6R5M

Crystal structure of toxin MT9 from mamba venom

Replaces:  6F21

Summary for 6R5M

• Entry DOI: 10.2210/pdb6r5m/pdb
• Descriptor: Dendroaspis polylepis MT9, SULFATE ION, S-1,2-PROPANEDIOL, ... (6 entities in total)
• Functional Keywords: mamba venom, aminergic toxin, toxin
• Biological source: Dendroaspis polylepis
• Total number of polymer chains: 3
• Total formula weight: 20276.32

Authors

Stura, E.A.,Tepshi, L.,Ciolek, J.,Triquigneaux, M.,Zoukimian, C.,De Waard, M.,Beroud, R.,Servent, D.,Gilles, N.,Legrand, P.,Ciccone, L. (deposition date: 2019-03-25, release date: 2020-02-12, Last modification date: 2022-05-25)

• Primary citation: Ciolek, J.,Zoukimian, C.,Dhot, J.,Burban, M.,Triquigneaux, M.,Lauzier, B.,Guimbert, C.,Boturyn, D.,Ferron, M.,Ciccone, L.,Tepshi, L.,Stura, E.,Legrand, P.,Robin, P.,Mourier, G.,Schaack, B.,Fellah, I.,Blanchet, G.,Gauthier-Erfanian, C.,Beroud, R.,Servent, D.,De Waard, M.,Gilles, N.; MT9, a natural peptide from black mamba venom antagonizes the muscarinic type 2 receptor and reverses the M2R-agonist-induced relaxation in rat and human arteries; Biomed Pharmacother, 150:113094-, 2022; DOI: 10.1016/j.biopha.2022.113094

Experimental method

X-RAY DIFFRACTION (1.9 Å)