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PDB: 122 results

5NK1
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Crystal Structure of Ephrin A2 (EphA2) Receptor Protein Kinase with Compound 1k
Descriptor: 2-[[3-[(4-azanyl-6-methyl-1,3,5-triazin-2-yl)carbamoyl]phenyl]amino]-~{N}-(2-chloranyl-6-methyl-phenyl)-1,3-thiazole-5-carboxamide, Ephrin type-A receptor 2
Authors:Kudlinzki, D, Linhard, V.L, Witt, K, Gande, S.L, Saxena, K, Heinzlmeir, S, Medard, G, Kuester, B, Schwalbe, H.
Deposit date:2017-03-31
Release date:2017-06-07
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.548 Å)
Cite:Chemoproteomics-Aided Medicinal Chemistry for the Discovery of EPHA2 Inhibitors.
ChemMedChem, 12, 2017
5NK6
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BU of 5nk6 by Molmil
Crystal Structure of Ephrin A2 (EphA2) Receptor Protein Kinase with Compound 2d
Descriptor: Ephrin type-A receptor 2, ~{N}-(2-chloranyl-6-methyl-phenyl)-2-[[3-[(4-oxidanylcyclohexyl)carbamoyl]phenyl]amino]-1,3-thiazole-5-carboxamide
Authors:Kudlinzki, D, Linhard, V.L, Witt, K, Gande, S.L, Saxena, K, Heinzlmeir, S, Medard, G, Kuester, B, Schwalbe, H.
Deposit date:2017-03-31
Release date:2017-06-07
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.267 Å)
Cite:Chemoproteomics-Aided Medicinal Chemistry for the Discovery of EPHA2 Inhibitors.
ChemMedChem, 12, 2017
5NK2
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Crystal Structure of Ephrin A2 (EphA2) Receptor Protein Kinase with Compound 2b
Descriptor: 1,2-ETHANEDIOL, Ephrin type-A receptor 2, ~{N}-(2-chloranyl-6-methyl-phenyl)-2-[[3-[[(3~{R},4~{R})-3-fluoranylpiperidin-4-yl]carbamoyl]phenyl]amino]-1,3-thiazole-5-carboxamide
Authors:Kudlinzki, D, Linhard, V.L, Witt, K, Gande, S.L, Saxena, K, Heinzlmeir, S, Medard, G, Kuester, B, Schwalbe, H.
Deposit date:2017-03-31
Release date:2017-06-07
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.649 Å)
Cite:Chemoproteomics-Aided Medicinal Chemistry for the Discovery of EPHA2 Inhibitors.
ChemMedChem, 12, 2017
5NKA
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BU of 5nka by Molmil
Crystal Structure of Ephrin A2 (EphA2) Receptor Protein Kinase with Compound 2g
Descriptor: 1,2-ETHANEDIOL, 4-[[3-[[5-[(2-chloranyl-6-methyl-phenyl)carbamoyl]-1,3-thiazol-2-yl]amino]phenyl]carbonylamino]cyclohexane-1-carboxylic acid, Ephrin type-A receptor 2
Authors:Kudlinzki, D, Linhard, V.L, Witt, K, Gande, S.L, Saxena, K, Heinzlmeir, S, Medard, G, Kuester, B, Schwalbe, H.
Deposit date:2017-03-31
Release date:2017-06-07
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.377 Å)
Cite:Chemoproteomics-Aided Medicinal Chemistry for the Discovery of EPHA2 Inhibitors.
ChemMedChem, 12, 2017
5MVB
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BU of 5mvb by Molmil
Solution structure of a human G-Quadruplex hybrid-2 form in complex with a Gold-ligand.
Descriptor: DNA (26-MER), POTASSIUM ION, bis(m2-Oxo)-bis(2-methyl-2,2'-bipyridine)-di-gold(iii)
Authors:Wirmer-Bartoschek, J, Jonker, H.R.A, Bendel, L.E, Gruen, T, Bazzicalupi, C, Messori, L, Gratteri, P, Schwalbe, H.
Deposit date:2017-01-16
Release date:2017-05-31
Last modified:2024-06-19
Method:SOLUTION NMR
Cite:Solution NMR Structure of a Ligand/Hybrid-2-G-Quadruplex Complex Reveals Rearrangements that Affect Ligand Binding.
Angew. Chem. Int. Ed. Engl., 56, 2017
8BM8
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BU of 8bm8 by Molmil
Crystal Structure of Ephrin A2 (EphA2) Receptor Protein Kinase with Compound 11
Descriptor: Ephrin type-A receptor 2, ~{N}-(3-cyanophenyl)-4-methyl-3-[(1-methyl-6-pyridin-3-yl-pyrazolo[3,4-d]pyrimidin-4-yl)amino]benzamide
Authors:Linhard, V, Witt, K, Gande, S, Wollenhaupt, J, Lennartz, F, Weiss, M.S, Schwalbe, H.
Deposit date:2022-11-10
Release date:2024-06-05
Method:X-RAY DIFFRACTION (1.68 Å)
Cite:(placeholder, will be filled after publication)
To Be Published
2K5B
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Human CDC37-HSP90 docking model based on NMR
Descriptor: Heat shock protein HSP 90-alpha, Hsp90 co-chaperone Cdc37
Authors:Sreeramulu, S, Jonker, H.R.A, Lancaster, C.R, Richter, C, Langer, T, Schwalbe, H.
Deposit date:2008-06-26
Release date:2008-12-09
Last modified:2024-05-29
Method:SOLUTION NMR
Cite:The human Cdc37.Hsp90 complex studied by heteronuclear NMR spectroscopy
J.Biol.Chem., 284, 2009
2KMJ
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High resolution NMR solution structure of a complex of HIV-2 TAR RNA and a synthetic tripeptide in a 1:2 stoichiometry
Descriptor: Pyrimidinylpeptide, RNA (28-MER)
Authors:Ferner, J, Suhartono, M, Breitung, S, Jonker, H.R.A, Hennig, M, Woehnert, J, Goebel, M, Schwalbe, H.
Deposit date:2009-07-30
Release date:2009-08-18
Last modified:2023-11-15
Method:SOLUTION NMR
Cite:Structures of HIV TAR RNA-ligand complexes reveal higher binding stoichiometries.
Chembiochem, 10, 2009
2L2X
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Thiostrepton, oxidized at CA-CB bond of residue 9
Descriptor: Thiostrepton
Authors:Jonker, H.R.A, Baumann, S, Wolf, A, Schoof, S, Hiller, F, Schulte, K.W, Kirschner, K.N, Schwalbe, H, Arndt, H.-D.
Deposit date:2010-08-27
Release date:2011-02-02
Last modified:2013-06-26
Method:SOLUTION NMR
Cite:NMR structures of thiostrepton derivatives for characterization of the ribosomal binding site.
Angew.Chem.Int.Ed.Engl., 50, 2011
2LUB
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BU of 2lub by Molmil
High resolution NMR solution structure of helix H1 of the human HAR1 RNA
Descriptor: RNA (37-MER)
Authors:Cevec, M, Ziegeler, M, Richter, C, Schwalbe, H.
Deposit date:2012-06-11
Release date:2012-07-25
Last modified:2024-05-01
Method:SOLUTION NMR
Cite:NMR Studies of HAR1 RNA Secondary Structures Reveal Conformational Dynamics in the Human RNA.
Chembiochem, 13, 2012
2LUO
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BU of 2luo by Molmil
NMR solution structure of apo-MptpA
Descriptor: LOW MOLECULAR WEIGHT PROTEIN-TYROSINE-PHOSPHATASE A
Authors:Stehle, T, Sreeramulu, S, Loehr, F, Richter, C, Saxena, K, Jonker, H.R.A, Schwalbe, H.
Deposit date:2012-06-19
Release date:2012-08-15
Last modified:2024-05-15
Method:SOLUTION NMR
Cite:The Apo-structure of the Low Molecular Weight Protein-tyrosine Phosphatase A (MptpA) from Mycobacterium tuberculosis Allows for Better Target-specific Drug Development.
J.Biol.Chem., 287, 2012
5X1X
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BU of 5x1x by Molmil
Solution NMR Structure of DNA Mismatch Repair Protein MutT (Family Nudix Hydrolase) from Methicillin Resistant Staphylococcus aureus 252
Descriptor: Mutator mutT protein
Authors:Wahab, A, Durreshahwar, S, Schwalbe, H, Richter, C, Choudhary, M.I.
Deposit date:2017-01-27
Release date:2017-02-22
Last modified:2024-05-15
Method:SOLUTION NMR
Cite:Solution NMR Structure of DNA Mismatch Repair Protein MutT (Family Nudix Hydrolase) from Methicillin Resistant Staphylococcus aureus 252
To Be Published
2N9Q
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BU of 2n9q by Molmil
Photoswitchable G-quadruplex
Descriptor: DNA (5'-D(*GP*GP*(AZW)P*GP*G)-3'), POTASSIUM ION
Authors:Thevarpadam, J, Bessi, I, Binas, O, Goncalves, D.P.N, Slavov, C, Jonker, H.R.A, Richter, C, Wachtveitl, J, Schwalbe, H, Heckel, A.
Deposit date:2015-12-02
Release date:2016-02-17
Last modified:2024-05-15
Method:SOLUTION NMR
Cite:Photoresponsive Formation of an Intermolecular Minimal G-Quadruplex Motif.
Angew.Chem.Int.Ed.Engl., 55, 2016
2MW4
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BU of 2mw4 by Molmil
Tetramerization domain of the Ciona intestinalis p53/p73-b transcription factor protein
Descriptor: Transcription factor protein
Authors:Heering, J.P, Jonker, H.R.A, Loehr, F, Schwalbe, H, Doetsch, V.
Deposit date:2014-10-27
Release date:2015-10-28
Last modified:2024-05-15
Method:SOLUTION NMR
Cite:Structural investigations of the p53/p73 homologs from the tunicate species Ciona intestinalis reveal the sequence requirements for the formation of a tetramerization domain.
Protein Sci., 25, 2016
2JQ7
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BU of 2jq7 by Molmil
Model for thiostrepton binding to the ribosomal L11-RNA
Descriptor: 50S RIBOSOMAL PROTEIN L11, RIBOSOMAL RNA, THIOSTREPTON
Authors:Jonker, H.R.A, Ilin, S, Grimm, S.K, Woehnert, J, Schwalbe, H.
Deposit date:2007-05-30
Release date:2007-07-03
Last modified:2021-08-18
Method:SOLUTION NMR
Cite:L11 Domain Rearrangement Upon Binding to RNA and Thiostrepton Studied by NMR Spectroscopy
Nucleic Acids Res., 35, 2007
2KOC
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BU of 2koc by Molmil
NMR solution structure of a 14-mer hairpin RNA with cUUCGg tetraloop
Descriptor: RNA (5'-R(P*GP*GP*CP*AP*CP*UP*UP*CP*GP*GP*UP*GP*CP*C)-3')
Authors:Nozinovic, S, Fuertig, B, Jonker, H.R.A, Richter, C, Schwalbe, H.
Deposit date:2009-09-17
Release date:2009-12-01
Last modified:2024-05-15
Method:SOLUTION NMR
Cite:High-resolution NMR structure of an RNA model system: the 14-mer cUUCGg tetraloop hairpin RNA
Nucleic Acids Res., 2009
2L2Z
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BU of 2l2z by Molmil
Thiostrepton, reduced at N-CA bond of residue 14
Descriptor: Thiostrepton
Authors:Jonker, H.R.A, Baumann, S, Wolf, A, Schoof, S, Hiller, F, Schulte, K.W, Kirschner, K.N, Schwalbe, H, Arndt, H.-D.
Deposit date:2010-08-27
Release date:2011-02-02
Last modified:2013-06-26
Method:SOLUTION NMR
Cite:NMR structures of thiostrepton derivatives for characterization of the ribosomal binding site.
Angew.Chem.Int.Ed.Engl., 50, 2011
2L2W
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BU of 2l2w by Molmil
Thiostrepton
Descriptor: Thiostrepton
Authors:Jonker, H.R.A, Baumann, S, Wolf, A, Schoof, S, Hiller, F, Schulte, K.W, Kirschner, K.N, Schwalbe, H, Arndt, H.-D.
Deposit date:2010-08-27
Release date:2011-02-02
Last modified:2013-05-08
Method:SOLUTION NMR
Cite:NMR structures of thiostrepton derivatives for characterization of the ribosomal binding site.
Angew.Chem.Int.Ed.Engl., 50, 2011
2L6X
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BU of 2l6x by Molmil
Solution NMR Structure of Proteorhodopsin.
Descriptor: Green-light absorbing proteorhodopsin, RETINAL
Authors:Reckel, S, Gottstein, D, Stehle, J, Loehr, F, Takeda, M, Silvers, R, Kainosho, M, Glaubitz, C, Bernhard, F, Schwalbe, H, Guntert, P, Doetsch, V, Membrane Protein Structures by Solution NMR (MPSbyNMR)
Deposit date:2010-11-29
Release date:2011-11-09
Last modified:2020-02-05
Method:SOLUTION NMR
Cite:Solution NMR structure of proteorhodopsin.
Angew.Chem.Int.Ed.Engl., 50, 2011
2LHP
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BU of 2lhp by Molmil
High resolution NMR solution structure of helix H1 of the chimpanzee HAR1 RNA
Descriptor: RNA (37-MER)
Authors:Cevec, M, Ziegeler, M, Richter, C, Schwalbe, H.
Deposit date:2011-08-12
Release date:2012-07-25
Last modified:2024-05-01
Method:SOLUTION NMR
Cite:NMR Studies of HAR1 RNA Secondary Structures Reveal Conformational Dynamics in the Human RNA.
Chembiochem, 13, 2012
2L2Y
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Thiostrepton, epimer form of residue 9
Descriptor: Thiostrepton
Authors:Jonker, H.R.A, Baumann, S, Wolf, A, Schoof, S, Hiller, F, Schulte, K.W, Kirschner, K.N, Schwalbe, H, Arndt, H.-D.
Deposit date:2010-08-27
Release date:2011-02-02
Last modified:2013-06-26
Method:SOLUTION NMR
Cite:NMR structures of thiostrepton derivatives for characterization of the ribosomal binding site.
Angew.Chem.Int.Ed.Engl., 50, 2011
2KER
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BU of 2ker by Molmil
alpha-amylase inhibitor Parvulustat (Z-2685) from Streptomyces parvulus
Descriptor: Alpha-amylase inhibitor Z-2685
Authors:Rehm, S, Han, S, Hassani, I, Sokocevic, A, Jonker, H.R.A, Engels, J.W, Schwalbe, H.
Deposit date:2009-02-02
Release date:2009-02-17
Last modified:2022-03-16
Method:SOLUTION NMR
Cite:The high resolution NMR structure of parvulustat (Z-2685) from Streptomyces parvulus FH-1641: comparison with tendamistat from Streptomyces tendae 4158
Chembiochem, 10, 2009

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