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PDB: 792 件
2I3V
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Measurement of conformational changes accompanying desensitization in an ionotropic glutamate receptor: Structure of G725C mutant
分子名称: GLUTAMIC ACID, Glutamate receptor 2, ZINC ION
著者Armstrong, N, Jasti, J, Beich-Frandsen, M, Gouaux, E.
登録日2006-08-21
公開日2006-10-17
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Measurement of Conformational Changes accompanying Desensitization in an Ionotropic Glutamate Receptor.
Cell(Cambridge,Mass.), 127, 2006
2BX7
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Crystal structure of L. lactis dihydroorotate dehydrogense A in complex with 3,5-dihydroxybenzoate
分子名称: 3,5-DIHYDROXYBENZOATE, ACETATE ION, DIHYDROOROTATE DEHYDROGENASE, ...
著者Wolfe, A.E, Hansen, M, Gattis, S.G, Hu, Y.-C, Johansson, E, Arent, S, Larsen, S, Palfey, B.A.
登録日2005-07-25
公開日2006-08-29
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.04 Å)
主引用文献Interaction of Benzoate Pyrimidine Analogues with Class 1A Dihydroorotate Dehydrogenase from Lactococcus Lactis.
Biochemistry, 46, 2007
1OCI
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[3.2.0]bcANA:DNA
分子名称: 5'-D(*CP*TP*GP*A TLBP*AP*TP*GP*CP)-3', 5'-D(*GP*CP*AP*TP*AP*TP*CP*AP*GP)-3'
著者Tommerholt, H.V, Christensen, N.K, Nielsen, P, Wengel, J, Stein, P.C, Jacobsen, J.P, Petersen, M.
登録日2003-02-07
公開日2003-07-14
最終更新日2024-05-15
実験手法SOLUTION NMR
主引用文献NMR Solution Structure of a DsDNA Containing a Bicyclic D-Arabino-Configured Nucleotide Fixed in an O4'-Endo Sugar Conformation
Org.Biomol.Chem., 1, 2003
1BY1
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DBL homology domain from beta-PIX
分子名称: PROTEIN (PIX)
著者Aghazadeh, B, Zhu, K, Kubiseski, T.J, Liu, G.A, Pawson, T, Zheng, Y, Rosen, M.K.
登録日1998-10-22
公開日1999-10-24
最終更新日2023-12-27
実験手法SOLUTION NMR
主引用文献Structure and Mutagenesis of the Dbl Homology Domain
Nat.Struct.Biol., 5, 1998
3UOM
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Ca2+ complex of Human skeletal calsequestrin
分子名称: (4R)-2-METHYLPENTANE-2,4-DIOL, (4S)-2-METHYL-2,4-PENTANEDIOL, CALCIUM ION, ...
著者Sanchez, E.J, Lewis, K.M, Danna, B.R, Nissen, M.S, Kang, C.H.
登録日2011-11-16
公開日2012-02-22
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.02 Å)
主引用文献High-capacity Ca2+ Binding of Human Skeletal Calsequestrin.
J.Biol.Chem., 287, 2012
2WI6
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Orally Active 2-Amino Thienopyrimidine Inhibitors of the Hsp90 Chaperone
分子名称: 2-AMINO-4-(2,4-DICHLOROPHENYL)-N-ETHYLTHIENO[2,3-D]PYRIMIDINE-6-CARBOXAMIDE, HEAT SHOCK PROTEIN, HSP90-ALPHA
著者Brough, P.A, Barril, X, Borgognoni, J, Chene, P, Davies, N.G.M, Davis, B, Drysdale, M.J, Dymock, B, Eccles, S.A, Garcia-Echeverria, C, Fromont, C, Hayes, A, Hubbard, R.E, Jordan, A.M, Rugaard-Jensen, M, Massey, A, Merret, A, Padfield, A, Parsons, R, Radimerski, T, Raynaud, F.I, Robertson, A, Roughley, S.D, Schoepfer, J, Simmonite, H, Surgenor, A, Valenti, M, Walls, S, Webb, P, Wood, M, Workman, P, Wright, L.M.
登録日2009-05-08
公開日2009-07-28
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.18 Å)
主引用文献Combining Hit Identification Strategies: Fragment- Based and in Silico Approaches to Orally Active 2-Aminothieno[2,3-D]Pyrimidine Inhibitors of the Hsp90 Molecular Chaperone.
J.Med.Chem., 52, 2009
1CEE
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SOLUTION STRUCTURE OF CDC42 IN COMPLEX WITH THE GTPASE BINDING DOMAIN OF WASP
分子名称: GTP-BINDING RHO-LIKE PROTEIN, MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID GUANYLATE ESTER, ...
著者Abdul-Manan, N, Aghazadeh, B, Liu, G.A, Majumdar, A, Ouerfelli, O, Rosen, M.K.
登録日1999-03-08
公開日1999-06-30
最終更新日2023-12-27
実験手法SOLUTION NMR
主引用文献Structure of Cdc42 in complex with the GTPase-binding domain of the 'Wiskott-Aldrich syndrome' protein.
Nature, 399, 1999
2WI1
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Orally Active 2-Amino Thienopyrimidine Inhibitors of the Hsp90 Chaperone
分子名称: 4-(2-methoxyethoxy)-6-methylpyrimidin-2-amine, HEAT SHOCK PROTEIN HSP 90-ALPHA, MAGNESIUM ION
著者Brough, P.A, Barril, X, Borgognoni, J, Chene, P, Davies, N.G.M, Davis, B, Drysdale, M.J, Dymock, B, Eccles, S.A, Garcia-Echeverria, C, Fromont, C, Hayes, A, Hubbard, R.E, Jordan, A.M, Rugaard-Jensen, M, Massey, A, Merret, A, Padfield, A, Parsons, R, Radimerski, T, Raynaud, F.I, Robertson, A, Roughley, S.D, Schoepfer, J, Simmonite, H, Surgenor, A, Valenti, M, Walls, S, Webb, P, Wood, M, Workman, P, Wright, L.M.
登録日2009-05-08
公開日2009-07-28
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Combining Hit Identification Strategies: Fragment- Based and in Silico Approaches to Orally Active 2-Aminothieno[2,3-D]Pyrimidine Inhibitors of the Hsp90 Molecular Chaperone.
J.Med.Chem., 52, 2009
2WI5
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Orally Active 2-Amino Thienopyrimidine Inhibitors of the Hsp90 Chaperone
分子名称: 3,6-DIAMINO-5-CYANO-4-(4-ETHOXYPHENYL)THIENO[2,3-B]PYRIDINE-2-CARBOXAMIDE, HEAT SHOCK PROTEIN HSP 90-ALPHA
著者Brough, P.A, Barril, X, Borgognoni, J, Chene, P, Davies, N.G.M, Davis, B, Drysdale, M.J, Dymock, B, Eccles, S.A, Garcia-Echeverria, C, Fromont, C, Hayes, A, Hubbard, R.E, Jordan, A.M, Rugaard-Jensen, M, Massey, A, Merret, A, Padfield, A, Parsons, R, Radimerski, T, Raynaud, F.I, Robertson, A, Roughley, S.D, Schoepfer, J, Simmonite, H, Surgenor, A, Valenti, M, Walls, S, Webb, P, Wood, M, Workman, P, Wright, L.M.
登録日2009-05-08
公開日2009-07-28
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Combining Hit Identification Strategies: Fragment- Based and in Silico Approaches to Orally Active 2-Aminothieno[2,3-D]Pyrimidine Inhibitors of the Hsp90 Molecular Chaperone.
J.Med.Chem., 52, 2009
2WI3
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Orally Active 2-Amino Thienopyrimidine Inhibitors of the Hsp90 Chaperone
分子名称: 4-METHYL-6-(METHYLSULFANYL)-1,3,5-TRIAZIN-2-AMINE, HEAT SHOCK PROTEIN, HSP 90-ALPHA, ...
著者Brough, P.A, Barril, X, Borgognoni, J, Chene, P, Davies, N.G.M, Davis, B, Drysdale, M.J, Dymock, B, Eccles, S.A, Garcia-Echeverria, C, Fromont, C, Hayes, A, Hubbard, R.E, Jordan, A.M, Rugaard-Jensen, M, Massey, A, Merret, A, Padfield, A, Parsons, R, Radimerski, T, Raynaud, F.I, Robertson, A, Roughley, S.D, Schoepfer, J, Simmonite, H, Surgenor, A, Valenti, M, Walls, S, Webb, P, Wood, M, Workman, P, Wright, L.M.
登録日2009-05-08
公開日2009-07-28
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Combining Hit Identification Strategies: Fragment- Based and in Silico Approaches to Orally Active 2-Aminothieno[2,3-D]Pyrimidine Inhibitors of the Hsp90 Molecular Chaperone.
J.Med.Chem., 52, 2009
2WI7
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Orally Active 2-Amino Thienopyrimidine Inhibitors of the Hsp90 Chaperone
分子名称: 2-amino-4-[2,4-dichloro-5-(2-pyrrolidin-1-ylethoxy)phenyl]-N-ethylthieno[2,3-d]pyrimidine-6-carboxamide, HEAT SHOCK PROTEIN HSP 90-ALPHA
著者Brough, P.A, Barril, X, Borgognoni, J, Chene, P, Davies, N.G.M, Davis, B, Drysdale, M.J, Dymock, B, Eccles, S.A, Garcia-Echeverria, C, Fromont, C, Hayes, A, Hubbard, R.E, Jordan, A.M, Rugaard-Jensen, M, Massey, A, Merret, A, Padfield, A, Parsons, R, Radimerski, T, Raynaud, F.I, Robertson, A, Roughley, S.D, Schoepfer, J, Simmonite, H, Surgenor, A, Valenti, M, Walls, S, Webb, P, Wood, M, Workman, P, Wright, L.M.
登録日2009-05-08
公開日2009-07-28
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Combining Hit Identification Strategies: Fragment- Based and in Silico Approaches to Orally Active 2-Aminothieno[2,3-D]Pyrimidine Inhibitors of the Hsp90 Molecular Chaperone.
J.Med.Chem., 52, 2009
2WI2
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Orally Active 2-Amino Thienopyrimidine Inhibitors of the Hsp90 Chaperone
分子名称: 4-METHYL-6-(METHYLSULFANYL)-1,3,5-TRIAZIN-2-AMINE, DIMETHYL SULFOXIDE, HEAT SHOCK PROTEIN HSP 90-ALPHA
著者Brough, P.A, Barril, X, Borgognoni, J, Chene, P, Davies, N.G.M, Davis, B, Drysdale, M.J, Dymock, B, Eccles, S.A, Garcia-Echeverria, C, Fromont, C, Hayes, A, Hubbard, R.E, Jordan, A.M, Rugaard-Jensen, M, Massey, A, Merret, A, Padfield, A, Parsons, R, Radimerski, T, Raynaud, F.I, Robertson, A, Roughley, S.D, Schoepfer, J, Simmonite, H, Surgenor, A, Valenti, M, Walls, S, Webb, P, Wood, M, Workman, P, Wright, L.M.
登録日2009-05-08
公開日2009-07-28
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.09 Å)
主引用文献Combining Hit Identification Strategies: Fragment- Based and in Silico Approaches to Orally Active 2-Aminothieno[2,3-D]Pyrimidine Inhibitors of the Hsp90 Molecular Chaperone.
J.Med.Chem., 52, 2009
2WI4
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Orally Active 2-Amino Thienopyrimidine Inhibitors of the Hsp90 Chaperone
分子名称: 4-(2,4-dichlorophenyl)-5-phenyldiazenyl-pyrimidin-2-amine, HEAT SHOCK PROTEIN, HSP 90-ALPHA
著者Brough, P.A, Barril, X, Borgognoni, J, Chene, P, Davies, N.G.M, Davis, B, Drysdale, M.J, Dymock, B, Eccles, S.A, Garcia-Echeverria, C, Fromont, C, Hayes, A, Hubbard, R.E, Jordan, A.M, Rugaard-Jensen, M, Massey, A, Merret, A, Padfield, A, Parsons, R, Radimerski, T, Raynaud, F.I, Robertson, A, Roughley, S.D, Schoepfer, J, Simmonite, H, Surgenor, A, Valenti, M, Walls, S, Webb, P, Wood, M, Workman, P, Wright, L.M.
登録日2009-05-08
公開日2009-07-28
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Combining Hit Identification Strategies: Fragment- Based and in Silico Approaches to Orally Active 2-Aminothieno[2,3-D]Pyrimidine Inhibitors of the Hsp90 Molecular Chaperone.
J.Med.Chem., 52, 2009
2P05
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Structural Insights into the Evolution of a Non-Biological Protein
分子名称: ADENOSINE-5'-DIPHOSPHATE, CHLORIDE ION, PENTAETHYLENE GLYCOL, ...
著者Smith, M, Rosenow, M, Wang, M, Allen, J.P, Szostak, J.W, Chaput, J.C.
登録日2007-02-28
公開日2007-06-05
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Structural insights into the evolution of a non-biological protein: importance of surface residues in protein fold optimization.
PLoS ONE, 2, 2007
3US3
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Recombinant rabbit skeletal calsequestrin-MPD complex
分子名称: (4R)-2-METHYLPENTANE-2,4-DIOL, (4S)-2-METHYL-2,4-PENTANEDIOL, CALCIUM ION, ...
著者Sanchez, E.J, Lewis, K.M, Nissen, M.S, Munske, G.R, Kang, C.
登録日2011-11-22
公開日2011-12-21
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (1.738 Å)
主引用文献Glycosylation of skeletal calsequestrin: implications for its function.
J.Biol.Chem., 287, 2012
3V1W
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Molecular Basis for Multiple Ligand Binding of Calsequestrin and Potential Inhibition by Caffeine and Gallocatecin
分子名称: (4R)-2-METHYLPENTANE-2,4-DIOL, (4S)-2-METHYL-2,4-PENTANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Subramanian, A.K, Nissen, M.N, Lewis, K.M, Sanchez, E.J, Muralidharan, A.K, Kang, C.
登録日2011-12-10
公開日2012-12-12
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (1.908 Å)
主引用文献Molecular Basis for Multiple Ligand Binding of Calsequestrin and Potential Inhibition by Caffeine and Gallocatecin
To be Published
1F91
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BETA-KETOACYL-[ACYL-CARRIER-PROTEIN] SYNTHASE I IN COMPLEX WITH C10 FATTY ACID SUBSTRATE
分子名称: BETA-KETOACYL-[ACYL-CARRIER-PROTEIN] SYNTHASE I, DECANOIC ACID, HYDROXIDE ION
著者Olsen, J.G, Kadziola, A, Wettstein-Knowles, P.V, Siggaard-Andersen, M, Larsen, S.
登録日2000-07-06
公開日2001-04-11
最終更新日2021-11-03
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Structures of beta-ketoacyl-acyl carrier protein synthase I complexed with fatty acids elucidate its catalytic machinery.
Structure, 9, 2001
2P09
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Structural Insights into the Evolution of a Non-Biological Protein
分子名称: ADENOSINE-5'-TRIPHOSPHATE, CHLORIDE ION, PENTAETHYLENE GLYCOL, ...
著者Smith, M, Rosenow, M, Wang, M, Allen, J.P, Szostak, J.W, Chaput, J.C.
登録日2007-02-28
公開日2007-06-05
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (1.65 Å)
主引用文献Structural insights into the evolution of a non-biological protein: importance of surface residues in protein fold optimization.
PLoS ONE, 2, 2007
1EK4
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BETA-KETOACYL [ACYL CARRIER PROTEIN] SYNTHASE I IN COMPLEX WITH DODECANOIC ACID TO 1.85 RESOLUTION
分子名称: BETA-KETOACYL [ACYL CARRIER PROTEIN] SYNTHASE I, LAURIC ACID
著者Olsen, J.G, Kadziola, A, Siggaard-Andersen, M, von Wettstein-Knowles, P, Larsen, S.
登録日2000-03-06
公開日2001-04-11
最終更新日2021-11-03
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Structures of beta-ketoacyl-acyl carrier protein synthase I complexed with fatty acids elucidate its catalytic machinery.
Structure, 9, 2001
2PHI
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A LARGE CONFORMATIONAL CHANGE IS FOUND IN THE CRYSTAL STRUCTURE OF THE PORCINE PANCREATIC PHOSPHOLIPASE A2 POINT MUTANT F63V
分子名称: CALCIUM ION, PHOSPHOLIPASE A2
著者Dijkstra, B.W, Thunnissen, M.M.G.M, Kalk, K.H, Drenth, J.
登録日1993-04-08
公開日1993-07-15
最終更新日2024-06-05
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Crystal structure of a porcine pancreatic phospholipase A2 mutant. A large conformational change caused by the F63V point mutation.
J.Mol.Biol., 232, 1993
2QPS
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"Sugar tongs" mutant Y380A in complex with acarbose
分子名称: Alpha-amylase type A isozyme, CALCIUM ION
著者Aghajari, N, Jensen, M.H, Tranier, S, Haser, R.
登録日2007-07-25
公開日2008-02-12
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献The 'pair of sugar tongs' site on the non-catalytic domain C of barley alpha-amylase participates in substrate binding and activity
Febs J., 274, 2007
1W86
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Solution structure of an dsDNA:LNA triplex
分子名称: INTRAMOLECULAR DSDNA-LNA TRIPLEX
著者Sorensen, J.J, Nielsen, J.T, Petersen, M.
登録日2004-09-16
公開日2004-11-25
最終更新日2024-05-15
実験手法SOLUTION NMR
主引用文献Solution Structure of a DsDNA:Lna Triplex
Nucleic Acids Res., 32, 2004
2GR0
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Crystal structure of Ferredoxin reductase, BphA4 (oxidized form, NAD+ complex)
分子名称: ADENOSINE-5'-DIPHOSPHATE, FLAVIN-ADENINE DINUCLEOTIDE, ferredoxin reductase
著者Senda, T, Senda, M.
登録日2006-04-22
公開日2007-05-22
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Molecular Mechanism of the Redox-dependent Interaction between NADH-dependent Ferredoxin Reductase and Rieske-type [2Fe-2S] Ferredoxin
J.Mol.Biol., 373, 2007
2GQW
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Crystal structure of Ferredoxin reductase, BphA4 (oxidized form)
分子名称: FLAVIN-ADENINE DINUCLEOTIDE, FORMIC ACID, GLYCEROL, ...
著者Senda, T, Senda, M.
登録日2006-04-22
公開日2007-05-22
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献Molecular Mechanism of the Redox-dependent Interaction between NADH-dependent Ferredoxin Reductase and Rieske-type [2Fe-2S] Ferredoxin
J.Mol.Biol., 373, 2007
1GV6
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Solution structure of alfa-L-LNA:DNA duplex
分子名称: 5- D(*CP*(ATL)P*GP*CP*(ATL)P*(ATL)P*CP*(ATL)P* GP*C) -3, 5- D(*GP*CP*AP*GP*AP*AP*GP*CP*AP*G) -3
著者Nielsen, K.M.E, Petersen, M, Haakansson, A.E, Wengel, J, Jacobsen, J.P.
登録日2002-02-06
公開日2002-07-05
最終更新日2024-05-15
実験手法SOLUTION NMR
主引用文献Alfa-L-Lna (Alfa-L-Ribo Configured Locked Nucleic Acid) Recognition of DNA: An NMR Spectroscopic Study
Chemistry, 8, 2002

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