6MSO
 
 | | Crystal structure of mitochondrial fumarate hydratase from Leishmania major in a complex with inhibitor thiomalate | | 分子名称: | (2S)-2-sulfanylbutanedioic acid, GLYCEROL, IRON/SULFUR CLUSTER, ... | | 著者 | Feliciano, P.R, Drennan, C.L, Nonato, M.C. | | 登録日 | 2018-10-17 | | 公開日 | 2019-01-30 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2.053 Å) | | 主引用文献 | Crystal Structures of Fumarate Hydratases from Leishmania major in a Complex with Inhibitor 2-Thiomalate.
ACS Chem. Biol., 14, 2019
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6VUE
 | | wild-type choline TMA lyase in complex with 1-methyl-1,2,3,6-tetrahydropyridin-3-ol | | 分子名称: | (3S)-1-methyl-1,2,3,6-tetrahydropyridin-3-ol, Choline trimethylamine-lyase, SODIUM ION | | 著者 | Ortega, M.A, Drennan, C.L. | | 登録日 | 2020-02-15 | | 公開日 | 2020-11-04 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2.28 Å) | | 主引用文献 | Discovery of a Cyclic Choline Analog That Inhibits Anaerobic Choline Metabolism by Human Gut Bacteria.
Acs Med.Chem.Lett., 11, 2020
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6VXC
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5D1Y
 | | Low resolution crystal structure of human ribonucleotide reductase alpha6 hexamer in complex with dATP | | 分子名称: | Ribonucleoside-diphosphate reductase large subunit | | 著者 | Ando, N, Li, H, Brignole, E.J, Thompson, S, McLaughlin, M.I, Page, J, Asturias, F, Stubbe, J, Drennan, C.L. | | 登録日 | 2015-08-04 | | 公開日 | 2016-01-20 | | 最終更新日 | 2024-10-09 | | 実験手法 | X-RAY DIFFRACTION (9.005 Å) | | 主引用文献 | Allosteric Inhibition of Human Ribonucleotide Reductase by dATP Entails the Stabilization of a Hexamer.
Biochemistry, 55, 2016
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4K38
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4PKF
 | | Benzylsuccinate synthase alpha-beta-gamma complex | | 分子名称: | CHLORIDE ION, GLYCEROL, IRON/SULFUR CLUSTER, ... | | 著者 | Funk, M.A, Drennan, C.L. | | 登録日 | 2014-05-14 | | 公開日 | 2014-07-02 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (2.002 Å) | | 主引用文献 | Structures of benzylsuccinate synthase elucidate roles of accessory subunits in glycyl radical enzyme activation and activity.
Proc.Natl.Acad.Sci.USA, 111, 2014
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8VHQ
 | | Crystal structure of E. coli class Ia ribonucleotide reductase alpha subunit W28A variant bound to dATP and ATP | | 分子名称: | 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | | 著者 | Funk, M.A, Zimanyi, C.M, Drennan, C.L. | | 登録日 | 2024-01-02 | | 公開日 | 2024-09-04 | | 最終更新日 | 2024-10-09 | | 実験手法 | X-RAY DIFFRACTION (3.4 Å) | | 主引用文献 | How ATP and dATP Act as Molecular Switches to Regulate Enzymatic Activity in the Prototypical Bacterial Class Ia Ribonucleotide Reductase.
Biochemistry, 63, 2024
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8VHR
 | | Crystal structure of E. coli class Ia ribonucleotide reductase alpha subunit W28A variant bound to dATP and GTP | | 分子名称: | 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | | 著者 | Funk, M.A, Zimanyi, C.M, Drennan, C.L. | | 登録日 | 2024-01-02 | | 公開日 | 2024-09-04 | | 最終更新日 | 2024-10-09 | | 実験手法 | X-RAY DIFFRACTION (3.55 Å) | | 主引用文献 | How ATP and dATP Act as Molecular Switches to Regulate Enzymatic Activity in the Prototypical Bacterial Class Ia Ribonucleotide Reductase.
Biochemistry, 63, 2024
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8VHP
 | | Crystal structure of E. coli class Ia ribonucleotide reductase alpha subunit W28A variant bound to CDP and two molecules of ATP | | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, CYTIDINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... | | 著者 | Funk, M.A, Zimanyi, C.M, Drennan, C.L. | | 登録日 | 2024-01-02 | | 公開日 | 2024-09-04 | | 最終更新日 | 2024-10-09 | | 実験手法 | X-RAY DIFFRACTION (2.608 Å) | | 主引用文献 | How ATP and dATP Act as Molecular Switches to Regulate Enzymatic Activity in the Prototypical Bacterial Class Ia Ribonucleotide Reductase.
Biochemistry, 63, 2024
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6ONS
 | | Crystal structure of Desulfovibrio vulgaris carbon monoxide dehydrogenase with the D-cluster ligating cysteines mutated to alanines, coexpressed with CooC, as-isolated | | 分子名称: | Carbon monoxide dehydrogenase, FE(4)-NI(1)-S(4) CLUSTER, IRON/SULFUR CLUSTER | | 著者 | Cohen, S.E, Wittenborn, E.C, Drennan, C.L. | | 登録日 | 2019-04-22 | | 公開日 | 2019-07-24 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2.485 Å) | | 主引用文献 | Structural insight into metallocofactor maturation in carbon monoxide dehydrogenase.
J.Biol.Chem., 294, 2019
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6DS2
 | | Crystal structure of Ni(II)-bound human calprotectin | | 分子名称: | NICKEL (II) ION, Protein S100-A8, Protein S100-A9, ... | | 著者 | Nolan, E.M, Drennan, C.L, Nakashige, T.G. | | 登録日 | 2018-06-13 | | 公開日 | 2018-07-04 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Biophysical Examination of the Calcium-Modulated Nickel-Binding Properties of Human Calprotectin Reveals Conformational Change in the EF-Hand Domains and His3Asp Site.
Biochemistry, 57, 2018
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6ONC
 | | Crystal structure of Desulfovibrio vulgaris carbon monoxide dehydrogenase produced without CooC, as-isolated | | 分子名称: | CHLORIDE ION, Carbon monoxide dehydrogenase, FE (III) ION, ... | | 著者 | Wittenborn, E.C, Cohen, S.E, Drennan, C.L. | | 登録日 | 2019-04-21 | | 公開日 | 2019-07-24 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | Structural insight into metallocofactor maturation in carbon monoxide dehydrogenase.
J.Biol.Chem., 294, 2019
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2Z8Y
 | | Xenon-bound structure of bifunctional carbon monoxide dehydrogenase/acetyl-CoA synthase(CODH/ACS) from Moorella thermoacetica | | 分子名称: | COPPER (I) ION, Carbon monoxide dehydrogenase/acetyl CoA synthase subunit alpha, Carbon monoxide dehydrogenase/acetyl CoA synthase subunit beta, ... | | 著者 | Doukov, T.I, Blasiak, L.C, Drennan, C.L. | | 登録日 | 2007-09-12 | | 公開日 | 2008-03-11 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (2.51 Å) | | 主引用文献 | Xenon in and at the End of the Tunnel of Bifunctional Carbon Monoxide Dehydrogenase/Acetyl-CoA Synthase
Biochemistry, 47, 2008
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2E7F
 | | 5-methyltetrahydrofolate corrinoid/iron sulfur protein methyltransferase complexed with methyltetrahydrofolate to 2.2 Angsrom resolution | | 分子名称: | 5-METHYL-5,6,7,8-TETRAHYDROFOLIC ACID, 5-methyltetrahydrofolate corrinoid/iron sulfur protein methyltransferase, CALCIUM ION | | 著者 | Doukov, T.I, Drennan, C.L, Hemmi, H, Ragsdale, S.W. | | 登録日 | 2007-01-09 | | 公開日 | 2007-01-30 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Structural and kinetic evidence for an extended hydrogen-bonding network in catalysis of methyl group transfer. Role of an active site asparagine residue in activation of methyl transfer by methyltransferases.
J.Biol.Chem., 282, 2007
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4K36
 | | His6 tagged anSMEcpe with bound AdoMet | | 分子名称: | Anaerobic sulfatase-maturating enzyme, CHLORIDE ION, IRON/SULFUR CLUSTER, ... | | 著者 | Goldman, P.J, Drennan, C.L. | | 登録日 | 2013-04-10 | | 公開日 | 2013-05-08 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (1.619 Å) | | 主引用文献 | X-ray structure of an AdoMet radical activase reveals an anaerobic solution for formylglycine posttranslational modification.
Proc.Natl.Acad.Sci.USA, 110, 2013
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7LHS
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4PKC
 | | Benzylsuccinate alpha-gamma complex | | 分子名称: | CHLORIDE ION, GLYCEROL, TutD, ... | | 著者 | Funk, M.A, Drennan, C.L. | | 登録日 | 2014-05-14 | | 公開日 | 2014-07-02 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Structures of benzylsuccinate synthase elucidate roles of accessory subunits in glycyl radical enzyme activation and activity.
Proc.Natl.Acad.Sci.USA, 111, 2014
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4M7S
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4NJK
 | | Crystal Structure of QueE from Burkholderia multivorans in complex with AdoMet, 7-carboxy-7-deazaguanine, and Mg2+ | | 分子名称: | 2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidine-5-carboxylic acid, 7-carboxy-7-deazaguanine synthase, IRON/SULFUR CLUSTER, ... | | 著者 | Dowling, D.P, Bruender, N.A, Young, A.P, McCarty, R.M, Bandarian, V, Drennan, C.L. | | 登録日 | 2013-11-10 | | 公開日 | 2013-12-25 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (1.911 Å) | | 主引用文献 | Radical SAM enzyme QueE defines a new minimal core fold and metal-dependent mechanism.
Nat.Chem.Biol., 10, 2014
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6B9T
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6B9S
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6V59
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4IXM
 | | Crystal structure of Zn(II)-bound YjiA GTPase from E. coli | | 分子名称: | SULFATE ION, Uncharacterized GTP-binding protein YjiA, ZINC ION | | 著者 | Jost, M, Ryan, K.S, Turo, K.E, Drennan, C.L. | | 登録日 | 2013-01-26 | | 公開日 | 2013-02-27 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2.57 Å) | | 主引用文献 | Metal binding properties of Escherichia coli YjiA, a member of the metal homeostasis-associated COG0523 family of GTPases.
Biochemistry, 52, 2013
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7KQ4
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7KQ3
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