2N9Q

Photoswitchable G-quadruplex

Summary for 2N9Q

• Entry DOI: 10.2210/pdb2n9q/pdb
• NMR Information: BMRB: 25915
• Descriptor: DNA (5'-D(*GP*GP*(AZW)P*GP*G)-3'), POTASSIUM ION (2 entities in total)
• Functional Keywords: quadruplex, photoswitch, dna
• Total number of polymer chains: 4
• Total formula weight: 6421.71

Authors

Thevarpadam, J.,Bessi, I.,Binas, O.,Goncalves, D.P.N.,Slavov, C.,Jonker, H.R.A.,Richter, C.,Wachtveitl, J.,Schwalbe, H.,Heckel, A. (deposition date: 2015-12-02, release date: 2016-02-17, Last modification date: 2024-05-15)

Primary citation

Thevarpadam, J.,Bessi, I.,Binas, O.,Goncalves, D.P.,Slavov, C.,Jonker, H.R.,Richter, C.,Wachtveitl, J.,Schwalbe, H.,Heckel, A.
Photoresponsive Formation of an Intermolecular Minimal G-Quadruplex Motif.
Angew.Chem.Int.Ed.Engl., 55:2738-2742, 2016

PubMed Abstract: The ability of three different bifunctional azobenzene linkers to enable the photoreversible formation of a defined intermolecular two-tetrad G-quadruplex upon UV/Vis irradiation was investigated. Circular dichroism and NMR spectroscopic data showed the formation of G-quadruplexes with K(+)  ions at room temperature in all three cases with the corresponding azobenzene linker in an E conformation. However, only the para-para-substituted azobenzene derivative enables photoswitching between a nonpolymorphic, stacked, tetramolecular G-quadruplex and an unstructured state after E-Z isomerization.

PubMed: 26805928
DOI: 10.1002/anie.201510269

Experimental method

SOLUTION NMR