6VGQ

ClpP1P2 complex from M. tuberculosis with GLF-CMK bound to ClpP1

Summary for 6VGQ

Entry DOI	10.2210/pdb6vgq/pdb
Related	6VGK
EMDB information	21197 21199
Descriptor	ATP-dependent Clp protease proteolytic subunit 1, ATP-dependent Clp protease proteolytic subunit, Z-Gly-leu-phe-CH2Cl (3 entities in total)
Functional Keywords	complex, protease, clpp, tuberculosis, hydrolase
Biological source	Mycobacterium tuberculosis More
Total number of polymer chains	21
Total formula weight	304509.38
Authors	Ripstein, Z.A.,Vahidi, S.,Rubinstein, J.L.,Kay, L.E. (deposition date: 2020-01-08, release date: 2020-03-18, Last modification date: 2020-04-01)
Primary citation	Vahidi, S.,Ripstein, Z.A.,Juravsky, J.B.,Rennella, E.,Goldberg, A.L.,Mittermaier, A.K.,Rubinstein, J.L.,Kay, L.E. An allosteric switch regulatesMycobacterium tuberculosisClpP1P2 protease function as established by cryo-EM and methyl-TROSY NMR. Proc.Natl.Acad.Sci.USA, 117:5895-5906, 2020 Cited by PubMed: 32123115 DOI: 10.1073/pnas.1921630117 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.5 Å)

Structure validation