2FXP
 
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4FUA
 | | L-FUCULOSE-1-PHOSPHATE ALDOLASE COMPLEX WITH PGH | | Descriptor: | BETA-MERCAPTOETHANOL, L-FUCULOSE-1-PHOSPHATE ALDOLASE, PHOSPHOGLYCOLOHYDROXAMIC ACID, ... | | Authors: | Dreyer, M.K, Schulz, G.E. | | Deposit date: | 1996-02-14 | | Release date: | 1996-10-14 | | Last modified: | 2024-06-05 | | Method: | X-RAY DIFFRACTION (2.43 Å) | | Cite: | Catalytic mechanism of the metal-dependent fuculose aldolase from Escherichia coli as derived from the structure.
J.Mol.Biol., 259, 1996
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8D14
 | | Helical ADP-Pi-F-actin | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Actin, alpha skeletal muscle, ... | | Authors: | Reynolds, M.J, Alushin, G.M. | | Deposit date: | 2022-05-26 | | Release date: | 2022-09-07 | | Last modified: | 2022-11-23 | | Method: | ELECTRON MICROSCOPY (2.51 Å) | | Cite: | Bending forces and nucleotide state jointly regulate F-actin structure.
Nature, 611, 2022
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8D18
 | | Straight ADP-F-actin 2 | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Actin, alpha skeletal muscle, ... | | Authors: | Reynolds, M.J, Alushin, G.M. | | Deposit date: | 2022-05-26 | | Release date: | 2022-09-07 | | Last modified: | 2022-11-23 | | Method: | ELECTRON MICROSCOPY (3.66 Å) | | Cite: | Bending forces and nucleotide state jointly regulate F-actin structure.
Nature, 611, 2022
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8D15
 | | Bent ADP-F-actin | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Actin, alpha skeletal muscle, ... | | Authors: | Reynolds, M.J, Alushin, G.M. | | Deposit date: | 2022-05-26 | | Release date: | 2022-09-07 | | Last modified: | 2022-11-23 | | Method: | ELECTRON MICROSCOPY (3.61 Å) | | Cite: | Bending forces and nucleotide state jointly regulate F-actin structure.
Nature, 611, 2022
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8D17
 | | Straight ADP-F-actin 1 | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Actin, alpha skeletal muscle, ... | | Authors: | Reynolds, M.J, Alushin, G.M. | | Deposit date: | 2022-05-26 | | Release date: | 2022-09-07 | | Last modified: | 2022-11-23 | | Method: | ELECTRON MICROSCOPY (3.69 Å) | | Cite: | Bending forces and nucleotide state jointly regulate F-actin structure.
Nature, 611, 2022
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8D16
 | | Bent ADP-Pi-F-actin | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Actin, alpha skeletal muscle, ... | | Authors: | Reynolds, M.J, Alushin, G.M. | | Deposit date: | 2022-05-26 | | Release date: | 2022-09-07 | | Last modified: | 2022-11-23 | | Method: | ELECTRON MICROSCOPY (3.71 Å) | | Cite: | Bending forces and nucleotide state jointly regulate F-actin structure.
Nature, 611, 2022
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8PYI
 | | Human IGF1R with inhibitor 6 | | Descriptor: | 3-[8-azanyl-1-(4-ethoxy-8-fluoranyl-2-phenyl-quinolin-7-yl)imidazo[1,5-a]pyrazin-3-yl]-1-methyl-cyclobutan-1-ol, Insulin-like growth factor 1 receptor beta chain | | Authors: | Dreyer, M.K, Wang, J, Elkins, J.M. | | Deposit date: | 2023-07-25 | | Release date: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (3.06 Å) | | Cite: | Human IGF1R with inhibitor 6
To Be Published
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8D13
 | | Helical ADP-F-actin | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Actin, alpha skeletal muscle, ... | | Authors: | Reynolds, M.J, Alushin, G.M. | | Deposit date: | 2022-05-26 | | Release date: | 2022-09-07 | | Last modified: | 2022-11-23 | | Method: | ELECTRON MICROSCOPY (2.43 Å) | | Cite: | Bending forces and nucleotide state jointly regulate F-actin structure.
Nature, 611, 2022
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8PYJ
 | | Human IGF1R with inhibitor 8 | | Descriptor: | 5,5-dimethyl-1-(quinolin-4-ylmethyl)-3-[4-(trifluoromethylsulfonyl)phenyl]imidazolidine-2,4-dione, CADMIUM ION, Insulin-like growth factor 1 receptor beta chain, ... | | Authors: | Dreyer, M.K, Wang, J, Elkins, J.M. | | Deposit date: | 2023-07-25 | | Release date: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (2.702 Å) | | Cite: | Human IGF1R with inhibitor 8
To Be Published
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8PYK
 | | Human IGF1R with inhibitor 47 | | Descriptor: | 5,5-dimethyl-1-(1H-pyrrolo[2,3-b]pyridin-3-ylmethyl)-3-[4-(trifluoromethylsulfanyl)phenyl]imidazolidine-2,4-dione, Insulin-like growth factor 1 receptor beta chain, NICKEL (II) ION | | Authors: | Dreyer, M.K, Wang, J, Elkins, J.M. | | Deposit date: | 2023-07-25 | | Release date: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (2.23 Å) | | Cite: | Human IGF1R with inhibitor 47
To Be Published
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8PYL
 | | Human IGF1R with inhibitor 53 | | Descriptor: | (5S)-5-methyl-1-(1H-pyrrolo[2,3-b]pyridin-4-ylmethyl)-3-[4-(trifluoromethylsulfanyl)phenyl]imidazolidine-2,4-dione, CADMIUM ION, Insulin-like growth factor 1 receptor beta chain, ... | | Authors: | Dreyer, M.K, Wang, J, Elkins, J.M. | | Deposit date: | 2023-07-25 | | Release date: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (2.93 Å) | | Cite: | Human IGF1R with inhibitor 53
To Be Published
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8PYN
 | | Human IGF1R with inhibitor 56 | | Descriptor: | 5,5-dimethyl-1-(1H-pyrrolo[2,3-b]pyridin-4-ylmethyl)-3-[4-(trifluoromethylsulfonyl)phenyl]imidazolidine-2,4-dione, CADMIUM ION, Insulin-like growth factor 1 receptor beta chain, ... | | Authors: | Dreyer, M.K, Wang, J, Elkins, J.M. | | Deposit date: | 2023-07-25 | | Release date: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (1.71 Å) | | Cite: | Human IGF1R with inhibitor 56
To Be Published
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8PYM
 | | Human IGF1R with inhibitor 54 | | Descriptor: | 5,5-dimethyl-1-(1H-pyrrolo[2,3-b]pyridin-4-ylmethyl)-3-[4-(trifluoromethylsulfanyl)phenyl]imidazolidine-2,4-dione, CADMIUM ION, Insulin-like growth factor 1 receptor beta chain, ... | | Authors: | Dreyer, M.K, Wang, J, Elkins, J.M. | | Deposit date: | 2023-07-25 | | Release date: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (2.652 Å) | | Cite: | Human IGF1R with inhibitor 54
To Be Published
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1FXR
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1FUA
 | | L-FUCULOSE 1-PHOSPHATE ALDOLASE CRYSTAL FORM T | | Descriptor: | BETA-MERCAPTOETHANOL, L-FUCULOSE-1-PHOSPHATE ALDOLASE, SULFATE ION, ... | | Authors: | Dreyer, M.K, Schulz, G.E. | | Deposit date: | 1996-02-14 | | Release date: | 1996-10-14 | | Last modified: | 2024-06-05 | | Method: | X-RAY DIFFRACTION (1.92 Å) | | Cite: | Refined high-resolution structure of the metal-ion dependent L-fuculose-1-phosphate aldolase (class II) from Escherichia coli.
Acta Crystallogr.,Sect.D, 52, 1996
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7PUE
 | | Human serum and glucocorticoid-regulated kinase 1 in complex with pyrazolopyridine inhibitor 3a | | Descriptor: | 6-[4-[[2,3-bis(chloranyl)phenyl]sulfonylamino]phenyl]-~{N}-[(3~{R})-pyrrolidin-3-yl]-2~{H}-pyrazolo[3,4-b]pyridine-4-carboxamide, GLYCEROL, Serine/threonine-protein kinase Sgk1 | | Authors: | Dreyer, M.K, Halland, N, Nazare, M. | | Deposit date: | 2021-09-29 | | Release date: | 2021-12-01 | | Last modified: | 2024-05-01 | | Method: | X-RAY DIFFRACTION (2.506 Å) | | Cite: | Rational Design of Highly Potent, Selective, and Bioavailable SGK1 Protein Kinase Inhibitors for the Treatment of Osteoarthritis.
J.Med.Chem., 65, 2022
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3LFS
 | | Crystal structure of CDK2 with SAR37, an aminoindazole type inhibitor | | Descriptor: | Cell division protein kinase 2, N-(6-chloro-5-phenyl-1H-indazol-3-yl)butanamide | | Authors: | Dreyer, M.K, Wendt, K.U, Schimanski-Breves, S, Loenze, P. | | Deposit date: | 2010-01-18 | | Release date: | 2010-03-02 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Rational design of potent GSK3beta inhibitors with selectivity for Cdk1 and Cdk2.
Bioorg.Med.Chem.Lett., 20, 2010
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3LFQ
 | | Crystal structure of CDK2 with SAR60, an aminoindazole type inhibitor | | Descriptor: | Cell division protein kinase 2, N-(6,7-difluoro-5-phenyl-1H-indazol-3-yl)butanamide | | Authors: | Dreyer, M.K, Wendt, K.U, Schimanski-Breves, S, Loenze, P. | | Deposit date: | 2010-01-18 | | Release date: | 2010-03-02 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (2.03 Å) | | Cite: | Rational design of potent GSK3beta inhibitors with selectivity for Cdk1 and Cdk2.
Bioorg.Med.Chem.Lett., 20, 2010
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3LFN
 | | Crystal structure of CDK2 with SAR57, an aminoindazole type inhibitor | | Descriptor: | Cell division protein kinase 2, N-[6-(4-hydroxyphenyl)-5-phenyl-1H-indazol-3-yl]butanamide | | Authors: | Dreyer, M.K, Wendt, K.U, Schimanski-Breves, S, Loenze, P. | | Deposit date: | 2010-01-18 | | Release date: | 2010-03-02 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (2.28 Å) | | Cite: | Rational design of potent GSK3beta inhibitors with selectivity for Cdk1 and Cdk2.
Bioorg.Med.Chem.Lett., 20, 2010
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1RDG
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2EZP
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2EZS
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2EZO
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2EZR
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