3J1Q
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![BU of 3j1q by Molmil](/molmil-images/mine/3j1q) | Structure of AAV-DJ, a Retargeted Gene Therapy Vector: Cryo-Electron Microscopy at 4.5A resolution | 分子名称: | Adeno-associated virus DJ | 著者 | Lerch, T.F, O'Donnell, J.K, Meyer, N.L, Xie, Q, Taylor, K.A, Stagg, S.M, Chapman, M.S. | 登録日 | 2012-04-30 | 公開日 | 2012-08-22 | 最終更新日 | 2024-02-21 | 実験手法 | ELECTRON MICROSCOPY (4.5 Å) | 主引用文献 | Structure of AAV-DJ, a retargeted gene therapy vector: cryo-electron microscopy at 4.5 A resolution. Structure, 20, 2012
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2F53
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![BU of 2f53 by Molmil](/molmil-images/mine/2f53) | Directed Evolution of Human T-cell Receptor CDR2 residues by phage display dramatically enhances affinity for cognate peptide-MHC without apparent cross-reactivity | 分子名称: | Beta-2-microglobulin, Cancer/testis antigen 1B, GLYCEROL, ... | 著者 | Rizkallah, P.J, Jakobsen, B.K, Dunn, S.M, Sami, M. | 登録日 | 2005-11-25 | 公開日 | 2006-04-25 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Directed evolution of human T cell receptor CDR2 residues by phage display dramatically enhances affinity for cognate peptide-MHC without increasing apparent cross-reactivity. Protein Sci., 15, 2006
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5JNW
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![BU of 5jnw by Molmil](/molmil-images/mine/5jnw) | Crystal structure of bovine low molecular weight protein tyrosine phosphatase (LMPTP) mutant (W49Y N50E) complexed with vanadate and uncompetitive inhibitor | 分子名称: | 2-(4-{[3-(piperidin-1-yl)propyl]amino}quinolin-2-yl)benzonitrile, Low molecular weight phosphotyrosine protein phosphatase, VANADATE ION | 著者 | Stanford, S.M, Aleshin, A.E, Liddington, R.C, Bankston, L, Cadwell, G, Bottini, N. | 登録日 | 2016-04-30 | 公開日 | 2017-03-29 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.86 Å) | 主引用文献 | Diabetes reversal by inhibition of the low-molecular-weight tyrosine phosphatase. Nat. Chem. Biol., 13, 2017
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3K1S
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![BU of 3k1s by Molmil](/molmil-images/mine/3k1s) | Crystal Structure of the PTS Cellobiose Specific Enzyme IIA from Bacillus anthracis | 分子名称: | CHLORIDE ION, MAGNESIUM ION, PTS system, ... | 著者 | Anderson, S.M, Wawrzak, Z, Onopriyenko, O, Kwon, K, Anderson, W.F, Savchenko, A, Center for Structural Genomics of Infectious Diseases (CSGID) | 登録日 | 2009-09-28 | 公開日 | 2009-10-13 | 最終更新日 | 2017-11-01 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Crystal Structure of the PTS Cellobiose Specific Enzyme IIA from Bacillus anthracis To be Published
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5JGY
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![BU of 5jgy by Molmil](/molmil-images/mine/5jgy) | Crystal structure of maize AKR4C13 in P21 space group | 分子名称: | 1,2-ETHANEDIOL, 4-{[(2R,3R,4S,5R)-5-({[(R)-{[(R)-{[(2R,3R,4R,5R)-5-(6-amino-9H-purin-9-yl)-3-hydroxy-4-(phosphonooxy)tetrahydrofuran-2-yl]methoxy}(hydroxy)phosphoryl]oxy}(hydroxy)phosphoryl]oxy}methyl)-3,4-dihydroxytetrahydrofuran-2-yl]oxy}butanoic acid (non-preferred name), Aldose reductase, ... | 著者 | Santos, M.L, Giuseppe, P.O, Kiyota, E, Sousa, S.M, Schmelz, E.A, Yunes, J.A, Koch, K.E, Murakami, M.T, Aparicio, R. | 登録日 | 2016-04-20 | 公開日 | 2017-05-03 | 実験手法 | X-RAY DIFFRACTION (1.45 Å) | 主引用文献 | Crystal structure of maize AKR4C13 in P21 space group To Be Published
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5J62
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![BU of 5j62 by Molmil](/molmil-images/mine/5j62) | FMN-dependent Nitroreductase (CDR20291_0684) from Clostridium difficile R20291 | 分子名称: | FLAVIN MONONUCLEOTIDE, GLYCEROL, PHOSPHATE ION, ... | 著者 | Wang, B, Powell, S.M, Hessami, N, Najar, F.Z, Thomas, L.M, West, A.H, Karr, E.A, Richter-Addo, G.B. | 登録日 | 2016-04-04 | 公開日 | 2016-09-21 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | 主引用文献 | Crystal structures of two nitroreductases from hypervirulent Clostridium difficile and functionally related interactions with the antibiotic metronidazole. Nitric Oxide, 60, 2016
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4XNN
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![BU of 4xnn by Molmil](/molmil-images/mine/4xnn) | Crystal Structure of a GH7 Family Cellobiohydrolase from Daphnia pulex | 分子名称: | Cellobiohydrolase CHBI, GLYCEROL | 著者 | Ebrahim, A, Hobdey, S.E, Podkaminer, K, Taylor II, L.E, Beckham, G.T, Decker, S.R, Himmel, M.E, Cragg, S.M, McGeehan, J.E. | 登録日 | 2015-01-15 | 公開日 | 2016-01-27 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Characterization of a GH7 Family Cellobiohydrolase from Daphnia pulex To Be Published
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5JNU
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![BU of 5jnu by Molmil](/molmil-images/mine/5jnu) | Crystal structure of mouse Low-Molecular Weight Protein Tyrosine Phosphatase type A (LMPTP-A) complexed with phosphate | 分子名称: | Low molecular weight phosphotyrosine protein phosphatase, PHOSPHATE ION | 著者 | Stanford, S.M, Aleshin, A.E, Liddington, R.C, Bankston, L, Cadwell, G, Bottini, N. | 登録日 | 2016-04-30 | 公開日 | 2017-03-29 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.535 Å) | 主引用文献 | Diabetes reversal by inhibition of the low-molecular-weight tyrosine phosphatase. Nat. Chem. Biol., 13, 2017
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4NMM
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![BU of 4nmm by Molmil](/molmil-images/mine/4nmm) | Crystal Structure of a G12C Oncogenic Variant of Human KRas Bound to a Novel GDP Competitive Covalent Inhibitor | 分子名称: | 5'-O-[(S)-{[(S)-[2-(acetylamino)ethoxy](hydroxy)phosphoryl]oxy}(hydroxy)phosphoryl]guanosine, GTPase KRas, MAGNESIUM ION | 著者 | Hunter, J.C, Gurbani, D, Lim, S.M, Westover, K.D. | 登録日 | 2013-11-15 | 公開日 | 2014-06-04 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.89 Å) | 主引用文献 | In situ selectivity profiling and crystal structure of SML-8-73-1, an active site inhibitor of oncogenic K-Ras G12C. Proc.Natl.Acad.Sci.USA, 111, 2014
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5JNS
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![BU of 5jns by Molmil](/molmil-images/mine/5jns) | Crystal structure of human low molecular weight protein tyrosine phosphatase (LMPTP) type A complexed with phosphate | 分子名称: | DIMETHYL SULFOXIDE, Low molecular weight phosphotyrosine protein phosphatase, PHOSPHATE ION | 著者 | Stanford, S.M, Aleshin, A.E, Liddington, R.C, Bankston, L, Cadwell, G, Bottini, N. | 登録日 | 2016-04-30 | 公開日 | 2017-03-29 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Diabetes reversal by inhibition of the low-molecular-weight tyrosine phosphatase. Nat. Chem. Biol., 13, 2017
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1YAI
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![BU of 1yai by Molmil](/molmil-images/mine/1yai) | X-RAY STRUCTURE OF A BACTERIAL COPPER,ZINC SUPEROXIDE DISMUTASE | 分子名称: | COPPER (II) ION, COPPER, ZINC SUPEROXIDE DISMUTASE, ... | 著者 | Bourne, Y, Redford, S.M, Lo, T.P, Tainer, J.A, Getzoff, E.D. | 登録日 | 1996-02-03 | 公開日 | 1997-08-20 | 最終更新日 | 2023-08-09 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Novel dimeric interface and electrostatic recognition in bacterial Cu,Zn superoxide dismutase. Proc.Natl.Acad.Sci.USA, 93, 1996
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4B4A
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![BU of 4b4a by Molmil](/molmil-images/mine/4b4a) | Structure of the TatC core of the twin arginine protein translocation system | 分子名称: | Lauryl Maltose Neopentyl Glycol, SEC-INDEPENDENT PROTEIN TRANSLOCASE PROTEIN TATC | 著者 | Rollauer, S.E, Tarry, M.J, Jaaskelainen, M, Graham, J.E, Jaeger, F, Krehenbrink, M, Roversi, P, McDowell, M.A, Stansfeld, P.J, Johnson, S, Liu, S.M, Lukey, M.J, Marcoux, J, Robinson, C.V, Sansom, M.S, Palmer, T, Hogbom, M, Berks, B.C, Lea, S.M. | 登録日 | 2012-07-30 | 公開日 | 2012-12-05 | 最終更新日 | 2012-12-19 | 実験手法 | X-RAY DIFFRACTION (3.5 Å) | 主引用文献 | Structure of the Tatc Core of the Twin-Arginine Protein Transport System. Nature, 49, 2012
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2G8S
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![BU of 2g8s by Molmil](/molmil-images/mine/2g8s) | Crystal structure of the soluble Aldose sugar dehydrogenase (Asd) from Escherichia coli in the apo-form | 分子名称: | 1,2-ETHANEDIOL, CALCIUM ION, Glucose/sorbosone dehydrogenases, ... | 著者 | Southall, S.M, Doel, J.J, Richardson, D.J, Oubrie, A. | 登録日 | 2006-03-03 | 公開日 | 2006-08-08 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Soluble Aldose Sugar Dehydrogenase from Escherichia coli: A HIGHLY EXPOSED ACTIVE SITE CONFERRING BROAD SUBSTRATE SPECIFICITY. J.Biol.Chem., 281, 2006
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4NTJ
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![BU of 4ntj by Molmil](/molmil-images/mine/4ntj) | Structure of the human P2Y12 receptor in complex with an antithrombotic drug | 分子名称: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, CHOLESTEROL, P2Y purinoceptor 12,Soluble cytochrome b562,P2Y purinoceptor 12, ... | 著者 | Zhang, K, Zhang, J, Gao, Z.-G, Zhang, D, Zhu, L, Han, G.W, Moss, S.M, Paoletta, S, Kiselev, E, Lu, W, Fenalti, G, Zhang, W, Muller, C.E, Yang, H, Jiang, H, Cherezov, V, Katritch, V, Jacobson, K.A, Stevens, R.C, Wu, B, Zhao, Q, GPCR Network (GPCR) | 登録日 | 2013-12-02 | 公開日 | 2014-03-26 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.62 Å) | 主引用文献 | Structure of the human P2Y12 receptor in complex with an antithrombotic drug Nature, 509, 2014
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4O24
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![BU of 4o24 by Molmil](/molmil-images/mine/4o24) | DNA Double-Strand Break Repair Pathway Choice Is Directed by Distinct MRE11 Nuclease Activities | 分子名称: | (5~{Z})-5-[(4-hydroxyphenyl)methylidene]-3-(2-methylpropyl)-2-sulfanylidene-1,3-thiazolidin-4-one, Exonuclease, putative, ... | 著者 | Shibata, A, Moiani, D, Arvai, A.S, Perry, J, Harding, S.M, Genois, M, Maity, R, Rossum-Fikkert, S, Kertokalio, A, Romoli, F, Ismail, A, Ismalaj, E, Petricci, E, Neale, M.J, Bristow, R.G, Masson, J, Wyman, C, Jeggo, P.A, Tainer, J.A. | 登録日 | 2013-12-16 | 公開日 | 2014-01-15 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | DNA Double-Strand Break Repair Pathway Choice Is Directed by Distinct MRE11 Nuclease Activities. Mol.Cell, 53, 2014
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5J6C
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![BU of 5j6c by Molmil](/molmil-images/mine/5j6c) | FMN-dependent Nitroreductase (CDR20291_0767) from Clostridium difficile R20291 | 分子名称: | FLAVIN MONONUCLEOTIDE, IMIDAZOLE, Putative reductase | 著者 | Powell, S.M, Wang, B, Hessami, N, Najar, F.Z, Thomas, L.M, West, A.H, Karr, E.A, Richter-Addo, G.B. | 登録日 | 2016-04-04 | 公開日 | 2016-09-21 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.096 Å) | 主引用文献 | Crystal structures of two nitroreductases from hypervirulent Clostridium difficile and functionally related interactions with the antibiotic metronidazole. Nitric Oxide, 60, 2016
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4XDN
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![BU of 4xdn by Molmil](/molmil-images/mine/4xdn) | |
4XPI
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![BU of 4xpi by Molmil](/molmil-images/mine/4xpi) | Fe protein independent substrate reduction by nitrogenase variants altered in intramolecular electron transfer | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 3-HYDROXY-3-CARBOXY-ADIPIC ACID, CALCIUM ION, ... | 著者 | Danyal, K, Rasmusen, A.J, Keable, S.M, Shaw, S, Zadvornyy, O, Duval, S, Dean, D.R, Raugei, S, Peters, J.W, Seefeldt, L.C. | 登録日 | 2015-01-17 | 公開日 | 2015-10-14 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.97 Å) | 主引用文献 | Fe protein-independent substrate reduction by nitrogenase MoFe protein variants. Biochemistry, 54, 2015
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4XHP
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3JBA
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![BU of 3jba by Molmil](/molmil-images/mine/3jba) | The U4 antibody epitope on human papillomavirus 16 identified by cryo-EM | 分子名称: | H16.U4 antibody heavy chain, H16.U4 antibody light chain, Major capsid protein L1 | 著者 | Guan, J, Bywaters, S.M, Brendle, S.A, Lee, H, Ashley, R.E, Christensen, N.D, Hafenstein, S. | 登録日 | 2015-08-11 | 公開日 | 2015-10-07 | 最終更新日 | 2018-07-18 | 実験手法 | ELECTRON MICROSCOPY (12 Å) | 主引用文献 | The U4 Antibody Epitope on Human Papillomavirus 16 Identified by Cryo-electron Microscopy. J.Virol., 89, 2015
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4V48
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![BU of 4v48 by Molmil](/molmil-images/mine/4v48) | Real space refined coordinates of the 30S and 50S subunits fitted into the low resolution cryo-EM map of the initiation-like state of E. coli 70S ribosome | 分子名称: | 16S RIBOSOMAL RNA, 23S ribosomal RNA, 30S RIBOSOMAL PROTEIN S10, ... | 著者 | Gao, H, Sengupta, J, Valle, M, Korostelev, A, Eswar, N, Stagg, S.M, Van Roey, P, Agrawal, R.K, Harvey, S.T, Sali, A, Chapman, M.S, Frank, J. | 登録日 | 2003-05-06 | 公開日 | 2014-07-09 | 最終更新日 | 2024-02-28 | 実験手法 | ELECTRON MICROSCOPY (11.5 Å) | 主引用文献 | Study of the structural dynamics of the E. coli 70S ribosome using real space refinement Cell(Cambridge,Mass.), 113, 2003
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4O4K
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![BU of 4o4k by Molmil](/molmil-images/mine/4o4k) | DNA Double-Strand Break Repair Pathway Choice Is Directed by Distinct MRE11 Nuclease Activities | 分子名称: | (5~{E})-2-azanylidene-5-[(4-hydroxyphenyl)methylidene]-1,3-thiazolidin-4-one, Exonuclease, putative, ... | 著者 | Shibata, A, Moiani, D, Arvai, A.S, Perry, J, Harding, S.M, Genois, M, Maity, R, Rossum-Fikkert, S, Kertokalio, A, Romoli, F, Ismail, A, Ismalaj, E, Petricci, E, Neale, M.J, Bristow, R.G, Masson, J, Wyman, C, Jeggo, P.A, Tainer, J.A. | 登録日 | 2013-12-18 | 公開日 | 2014-01-08 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | DNA Double-Strand Break Repair Pathway Choice Is Directed by Distinct MRE11 Nuclease Activities. Mol.Cell, 53, 2014
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8SYL
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![BU of 8syl by Molmil](/molmil-images/mine/8syl) | Cryo-EM structure of the Escherichia coli 70S ribosome in complex with amikacin, mRNA, and A-, P-, and E-site tRNAs | 分子名称: | (2S)-N-[(1R,2S,3S,4R,5S)-4-[(2R,3R,4S,5S,6R)-6-(aminomethyl)-3,4,5-tris(oxidanyl)oxan-2-yl]oxy-5-azanyl-2-[(2S,3R,4S,5S ,6R)-4-azanyl-6-(hydroxymethyl)-3,5-bis(oxidanyl)oxan-2-yl]oxy-3-oxidanyl-cyclohexyl]-4-azanyl-2-oxidanyl-butanamide, 16S Ribosomal RNA, 23S Ribosomal RNA, ... | 著者 | Seely, S.M, Gagnon, M.G. | 登録日 | 2023-05-25 | 公開日 | 2023-08-09 | 最終更新日 | 2023-11-15 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Molecular basis of the pleiotropic effects by the antibiotic amikacin on the ribosome. Nat Commun, 14, 2023
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4V1J
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![BU of 4v1j by Molmil](/molmil-images/mine/4v1j) | Structure of Neisseria meningitidis Major Pillin | 分子名称: | 1,2-ETHANEDIOL, CHLORIDE ION, FIMBRIAL PROTEIN | 著者 | Harding, R.J, Exley, R, Tang, C.M, Caesar, J.J.E, Lea, S.M. | 登録日 | 2014-09-29 | 公開日 | 2016-01-13 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.43 Å) | 主引用文献 | Tstructure of Neisseria Meningitidis Major Pillin To be Published
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4V81
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![BU of 4v81 by Molmil](/molmil-images/mine/4v81) | The crystal structure of yeast CCT reveals intrinsic asymmetry of eukaryotic cytosolic chaperonins | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, SULFATE ION, ... | 著者 | Dekker, C, Roe, S.M, McCormack, E.A, Beuron, F, Pearl, L.H, Willison, K.R. | 登録日 | 2010-10-17 | 公開日 | 2014-07-09 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (3.8 Å) | 主引用文献 | The crystal structure of yeast CCT reveals intrinsic asymmetry of eukaryotic cytosolic chaperonins. Embo J., 30, 2011
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