8AJ7
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![BU of 8aj7 by Molmil](/molmil-images/mine/8aj7) | Kunitz domain of Amblyomin-X | Descriptor: | 1,2-ETHANEDIOL, Kunitz domain of Amblyomin-X | Authors: | Ciccone, L, Servent, D, Stura, E.A. | Deposit date: | 2022-07-27 | Release date: | 2023-02-15 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Structural and functional properties of the Kunitz-type and C-terminal domains of Amblyomin-X supporting its antitumor activity. Front Mol Biosci, 10, 2023
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1G2G
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![BU of 1g2g by Molmil](/molmil-images/mine/1g2g) | MINIMAL CONFORMATION OF THE ALPHA-CONOTOXIN IMI FOR THE ALPHA7 NEURONAL NICOTINIC ACETYLCHOLINE RECEPTOR RECOGNITION | Descriptor: | ALPHA-CONOTOXIN IMI | Authors: | Lamthanh, H, Jegou-Matheron, C, Servent, D, Menez, A, Lancelin, J.M. | Deposit date: | 2000-10-19 | Release date: | 2000-11-08 | Last modified: | 2022-02-23 | Method: | SOLUTION NMR | Cite: | Minimal conformation of the alpha-conotoxin ImI for the alpha7 neuronal nicotinic acetylcholine receptor recognition: correlated CD, NMR and binding studies. FEBS Lett., 454, 1999
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3ZKT
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![BU of 3zkt by Molmil](/molmil-images/mine/3zkt) | SOLUTION STRUCTURE OF THE SOMATOSTATIN SST3 RECEPTOR ANTAGONIST TAU- CONOTOXIN CnVA | Descriptor: | TAU-CNVA | Authors: | Petrel, C, Hocking, H.G, Reynaud, M, Favreau, P, Paolini-Bertrand, M, Peigneur, S, Upert, G, Tytgat, J, Gilles, N, Hartley, O, Boelens, R, Stocklin, R, Servent, D. | Deposit date: | 2013-01-24 | Release date: | 2013-04-24 | Last modified: | 2023-06-14 | Method: | SOLUTION NMR | Cite: | Identification, Structural and Pharmacological Characterization of Tau-Cnva, a Conopeptide that Selectively Interacts with Somatostatin Sst3 Receptor. Biochem.Pharmacol, 85, 2013
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1B45
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![BU of 1b45 by Molmil](/molmil-images/mine/1b45) | ALPHA-CNIA CONOTOXIN FROM CONUS CONSORS, NMR, 43 STRUCTURES | Descriptor: | ALPHA-CNIA | Authors: | Favreau, P, Krimm, I, Le Gall, F, Bobenrieth, M.J, Lamthanh, H, Bouet, F, Servent, D, Molgo, J, Menez, A, Letourneux, Y, Lancelin, J.M. | Deposit date: | 1999-01-05 | Release date: | 1999-07-09 | Last modified: | 2022-02-16 | Method: | SOLUTION NMR | Cite: | Biochemical characterization and nuclear magnetic resonance structure of novel alpha-conotoxins isolated from the venom of Conus consors. Biochemistry, 38, 1999
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3NEQ
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![BU of 3neq by Molmil](/molmil-images/mine/3neq) | Crystal structure of the chimeric muscarinic toxin MT7 with loop 3 from MT1 | Descriptor: | SULFATE ION, Three-finger muscarinic toxin 7 | Authors: | Stura, E.A, Servent, D, Menez, R, Mournier, G, Menez, A, Fruchart-Gaillard, C. | Deposit date: | 2010-06-09 | Release date: | 2011-08-24 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.25 Å) | Cite: | Engineering of three-finger fold toxins creates ligands with original pharmacological profiles for muscarinic and adrenergic receptors. Plos One, 7, 2012
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4DO8
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![BU of 4do8 by Molmil](/molmil-images/mine/4do8) | Crystal structure of the muscarinic toxin MT1 | Descriptor: | ACETATE ION, Muscarinic toxin 1, THIOCYANATE ION | Authors: | Fruchart-Gaillard, C, Mournier, G, Vera, L, Servent, D, Stura, E.A. | Deposit date: | 2012-02-09 | Release date: | 2012-06-27 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.802 Å) | Cite: | Engineering of three-finger fold toxins creates ligands with original pharmacological profiles for muscarinic and adrenergic receptors. Plos One, 7, 2012
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5DU1
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![BU of 5du1 by Molmil](/molmil-images/mine/5du1) | Crystal structure of Dendroaspis polylepis mambalgin-1 wild-type in P21 space group. | Descriptor: | Mambalgin-1 | Authors: | Stura, E.A, Tepshi, L, Mourier, G, Kessler, P, Servent, D. | Deposit date: | 2015-09-18 | Release date: | 2015-12-30 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Mambalgin-1 Pain-relieving Peptide, Stepwise Solid-phase Synthesis, Crystal Structure, and Functional Domain for Acid-sensing Ion Channel 1a Inhibition. J.Biol.Chem., 291, 2016
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5DO6
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![BU of 5do6 by Molmil](/molmil-images/mine/5do6) | Crystal structure of Dendroaspis polylepis venom mambalgin-1 T23A mutant | Descriptor: | 1,2-ETHANEDIOL, IODIDE ION, Mambalgin-1, ... | Authors: | Stura, E.A, Tepshi, L, Kessler, P, Gilles, M, Servent, D. | Deposit date: | 2015-09-10 | Release date: | 2015-12-30 | Last modified: | 2017-01-25 | Method: | X-RAY DIFFRACTION (1.697 Å) | Cite: | Mambalgin-1 Pain-relieving Peptide, Stepwise Solid-phase Synthesis, Crystal Structure, and Functional Domain for Acid-sensing Ion Channel 1a Inhibition. J.Biol.Chem., 291, 2016
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5DZ5
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![BU of 5dz5 by Molmil](/molmil-images/mine/5dz5) | Crystal structure of Dendroaspis polylepis mambalgin-1 wild-type in P41212 space group | Descriptor: | Mambalgin-1 | Authors: | Stura, E.A, Tepshi, L, Mourier, G, Kessler, P, Servent, D. | Deposit date: | 2015-09-25 | Release date: | 2015-12-30 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Mambalgin-1 Pain-relieving Peptide, Stepwise Solid-phase Synthesis, Crystal Structure, and Functional Domain for Acid-sensing Ion Channel 1a Inhibition. J.Biol.Chem., 291, 2016
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6R5M
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![BU of 6r5m by Molmil](/molmil-images/mine/6r5m) | Crystal structure of toxin MT9 from mamba venom | Descriptor: | ACETYL GROUP, Dendroaspis polylepis MT9, GLYCEROL, ... | Authors: | Stura, E.A, Tepshi, L, Ciolek, J, Triquigneaux, M, Zoukimian, C, De Waard, M, Beroud, R, Servent, D, Gilles, N, Legrand, P, Ciccone, L. | Deposit date: | 2019-03-25 | Release date: | 2020-02-12 | Last modified: | 2022-05-25 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | MT9, a natural peptide from black mamba venom antagonizes the muscarinic type 2 receptor and reverses the M2R-agonist-induced relaxation in rat and human arteries Biomed Pharmacother, 150, 2022
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2LDE
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![BU of 2lde by Molmil](/molmil-images/mine/2lde) | Solution structure of the long sarafotoxin srtx-i3 | Descriptor: | Sarafotoxin-i3 | Authors: | Cordier, F, Zorba, A, Hajj, M, Ducancel, F, Servent, D, Delepierre, M. | Deposit date: | 2011-05-24 | Release date: | 2011-09-21 | Last modified: | 2023-06-14 | Method: | SOLUTION NMR | Cite: | Pharmacological and structural characterization of long-sarafotoxins, a new family of endothelin-like peptides: Role of the C-terminus extension. Biochimie, 94, 2012
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5MG9
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![BU of 5mg9 by Molmil](/molmil-images/mine/5mg9) | Putative Ancestral Mamba toxin 1 (AncTx1-W28R/I38S) | Descriptor: | 1,2-ETHANEDIOL, AncTx1-W28R/I38S, S-1,2-PROPANEDIOL, ... | Authors: | Stura, E.A, Tepshi, L, Blanchet, G, Mourier, G, Servent, D. | Deposit date: | 2016-11-21 | Release date: | 2017-05-03 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.801 Å) | Cite: | Ancestral protein resurrection and engineering opportunities of the mamba aminergic toxins. Sci Rep, 7, 2017
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2LDF
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![BU of 2ldf by Molmil](/molmil-images/mine/2ldf) | Solution structure of the long sarafotoxin srtx-m | Descriptor: | Sarafotoxin-m | Authors: | Cordier, F, Zorba, A, Hajj, M, Ducancel, F, Servent, D, Delepierre, M. | Deposit date: | 2011-05-24 | Release date: | 2011-09-21 | Last modified: | 2023-06-14 | Method: | SOLUTION NMR | Cite: | Pharmacological and structural characterization of long-sarafotoxins, a new family of endothelin-like peptides: Role of the C-terminus extension. Biochimie, 94, 2012
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2X00
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![BU of 2x00 by Molmil](/molmil-images/mine/2x00) | CRYSTAL STRUCTURE OF A-ACHBP IN COMPLEX WITH GYMNODIMINE A | Descriptor: | GYMNODIMINE A, SOLUBLE ACETYLCHOLINE RECEPTOR | Authors: | Bourne, Y, Radic, Z, Araoz, R, Talley, T.T, Benoit, E, Servent, D, Taylor, P, Molgo, J, Marchot, P. | Deposit date: | 2009-12-04 | Release date: | 2010-03-02 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structural Determinants in Phycotoxins and Achbp Conferring High Affinity Binding and Nicotinic Achr Antagonism. Proc.Natl.Acad.Sci.USA, 107, 2010
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2WZY
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![BU of 2wzy by Molmil](/molmil-images/mine/2wzy) | Crystal structure of A-AChBP in complex with 13-desmethyl spirolide C | Descriptor: | 13-DESMETHYL SPIROLIDE C, SOLUBLE ACETYLCHOLINE RECEPTOR | Authors: | Bourne, Y, Radic, Z, Araoz, R, Talley, T.T, Benoit, E, Servent, D, Taylor, P, Molgo, J, Marchot, P. | Deposit date: | 2009-12-03 | Release date: | 2010-03-02 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.51 Å) | Cite: | Structural Determinants in Phycotoxins and Achbp Conferring High Affinity Binding and Nicotinic Achr Antagonism. Proc.Natl.Acad.Sci.USA, 107, 2010
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