8G09
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8G0B
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![BU of 8g0b by Molmil](/molmil-images/mine/8g0b) | Cryo-EM structure of TBAJ-876-bound Mycobacterium smegmatis ATP synthase FO region | Descriptor: | (1R,2S)-1-(6-bromo-2-methoxyquinolin-3-yl)-2-(2,6-dimethoxypyridin-4-yl)-4-(dimethylamino)-1-(2,3,6-trimethoxypyridin-4-yl)butan-2-ol, ATP synthase subunit a, ATP synthase subunit b, ... | Authors: | Courbon, G.M, Rubinstein, J.L. | Deposit date: | 2023-01-31 | Release date: | 2023-02-15 | Last modified: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (2.8 Å) | Cite: | Mechanism of mycobacterial ATP synthase inhibition by squaramides and second generation diarylquinolines. Embo J., 42, 2023
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8G0C
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![BU of 8g0c by Molmil](/molmil-images/mine/8g0c) | Cryo-EM structure of TBAJ-876-bound Mycobacterium smegmatis ATP synthase rotational state 1 (backbone model) | Descriptor: | (1R,2S)-1-(6-bromo-2-methoxyquinolin-3-yl)-2-(2,6-dimethoxypyridin-4-yl)-4-(dimethylamino)-1-(2,3,6-trimethoxypyridin-4-yl)butan-2-ol, ADENOSINE-5'-TRIPHOSPHATE, ATP synthase epsilon chain, ... | Authors: | Courbon, G.M, Rubinstein, J.L. | Deposit date: | 2023-01-31 | Release date: | 2023-02-15 | Last modified: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (2.8 Å) | Cite: | Mechanism of mycobacterial ATP synthase inhibition by squaramides and second generation diarylquinolines. Embo J., 42, 2023
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8G0E
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![BU of 8g0e by Molmil](/molmil-images/mine/8g0e) | Cryo-EM structure of TBAJ-876-bound Mycobacterium smegmatis ATP synthase rotational state 3 | Descriptor: | (1R,2S)-1-(6-bromo-2-methoxyquinolin-3-yl)-2-(2,6-dimethoxypyridin-4-yl)-4-(dimethylamino)-1-(2,3,6-trimethoxypyridin-4-yl)butan-2-ol, ADENOSINE-5'-TRIPHOSPHATE, ATP synthase epsilon chain, ... | Authors: | Courbon, G.M, Rubinstein, J.L. | Deposit date: | 2023-01-31 | Release date: | 2023-02-15 | Last modified: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (2.6 Å) | Cite: | Mechanism of mycobacterial ATP synthase inhibition by squaramides and second generation diarylquinolines. Embo J., 42, 2023
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8G0A
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8G07
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8G0D
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![BU of 8g0d by Molmil](/molmil-images/mine/8g0d) | Cryo-EM structure of TBAJ-876-bound Mycobacterium smegmatis ATP synthase rotational state 2 (backbone model) | Descriptor: | (1R,2S)-1-(6-bromo-2-methoxyquinolin-3-yl)-2-(2,6-dimethoxypyridin-4-yl)-4-(dimethylamino)-1-(2,3,6-trimethoxypyridin-4-yl)butan-2-ol, ADENOSINE-5'-TRIPHOSPHATE, ATP synthase epsilon chain, ... | Authors: | Courbon, G.M, Rubinstein, J.L. | Deposit date: | 2023-01-31 | Release date: | 2023-02-15 | Last modified: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Mechanism of mycobacterial ATP synthase inhibition by squaramides and second generation diarylquinolines. Embo J., 42, 2023
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5TJ5
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![BU of 5tj5 by Molmil](/molmil-images/mine/5tj5) | Atomic model for the membrane-embedded motor of a eukaryotic V-ATPase | Descriptor: | V-type proton ATPase subunit a, V-type proton ATPase subunit c, V-type proton ATPase subunit c', ... | Authors: | Mazhab-Jafari, M.T, Rohou, A, Schmidt, C, Bueler, S.A, Benlekbir, S, Robinson, C.V, Rubinstein, J.L. | Deposit date: | 2016-10-03 | Release date: | 2016-10-26 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (3.9 Å) | Cite: | Atomic model for the membrane-embedded VO motor of a eukaryotic V-ATPase. Nature, 539, 2016
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5VCA
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![BU of 5vca by Molmil](/molmil-images/mine/5vca) | VCP like ATPase from T. acidophilum (VAT)-Substrate bound conformation | Descriptor: | VCP-like ATPase | Authors: | Ripstein, Z.A, Huang, R, Augustyniak, R, Kay, L.E, Rubinstein, J.L. | Deposit date: | 2017-03-31 | Release date: | 2017-04-26 | Last modified: | 2020-01-15 | Method: | ELECTRON MICROSCOPY (4.8 Å) | Cite: | Structure of a AAA+ unfoldase in the process of unfolding substrate. Elife, 6, 2017
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5VC7
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![BU of 5vc7 by Molmil](/molmil-images/mine/5vc7) | VCP like ATPase from T. acidophilum (VAT) - conformation 1 | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, VCP-like ATPase | Authors: | Ripstein, Z.A, Huang, R, Augustyniak, R, Kay, L.E, Rubinstein, J.L. | Deposit date: | 2017-03-31 | Release date: | 2017-04-26 | Last modified: | 2020-01-15 | Method: | ELECTRON MICROSCOPY (3.9 Å) | Cite: | Structure of a AAA+ unfoldase in the process of unfolding substrate. Elife, 6, 2017
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7RJD
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![BU of 7rjd by Molmil](/molmil-images/mine/7rjd) | Complex III2 from Candida albicans, inhibitor free, Rieske head domain in c position | Descriptor: | Cytochrome b, Cytochrome b-c1 complex subunit 2, mitochondrial, ... | Authors: | Di Trani, J.M, Rubinstein, J.L. | Deposit date: | 2021-07-20 | Release date: | 2021-09-15 | Last modified: | 2022-01-19 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Rieske head domain dynamics and indazole-derivative inhibition of Candida albicans complex III. Structure, 30, 2022
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7RJA
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7RJE
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![BU of 7rje by Molmil](/molmil-images/mine/7rje) | Complex III2 from Candida albicans, Inz-5 bound | Descriptor: | 3-[2-fluoro-5-(trifluoromethyl)phenyl]-7-methyl-1-[(2-methyl-2H-tetrazol-5-yl)methyl]-1H-indazole, Cytochrome b, Cytochrome b-c1 complex subunit 2, ... | Authors: | Di Trani, J.M, Rubinstein, J.L. | Deposit date: | 2021-07-20 | Release date: | 2021-09-15 | Last modified: | 2022-01-19 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Rieske head domain dynamics and indazole-derivative inhibition of Candida albicans complex III. Structure, 30, 2022
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7RJC
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![BU of 7rjc by Molmil](/molmil-images/mine/7rjc) | Complex III2 from Candida albicans, inhibitor free, Rieske head domain in intermediate position | Descriptor: | Cytochrome b, Cytochrome b-c1 complex subunit 2, mitochondrial, ... | Authors: | Di Trani, J.M, Rubinstein, J.L. | Deposit date: | 2021-07-20 | Release date: | 2021-09-15 | Last modified: | 2022-01-19 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Rieske head domain dynamics and indazole-derivative inhibition of Candida albicans complex III. Structure, 30, 2022
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7RJB
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![BU of 7rjb by Molmil](/molmil-images/mine/7rjb) | Complex III2 from Candida albicans, inhibitor free, Rieske head domain in b position | Descriptor: | Cytochrome b, Cytochrome b-c1 complex subunit 2, mitochondrial, ... | Authors: | Di Trani, J.M, Rubinstein, J.L. | Deposit date: | 2021-07-20 | Release date: | 2021-09-15 | Last modified: | 2022-01-19 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Rieske head domain dynamics and indazole-derivative inhibition of Candida albicans complex III. Structure, 30, 2022
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6VE4
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![BU of 6ve4 by Molmil](/molmil-images/mine/6ve4) | Pentadecameric PilQ from Pseudomonas aeruginosa | Descriptor: | Fimbrial assembly protein PilQ | Authors: | McCallum, M, Tammam, S, Rubinstein, J.L, Burrows, L.L, Howell, P.L. | Deposit date: | 2019-12-28 | Release date: | 2020-12-23 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (6.9 Å) | Cite: | CryoEM map of Pseudomonas aeruginosa PilQ enables structural characterization of TsaP. Structure, 29, 2021
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6VGQ
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![BU of 6vgq by Molmil](/molmil-images/mine/6vgq) | ClpP1P2 complex from M. tuberculosis with GLF-CMK bound to ClpP1 | Descriptor: | ATP-dependent Clp protease proteolytic subunit, ATP-dependent Clp protease proteolytic subunit 1, Z-Gly-leu-phe-CH2Cl | Authors: | Ripstein, Z.A, Vahidi, S, Rubinstein, J.L, Kay, L.E. | Deposit date: | 2020-01-08 | Release date: | 2020-03-18 | Last modified: | 2020-04-01 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | An allosteric switch regulatesMycobacterium tuberculosisClpP1P2 protease function as established by cryo-EM and methyl-TROSY NMR. Proc.Natl.Acad.Sci.USA, 117, 2020
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6VGK
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![BU of 6vgk by Molmil](/molmil-images/mine/6vgk) | ClpP1P2 complex from M. tuberculosis | Descriptor: | ATP-dependent Clp protease proteolytic subunit 1, ATP-dependent Clp protease proteolytic subunit 2 | Authors: | Ripstein, Z.A, Vahidi, S, Rubinstein, J.L, Kay, L.E. | Deposit date: | 2020-01-08 | Release date: | 2020-03-18 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | An allosteric switch regulatesMycobacterium tuberculosisClpP1P2 protease function as established by cryo-EM and methyl-TROSY NMR. Proc.Natl.Acad.Sci.USA, 117, 2020
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6VFX
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![BU of 6vfx by Molmil](/molmil-images/mine/6vfx) | ClpXP from Neisseria meningitidis - Conformation B | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ATP-dependent Clp protease ATP-binding subunit ClpX, ... | Authors: | Ripstein, Z.A, Vahidi, S, Houry, W.A, Rubinstein, J.L, Kay, L.E. | Deposit date: | 2020-01-06 | Release date: | 2020-01-22 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | A processive rotary mechanism couples substrate unfolding and proteolysis in the ClpXP degradation machinery. Elife, 9, 2020
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6VFS
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![BU of 6vfs by Molmil](/molmil-images/mine/6vfs) | ClpXP from Neisseria meningitidis - Conformation A | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ATP-dependent Clp protease ATP-binding subunit ClpX, ... | Authors: | Ripstein, Z.A, Vahidi, S, Houry, W.A, Rubinstein, J.L, Kay, L.E. | Deposit date: | 2020-01-06 | Release date: | 2020-01-22 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | A processive rotary mechanism couples substrate unfolding and proteolysis in the ClpXP degradation machinery. Elife, 9, 2020
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6VE2
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![BU of 6ve2 by Molmil](/molmil-images/mine/6ve2) | Tetradecameric PilQ bound by TsaP heptamer from Pseudomonas aeruginosa | Descriptor: | Fimbrial assembly protein PilQ, LysM domain-containing protein | Authors: | McCallum, M, Tammam, S, Rubinstein, J.L, Burrows, L.L, Howell, P.L. | Deposit date: | 2019-12-28 | Release date: | 2020-12-23 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (4.3 Å) | Cite: | CryoEM map of Pseudomonas aeruginosa PilQ enables structural characterization of TsaP. Structure, 29, 2021
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6VGN
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![BU of 6vgn by Molmil](/molmil-images/mine/6vgn) | ClpP1P2 complex from M. tuberculosis bound to ADEP | Descriptor: | ATP-dependent Clp protease proteolytic subunit, ATP-dependent Clp protease proteolytic subunit 1, R0M-WFP-ALO-PRO-YCP-ALA-MP8 | Authors: | Ripstein, Z.A, Vahidi, S, Rubinstein, J.L, Kay, L.E. | Deposit date: | 2020-01-08 | Release date: | 2020-03-18 | Last modified: | 2020-04-01 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | An allosteric switch regulatesMycobacterium tuberculosisClpP1P2 protease function as established by cryo-EM and methyl-TROSY NMR. Proc.Natl.Acad.Sci.USA, 117, 2020
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6VE3
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![BU of 6ve3 by Molmil](/molmil-images/mine/6ve3) | Tetradecameric PilQ from Pseudomonas aeruginosa | Descriptor: | Fimbrial assembly protein PilQ | Authors: | McCallum, M, Tammam, S, Rubinstein, J.L, Burrows, L.L, Howell, P.L. | Deposit date: | 2019-12-28 | Release date: | 2020-12-23 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (4.3 Å) | Cite: | CryoEM map of Pseudomonas aeruginosa PilQ enables structural characterization of TsaP. Structure, 29, 2021
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6VQJ
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6VQI
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