate
著者Shang, N, Li, Q, Ko, T.P, Chan, H.C, Huang, C.H, Ren, F, Zheng, Y, Zhu, Z, Chen, C.C, Guo, R.T.
登録日2013-05-28
公開日2014-06-18
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.24 Å)
主引用文献Squalene synthase as a target for Chagas disease therapeutics.
Plos Pathog., 10, 2014
3WCI
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BU of 3wci by Molmil
The complex structure of HsSQS wtih ligand,BPH1325
分子名称: Squalene synthase, hydrogen [(1R)-1-hydroxy-2-(3-pentadecyl-1H-imidazol-3-ium-1-yl)-1-phosphonoethyl]phosphonate
著者Shang, N, Li, Q, Ko, T.P, Chan, H.C, Huang, C.H, Ren, F, Zheng, Y, Zhu, Z, Chen, C.C, Guo, R.T.
登録日2013-05-27
公開日2014-06-18
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Squalene synthase as a target for Chagas disease therapeutics.
Plos Pathog., 10, 2014
3WSB
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BU of 3wsb by Molmil
The Tuberculosis Drug SQ109 Inhibits Trypanosoma cruzi Cell Proliferation and acts Synergistically with Posaconazole
分子名称: Farnesyltransferase, putative, N-[(2Z)-3,7-dimethylocta-2,6-dien-1-yl]-N'-[(1R,3S,5R,7R)-tricyclo[3.3.1.1~3,7~]dec-2-yl]ethane-1,2-diamine, ...
著者Shang, N, Li, Q, Huang, C.H, Oldfield, E, Guo, R.T.
登録日2014-03-05
公開日2015-04-01
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献The Tuberculosis Drug SQ109 Inhibits Trypanosoma cruzi Cell Proliferation and acts Synergistically with Posaconazole
To be Published
3WCA
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BU of 3wca by Molmil
The complex structure of TcSQS with ligand, FSPP
分子名称: Farnesyltransferase, putative, MAGNESIUM ION, ...
著者Shang, N, Li, Q, Ko, T.P, Chan, H.C, Huang, C.H, Oldfield, E, Guo, R.T.
登録日2013-05-26
公開日2014-06-18
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.24 Å)
主引用文献Squalene synthase as a target for Chagas disease therapeutics.
Plos Pathog., 10, 2014
3WCH
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BU of 3wch by Molmil
The complex structure of HsSQS wtih ligand BPH1237
分子名称: Squalene synthase, hydrogen [(1R)-2-(3-decyl-1H-imidazol-3-ium-1-yl)-1-hydroxy-1-phosphonoethyl]phosphonate
著者Shang, N, Li, Q, Ko, T.P, Chan, H.C, Huang, C.H, Ren, F, Zheng, Y, Zhu, Z, Chen, C.C, Guo, R.T.
登録日2013-05-27
公開日2014-06-18
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Squalene synthase as a target for Chagas disease therapeutics.
Plos Pathog., 10, 2014
3WCD
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BU of 3wcd by Molmil
The complex structure of HsSQS wtih ligand, WC-9
分子名称: 2-(4-phenoxyphenoxy)ethyl thiocyanate, Squalene synthase
著者Shang, N, Li, Q, Ko, T.P, Chan, H.C, Huang, C.H, Ren, F, Zheng, Y, Zhu, Z, Chen, C.C, Guo, R.T.
登録日2013-05-27
公開日2014-06-18
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.75 Å)
主引用文献Squalene synthase as a target for Chagas disease therapeutics.
Plos Pathog., 10, 2014
3WCM
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BU of 3wcm by Molmil
The complex structure of HsSQS wtih ligand, ER119884
分子名称: (3R)-3-{[2-benzyl-6-(3-methoxypropoxy)pyridin-3-yl]ethynyl}-1-azabicyclo[2.2.2]octan-3-ol, Squalene synthase
著者Shang, N, Li, Q, Ko, T.P, Chan, H.C, Huang, C.H, Ren, F, Zheng, Y, Zhu, Z, Chen, C.C, Guo, R.T.
登録日2013-05-28
公開日2014-06-18
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (2.06 Å)
主引用文献Squalene synthase as a target for Chagas disease therapeutics.
Plos Pathog., 10, 2014
3WC9
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The complex structure of HsSQS wtih ligand, FSPP
分子名称: S-[(2E,6E)-3,7,11-TRIMETHYLDODECA-2,6,10-TRIENYL] TRIHYDROGEN THIODIPHOSPHATE, Squalene synthase
著者Shang, N, Li, Q, Ko, T.P, Chan, H.C, Huang, C.H, Ren, F, Zheng, Y, Zhu, Z, Chen, C.C, Guo, R.T.
登録日2013-05-26
公開日2014-06-18
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.82 Å)
主引用文献Squalene synthase as a target for Chagas disease therapeutics.
Plos Pathog., 10, 2014
3WCF
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BU of 3wcf by Molmil
The complex structure of HsSQS wtih ligand,BPH1218
分子名称: Squalene synthase, hydrogen [(1S)-2-(3-decyl-1H-imidazol-3-ium-1-yl)-1-phosphonoethyl]phosphonate
著者Shang, N, Li, Q, Ko, T.P, Chan, H.C, Huang, C.H, Ren, F, Zheng, Y, Zhu, Z, Chen, C.C, Guo, R.T.
登録日2013-05-27
公開日2014-06-18
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.22 Å)
主引用文献Squalene synthase as a target for Chagas disease therapeutics.
Plos Pathog., 10, 2014
3WCJ
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BU of 3wcj by Molmil
The complex structure of HsSQS wtih ligand,E5700
分子名称: (3R)-3-({2-benzyl-6-[(3R,4S)-3-hydroxy-4-methoxypyrrolidin-1-yl]pyridin-3-yl}ethynyl)-1-azabicyclo[2.2.2]octan-3-ol, Squalene synthase
著者Shang, N, Li, Q, Ko, T.P, Chan, H.C, Huang, C.H, Ren, F, Zheng, Y, Zhu, Z, Chen, C.C, Guo, R.T.
登録日2013-05-27
公開日2014-06-18
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Squalene synthase as a target for Chagas disease therapeutics.
Plos Pathog., 10, 2014
3WSA
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BU of 3wsa by Molmil
The Tuberculosis Drug SQ109 Inhibits Trypanosoma cruzi Cell Proliferation and acts Synergistically with Posaconazole
分子名称: N-[(2Z)-3,7-dimethylocta-2,6-dien-1-yl]-N'-[(1R,3S,5R,7R)-tricyclo[3.3.1.1~3,7~]dec-2-yl]ethane-1,2-diamine, Squalene synthase
著者Shang, N, Li, Q, Huang, C.H, Oldfield, E, Guo, R.T.
登録日2014-03-05
公開日2015-04-01
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献SQ109, a new drug lead for Chagas disease.
Antimicrob.Agents Chemother., 59, 2015
3WCG
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BU of 3wcg by Molmil
The complex structure of TcSQS with ligand, BPH1344
分子名称: Farnesyltransferase, putative, hydrogen [(1R)-2-(3-pentadecyl-1H-imidazol-3-ium-1-yl)-1-phosphonoethyl]phosphonate
著者Shang, N, Li, Q, Ko, T.P, Chan, H.C, Huang, C.H, Ren, F, Zheng, Y, Zhu, Z, Chen, C.C, Guo, R.T.
登録日2013-05-27
公開日2014-06-18
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Squalene synthase as a target for Chagas disease therapeutics.
Plos Pathog., 10, 2014
3WCB
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BU of 3wcb by Molmil
The complex structure of TcSQS with ligand, BPH1237
分子名称: Farnesyltransferase, putative, hydrogen [(1R)-2-(3-decyl-1H-imidazol-3-ium-1-yl)-1-hydroxy-1-phosphonoethyl]phosphonate
著者Shang, N, Li, Q, Ko, T.P, Chan, H.C, Huang, C.H, Ren, F, Zheng, Y, Zhu, Z, Chen, C.C, Guo, R.T.
登録日2013-05-27
公開日2014-06-18
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Squalene synthase as a target for Chagas disease therapeutics.
Plos Pathog., 10, 2014
3WCE
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BU of 3wce by Molmil
The complex structure of TcSQS with ligand, ER119884
分子名称: (3R)-3-{[2-benzyl-6-(3-methoxypropoxy)pyridin-3-yl]ethynyl}-1-azabicyclo[2.2.2]octan-3-ol, Farnesyltransferase, putative
著者Shang, N, Li, Q, Ko, T.P, Chan, H.C, Huang, C.H, Ren, F, Zheng, Y, Zhu, Z, Chen, C.C, Guo, R.T.
登録日2013-05-27
公開日2014-06-18
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.75 Å)
主引用文献Squalene synthase as a target for Chagas disease therapeutics.
Plos Pathog., 10, 2014
3WCC
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BU of 3wcc by Molmil
The complex structure of TcSQS with ligand, E5700
分子名称: (3R)-3-({2-benzyl-6-[(3R,4S)-3-hydroxy-4-methoxypyrrolidin-1-yl]pyridin-3-yl}ethynyl)-1-azabicyclo[2.2.2]octan-3-ol, Farnesyltransferase, putative
著者Shang, N, Li, Q, Ko, T.P, Chan, H.C, Huang, C.H, Ren, F, Zheng, Y, Zhu, Z, Chen, C.C, Guo, R.T.
登録日2013-05-27
公開日2014-06-18
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.32 Å)
主引用文献Squalene synthase as a target for Chagas disease therapeutics.
Plos Pathog., 10, 2014
2JSE
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BU of 2jse by Molmil
NMR reveals absence of hydrogen bonding in adjacent UU and AG mismatches in an isolated internal loop from ribosomal RNA.
分子名称: RNA (5'-R(*GP*GP*AP*GP*UP*GP*GP*CP*CP*GP*AP*AP*AP*GP*GP*CP*AP*UP*CP*UP*CP*C)-3')
著者Shankar, N.
登録日2007-07-03
公開日2007-11-20
最終更新日2024-05-29
実験手法SOLUTION NMR
主引用文献NMR Reveals the Absence of Hydrogen Bonding in Adjacent UU and AG Mismatches in an Isolated Internal Loop from Ribosomal RNA
Biochemistry, 46, 2007
2H49
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The NMR Structure of an Internal Loop from 23S Ribosomal RNA of Deinococcus radiodurans Differs from the Structure in the Crystal of the Ribosomal Subunit
分子名称: 5'-R(*GP*GP*CP*UP*AP*AP*GP*AP*C)-3', 5'-R(*GP*UP*CP*GP*AP*AP*GP*CP*C)-3'
著者Shankar, N.
登録日2006-05-23
公開日2006-11-21
最終更新日2024-05-29
実験手法SOLUTION NMR
主引用文献The NMR structure of an internal loop from 23S ribosomal RNA differs from its structure in crystals of 50s ribosomal subunits.
Biochemistry, 45, 2006
7BV3
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BU of 7bv3 by Molmil
Crystal structure of a ugt transferase from Siraitia grosvenorii in complex with UDP
分子名称: Glycosyltransferase, URIDINE-5'-DIPHOSPHATE
著者Li, J, Shan, N, Yang, J.G, Liu, W.D, Sun, Y.X.
登録日2020-04-09
公開日2021-03-03
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Near-perfect control of the regioselective glucosylation enabled by rational design of glycosyltransferases
Green Synth Catal, 2021
6L8Z
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BU of 6l8z by Molmil
Crystal structure of ugt transferase mutant in complex with UPG
分子名称: Glycosyltransferase, URIDINE-5'-DIPHOSPHATE-GLUCOSE
著者Li, J, Shan, N, Yang, J.G, Liu, W.D, Sun, Y.X.
登録日2019-11-07
公開日2020-04-01
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Efficient O-Glycosylation of Triterpenes Enabled by Protein Engineering of Plant Glycosyltransferase UGT74AC1
Acs Catalysis, 2020
6L8W
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BU of 6l8w by Molmil
Crystal structure of ugt transferase mutant2
分子名称: Glycosyltransferase
著者Li, J, Shan, N, Yang, J.G, Liu, W.D, Sun, Y.X.
登録日2019-11-07
公開日2020-04-01
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.05 Å)
主引用文献Efficient O-Glycosylation of Triterpenes Enabled by Protein Engineering of Plant Glycosyltransferase UGT74AC1
Acs Catalysis, 2020
6L90
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BU of 6l90 by Molmil
Crystal structure of ugt transferase enzyme
分子名称: Glycosyltransferase, SULFATE ION
著者Li, J, Shan, N, Yang, J.G, Liu, W.D, Sun, Y.X.
登録日2019-11-07
公開日2020-04-01
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.02 Å)
主引用文献Efficient O-Glycosylation of Triterpenes Enabled by Protein Engineering of Plant Glycosyltransferase UGT74AC1
Acs Catalysis, 2020
6L8X
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BU of 6l8x by Molmil
Crystal structure of Siraitia grosvenorii ugt transferase mutant2
分子名称: Glycosyltransferase
著者Li, J, Shan, N, Yang, J.G, Liu, W.D, Sun, Y.X.
登録日2019-11-07
公開日2020-04-08
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (1.55 Å)
主引用文献Efficient O-Glycosylation of Triterpenes Enabled by Protein Engineering of Plant Glycosyltransferase UGT74AC1
Acs Catalysis, 10, 2020
5D8Z
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BU of 5d8z by Molmil
Structrue of a lucidum protein
分子名称: beta-D-glucopyranose-(1-4)-beta-D-glucopyranose, endoglucanase
著者Guo, R, Li, Q, Shang, N, Liu, G, Ko, T.P, Chen, C.C, Liu, W.
登録日2015-08-18
公開日2016-06-29
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Functional and structural analyses of a 1,4-beta-endoglucanase from Ganoderma lucidum.
Enzyme.Microb.Technol., 86, 2016

 

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