2QEJ
| Crystal structure of a Staphylococcus aureus protein (SSL7) in complex with Fc of human IgA1 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, GLYCEROL, ... | 著者 | Ramsland, P.A, Willoughby, N, Trist, H.M, Farrugia, W, Hogarth, P.M, Fraser, J.D, Wines, B.D. | 登録日 | 2007-06-26 | 公開日 | 2007-09-18 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | 主引用文献 | Structural basis for evasion of IgA immunity by Staphylococcus aureus revealed in the complex of SSL7 with Fc of human IgA1 Proc.Natl.Acad.Sci.Usa, 104, 2007
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2AGJ
| Crystal Structure of a glycosylated Fab from an IgM cryoglobulin with properties of a natural proteolytic antibody | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Yvo Fab, Heavy Chain, ... | 著者 | Ramsland, P.A, Terzyan, S.S, Cloud, G, Bourne, C.R, Farrugia, W, Tribbick, G, Geysen, H.M, Moomaw, C.R, Slaughter, C.A, Edmundson, A.B. | 登録日 | 2005-07-27 | 公開日 | 2006-05-02 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Crystal structure of a glycosylated Fab from an IgM cryoglobulin with properties of a natural proteolytic antibody Biochem.J., 395, 2006
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1S3K
| Crystal Structure of a Humanized Fab (hu3S193) in Complex with the Lewis Y Tetrasaccharide | 分子名称: | GLYCEROL, HU3S193 Fab fragment, heavy chain, ... | 著者 | Ramsland, P.A, Farrugia, W, Bradford, T.M, Hogarth, P.M, Scott, A.M. | 登録日 | 2004-01-13 | 公開日 | 2004-07-13 | 最終更新日 | 2024-10-30 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Structural convergence of antibody binding of carbohydrate determinants in lewis y tumor antigens J.Mol.Biol., 340, 2004
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3RY4
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3RY6
| Complex of fcgammariia (CD32) and the FC of human IGG1 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, Ig gamma-1 chain C region, ... | 著者 | Ramsland, P.A, Farrugia, W, Scott, A.M, Hogarth, P.M. | 登録日 | 2011-05-11 | 公開日 | 2011-08-31 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (3.8 Å) | 主引用文献 | Structural Basis for Fc{gamma}RIIa Recognition of Human IgG and Formation of Inflammatory Signaling Complexes. J.Immunol., 187, 2011
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3RY5
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1DQL
| CRYSTAL STRUCTURE OF AN UNLIGANDED (NATIVE) FV FROM A HUMAN IGM ANTI-PEPTIDE ANTIBODY | 分子名称: | IGM MEZ IMMUNOGLOBULIN | 著者 | Ramsland, P.A, Shan, L, Moomaw, C.R, Slaughter, C.A, Guddat, L.W, Edmundson, A.B. | 登録日 | 2000-01-04 | 公開日 | 2000-10-04 | 最終更新日 | 2019-12-25 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | An unusual human IgM antibody with a protruding HCDR3 and high avidity for its peptide ligands. Mol.Immunol., 37, 2000
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6UG9
| Complex of ch28/11 Fab and SSEA-4 (hexagonal form) | 分子名称: | N-acetyl-alpha-neuraminic acid-(2-3)-beta-D-galactopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-galactopyranose-(1-3)-alpha-D-galactopyranose-(1-4)-beta-D-galactopyranose-(1-4)-beta-D-glucopyranose, ch28/11 Fab heavy chain, ch28/11 Fab light chain | 著者 | Soliman, C, Ramsland, P.A. | 登録日 | 2019-09-26 | 公開日 | 2019-12-18 | 最終更新日 | 2024-10-30 | 実験手法 | X-RAY DIFFRACTION (2.74 Å) | 主引用文献 | The terminal sialic acid of stage-specific embryonic antigen-4 has a crucial role in binding to a cancer-targeting antibody. J.Biol.Chem., 295, 2020
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6BE2
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3EYV
| Anti-Lewis Y Fab fragment with Lewis Y antigen in the presence of zinc ions | 分子名称: | GLYCEROL, ZINC ION, alpha-L-fucopyranose-(1-2)-beta-D-galactopyranose-(1-4)-[alpha-L-fucopyranose-(1-3)]2-acetamido-2-deoxy-alpha-D-glucopyranose, ... | 著者 | Farrugia, W, Scott, A.M, Ramsland, P.A. | 登録日 | 2008-10-22 | 公開日 | 2009-11-03 | 最終更新日 | 2024-10-09 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | A possible role for metallic ions in the carbohydrate cluster recognition displayed by a lewis y specific antibody. Plos One, 4, 2009
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6UGA
| ch28/11 Fab (monoclinic form) | 分子名称: | ch28/11 Fab heavy chain, ch28/11 Fab light chain, methanesulfonic acid | 著者 | Soliman, C, Ramsland, P.A. | 登録日 | 2019-09-26 | 公開日 | 2019-12-18 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | The terminal sialic acid of stage-specific embryonic antigen-4 has a crucial role in binding to a cancer-targeting antibody. J.Biol.Chem., 295, 2020
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6UG7
| Complex of ch28/11 Fab and SSEA-4 (tetragonal form) | 分子名称: | 1,2-ETHANEDIOL, N-acetyl-alpha-neuraminic acid-(2-3)-beta-D-galactopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-galactopyranose-(1-3)-alpha-D-galactopyranose-(1-4)-beta-D-galactopyranose-(1-4)-beta-D-glucopyranose, SULFATE ION, ... | 著者 | Soliman, C, Ramsland, P.A. | 登録日 | 2019-09-26 | 公開日 | 2019-12-18 | 最終更新日 | 2024-10-16 | 実験手法 | X-RAY DIFFRACTION (1.52 Å) | 主引用文献 | The terminal sialic acid of stage-specific embryonic antigen-4 has a crucial role in binding to a cancer-targeting antibody. J.Biol.Chem., 295, 2020
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6UG8
| Complex of ch28/11 Fab and SSEA-4 (monoclinic form) | 分子名称: | N-acetyl-alpha-neuraminic acid-(2-3)-beta-D-galactopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-galactopyranose-(1-3)-alpha-D-galactopyranose-(1-4)-beta-D-galactopyranose-(1-4)-beta-D-glucopyranose, ch28/11 Fab heavy chain, ch28/11 Fab light chain | 著者 | Soliman, C, Ramsland, P.A. | 登録日 | 2019-09-26 | 公開日 | 2019-12-18 | 最終更新日 | 2024-10-23 | 実験手法 | X-RAY DIFFRACTION (1.89 Å) | 主引用文献 | The terminal sialic acid of stage-specific embryonic antigen-4 has a crucial role in binding to a cancer-targeting antibody. J.Biol.Chem., 295, 2020
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6X5E
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6BE3
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6BE4
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6BZ4
| Human IgG1 lacking complement-dependent cytotoxicity: hu3S193 Fc mutant K322A | 分子名称: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Farrugia, W, Burvenich, I.G.J, Scott, A.M, Ramsland, P.A. | 登録日 | 2017-12-22 | 公開日 | 2018-06-13 | 最終更新日 | 2024-10-23 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Global conformational changes in IgG-Fc upon mutation of the FcRn-binding site are not associated with altered antibody-dependent effector functions. Biochem. J., 475, 2018
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4WI2
| Structural mapping of the human IgG1 binding site for FcRn: hu3S193 Fc (wild-type) | 分子名称: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Ig gamma-1 chain C region | 著者 | Farrugia, W, Burvenich, I.J.G, Scott, A.M, Ramsland, P.A. | 登録日 | 2014-09-25 | 公開日 | 2015-09-30 | 最終更新日 | 2024-10-23 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Structural and functional mapping of human IgG1 binding site for FcRn in vivo using human FcRn transgenic mice To Be Published
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4WI7
| Structural mapping of the human IgG1 binding site for FcRn: hu3S193 Fc mutation H435A | 分子名称: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Ig gamma-1 chain C region | 著者 | Farrugia, W, Burvenich, I.J.G, Scott, A.M, Ramsland, P.A. | 登録日 | 2014-09-25 | 公開日 | 2015-09-30 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Structural and functional mapping of human IgG1 binding site for FcRn in vivo using human FcRn transgenic mice To Be Published
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4WI8
| Structural mapping of the human IgG1 binding site for FcRn: hu3S193 Fc mutation Y436A | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-beta-D-mannopyranose, ... | 著者 | Farrugia, W, Burvenich, I.J.G, Scott, A.M, Ramsland, P.A. | 登録日 | 2014-09-25 | 公開日 | 2015-09-30 | 最終更新日 | 2024-10-09 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Structural and functional mapping of human IgG1 binding site for FcRn in vivo using human FcRn transgenic mice To Be Published
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4WI5
| Structural mapping of the human IgG1 binding site for FcRn: hu3S193 Fc mutation H310A | 分子名称: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Ig gamma-1 chain C region | 著者 | Farrugia, W, Burvenich, I.J.G, Scott, A.M, Ramsland, P.A. | 登録日 | 2014-09-25 | 公開日 | 2015-09-30 | 最終更新日 | 2024-10-16 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Structural and functional mapping of human IgG1 binding site for FcRn in vivo using human FcRn transgenic mice To Be Published
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4WI3
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4WI6
| Structural mapping of the human IgG1 binding site for FcRn: hu3S193 Fc mutation N434A | 分子名称: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Ig gamma-1 chain C region | 著者 | Farrugia, W, Burvenich, I.J.G, Scott, A.M, Ramsland, P.A. | 登録日 | 2014-09-25 | 公開日 | 2015-09-30 | 最終更新日 | 2024-10-23 | 実験手法 | X-RAY DIFFRACTION (2.201 Å) | 主引用文献 | Structural and functional mapping of human IgG1 binding site for FcRn in vivo using human FcRn transgenic mice To Be Published
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4WI4
| Structural mapping of the human IgG1 binding site for FcRn: hu3S193 Fc mutation S254A | 分子名称: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Ig gamma-1 chain C region | 著者 | Farrugia, W, Burvenich, I.J.G, Scott, A.M, Ramsland, P.A. | 登録日 | 2014-09-25 | 公開日 | 2015-09-30 | 最終更新日 | 2024-10-09 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Structural and functional mapping of human IgG1 binding site for FcRn in vivo using human FcRn transgenic mice To Be Published
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4WI9
| Structural mapping of the human IgG1 binding site for FcRn: hu3S193 Fc mutation I253A/H310A | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Ig gamma-1 chain C region, ... | 著者 | Farrugia, W, Burvenich, I.J.G, Scott, A.M, Ramsland, P.A. | 登録日 | 2014-09-25 | 公開日 | 2015-09-30 | 最終更新日 | 2024-10-23 | 実験手法 | X-RAY DIFFRACTION (2.65 Å) | 主引用文献 | Structural and functional mapping of human IgG1 binding site for FcRn in vivo using human FcRn transgenic mice To Be Published
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