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PDB: 165 件

1T45
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STRUCTURAL BASIS FOR THE AUTOINHIBITION AND STI-571 INHIBITION OF C-KIT TYROSINE KINASE
分子名称: Homo sapiens v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
著者Mol, C.D, Dougan, D.R, Schneider, T.R, Skene, R.J, Kraus, M.L, Scheibe, D.N, Snell, G.P, Zou, H, Sang, B.C, Wilson, K.P.
登録日2004-04-28
公開日2004-06-15
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structural basis for the autoinhibition and STI-571 inhibition of c-Kit tyrosine kinase.
J.Biol.Chem., 279, 2004
8FXI
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Cryo-EM structure of Stanieria sp. CphA2 in complex with ADPCP and 4x(beta-Asp-Arg)
分子名称: 1-[(4-aminopyrimidin-5-yl)amino]-2,5-anhydro-1-deoxy-6-O-[(S)-hydroxy{[(R)-hydroxy(phosphonomethyl)phosphoryl]oxy}phosphoryl]-D-allitol, 4x(beta-Asp-Arg), MAGNESIUM ION, ...
著者Markus, L.M, Sharon, I, Strauss, M, Schmeing, T.M.
登録日2023-01-24
公開日2023-06-14
最終更新日2023-11-08
実験手法ELECTRON MICROSCOPY (2.7 Å)
主引用文献Structure and function of a hexameric cyanophycin synthetase 2.
Protein Sci., 32, 2023
8FXH
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Cryo-EM structure of Stanieria sp. CphA2
分子名称: RimK domain-containing protein ATP-grasp
著者Markus, L.M, Sharon, I, Strauss, M, Schmeing, T.M.
登録日2023-01-24
公開日2023-06-14
最終更新日2023-11-08
実験手法ELECTRON MICROSCOPY (2.8 Å)
主引用文献Structure and function of a hexameric cyanophycin synthetase 2.
Protein Sci., 32, 2023
4YE0
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Stress-induced protein 1 truncation mutant (43 - 140) from Caenorhabditis elegans
分子名称: SULFATE ION, Stress-induced protein 1
著者Fleckenstein, T, Kastenmueller, A, Stein, M.L, Peters, C, Daake, M, Krause, M, Weinfurtner, D, Haslbeck, M, Weinkauf, S, Groll, M, Buchner, J.
登録日2015-02-23
公開日2015-06-10
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献The Chaperone Activity of the Developmental Small Heat Shock Protein Sip1 Is Regulated by pH-Dependent Conformational Changes.
Mol.Cell, 58, 2015
4YDZ
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Stress-induced protein 1 from Caenorhabditis elegans
分子名称: Stress-induced protein 1
著者Fleckenstein, T, Kastenmueller, A, Stein, M.L, Peters, C, Daake, M, Krause, M, Weinfurtner, D, Haslbeck, M, Weinkauf, S, Groll, M, Buchner, J.
登録日2015-02-23
公開日2015-06-10
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (3.6 Å)
主引用文献The Chaperone Activity of the Developmental Small Heat Shock Protein Sip1 Is Regulated by pH-Dependent Conformational Changes.
Mol.Cell, 58, 2015
7THX
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Cryo-EM structure of W6 possum enterovirus
分子名称: Capsid protein VP1, Capsid protein VP2, Capsid protein VP3, ...
著者Wang, I, Jayawardena, N, Strauss, M, Bostina, M.
登録日2022-01-12
公開日2022-03-09
最終更新日2024-06-05
実験手法ELECTRON MICROSCOPY (2.96 Å)
主引用文献Cryo-EM Structure of a Possum Enterovirus.
Viruses, 14, 2022
9C0Z
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Clathrin terminal domain complexed with pitstop 2d
分子名称: 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ACETATE ION, ...
著者Bulut, H, Horatscheck, A, Krauss, M, Santos, K.F, McCluskey, A, Wahl, C.W, Nazare, M, Haucke, V.
登録日2024-05-28
公開日2024-06-26
実験手法X-RAY DIFFRACTION (1.51 Å)
主引用文献Acute inhibition of clathrin-mediated endocytosis by next-generation small molecule inhibitors of clathrin function
To Be Published
9C0Y
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Clathrin terminal domain complexed with Pitstop 2c
分子名称: 1,2-ETHANEDIOL, ACETATE ION, Clathrin heavy chain 1, ...
著者Bulut, H, Horatscheck, A, Krauss, M, Santos, K.F, McCluskey, A, Wahl, C.W, Nazare, M, Haucke, V.
登録日2024-05-28
公開日2024-06-26
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献Acute inhibition of clathrin-mediated endocytosis by next-generation small molecule inhibitors of clathrin function
To Be Published
6DKB
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Crystal structure of Trk-A in complex with the Pan-Trk Kinase Inhibitor, compound 10b.
分子名称: 2-{[(3R,4S)-3-fluoro-1-{[4-(trifluoromethoxy)phenyl]acetyl}piperidin-4-yl]oxy}-5-(1-methyl-1H-imidazol-4-yl)pyridine-3-carboxamide, High affinity nerve growth factor receptor
著者Greasley, S.E, Johnson, E, Kraus, M.L, Cronin, C.N.
登録日2018-05-29
公開日2018-07-11
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (2.68 Å)
主引用文献Discovery of Potent, Selective, and Peripherally Restricted Pan-Trk Kinase Inhibitors for the Treatment of Pain.
J. Med. Chem., 61, 2018
6DKI
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Crystal structure of Trk-A in complex with the Pan-Trk Kinase Inhibitor, compound 19.
分子名称: 5-phenylthieno[2,3-d]pyrimidin-4(3H)-one, 6-amino-5-{[(3S)-4,4-difluoro-1-{[4-(trifluoromethoxy)phenyl]acetyl}pyrrolidin-3-yl]oxy}-N-methylpyridine-3-carboxamide, High affinity nerve growth factor receptor
著者Greasley, S.E, Johnson, E, Kraus, M.L, Cronin, C.N.
登録日2018-05-29
公開日2018-07-11
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (2.11 Å)
主引用文献Discovery of Potent, Selective, and Peripherally Restricted Pan-Trk Kinase Inhibitors for the Treatment of Pain.
J. Med. Chem., 61, 2018
6DKG
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Crystal structure of Trk-A in complex with the Pan-Trk Kinase Inhibitor, compound 13b.
分子名称: 2-{[(3R,4S)-3-fluoro-1-{[4-(trifluoromethoxy)phenyl]acetyl}piperidin-4-yl]oxy}-4-(2-hydroxy-2-methylpropoxy)benzamide, 5-phenylthieno[2,3-d]pyrimidin-4(3H)-one, High affinity nerve growth factor receptor
著者Greasley, S.E, Johnson, E, Kraus, M.L, Cronin, C.N.
登録日2018-05-29
公開日2018-07-11
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (2.53 Å)
主引用文献Discovery of Potent, Selective, and Peripherally Restricted Pan-Trk Kinase Inhibitors for the Treatment of Pain.
J. Med. Chem., 61, 2018
7O40
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Structural basis for VIPP1 oligomerization and maintenance of thylakoid membrane integrity
分子名称: ADENOSINE-5'-DIPHOSPHATE, Protein sll0617
著者Gupta, T.K, Klumpe, S, Gries, K, Strauss, M, Rudack, T, Schuller, J.M, Schroda, M, Engel, B.D.
登録日2021-04-03
公開日2021-06-30
最終更新日2024-07-10
実験手法ELECTRON MICROSCOPY (4.3 Å)
主引用文献Structural basis for VIPP1 oligomerization and maintenance of thylakoid membrane integrity.
Cell, 184, 2021
7O3Y
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Structural basis for VIPP1 oligomerization and maintenance of thylakoid membrane integrity
分子名称: ADENOSINE-5'-DIPHOSPHATE, Protein sll0617
著者Gupta, T.K, Klumpe, S, Gries, K, Strauss, M, Rudack, T, Schuller, J.M, Schroda, M, Engel, B.D.
登録日2021-04-03
公開日2021-06-30
最終更新日2024-07-10
実験手法ELECTRON MICROSCOPY (3.8 Å)
主引用文献Structural basis for VIPP1 oligomerization and maintenance of thylakoid membrane integrity.
Cell, 184, 2021
7O3Z
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Structural basis for VIPP1 oligomerization and maintenance of thylakoid membrane integrity
分子名称: ADENOSINE-5'-DIPHOSPHATE, Protein sll0617
著者Gupta, T.K, Klumpe, S, Gries, K, Strauss, M, Rudack, T, Schuller, J.M, Schroda, M, Engel, B.D.
登録日2021-04-03
公開日2021-06-30
最終更新日2024-07-10
実験手法ELECTRON MICROSCOPY (5 Å)
主引用文献Structural basis for VIPP1 oligomerization and maintenance of thylakoid membrane integrity.
Cell, 184, 2021
7O3W
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BU of 7o3w by Molmil
Structural basis for VIPP1 oligomerization and maintenance of thylakoid membrane integrity
分子名称: ADENOSINE-5'-DIPHOSPHATE, Protein sll0617
著者Gupta, T.K, Klumpe, S, Gries, K, Strauss, M, Rudack, T, Schuller, J.M, Schroda, M, Engel, B.D.
登録日2021-04-03
公開日2021-06-30
最終更新日2024-07-10
実験手法ELECTRON MICROSCOPY (4.9 Å)
主引用文献Structural basis for VIPP1 oligomerization and maintenance of thylakoid membrane integrity.
Cell, 184, 2021
7O3X
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Structural basis for VIPP1 oligomerization and maintenance of thylakoid membrane integrity
分子名称: ADENOSINE-5'-DIPHOSPHATE, Protein sll0617
著者Gupta, T.K, Klumpe, S, Gries, K, Strauss, M, Rudack, T, Schuller, J.M, Schroda, M, Engel, B.D.
登録日2021-04-03
公開日2021-06-30
最終更新日2024-07-10
実験手法ELECTRON MICROSCOPY (3.9 Å)
主引用文献Structural basis for VIPP1 oligomerization and maintenance of thylakoid membrane integrity.
Cell, 184, 2021
7P5M
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Cryo-EM structure of human TTYH2 in lipid nanodiscs
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Protein tweety homolog 2
著者Sukalskaia, A, Straub, M.S, Sawicka, M, Deneka, D, Dutzler, R.
登録日2021-07-14
公開日2021-08-11
最終更新日2021-09-08
実験手法ELECTRON MICROSCOPY (3.92 Å)
主引用文献Cryo-EM structures of the TTYH family reveal a novel architecture for lipid interactions.
Nat Commun, 12, 2021
7P5C
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Cryo-EM structure of human TTYH3 in Ca2+ and GDN
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Protein tweety homolog 3
著者Sukalskaia, A, Straub, M.S, Sawicka, M, Deneka, D, Dutzler, R.
登録日2021-07-14
公開日2021-08-11
最終更新日2021-09-08
実験手法ELECTRON MICROSCOPY (3.2 Å)
主引用文献Cryo-EM structures of the TTYH family reveal a novel architecture for lipid interactions.
Nat Commun, 12, 2021
7P54
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Cryo-EM structure of human TTYH2 in GDN
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Protein tweety homolog 2
著者Sukalskaia, A, Straub, M.S, Sawicka, M, Deneka, D, Dutzler, R.
登録日2021-07-14
公開日2021-08-11
最終更新日2021-09-08
実験手法ELECTRON MICROSCOPY (3.3 Å)
主引用文献Cryo-EM structures of the TTYH family reveal a novel architecture for lipid interactions.
Nat Commun, 12, 2021
7P5J
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Cryo-EM structure of human TTYH1 in GDN
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Protein tweety homolog 1
著者Sukalskaia, A, Straub, M.S, Sawicka, M, Deneka, D, Dutzler, R.
登録日2021-07-14
公開日2021-08-11
最終更新日2021-09-08
実験手法ELECTRON MICROSCOPY (4 Å)
主引用文献Cryo-EM structures of the TTYH family reveal a novel architecture for lipid interactions.
Nat Commun, 12, 2021
4UAQ
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Crystal structure of the accessory translocation ATPase, SecA2, from Mycobacterium tuberculosis
分子名称: Protein translocase subunit SecA 2
著者Swanson-Smith, S, Ioerger, T.R, Rigel, N.W, Miller, B.K, Braunstein, M, Sacchettini, J.C, TB Structural Genomics Consortium (TBSGC)
登録日2014-08-11
公開日2015-09-09
最終更新日2016-02-10
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Structural Similarities and Differences between Two Functionally Distinct SecA Proteins, Mycobacterium tuberculosis SecA1 and SecA2.
J.Bacteriol., 198, 2015
6D1Y
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Crystal structure of Tyrosine-protein kinase receptor in complex with 2,4-dichloro-N-(3-methyl-1-phenyl-1H-pyrazol-5-yl)benzamide Inhibitor
分子名称: 2,4-dichloro-N-(3-methyl-1-phenyl-1H-pyrazol-5-yl)benzamide, High affinity nerve growth factor receptor
著者Greasley, S.E, Johnson, E, Kraus, M.L, Cronin, C.N.
登録日2018-04-12
公開日2018-05-02
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (1.93 Å)
主引用文献Discovery of Allosteric, Potent, Subtype Selective, and Peripherally Restricted TrkA Kinase Inhibitors.
J. Med. Chem., 62, 2019
6D1Z
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Crystal structure of Tyrosine-protein kinase receptor in complex with 5-(4-fluorophenyl)thieno[2,3-d]pyrimidin-4(3H)-one Inhibitor
分子名称: 5-(4-fluorophenyl)thieno[2,3-d]pyrimidin-4(3H)-one, 5-{[5-(6-aminopyridin-2-yl)-2-chlorobenzene-1-carbonyl]amino}-1-phenyl-1H-pyrazole-3-carboxamide, GLYCEROL, ...
著者Greasley, S.E, Johnson, E, Kraus, M.L, Cronin, C.N.
登録日2018-04-12
公開日2018-05-02
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (1.87 Å)
主引用文献Discovery of Allosteric, Potent, Subtype Selective, and Peripherally Restricted TrkA Kinase Inhibitors.
J. Med. Chem., 62, 2019
8BC0
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Cryo-EM structure of Ca2+-bound mTMEM16F F518A Q623A mutant in GDN open/closed
分子名称: Anoctamin-6, CALCIUM ION
著者Arndt, M, Alvadia, C, Straub, M, Clerico-Mosina, V, Paulino, C, Dutzler, R.
登録日2022-10-14
公開日2022-11-16
実験手法ELECTRON MICROSCOPY (3.09 Å)
主引用文献Structural basis for the activation of the lipid scramblase TMEM16F.
Nat Commun, 13, 2022
8EXO
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Crystal structure of PI3K-alpha in complex with compound 19
分子名称: 1-{(4S,11aM)-2-[(4R)-2-oxo-4-(propan-2-yl)-1,3-oxazolidin-3-yl]-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepin-9-yl}-L-prolinamide, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
著者Kiefer, J.R, Eigenbrot, C, Staben, S.T, Hanan, E.J, Wallweber, H.J.A, Ultsch, M, Braun, M.G, Friedman, L.S, Purkey, H.E.
登録日2022-10-25
公開日2022-11-30
最終更新日2024-05-22
実験手法X-RAY DIFFRACTION (2.46 Å)
主引用文献Discovery of GDC-0077 (Inavolisib), a Highly Selective Inhibitor and Degrader of Mutant PI3K alpha.
J.Med.Chem., 65, 2022

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