1QPQ
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![BU of 1qpq by Molmil](/molmil-images/mine/1qpq) | Structure of Quinolinic Acid Phosphoribosyltransferase from Mycobacterium Tuberculosis: A Potential TB Drug Target | Descriptor: | QUINOLINATE PHOSPHORIBOSYLTRANSFERASE, QUINOLINIC ACID, SULFATE ION | Authors: | Sharma, V, Grubmeyer, C, Sacchettini, J.C, TB Structural Genomics Consortium (TBSGC) | Deposit date: | 1998-11-20 | Release date: | 1998-11-25 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.45 Å) | Cite: | Crystal structure of quinolinic acid phosphoribosyltransferase from Mycobacterium tuberculosis: a potential TB drug target. Structure, 6, 1998
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1LD9
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![BU of 1ld9 by Molmil](/molmil-images/mine/1ld9) | THE THREE-DIMENSIONAL STRUCTURE OF AN H-2LD PEPTIDE COMPLEX EXPLAINS THE UNIQUE INTERACTION OF LD WITH BETA2M AND PEPTIDE | Descriptor: | BETA-2 MICROGLOBULIN, MHC CLASS I H-2LD HEAVY CHAIN, NANO-PEPTIDE | Authors: | Balendiran, G.K, Solheim, J.C, Young, A.C.M, Hansen, T.H, Nathenson, S.G, Sacchettini, J.C. | Deposit date: | 1997-04-24 | Release date: | 1998-05-06 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | The three-dimensional structure of an H-2Ld-peptide complex explains the unique interaction of Ld with beta-2 microglobulin and peptide. Proc.Natl.Acad.Sci.USA, 94, 1997
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1EAL
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![BU of 1eal by Molmil](/molmil-images/mine/1eal) | NMR STUDY OF ILEAL LIPID BINDING PROTEIN | Descriptor: | ILEAL LIPID BINDING PROTEIN | Authors: | Luecke, C, Zhang, F, Rueterjans, H, Hamilton, J.A, Sacchettini, J.C. | Deposit date: | 1996-08-28 | Release date: | 1997-01-22 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Flexibility is a likely determinant of binding specificity in the case of ileal lipid binding protein. Structure, 4, 1996
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2MHA
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![BU of 2mha by Molmil](/molmil-images/mine/2mha) | CRYSTAL STRUCTURE OF THE MAJOR HISTOCOMPATIBILITY COMPLEX CLASS I H-2KB MOLECULE CONTAINING A SINGLE VIRAL PEPTIDE: IMPLICATIONS FOR PEPTIDE BINDING AND T-CELL RECEPTOR RECOGNITION | Descriptor: | BETA 2-MICROGLOBULIN, CLASS I HISTOCOMPATIBILITY ANTIGEN (H-2KB) (ALPHA CHAIN), VIRAL OCTAPEPTIDE ARG-GLY-TYR-VAL-TYR-GLN-GLY-LEU | Authors: | Zhang, W, Young, A.C.M, Imarai, M, Nathenson, S.G, Sacchettini, J.C. | Deposit date: | 1993-07-21 | Release date: | 1993-10-31 | Last modified: | 2019-08-14 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Crystal structure of the major histocompatibility complex class I H-2Kb molecule containing a single viral peptide: implications for peptide binding and T-cell receptor recognition. Proc.Natl.Acad.Sci.USA, 89, 1992
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2NTJ
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![BU of 2ntj by Molmil](/molmil-images/mine/2ntj) | Mycobacterium tuberculosis InhA bound with PTH-NAD adduct | Descriptor: | Enoyl-[acyl-carrier-protein] reductase [NADH, {(2R,3S,4R,5R)-5-[(4S)-3-(AMINOCARBONYL)-4-(2-PROPYLISONICOTINOYL)PYRIDIN-1(4H)-YL]-3,4-DIHYDROXYTETRAHYDROFURAN-2-YL}M ETHYL [(2R,3S,4R,5R)-5-(6-AMINO-9H-PURIN-9-YL)-3,4-DIHYDROXYTETRAHYDROFURAN-2-YL]METHYL DIHYDROGEN DIPHOSPHATE | Authors: | Wang, F, Sacchettini, J.C. | Deposit date: | 2006-11-07 | Release date: | 2007-01-30 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Mechanism of thioamide drug action against tuberculosis and leprosy. J.Exp.Med., 204, 2007
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2NV6
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![BU of 2nv6 by Molmil](/molmil-images/mine/2nv6) | |
2NVO
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![BU of 2nvo by Molmil](/molmil-images/mine/2nvo) | |
2PA3
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![BU of 2pa3 by Molmil](/molmil-images/mine/2pa3) | |
2PCP
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![BU of 2pcp by Molmil](/molmil-images/mine/2pcp) | ANTIBODY FAB COMPLEXED WITH PHENCYCLIDINE | Descriptor: | 1-(PHENYL-1-CYCLOHEXYL)PIPERIDINE, IMMUNOGLOBULIN | Authors: | Lim, K, Owens, S.M, Arnold, L, Sacchettini, J.C, Linthicum, D.S. | Deposit date: | 1998-06-02 | Release date: | 1999-01-27 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Crystal structure of monoclonal 6B5 Fab complexed with phencyclidine. J.Biol.Chem., 273, 1998
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2P9C
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![BU of 2p9c by Molmil](/molmil-images/mine/2p9c) | |
2PKM
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![BU of 2pkm by Molmil](/molmil-images/mine/2pkm) | Crystal structure of M tuberculosis Adenosine Kinase complexed with adenosine | Descriptor: | ADENOSINE, Adenosine kinase | Authors: | Reddy, M.C.M, Palaninathan, S.K, Shetty, N.D, Owen, J.L, Watson, M.D, Sacchettini, J.C, TB Structural Genomics Consortium (TBSGC) | Deposit date: | 2007-04-17 | Release date: | 2007-06-26 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | High resolution crystal structures of Mycobacterium tuberculosis adenosine kinase: insights into the mechanism and specificity of this novel prokaryotic enzyme J.Biol.Chem., 282, 2007
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2PKK
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![BU of 2pkk by Molmil](/molmil-images/mine/2pkk) | Crystal structure of M tuberculosis Adenosine Kinase complexed with 2-fluro adenosine | Descriptor: | 2-(6-AMINO-2-FLUORO-PURIN-9-YL)-5-HYDROXYMETHYL-TETRAHYDRO-FURAN-3,4-DIOL, Adenosine kinase | Authors: | Reddy, M.C.M, Palaninathan, S.K, Shetty, N.D, Owen, J.L, Watson, M.D, Sacchettini, J.C, TB Structural Genomics Consortium (TBSGC) | Deposit date: | 2007-04-17 | Release date: | 2007-06-19 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.93 Å) | Cite: | High resolution crystal structures of Mycobacterium tuberculosis adenosine kinase: insights into the mechanism and specificity of this novel prokaryotic enzyme J.Biol.Chem., 282, 2007
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2NTV
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![BU of 2ntv by Molmil](/molmil-images/mine/2ntv) | Mycobacterium leprae InhA bound with PTH-NAD adduct | Descriptor: | Enoyl-[ACP] reductase, {(2R,3S,4R,5R)-5-[(4S)-3-(AMINOCARBONYL)-4-(2-PROPYLISONICOTINOYL)PYRIDIN-1(4H)-YL]-3,4-DIHYDROXYTETRAHYDROFURAN-2-YL}M ETHYL [(2R,3S,4R,5R)-5-(6-AMINO-9H-PURIN-9-YL)-3,4-DIHYDROXYTETRAHYDROFURAN-2-YL]METHYL DIHYDROGEN DIPHOSPHATE | Authors: | Wang, F, Sacchettini, J.C. | Deposit date: | 2006-11-08 | Release date: | 2007-01-30 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Mechanism of thioamide drug action against tuberculosis and leprosy. J.Exp.Med., 204, 2007
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2PKN
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![BU of 2pkn by Molmil](/molmil-images/mine/2pkn) | Crystal structure of M tuberculosis Adenosine Kinase complexed with AMP-PCP (non-hydrolyzable ATP analog) | Descriptor: | Adenosine kinase, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER | Authors: | Reddy, M.C.M, Palaninathan, S.K, Shetty, N.D, Owen, J.L, Watson, M.D, Sacchettini, J.C, TB Structural Genomics Consortium (TBSGC) | Deposit date: | 2007-04-18 | Release date: | 2007-06-19 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | High resolution crystal structures of Mycobacterium tuberculosis adenosine kinase: insights into the mechanism and specificity of this novel prokaryotic enzyme J.Biol.Chem., 282, 2007
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2P9G
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![BU of 2p9g by Molmil](/molmil-images/mine/2p9g) | |
2P9E
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2PKF
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![BU of 2pkf by Molmil](/molmil-images/mine/2pkf) | Crystal structure of M tuberculosis Adenosine Kinase (apo) | Descriptor: | Adenosine kinase | Authors: | Reddy, M.C.M, Palaninathan, S.K, Shetty, N.D, Owen, J.L, Watson, M.D, Sacchettini, J.C, TB Structural Genomics Consortium (TBSGC) | Deposit date: | 2007-04-17 | Release date: | 2007-06-19 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | High resolution crystal structures of Mycobacterium tuberculosis adenosine kinase: insights into the mechanism and specificity of this novel prokaryotic enzyme J.Biol.Chem., 282, 2007
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2PFC
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![BU of 2pfc by Molmil](/molmil-images/mine/2pfc) | Structure of Mycobacterium tuberculosis Rv0098 | Descriptor: | Hypothetical protein Rv0098/MT0107, PALMITIC ACID | Authors: | Wang, F, Sacchettini, J.C. | Deposit date: | 2007-04-04 | Release date: | 2008-04-08 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Identification of a type III thioesterase reveals the function of an operon crucial for Mtb virulence. Chem.Biol., 14, 2007
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2OZ0
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![BU of 2oz0 by Molmil](/molmil-images/mine/2oz0) | Mechanistic and Structural Studies of H373Q Flavocytochrome b2: Effects of Mutating the Active Site Base | Descriptor: | Cytochrome b2, FLAVIN MONONUCLEOTIDE, PROTOPORPHYRIN IX CONTAINING FE, ... | Authors: | Tsai, C.-L, Gokulan, K, Sobrado, P, Sacchettini, J.C, Fitzpatrick, P.F. | Deposit date: | 2007-02-23 | Release date: | 2007-09-11 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Mechanistic and structural studies of H373Q flavocytochrome b2: effects of mutating the active site base. Biochemistry, 46, 2007
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1DIH
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![BU of 1dih by Molmil](/molmil-images/mine/1dih) | |
2QZ8
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![BU of 2qz8 by Molmil](/molmil-images/mine/2qz8) | Crystal structure of Mycobacterium tuberculosis Leucine response regulatory protein (LrpA) | Descriptor: | Probable transcriptional regulatory protein | Authors: | Manchi, C.M.R, Gokulan, K, Ioerger, T, Jacobs Jr, W.R, Sacchettini, J.C, TB Structural Genomics Consortium (TBSGC) | Deposit date: | 2007-08-16 | Release date: | 2007-11-06 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.16 Å) | Cite: | Crystal structure of Mycobacterium tuberculosis LrpA, a leucine-responsive global regulator associated with starvation response. Protein Sci., 17, 2008
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4G2R
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![BU of 4g2r by Molmil](/molmil-images/mine/4g2r) | Crystal Structure of the carboxyltransferase subunit of ACC (AccD6) in complex with inhibitor haloxyfop from Mycobacterium tuberculosis | Descriptor: | (2R)-2-(4-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy}phenoxy)propanoic acid, AccD6, Carboxyltransferase beta-subunit of Acyl-CoA Carboxylase | Authors: | Reddy, M.C.M, Bruning, J.B, Thurman, C, Sherekar, M, Valluru, S, Ehrenfeld, H, Sacchettini, J.C, TB Structural Genomics Consortium (TBSGC) | Deposit date: | 2012-07-12 | Release date: | 2014-02-19 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.28 Å) | Cite: | Structure, Activity, and Inhibition of the Carboxyltransferase beta-Subunit of Acetyl Coenzyme A Carboxylase (AccD6) from Mycobacterium tuberculosis. Antimicrob.Agents Chemother., 58, 2014
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4I7E
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![BU of 4i7e by Molmil](/molmil-images/mine/4i7e) | Crystal Structure of the Bacillus stearothermophilus Phosphofructokinase Mutant D12A in Complex with PEP | Descriptor: | 6-phosphofructokinase, PHOSPHOENOLPYRUVATE | Authors: | Mosser, R, Reddy, M, Bruning, J.B, Sacchettini, J.C, Reinhart, G.D. | Deposit date: | 2012-11-30 | Release date: | 2013-07-31 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Redefining the Role of the Quaternary Shift in Bacillus stearothermophilus Phosphofructokinase. Biochemistry, 52, 2013
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4I36
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![BU of 4i36 by Molmil](/molmil-images/mine/4i36) | Crystal Structure of the Bacillus stearothermophilus Phosphofructokinase Mutant D12A | Descriptor: | 6-phosphofructokinase | Authors: | Mosser, R, Reddy, M, Bruning, J.B, Sacchettini, J.C, Reinhart, G.D. | Deposit date: | 2012-11-25 | Release date: | 2013-07-31 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Redefining the Role of the Quaternary Shift in Bacillus stearothermophilus Phosphofructokinase. Biochemistry, 52, 2013
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4IR7
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![BU of 4ir7 by Molmil](/molmil-images/mine/4ir7) | Crystal Structure of Mtb FadD10 in Complex with Dodecanoyl-AMP | Descriptor: | 5'-O-[(S)-(dodecanoyloxy)(hydroxy)phosphoryl]adenosine, Long chain fatty acid CoA ligase FadD10, MAGNESIUM ION | Authors: | Liu, Z, Wang, F, Sacchettini, J.C, TB Structural Genomics Consortium (TBSGC) | Deposit date: | 2013-01-14 | Release date: | 2013-05-08 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Structures of Mycobacterium tuberculosis FadD10 protein reveal a new type of adenylate-forming enzyme. J.Biol.Chem., 288, 2013
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