7PHH
 
 | | Human voltage-gated potassium channel Kv3.1 (apo condition) | | Descriptor: | 1,2-DIACYL-SN-GLYCERO-3-PHOSHOCHOLINE, POTASSIUM ION, Potassium voltage-gated channel, ... | | Authors: | Chi, G, Venkaya, S, Singh, N.K, McKinley, G, Mukhopadhyay, S.M.M, Marsden, B, MacLean, E.M, Fernandez-Cid, A, Pike, A.C.W, Savva, C, Ragan, T.J, Burgess-Brown, N.A, Duerr, K.L. | | Deposit date: | 2021-08-17 | | Release date: | 2022-03-02 | | Last modified: | 2024-07-17 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | Cryo-EM structure of the human Kv3.1 channel reveals gating control by the cytoplasmic T1 domain.
Nat Commun, 13, 2022
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7PHK
 | | Human voltage-gated potassium channel Kv3.1 in dimeric state (with Zn) | | Descriptor: | 1,2-DIACYL-SN-GLYCERO-3-PHOSHOCHOLINE, POTASSIUM ION, Potassium voltage-gated channel, ... | | Authors: | Chi, G, Qian, P, Castro-Hartmann, P, Venkaya, S, Singh, N.K, McKinley, G, Mukhopadhyay, S.M.M, Marsden, B, MacLean, E.M, Fernandez-Cid, A, Pike, A.C.W, Sader, K, Burgess-Brown, N.A, Duerr, K.L. | | Deposit date: | 2021-08-17 | | Release date: | 2022-03-02 | | Last modified: | 2024-07-17 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | Cryo-EM structure of the human Kv3.1 channel reveals gating control by the cytoplasmic T1 domain.
Nat Commun, 13, 2022
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7PHI
 | | Human voltage-gated potassium channel Kv3.1 (with Zn) | | Descriptor: | 1,2-DIACYL-SN-GLYCERO-3-PHOSHOCHOLINE, POTASSIUM ION, Potassium voltage-gated channel, ... | | Authors: | Chi, G, Qian, P, Castro-Hartmann, P, Venkaya, S, Singh, N.K, McKinley, G, Mukhopadhyay, S.M.M, Fernandez-Cid, A, Marsden, B, MacLean, E.M, Pike, A.C.W, Sader, K, Burgess-Brown, N.A, Duerr, K.L. | | Deposit date: | 2021-08-17 | | Release date: | 2022-03-02 | | Last modified: | 2024-07-17 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | Cryo-EM structure of the human Kv3.1 channel reveals gating control by the cytoplasmic T1 domain.
Nat Commun, 13, 2022
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5MGX
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5MCB
 | | Glycogen phosphorylase in complex with chlorogenic acid. | | Descriptor: | Chlorogenic acid, Glycogen phosphorylase, muscle form, ... | | Authors: | Leonidas, D.D, Stravodimos, G.A, Kyriakis, E, Chatzileontiadou, D.S.M, Kantsadi, A.L. | | Deposit date: | 2016-11-09 | | Release date: | 2017-09-20 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (1.95 Å) | | Cite: | Affinity Crystallography Reveals the Bioactive Compounds of Industrial Juicing Byproducts of Punica granatum for Glycogen Phosphorylase.
Curr Drug Discov Technol, 15, 2018
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5MWE
 | | Complex between the Leucine Zipper (LZ, residues 490-567) and Centrosomin-motif 2 (CM2) domains of Drosophila melanogaster Centrosomin (Cnn) | | Descriptor: | 1,2-ETHANEDIOL, 3,3',3''-phosphanetriyltripropanoic acid, Centrosomin, ... | | Authors: | Feng, Z, Johnson, S, Raff, J.W, Lea, S.M. | | Deposit date: | 2017-01-18 | | Release date: | 2017-06-28 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (2.02 Å) | | Cite: | Structural Basis for Mitotic Centrosome Assembly in Flies.
Cell, 169, 2017
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5MW9
 | | Complex between the Leucine Zipper (LZ) and Centrosomin-motif 2 (CM2) domains of Drosophila melanogaster Centrosomin (Cnn) - L535E mutant form | | Descriptor: | Centrosomin, ZINC ION | | Authors: | Feng, Z, Johnson, S, Raff, J.W, Lea, S.M. | | Deposit date: | 2017-01-18 | | Release date: | 2017-06-28 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Structural Basis for Mitotic Centrosome Assembly in Flies.
Cell, 169, 2017
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5MVW
 | | Complex between the Leucine Zipper (LZ) and Centrosomin-motif 2 (CM2) domains of Drosophila melanogaster Centrosomin (Cnn) | | Descriptor: | 1,2-ETHANEDIOL, CHLORIDE ION, Centrosomin, ... | | Authors: | Feng, Z, Johnson, S, Raff, J.W, Lea, S.M. | | Deposit date: | 2017-01-17 | | Release date: | 2017-06-28 | | Method: | X-RAY DIFFRACTION (1.82 Å) | | Cite: | Structural Basis for Mitotic Centrosome Assembly in Flies.
Cell, 169, 2017
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5MW0
 | | Complex between the Leucine Zipper (LZ) and Centrosomin-motif 2 (CM2) domains of Drosophila melanogaster Centrosomin (Cnn) - L535E mutant form | | Descriptor: | Centrosomin, ZINC ION | | Authors: | Feng, Z, Johnson, S, Raff, J.W, Lea, S.M. | | Deposit date: | 2017-01-17 | | Release date: | 2017-06-28 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Structural Basis for Mitotic Centrosome Assembly in Flies.
Cell, 169, 2017
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3JZB
 | | Crystal Structure of TR-alfa bound to the selective thyromimetic TRIAC | | Descriptor: | THRA protein, [4-(4-HYDROXY-3-IODO-PHENOXY)-3,5-DIIODO-PHENYL]-ACETIC ACID | | Authors: | Nascimento, A.S, Dias, S.M.G, Nunes, F.M, Aparicio, R. | | Deposit date: | 2009-09-23 | | Release date: | 2009-12-08 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (2.007 Å) | | Cite: | Gaining ligand selectivity in thyroid hormone receptors via entropy.
Proc.Natl.Acad.Sci.USA, 106, 2009
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5LRX
 | | Structure of A20 OTU domain bound to ubiquitin | | Descriptor: | Polyubiquitin-B, Tumor necrosis factor alpha-induced protein 3 | | Authors: | Mevissen, T.E.T, Kulathu, Y, Mulder, M.P.C, Geurink, P.P, Maslen, S.L, Gersch, M, Elliott, P.R, Burke, J.E, van Tol, B.D.M, Akutsu, M, El Oualid, F, Kawasaki, M, Freund, S.M.V, Ovaa, H, Komander, D. | | Deposit date: | 2016-08-22 | | Release date: | 2016-10-19 | | Last modified: | 2017-09-13 | | Method: | X-RAY DIFFRACTION (2.85 Å) | | Cite: | Molecular basis of Lys11-polyubiquitin specificity in the deubiquitinase Cezanne.
Nature, 538, 2016
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5LRU
 | | Structure of Cezanne/OTUD7B OTU domain | | Descriptor: | OTU domain-containing protein 7B | | Authors: | Mevissen, T.E.T, Kulathu, Y, Mulder, M.P.C, Geurink, P.P, Maslen, S.L, Gersch, M, Elliott, P.R, Burke, J.E, van Tol, B.D.M, Akutsu, M, El Oualid, F, Kawasaki, M, Freund, S.M.V, Ovaa, H, Komander, D. | | Deposit date: | 2016-08-22 | | Release date: | 2016-10-19 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Molecular basis of Lys11-polyubiquitin specificity in the deubiquitinase Cezanne.
Nature, 538, 2016
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5MPS
 | | Structure of a spliceosome remodeled for exon ligation | | Descriptor: | GUANOSINE-5'-TRIPHOSPHATE, INOSITOL HEXAKISPHOSPHATE, MAGNESIUM ION, ... | | Authors: | Fica, S.M, Oubridge, C, Galej, W.P, Wilkinson, M.E, Newman, A.J, Bai, X.-C, Nagai, K. | | Deposit date: | 2016-12-18 | | Release date: | 2017-01-18 | | Last modified: | 2020-10-07 | | Method: | ELECTRON MICROSCOPY (3.85 Å) | | Cite: | Structure of a spliceosome remodelled for exon ligation.
Nature, 542, 2017
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5MVX
 | | Human DLL4 C2-EGF3 | | Descriptor: | Delta-like protein 4, alpha-L-fucopyranose | | Authors: | Suckling, R.J, Handford, P.A, Lea, S.M. | | Deposit date: | 2017-01-17 | | Release date: | 2017-06-14 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (2.17 Å) | | Cite: | Structural and functional dissection of the interplay between lipid and Notch binding by human Notch ligands.
EMBO J., 36, 2017
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5MW7
 | | Human Jagged2 C2-EGF3 | | Descriptor: | Protein jagged-2, alpha-L-fucopyranose | | Authors: | Suckling, R.J, Handford, P.A, Lea, S.M. | | Deposit date: | 2017-01-18 | | Release date: | 2017-06-14 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Structural and functional dissection of the interplay between lipid and Notch binding by human Notch ligands.
EMBO J., 36, 2017
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5MWB
 | | Human Notch-2 EGF11-13 | | Descriptor: | CALCIUM ION, Neurogenic locus notch homolog protein 2, alpha-L-fucopyranose, ... | | Authors: | Suckling, R.J, Handford, P.A, Lea, S.M. | | Deposit date: | 2017-01-18 | | Release date: | 2017-06-14 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (1.86 Å) | | Cite: | Structural and functional dissection of the interplay between lipid and Notch binding by human Notch ligands.
EMBO J., 36, 2017
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5LJ5
 | | Overall structure of the yeast spliceosome immediately after branching. | | Descriptor: | CWC15, CWC22, Exon 1 (5' exon) of UBC4 pre-mRNA, ... | | Authors: | Galej, W.P, Wilkinson, M.F, Fica, S.M, Oubridge, C, Newman, A.J, Nagai, K. | | Deposit date: | 2016-07-17 | | Release date: | 2016-08-31 | | Last modified: | 2019-12-11 | | Method: | ELECTRON MICROSCOPY (3.8 Å) | | Cite: | Cryo-EM structure of the spliceosome immediately after branching.
Nature, 537, 2016
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5MWF
 | | Human Jagged2 C2-EGF2 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, CHLORIDE ION, ... | | Authors: | Suckling, R.J, Handford, P.A, Lea, S.M. | | Deposit date: | 2017-01-18 | | Release date: | 2017-06-14 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Structural and functional dissection of the interplay between lipid and Notch binding by human Notch ligands.
EMBO J., 36, 2017
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5MQ0
 | | Structure of a spliceosome remodeled for exon ligation | | Descriptor: | 3'-EXON OF UBC4 PRE-MRNA, BOUND BY PRP22 HELICASE, 5'-EXON OF UBC4 PRE-MRNA, ... | | Authors: | Fica, S.M, Oubridge, C, Galej, W.P, Wilkinson, M.E, Newman, A.J, Bai, X.-C, Nagai, K. | | Deposit date: | 2016-12-19 | | Release date: | 2017-01-18 | | Last modified: | 2020-10-07 | | Method: | ELECTRON MICROSCOPY (4.17 Å) | | Cite: | Structure of a spliceosome remodelled for exon ligation.
Nature, 542, 2017
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5MW5
 | | Human Jagged2 C2-EGF2 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Protein jagged-2 | | Authors: | Suckling, R.J, Handford, P.A, Lea, S.M. | | Deposit date: | 2017-01-18 | | Release date: | 2017-06-14 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Structural and functional dissection of the interplay between lipid and Notch binding by human Notch ligands.
EMBO J., 36, 2017
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5NJG
 | | Structure of an ABC transporter: part of the structure that could be built de novo | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 5D3-Fab heavy chain, 5D3-Fab light chain, ... | | Authors: | Taylor, N.M.I, Manolaridis, I, Jackson, S.M, Kowal, J, Stahlberg, H, Locher, K.P. | | Deposit date: | 2017-03-28 | | Release date: | 2017-06-07 | | Last modified: | 2020-07-29 | | Method: | ELECTRON MICROSCOPY (3.78 Å) | | Cite: | Structure of the human multidrug transporter ABCG2.
Nature, 546, 2017
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5JTU
 | | Crystal structure of GPb in complex with 8b | | Descriptor: | (1S)-1,5-anhydro-1-[5-(naphthalen-2-yl)-1H-imidazol-2-yl]-D-glucitol, DIMETHYL SULFOXIDE, Glycogen phosphorylase, ... | | Authors: | Kantsadi, A.L, Stravodimos, G.A, Chatzileontiadou, D.S.M, Leonidas, D.D. | | Deposit date: | 2016-05-09 | | Release date: | 2016-08-24 | | Last modified: | 2018-01-17 | | Method: | X-RAY DIFFRACTION (1.85 Å) | | Cite: | Synthetic, enzyme kinetic, and protein crystallographic studies of C-beta-d-glucopyranosyl pyrroles and imidazoles reveal and explain low nanomolar inhibition of human liver glycogen phosphorylase.
Eur.J.Med.Chem., 123, 2016
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5TUV
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5JTT
 | | Crystal structure of GPb in complex with 8a | | Descriptor: | (1S)-1,5-anhydro-1-(5-phenyl-1H-imidazol-2-yl)-D-glucitol, DIMETHYL SULFOXIDE, Glycogen phosphorylase, ... | | Authors: | Kantsadi, A.L, Stravodimos, G.A, Chatzileontiadou, D.S.M, Leonidas, D.D. | | Deposit date: | 2016-05-09 | | Release date: | 2016-08-24 | | Last modified: | 2018-01-17 | | Method: | X-RAY DIFFRACTION (1.85 Å) | | Cite: | Synthetic, enzyme kinetic, and protein crystallographic studies of C-beta-d-glucopyranosyl pyrroles and imidazoles reveal and explain low nanomolar inhibition of human liver glycogen phosphorylase.
Eur.J.Med.Chem., 123, 2016
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5TUU
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