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PDB: 121 件
7NBH
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BU of 7nbh by Molmil
Crystal structure of human serine racemase in complex with DSiP fragment Z26781964, XChem fragment screen.
分子名称: 1,2-ETHANEDIOL, CALCIUM ION, CHLORIDE ION, ...
著者Koulouris, C.R, Roe, S.M.
登録日2021-01-26
公開日2021-03-03
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.77 Å)
主引用文献Tyrosine 121 moves revealing a ligandable pocket that couples catalysis to ATP-binding in serine racemase.
Commun Biol, 5, 2022
7NBD
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Crystal structure of human serine racemase in complex with DSiP fragment Z235449082, XChem fragment screen.
分子名称: 1,2-ETHANEDIOL, CALCIUM ION, GLYCEROL, ...
著者Koulouris, C.R, Roe, S.M.
登録日2021-01-26
公開日2021-03-03
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.865 Å)
主引用文献Tyrosine 121 moves revealing a ligandable pocket that couples catalysis to ATP-binding in serine racemase.
Commun Biol, 5, 2022
7NBF
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BU of 7nbf by Molmil
Crystal structure of human serine racemase in complex with DSiP fragment Z126932614, XChem fragment screen.
分子名称: 1,2-ETHANEDIOL, 2-[(methylsulfonyl)methyl]-1H-benzimidazole, CALCIUM ION, ...
著者Koulouris, C.R, Roe, S.M.
登録日2021-01-26
公開日2021-03-03
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Tyrosine 121 moves revealing a ligandable pocket that couples catalysis to ATP-binding in serine racemase.
Commun Biol, 5, 2022
7NBC
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BU of 7nbc by Molmil
Crystal structure of human serine racemase in complex with DSiP fragment Z2856434779, XChem fragment screen.
分子名称: 1,2-ETHANEDIOL, 2-(2-METHOXYETHOXY)ETHANOL, CALCIUM ION, ...
著者Koulouris, C.R, Roe, S.M.
登録日2021-01-26
公開日2021-03-03
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.71 Å)
主引用文献Tyrosine 121 moves revealing a ligandable pocket that couples catalysis to ATP-binding in serine racemase.
Commun Biol, 5, 2022
2IZO
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BU of 2izo by Molmil
Structure of an Archaeal PCNA1-PCNA2-FEN1 Complex
分子名称: DNA POLYMERASE SLIDING CLAMP B, DNA POLYMERASE SLIDING CLAMP C, FLAP STRUCTURE-SPECIFIC ENDONUCLEASE, ...
著者Dore, A.S, Kilkenny, M.L, Roe, S.M, Pearl, L.H.
登録日2006-07-25
公開日2006-09-06
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Structure of an Archaeal PCNA1-PCNA2-Fen1 Complex: Elucidating PCNA Subunit and Client Enzyme Specificity.
Nucleic Acids Res., 34, 2006
2BGG
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BU of 2bgg by Molmil
The structure of a Piwi protein from Archaeoglobus fulgidus complexed with a 16nt siRNA duplex.
分子名称: 5'-R(*GP*UP*CP*GP*AP*AP*UP*UP)-3', 5'-R(*UP*UP*CP*GP*AP*CP*GP*CP)-3', MANGANESE (II) ION, ...
著者Parker, J.S, Roe, S.M, Barford, D.
登録日2004-12-22
公開日2005-03-31
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Structural Insights Into Mrna Recognition from a Piwi Domain-Sirna Guide Complex
Nature, 434, 2005
1QO0
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BU of 1qo0 by Molmil
Amide receptor of the amidase operon of Pseudomonas aeruginosa (AmiC) complexed with the negative regulator AmiR.
分子名称: AMIC, AMIR, BUTYRAMIDE
著者Pearl, L.H, O'Hara, B.P, Roe, S.M.
登録日1999-10-26
公開日1999-12-23
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.25 Å)
主引用文献Crystal Structure and Induction Mechanism of Amic-Amir: A Ligand-Regulated Transcription Antitermination Complex
Embo J., 18, 1999
1QNL
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AMIDE RECEPTOR/NEGATIVE REGULATOR OF THE AMIDASE OPERON OF PSEUDOMONAS AERUGINOSA (AMIC) COMPLEXED WITH BUTYRAMIDE
分子名称: ALIPHATIC AMIDASE EXPRESSION-REGULATING PROTEIN, BUTYRAMIDE
著者Pearl, L.H, O'Hara, B.P, Roe, S.M.
登録日1999-10-19
公開日1999-12-23
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Structural Adaptation to Selective Pressure for Altered Ligand Specificity in the Pseudomonas Aeruginosa Amide Receptor, Amic
Protein Eng., 13, 2000
1UWH
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The complex of wild type B-RAF and BAY439006.
分子名称: 4-{4-[({[4-CHLORO-3-(TRIFLUOROMETHYL)PHENYL]AMINO}CARBONYL)AMINO]PHENOXY}-N-METHYLPYRIDINE-2-CARBOXAMIDE, B-RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE, CHLORIDE ION
著者Barford, D, Roe, S.M, Wan, P.T.C, Cancer Genome Project
登録日2004-02-05
公開日2004-03-19
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.95 Å)
主引用文献Mechanism of Activation of the Raf-Erk Signaling Pathway by Oncogenic Mutations of B-Raf
Cell(Cambridge,Mass.), 116, 2004
1USV
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BU of 1usv by Molmil
The Structure of the complex between Aha1 and HSP90
分子名称: AHA1, HEAT SHOCK PROTEIN HSP82
著者Meyer, P, Roe, S.M, Pearl, L.H.
登録日2003-12-01
公開日2004-01-29
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Structural Basis for Recruitment of the ATPase Activator Aha1 to the Hsp90 Chaperone Machinery.
Embo J., 23, 2004
1AH6
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BU of 1ah6 by Molmil
STRUCTURE OF THE TETRAGONAL FORM OF THE N-TERMINAL DOMAIN OF THE YEAST HSP90 CHAPERONE
分子名称: HEAT SHOCK PROTEIN 90
著者Prodromou, C, Roe, S.M, Pearl, L.H.
登録日1997-04-14
公開日1997-10-22
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献A molecular clamp in the crystal structure of the N-terminal domain of the yeast Hsp90 chaperone.
Nat.Struct.Biol., 4, 1997
1A4H
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BU of 1a4h by Molmil
STRUCTURE OF THE N-TERMINAL DOMAIN OF THE YEAST HSP90 CHAPERONE IN COMPLEX WITH GELDANAMYCIN
分子名称: GELDANAMYCIN, HEAT SHOCK PROTEIN 90
著者Prodromou, C, Roe, S.M, Pearl, L.H.
登録日1998-01-29
公開日1998-08-05
最終更新日2023-08-02
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Identification and structural characterization of the ATP/ADP-binding site in the Hsp90 molecular chaperone
Cell(Cambridge,Mass.), 90, 1997
1AH8
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BU of 1ah8 by Molmil
STRUCTURE OF THE ORTHORHOMBIC FORM OF THE N-TERMINAL DOMAIN OF THE YEAST HSP90 CHAPERONE
分子名称: GLYCEROL, HEAT SHOCK PROTEIN 90
著者Prodromou, C, Roe, S.M, Pearl, L.H.
登録日1997-04-14
公開日1997-10-22
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献A molecular clamp in the crystal structure of the N-terminal domain of the yeast Hsp90 chaperone.
Nat.Struct.Biol., 4, 1997
1CBN
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BU of 1cbn by Molmil
ATOMIC RESOLUTION (0.83 ANGSTROMS) CRYSTAL STRUCTURE OF THE HYDROPHOBIC PROTEIN CRAMBIN AT 130 K
分子名称: CRAMBIN, ETHANOL
著者Teeter, M.M, Roe, S.M, Heo, N.H.
登録日1991-10-11
公開日1994-01-31
最終更新日2017-11-29
実験手法X-RAY DIFFRACTION (0.83 Å)
主引用文献Atomic resolution (0.83 A) crystal structure of the hydrophobic protein crambin at 130 K.
J.Mol.Biol., 230, 1993
2WMN
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BU of 2wmn by Molmil
Structure of the complex between DOCK9 and Cdc42-GDP.
分子名称: CELL DIVISION CONTROL PROTEIN 42 HOMOLOG, DEDICATOR OF CYTOKINESIS PROTEIN 9, GUANOSINE-5'-DIPHOSPHATE
著者Yang, J, Roe, S.M, Barford, D.
登録日2009-07-02
公開日2009-09-22
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.391 Å)
主引用文献Activation of Rho Gtpases by Dock Exchange Factors is Mediated by a Nucleotide Sensor.
Science, 325, 2009
2WM9
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BU of 2wm9 by Molmil
Structure of the complex between DOCK9 and Cdc42.
分子名称: CELL DIVISION CONTROL PROTEIN 42 HOMOLOG, DEDICATOR OF CYTOKINESIS PROTEIN 9, GLYCEROL
著者Yang, J, Roe, S.M, Barford, D.
登録日2009-06-30
公開日2009-09-22
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Activation of Rho Gtpases by Dock Exchange Factors is Mediated by a Nucleotide Sensor.
Science, 325, 2009
2XX4
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BU of 2xx4 by Molmil
Macrolactone Inhibitor bound to HSP90 N-term
分子名称: (E)-ETHYL 13-CHLORO-14,16-DIHYDROXY-1,11-DIOXO-1,2,3,4,7,8,9,10,11,12-DECAHYDROBENZO[C][1]AZACYCLOTETRADECINE-10-CARBOXYLATE, ATP-DEPENDENT MOLECULAR CHAPERONE HSP82
著者Moody, C.J, Prodromou, C, Pearl, L.H, Roe, S.M.
登録日2010-11-08
公開日2011-11-16
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.199 Å)
主引用文献Targeting the Hsp90 Molecular Chaperone with Novel Macrolactams. Synthesis, Structural, Binding, and Cellular Studies.
Acs Chem.Biol., 6, 2011
2XX5
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BU of 2xx5 by Molmil
Macrolactone Inhibitor bound to HSP90 N-term
分子名称: (5E,10R)-N-BENZYL-13-CHLORO-14,16-DIHYDROXY-1,11-DIOXO-1,2,3,4,7,8,9,10,11,12-DECAHYDRO-2-BENZAZACYCLOTETRADECINE-10-CARBOXAMIDE, ATP-DEPENDENT MOLECULAR CHAPERONE HSP82, GLYCEROL
著者Moody, C.J, Prodromou, C, Pearl, L.H, Roe, S.M.
登録日2010-11-08
公開日2011-11-16
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Targeting the Hsp90 Molecular Chaperone with Novel Macrolactams. Synthesis, Structural, Binding, and Cellular Studies.
Acs Chem.Biol., 6, 2011
2XX2
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BU of 2xx2 by Molmil
Macrolactone Inhibitor bound to HSP90 N-term
分子名称: (5E)-13-CHLORO-14,16-DIHYDROXY-3,4,7,8,9,10-HEXAHYDRO-2-BENZAZACYCLOTETRADECINE-1,11(2H,12H)-DIONE, ATP-DEPENDENT MOLECULAR CHAPERONE HSP82, GLYCEROL
著者Moody, C.J, Prodromou, C, Pearl, L.H, Roe, S.M.
登録日2010-11-08
公開日2011-11-16
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Targeting the Hsp90 Molecular Chaperone with Novel Macrolactams. Synthesis, Structural, Binding, and Cellular Studies.
Acs Chem.Biol., 6, 2011
4CV4
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BU of 4cv4 by Molmil
PIH N-terminal domain
分子名称: COBALT (II) ION, PIH1 DOMAIN-CONTAINING PROTEIN 1, SULFATE ION
著者Morgan, R.M, Roe, S.M.
登録日2014-03-23
公開日2014-05-14
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (1.902 Å)
主引用文献Structural Basis for Phosphorylation-Dependent Recruitment of Tel2 to Hsp90 by Pih1.
Structure, 22, 2014
4CKT
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BU of 4ckt by Molmil
PIH1 N-terminal domain
分子名称: PIH1 DOMAIN-CONTAINING PROTEIN 1, TELOMERE LENGTH REGULATION PROTEIN TEL2 HOMOLOG
著者Morgan, R.M, Roe, S.M.
登録日2014-01-08
公開日2014-05-14
最終更新日2014-06-25
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Structural Basis for Phosphorylation-Dependent Recruitment of Tel2 to Hsp90 by Pih1.
Structure, 22, 2014
4CSE
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BU of 4cse by Molmil
PIH N-terminal domain
分子名称: PIH1 DOMAIN-CONTAINING PROTEIN 1, TELOMERE LENGTH REGULATION PROTEIN TEL2 HOMOLOG
著者Morgan, R.M, Roe, S.M.
登録日2014-03-07
公開日2014-05-14
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (3.3 Å)
主引用文献Structural Basis for Phosphorylation-Dependent Recruitment of Tel2 to Hsp90 by Pih1.
Structure, 22, 2014
3BO6
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BU of 3bo6 by Molmil
Structure of the Chromobacterium violaceum VirA (SpvC) Phosphothreonine Lyase effector protein
分子名称: Hydrophilic protein, virA protein, SULFATE ION
著者Brennan, D.F, Roe, S.M, Barford, D.
登録日2007-12-17
公開日2008-11-25
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献Structure and Mechanism of the Chromobacterium violaceum VirA Phosphothreonine Lyase Type III Secretion System Effector
To be Published
4APO
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BU of 4apo by Molmil
AIP TPR domain in complex with human Tomm20 peptide
分子名称: AH RECEPTOR-INTERACTING PROTEIN, DODECAETHYLENE GLYCOL, MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM20 HOMOLOG, ...
著者Morgan, R.M.L, Roe, S.M, Pearl, L.H, Prodromou, C.
登録日2012-04-04
公開日2013-01-23
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (1.895 Å)
主引用文献Structure of the Tpr Domain of Aip: Lack of Client Protein Interaction with the C-Terminal Alpha-7 Helix of the Tpr Domain of Aip is Sufficient for Pituitary Adenoma Predisposition.
Plos One, 7, 2012
4AIF
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AIP TPR domain in complex with human Hsp90 peptide
分子名称: AH RECEPTOR-INTERACTING PROTEIN, HEAT SHOCK PROTEIN HSP 90-ALPHA, SULFATE ION
著者Morgan, R.M.L, Roe, S.M, Pearl, L.H, Prodromou, C.
登録日2012-02-09
公開日2013-01-23
最終更新日2024-05-01
実験手法X-RAY DIFFRACTION (2.006 Å)
主引用文献Structure of the Tpr Domain of Aip: Lack of Client Protein Interaction with the C-Terminal Alpha-7 Helix of the Tpr Domain of Aip is Sufficient for Pituitary Adenoma Predisposition.
Plos One, 7, 2012

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件を2024-05-15に公開中

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