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4WI6

Structural mapping of the human IgG1 binding site for FcRn: hu3S193 Fc mutation N434A

Summary for 4WI6
Entry DOI10.2210/pdb4wi6/pdb
Related4WI2 4WI3 4WI4 4WI7 4WI8 4WI9
DescriptorIg gamma-1 chain C region, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, 1,2-ETHANEDIOL, ... (4 entities in total)
Functional Keywordshuman igg1, fcrn binding site, therapeutic antibody, immune system
Biological sourceHomo sapiens (Human)
Total number of polymer chains2
Total formula weight50234.14
Authors
Farrugia, W.,Burvenich, I.J.G.,Scott, A.M.,Ramsland, P.A. (deposition date: 2014-09-25, release date: 2015-09-30, Last modification date: 2023-12-27)
Primary citationBurvenich, I.J.G.,Farrugia, W.,Lee, F.T.,Catimel, B.,Liu, Z.,Makris, D.,Cao, D.,O'Keefe, G.,Brechbiel, M.W.,King, D.,Spirkoska, V.,Allan, L.,Ramsland, P.A.,Scott, A.M.
Structural and functional mapping of human IgG1 binding site for FcRn in vivo using human FcRn transgenic mice
To Be Published,
Experimental method
X-RAY DIFFRACTION (2.201 Å)
Structure validation

217705

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