4CYO
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4cyo by Molmil](/molmil-images/mine/4cyo) | Leishmania major N-myristoyltransferase in complex with a hybrid inhibitor (compound 21). | Descriptor: | GLYCYLPEPTIDE N-TETRADECANOYLTRANSFERASE, MAGNESIUM ION, N-{5-[(3S,4R)-1-[(3R)-3-amino-4-(4-chlorophenyl)butanoyl]-4-(hydroxymethyl)pyrrolidin-3-yl]-2-chlorophenyl}-2-(4-fluorophenyl)acetamide, ... | Authors: | Hutton, J.A, Goncalves, V, Brannigan, J.A, Paape, D, Waugh, T, Roberts, S.M, Bell, A.S, Wilkinson, A.J, Smith, D.F, Leatherbarrow, R.J, Tate, E.W. | Deposit date: | 2014-04-14 | Release date: | 2014-10-01 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Structure-Based Design of Potent and Selective Leishmania N- Myristoyltransferase Inhibitors. J.Med.Chem., 57, 2014
|
|
4CGP
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4cgp by Molmil](/molmil-images/mine/4cgp) | Leishmania major N-myristoyltransferase in complex with cofactor | Descriptor: | GLYCYLPEPTIDE N-TETRADECANOYLTRANSFERASE, MAGNESIUM ION, TETRADECANOYL-COA | Authors: | Brannigan, J.A, Roberts, S.M, Bell, A.S, Hutton, J.A, Smith, D.F, Tate, E.W, Leatherbarrow, R.J, Wilkinson, A.J. | Deposit date: | 2013-11-25 | Release date: | 2014-07-09 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | Diverse Modes of Binding in Structures of Leishmania Major N-Myristoyltransferase with Selective Inhibitors Iucrj, 1, 2014
|
|
4CGM
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4cgm by Molmil](/molmil-images/mine/4cgm) | Leishmania major N-myristoyltransferase in complex with a biphenyl- derivative inhibitor | Descriptor: | GLYCYLPEPTIDE N-TETRADECANOYLTRANSFERASE, MAGNESIUM ION, N-[[3-[3-(6,7-dihydro-4H-[1,3]thiazolo[5,4-c]pyridin-5-ylmethyl)phenyl]phenyl]methyl]-2-pyridin-3-yl-ethanamine, ... | Authors: | Brannigan, J.A, Roberts, S.M, Bell, A.S, Hutton, J.A, Smith, D.F, Tate, E.W, Leatherbarrow, R.J, Wilkinson, A.J. | Deposit date: | 2013-11-25 | Release date: | 2014-07-09 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Diverse Modes of Binding in Structures of Leishmania Major N-Myristoyltransferase with Selective Inhibitors Iucrj, 1, 2014
|
|
4CYP
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4cyp by Molmil](/molmil-images/mine/4cyp) | Leishmania major N-myristoyltransferase in complex with a pyrrolidine inhibitor. | Descriptor: | (3R)-4-(4-chlorophenyl)-1-[(3S,4R)-3-(4-chlorophenyl)-4-(hydroxymethyl)pyrrolidin-1-yl]-3-hydroxybutan-1-one, GLYCYLPEPTIDE N-TETRADECANOYLTRANSFERASE, MAGNESIUM ION, ... | Authors: | Hutton, J.A, Goncalves, V, Brannigan, J.A, Paape, D, Waugh, T, Roberts, S.M, Bell, A.S, Wilkinson, A.J, Smith, D.F, Leatherbarrow, R.J, Tate, E.W. | Deposit date: | 2014-04-14 | Release date: | 2014-10-22 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.55 Å) | Cite: | Structure-Based Design of Potent and Selective Leishmania N- Myristoyltransferase Inhibitors. J.Med.Chem., 57, 2014
|
|
4BY2
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4by2 by Molmil](/molmil-images/mine/4by2) | SAS-4 (dCPAP) TCP domain in complex with a Proline Rich Motif of Ana2 (dSTIL) of Drosophila Melanogaster | Descriptor: | 1,2-ETHANEDIOL, ANASTRAL SPINDLE 2, SAS 4 | Authors: | Cottee, M.A, Muschalik, N, Wong, Y.L, Johnson, C.M, Johnson, S, Andreeva, A, Oegema, K, Lea, S.M, Raff, J.W, van Breugel, M. | Deposit date: | 2013-07-17 | Release date: | 2013-09-18 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.57 Å) | Cite: | Crystal structures of the CPAP/STIL complex reveal its role in centriole assembly and human microcephaly. Elife, 2, 2013
|
|
4C7I
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4c7i by Molmil](/molmil-images/mine/4c7i) | Leismania major N-myristoyltransferase in complex with a peptidomimetic (-OH) molecule | Descriptor: | DIMETHYL SULFOXIDE, GLYCYLPEPTIDE N-TETRADECANOYLTRANSFERASE, MAGNESIUM ION, ... | Authors: | Olaleye, T.O, Brannigan, J.A, Goncalves, V, Roberts, S.M, Leatherbarrow, R.J, Wilkinson, A.J, Tate, E.W. | Deposit date: | 2013-09-20 | Release date: | 2014-09-24 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.3 Å) | Cite: | Peptidomimetic Inhibitors of N-Myristoyltransferase from Human Malaria and Leishmaniasis Parasites. Org.Biomol.Chem., 12, 2014
|
|
4CBZ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4cbz by Molmil](/molmil-images/mine/4cbz) | Notch ligand, Jagged-1, contains an N-terminal C2 domain | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, PROTEIN JAGGED-1, alpha-L-fucopyranose | Authors: | Chilakuri, C.R, Sheppard, D, Ilagan, M.X.G, Holt, L.R, Abbott, F, Liang, S, Kopan, R, Handford, P.A, Lea, S.M. | Deposit date: | 2013-10-17 | Release date: | 2013-11-27 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structural Analysis Uncovers Lipid-Binding Properties of Notch Ligands Cell Rep., 5, 2013
|
|
4CC1
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4cc1 by Molmil](/molmil-images/mine/4cc1) | Notch ligand, Jagged-1, contains an N-terminal C2 domain | Descriptor: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | Authors: | Chilakuri, C.R, Sheppard, D, Ilagan, M.X.G, Holt, L.R, Abbott, F, Liang, S, Kopan, R, Handford, P.A, Lea, S.M. | Deposit date: | 2013-10-17 | Release date: | 2013-11-27 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.84 Å) | Cite: | Structural Analysis Uncovers Lipid-Binding Properties of Notch Ligands Cell Rep., 5, 2013
|
|
2B0Y
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2b0y by Molmil](/molmil-images/mine/2b0y) | Solution Structure of a peptide mimetic of the fourth cytoplasmic loop of the G-protein coupled CB1 cannabinoid receptor | Descriptor: | Cannabinoid receptor 1 | Authors: | Grace, C.R, Cowsik, S.M, Shim, J.Y, Welsh, W.J, Howlett, A.C. | Deposit date: | 2005-09-15 | Release date: | 2006-08-29 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Unique helical conformation of the fourth cytoplasmic loop of the CB1 cannabinoid receptor in a negatively charged environment. J.Struct.Biol., 159, 2007
|
|
2AXD
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2axd by Molmil](/molmil-images/mine/2axd) | solution structure of the theta subunit of escherichia coli DNA polymerase III in complex with the epsilon subunit | Descriptor: | DNA polymerase III, theta subunit | Authors: | Keniry, M.A, Park, A.Y, Owen, E.A, Hamdan, S.M, Pintacuda, G, Otting, G, Dixon, N.E. | Deposit date: | 2005-09-05 | Release date: | 2006-07-04 | Last modified: | 2024-05-29 | Method: | SOLUTION NMR | Cite: | Structure of the theta subunit of Escherichia coli DNA polymerase III in complex with the epsilon subunit J.Bacteriol., 188, 2006
|
|
3ZCO
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3zco by Molmil](/molmil-images/mine/3zco) | Crystal structure of S. cerevisiae Sir3 C-terminal domain | Descriptor: | REGULATORY PROTEIN SIR3 | Authors: | Oppikofer, M, Kueng, S, Keusch, J.J, Hassler, M, Ladurner, A.G, Gut, H, Gasser, S.M. | Deposit date: | 2012-11-21 | Release date: | 2013-04-03 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Dimerization of Sir3 Via its C-Terminal Winged Helix Domain is Essential for Yeast Heterochromatin Formation. Embo J., 32, 2013
|
|
4AE3
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4ae3 by Molmil](/molmil-images/mine/4ae3) | Crystal structure of ammosamide 272:myosin-2 motor domain complex | Descriptor: | 1,2-ETHANEDIOL, ADP ORTHOVANADATE, AMMOSAMIDE 272, ... | Authors: | Chinthalapudi, K, Heissler, S.M, Fenical, W, Manstein, D.J. | Deposit date: | 2012-01-05 | Release date: | 2013-01-16 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structural Basis for Ammosamide Mediated Myosin Motor Activity Inhibition To be Published
|
|
4D2I
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4d2i by Molmil](/molmil-images/mine/4d2i) | Crystal structure of the HerA hexameric DNA translocase from Sulfolobus solfataricus bound to AMP-PNP | Descriptor: | HERA, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | Authors: | Rzechorzek, N.J, Blackwood, J.K, Bray, S.M, Maman, J.D, Pellegrini, L, Robinson, N.P. | Deposit date: | 2014-05-09 | Release date: | 2014-12-03 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.841 Å) | Cite: | Structure of the Hexameric Hera ATPase Reveals a Mechanism of Translocation-Coupled DNA-End Processing in Archaea Nat.Commun., 5, 2014
|
|
4CGO
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4cgo by Molmil](/molmil-images/mine/4cgo) | Leishmania major N-myristoyltransferase in complex with a thienopyrimidine inhibitor | Descriptor: | 3-[methyl-[2-[methyl-(1-methylpiperidin-4-yl)amino]thieno[3,2-d]pyrimidin-4-yl]amino]propanenitrile, GLYCYLPEPTIDE N-TETRADECANOYLTRANSFERASE, MAGNESIUM ION, ... | Authors: | Brannigan, J.A, Roberts, S.M, Bell, A.S, Hutton, J.A, Smith, D.F, Tate, E.W, Leatherbarrow, R.J, Wilkinson, A.J. | Deposit date: | 2013-11-25 | Release date: | 2014-07-09 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.3 Å) | Cite: | Diverse Modes of Binding in Structures of Leishmania Major N-Myristoyltransferase with Selective Inhibitors Iucrj, 1, 2014
|
|
1YVW
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1yvw by Molmil](/molmil-images/mine/1yvw) | Crystal structure of Phosphoribosyl-ATP pyrophosphohydrolase from Bacillus cereus. NESGC target BcR13. | Descriptor: | Phosphoribosyl-ATP pyrophosphatase | Authors: | Benach, J, Kuzin, A.P, Forouhar, F, Abashidze, M, Vorobiev, S.M, Shastry, R, Rong, X, Acton, T.B, Montelione, G.T, Hunt, J.F, Northeast Structural Genomics Consortium (NESG) | Deposit date: | 2005-02-16 | Release date: | 2005-03-01 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Crystal structure of Phosphoribosyl-ATP pyrophosphohydrolase from Bacillus cereus at 2.6 A resolution. To be Published
|
|
1YXB
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1yxb by Molmil](/molmil-images/mine/1yxb) | Crystal structure of Phosphoribosyl-ATP pyrophosphatase from Streptomyces coelicolor. NESG target RR8. | Descriptor: | Phosphoribosyl-ATP pyrophosphatase | Authors: | Benach, J, Kuzin, A.P, Forouhar, F, Abashidze, M, Vorobiev, S.M, Rong, X, Acton, T.B, Montelione, G.T, Hunt, J.F, Northeast Structural Genomics Consortium (NESG) | Deposit date: | 2005-02-20 | Release date: | 2005-03-01 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Crystal structure of Phosphoribosyl-ATP pyrophosphatase from Streptomyces coelicolor. NESG target RR8. To be Published
|
|
4CC0
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4cc0 by Molmil](/molmil-images/mine/4cc0) | Notch ligand, Jagged-1, contains an N-terminal C2 domain | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, PROTEIN JAGGED-1, ... | Authors: | Chilakuri, C.R, Sheppard, D, Ilagan, M.X.G, Holt, L.R, Abbott, F, Liang, S, Kopan, R, Handford, P.A, Lea, S.M. | Deposit date: | 2013-10-17 | Release date: | 2013-11-27 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.32 Å) | Cite: | Structural Analysis Uncovers Lipid-Binding Properties of Notch Ligands Cell Rep., 5, 2013
|
|
1ZK7
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1zk7 by Molmil](/molmil-images/mine/1zk7) | Crystal Structure of Tn501 MerA | Descriptor: | FLAVIN-ADENINE DINUCLEOTIDE, GLYCEROL, Mercuric reductase, ... | Authors: | Dong, A, Ledwidge, R, Patel, B, Fiedler, D, Falkowski, M, Zelikova, J, Summers, A.O, Pai, E.F, Miller, S.M. | Deposit date: | 2005-05-02 | Release date: | 2005-07-05 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | NmerA, the Metal Binding Domain of Mercuric Ion Reductase, Removes Hg(2+) from Proteins, Delivers It to the Catalytic Core, and Protects Cells under Glutathione-Depleted Conditions Biochemistry, 44, 2005
|
|
4BQU
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4bqu by Molmil](/molmil-images/mine/4bqu) | Japanin from Rhipicephalus appendiculatus bound to cholesterol: Orthorhombic crystal form | Descriptor: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, ... | Authors: | Roversi, P, Johnson, S, Preston, S, Austyn, J.M, Nuttall, P, Lea, S.M. | Deposit date: | 2013-06-02 | Release date: | 2014-06-18 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.36 Å) | Cite: | Structural basis of cholesterol binding by a novel clade of dendritic cell modulators from ticks. Sci Rep, 7, 2017
|
|
2AJ2
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2aj2 by Molmil](/molmil-images/mine/2aj2) | X-Ray Crystal Structure of Protein VC0467 from Vibrio cholerae. Northeast Structural Genomics Consortium Target VcR8. | Descriptor: | Hypothetical UPF0301 protein VC0467 | Authors: | Kuzin, A.P, Abashidze, M, Vorobiev, S.M, Acton, T, Xiao, R, Conover, K, Ma, L.-C, Kellie, R, Montelione, G.T, Hunt, J.F, Tong, L, Northeast Structural Genomics Consortium (NESG) | Deposit date: | 2005-08-01 | Release date: | 2005-09-20 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (3.21 Å) | Cite: | X-Ray structure of hypothetical protein VC0467 from Vibrio cholerae: new fold. Northeast Structural Genomics Consortium target VcR8. To be Published
|
|
4DXD
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4dxd by Molmil](/molmil-images/mine/4dxd) | Staphylococcal Aureus FtsZ in complex with 723 | Descriptor: | 3-[(6-chloro[1,3]thiazolo[5,4-b]pyridin-2-yl)methoxy]-2,6-difluorobenzamide, Cell division protein FtsZ, GUANOSINE-5'-DIPHOSPHATE | Authors: | Lu, J, Soisson, S.M. | Deposit date: | 2012-02-27 | Release date: | 2012-05-23 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.01 Å) | Cite: | Restoring methicillin-resistant Staphylococcus aureus susceptibility to beta-lactam antibiotics. Sci Transl Med, 4, 2012
|
|
4E3F
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4e3f by Molmil](/molmil-images/mine/4e3f) | |
1ZBS
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1zbs by Molmil](/molmil-images/mine/1zbs) | Crystal Structure of the Putative N-acetylglucosamine Kinase (PG1100) from Porphyromonas gingivalis, Northeast Structural Genomics Target PgR18 | Descriptor: | hypothetical protein PG1100 | Authors: | Forouhar, F, Abashidze, M, Kuzin, A, Vorobiev, S.M, Conover, K, Acton, T.B, Montelione, G.T, Tong, L, Hunt, J.F, Northeast Structural Genomics Consortium (NESG) | Deposit date: | 2005-04-08 | Release date: | 2005-11-15 | Last modified: | 2017-10-11 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Crystal Structure of the Putative N-acetylglucosamine Kinase (PG1100) from Porphyromonas gingivalis, Northeast Structural Genomics Target PgR18 To be Published
|
|
1ZEE
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1zee by Molmil](/molmil-images/mine/1zee) | X-Ray Crystal Structure of Protein SO4414 from Shewanella oneidensis. Northeast Structural Genomics Consortium Target SoR52. | Descriptor: | hypothetical protein SO4414 | Authors: | Forouhar, F, Abashidze, M, Vorobiev, S.M, Conover, K, Acton, T.B, Montelione, G.T, Hunt, J.F, Tong, L, Northeast Structural Genomics Consortium (NESG) | Deposit date: | 2005-04-18 | Release date: | 2005-05-03 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.31 Å) | Cite: | Crystal Structure of the Hypothetical Protein SO4414 from Shewanella oneidensis, NESG Target SoR52 To be Published
|
|
1YVN
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1yvn by Molmil](/molmil-images/mine/1yvn) | THE YEAST ACTIN VAL 159 ASN MUTANT COMPLEX WITH HUMAN GELSOLIN SEGMENT 1. | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, CALCIUM ION, MAGNESIUM ION, ... | Authors: | Vorobiev, S.M, Belmont, L.D, Drubin, D.G, Almo, S.C. | Deposit date: | 1999-03-23 | Release date: | 2000-03-23 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Crystal structure of yeast actin V159N mutant To be Published
|
|