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PDB: 301 results

8ES4
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BU of 8es4 by Molmil
Focused reconstruction of HRP29 tail
Descriptor: Gp35, Gp39, Gp40, ...
Authors:Subramanian, S, Bergland Drarvik, S.M, Parent, K.N.
Deposit date:2022-10-13
Release date:2023-10-18
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Structure of Shigella bacteriophage HRP29
To Be Published
1Z0H
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BU of 1z0h by Molmil
N-terminal helix reorients in recombinant C-fragment of Clostridium botulinum type B
Descriptor: Botulinum neurotoxin type B
Authors:Jayaraman, S, Eswarmoorthy, S, Ashraf, S.A, Smith, L.A, Swaminathan, S.
Deposit date:2005-03-01
Release date:2005-03-15
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2 Å)
Cite:N-terminal helix reorients in recombinant C-fragment of Clostridium botulinum type B.
Biochem.Biophys.Res.Commun., 330, 2005
1FBB
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BU of 1fbb by Molmil
CRYSTAL STRUCTURE OF NATIVE CONFORMATION OF BACTERIORHODOPSIN
Descriptor: BACTERIORHODOPSIN, RETINAL
Authors:Subramaniam, S, Henderson, R.
Deposit date:2000-07-15
Release date:2000-08-09
Last modified:2018-02-28
Method:ELECTRON CRYSTALLOGRAPHY (3.2 Å)
Cite:Molecular mechanism of vectorial proton translocation by bacteriorhodopsin.
Nature, 406, 2000
3H2Q
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BU of 3h2q by Molmil
Human SOD1 H80R variant, P21 crystal form
Descriptor: SULFATE ION, Superoxide dismutase [Cu-Zn], ZINC ION
Authors:Seetharaman, S.V, Winkler, D.D, Taylor, A.B, Cao, X, Whitson, L.J, Doucette, P.A, Valentine, J.S, Carroll, M.C, Culotta, V.C, Hart, P.J.
Deposit date:2009-04-14
Release date:2010-05-05
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Structures of Pathogenic SOD1 Mutants H80R and D124V: Disrupted Zinc-binding and Compromised Post-translational Modification by the Copper Chaperone CCS
To be Published
3H2P
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BU of 3h2p by Molmil
Human SOD1 D124V Variant
Descriptor: ACETYL GROUP, MALONATE ION, Superoxide dismutase [Cu-Zn], ...
Authors:Seetharaman, S.V, Winkler, D.D, Taylor, A.B, Cao, X, Whitson, L.J, Doucette, P.A, Valentine, J.S, Carroll, M.C, Culotta, V.C, Hart, P.J.
Deposit date:2009-04-14
Release date:2010-05-05
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Structures of Pathogenic SOD1 Mutants H80R and D124V: Disrupted Zinc-binding and Compromised Post-translational Modification by the Copper Chaperone CCS
To be Published
1YXW
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BU of 1yxw by Molmil
A common binding site for disialyllactose and a tri-peptide in the C-fragment of tetanus neurotoxin
Descriptor: GLUTAMIC ACID, TRYPTOPHAN, TYROSINE, ...
Authors:Jayaraman, S, Eswaramoorthy, S, Kumaran, D, Swaminathan, S.
Deposit date:2005-02-22
Release date:2005-03-15
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Common binding site for disialyllactose and tri-peptide in C-fragment of tetanus neurotoxin
Proteins, 61, 2005
3GTV
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BU of 3gtv by Molmil
Human-mouse SOD1 chimera
Descriptor: Superoxide dismutase [Cu-Zn], ZINC ION
Authors:Seetharaman, S.V, Taylor, A.B, Hart, P.J.
Deposit date:2009-03-28
Release date:2010-09-08
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structures of mouse SOD1 and human/mouse SOD1 chimeras.
Arch.Biochem.Biophys., 503, 2010
3GTT
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BU of 3gtt by Molmil
Mouse SOD1
Descriptor: Superoxide dismutase [Cu-Zn], ZINC ION
Authors:Seetharaman, S.V, Taylor, A.B, Hart, P.J.
Deposit date:2009-03-28
Release date:2010-09-08
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structures of mouse SOD1 and human/mouse SOD1 chimeras.
Arch.Biochem.Biophys., 503, 2010
2F9U
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BU of 2f9u by Molmil
HCV NS3 protease domain with NS4a peptide and a ketoamide inhibitor with a P2 norborane
Descriptor: 1,1-DIMETHYLETHYL [1-CYCLOHEXYL-2-[3-[[[1-[2-[[2-[[2-(DIMETHYLAMINO)-2-OXO-1-PHENYLETHYL]AMINO]-2-OXOETHYL]AMINO]-1,2-DIOXOETHYL]PENTYL]AMINO]CARBONYL]-2-AZABICYCLO[2.2.1]HEPTAN-2-YL]-2-OXOETHYL]CARBAMATE, NS3 protease/helicase', ZINC ION, ...
Authors:Venkatraman, S, Njoroge, F.G, Wu, W, Girijavallabhan, V, Prongay, A.J, Butkiewicz, N, Pichardo, J.
Deposit date:2005-12-06
Release date:2006-06-06
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Novel Inhibitors of Hepatitis C NS3-NS4A Serine Protease Derived from 2-Aza-bicyclo[2.2.1]heptane-3-carboxylic acid.
Bioorg.Med.Chem.Lett., 16, 2006
3QQD
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BU of 3qqd by Molmil
Human SOD1 H80R variant, P212121 crystal form
Descriptor: SULFATE ION, Superoxide dismutase [Cu-Zn], ZINC ION
Authors:Seetharaman, S.V, Winkler, D.D, Taylor, A.B, Cao, X, Whitson, L.J, Doucette, P.A, Valentine, J.S, Schirf, V, Demeler, B, Carroll, M.C, Culotta, V.C, Hart, P.J.
Deposit date:2011-02-15
Release date:2011-03-09
Last modified:2023-12-06
Method:X-RAY DIFFRACTION (1.653 Å)
Cite:Disrupted zinc-binding sites in structures of pathogenic SOD1 variants D124V and H80R.
Biochemistry, 49, 2010
3KNX
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BU of 3knx by Molmil
HCV NS3 protease domain with P1-P3 macrocyclic ketoamide inhibitor
Descriptor: (2R)-2-{(3S,13S,16aS,17aR,17bS)-13-[({(1S)-1-[(4,4-dimethyl-2,6-dioxopiperidin-1-yl)methyl]-2,2-dimethylpropyl}carbamoyl)amino]-17,17-dimethyl-1,14-dioxooctadecahydro-2H-cyclopropa[3,4]pyrrolo[1,2-a][1,4]diazacyclohexadecin-3-yl}-2-hydroxy-N-prop-2-en-1-ylethanamide, BETA-MERCAPTOETHANOL, HCV NS3 Protease, ...
Authors:Venkatraman, S, Velazquez, F, Wu, W, Blackman, M, Chen, K.X, Bogen, S, Nair, L, Tong, X, Chase, R, Hart, A, Agrawal, S, Pichardo, J, Prongay, A, Cheng, K.-C, Girijavallabhan, V, Piwinski, J, Shih, N.-Y, Njoroge, F.G.
Deposit date:2009-11-12
Release date:2010-10-27
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Discovery and structure-activity relationship of P1-P3 ketoamide derived macrocyclic inhibitors of hepatitis C virus NS3 protease.
J.Med.Chem., 52, 2009
3EYD
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BU of 3eyd by Molmil
Structure of HCV NS3-4A Protease with an Inhibitor Derived from a Boronic Acid
Descriptor: HCV NS3, HCV NS4a peptide, ZINC ION, ...
Authors:Venkatraman, S, Wu, W, Prongay, A.J, Girijavallabhan, V, Njoroge, F.G.
Deposit date:2008-10-20
Release date:2009-02-10
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Potent inhibitors of HCV-NS3 protease derived from boronic acids.
Bioorg.Med.Chem.Lett., 19, 2009
7KD8
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BU of 7kd8 by Molmil
TtgR C137I I141W M167L F168Y mutant in complex with resveratrol
Descriptor: HTH-type transcriptional regulator TtgR, MAGNESIUM ION, RESVERATROL
Authors:Bingman, C.A, Nishikawa, K.K, Smith, R.W, Raman, S.
Deposit date:2020-10-08
Release date:2021-10-06
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.71 Å)
Cite:Epistasis shapes the fitness landscape of an allosteric specificity switch.
Nat Commun, 12, 2021
7K1A
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BU of 7k1a by Molmil
TtgR quadruple mutant (C137I I141W M167L F168Y)
Descriptor: HTH-type transcriptional regulator TtgR, MAGNESIUM ION
Authors:Bingman, C.A, Nishikawa, K.K, Smith, R.W, Raman, S.
Deposit date:2020-09-07
Release date:2021-10-06
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Epistasis shapes the fitness landscape of an allosteric specificity switch.
Nat Commun, 12, 2021
7K1C
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BU of 7k1c by Molmil
TtgR in complex with resveratrol
Descriptor: HTH-type transcriptional regulator TtgR, MAGNESIUM ION, RESVERATROL
Authors:Bingman, C.A, Nishikawa, K.K, Smith, R.W, Raman, S.
Deposit date:2020-09-07
Release date:2021-10-06
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Epistasis shapes the fitness landscape of an allosteric specificity switch.
Nat Commun, 12, 2021
8ILU
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BU of 8ilu by Molmil
Crystal structure of mouse Galectin-3 in complex with small molecule inhibitor
Descriptor: (2R,3R,4R,5R,6S)-2-(hydroxymethyl)-6-[2-(2-methyl-1,3-benzothiazol-6-yl)-1,2,4-triazol-3-yl]-4-[4-[3,4,5-tris(fluoranyl)phenyl]-1,2,3-triazol-1-yl]oxane-3,5-diol, Galectin-3, SODIUM ION, ...
Authors:Kumar, A, Jinal, S, Raman, S, Ghosh, K.
Deposit date:2023-03-04
Release date:2024-03-06
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Identification of Benzothiazole Derived Monosaccharides as Potent, Selective, and Orally Bioavailable Inhibitors of Human and Mouse Galectin-3
To Be Published
2L15
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BU of 2l15 by Molmil
Solution Structure of Cold Shock Protein CspA Using Combined NMR and CS-Rosetta method
Descriptor: Cold shock protein CspA
Authors:Tang, Y, Schneider, W.M, Shen, Y, Raman, S, Inouye, M, Baker, D, Roth, M.J, Montelione, G.T.
Deposit date:2010-07-22
Release date:2010-09-15
Last modified:2024-05-01
Method:SOLUTION NMR
Cite:Fully automated high-quality NMR structure determination of small (2)H-enriched proteins.
J Struct Funct Genomics, 11, 2010
7XFA
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BU of 7xfa by Molmil
Structure of human Galectin-3 CRD in complex with monosaccharide inhibitor
Descriptor: (2~{S},3~{R},4~{R},5~{R},6~{R})-4-[4-[4-chloranyl-3,5-bis(fluoranyl)phenyl]-1,2,3-triazol-1-yl]-2-[2-[5-chloranyl-2-(trifluoromethyl)phenyl]-5-methyl-1,2,4-triazol-3-yl]-6-(hydroxymethyl)oxane-3,5-diol, Galectin-3
Authors:Shukla, J, Raman, S, Ghosh, K.
Deposit date:2022-04-01
Release date:2022-10-12
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (0.98 Å)
Cite:Identification of Monosaccharide Derivatives as Potent, Selective, and Orally Bioavailable Inhibitors of Human and Mouse Galectin-3.
J.Med.Chem., 65, 2022
4V95
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Crystal structure of YAEJ bound to the 70S ribosome
Descriptor: 16S Ribosomal RNA, 23S Ribosomal RNA, 30S Ribosomal Protein S10, ...
Authors:Gagnon, M.G, Seetharaman, S.V, Bulkley, D.P, Steitz, T.A.
Deposit date:2012-01-27
Release date:2014-07-09
Last modified:2018-07-11
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structural basis for the rescue of stalled ribosomes: structure of YaeJ bound to the ribosome.
Science, 335, 2012
3CQP
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BU of 3cqp by Molmil
Human SOD1 G85R Variant, Structure I
Descriptor: COPPER (II) ION, MALONATE ION, Superoxide dismutase [Cu-Zn], ...
Authors:Cao, X, Antonyuk, S, Seetharaman, S.V, Whitson, L.J, Taylor, A.B, Holloway, S.P, Strange, R.W, Doucette, P.A, Valentine, J.S, Tiwari, A, Hayward, L.J, Padua, S, Cohlberg, J.A, Hasnain, S.S, Hart, P.J.
Deposit date:2008-04-03
Release date:2008-04-29
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structures of the G85R Variant of SOD1 in Familial Amyotrophic Lateral Sclerosis.
J.Biol.Chem., 283, 2008
4UQK
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BU of 4uqk by Molmil
Electron density map of GluA2em in complex with quisqualate and LY451646
Descriptor: (S)-2-AMINO-3-(3,5-DIOXO-[1,2,4]OXADIAZOLIDIN-2-YL)-PROPIONIC ACID, GLUTAMATE RECEPTOR 2
Authors:Meyerson, J.R, Kumar, J, Chittori, S, Rao, P, Pierson, J, Bartesaghi, A, Mayer, M.L, Subramaniam, S.
Deposit date:2014-06-24
Release date:2014-08-13
Last modified:2017-08-02
Method:ELECTRON MICROSCOPY (16.4 Å)
Cite:Structural Mechanism of Glutamate Receptor Activation and Desensitization
Nature, 514, 2014
2GVF
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BU of 2gvf by Molmil
HCV NS3-4A protease domain complexed with a macrocyclic ketoamide inhibitor, SCH419021
Descriptor: (6R,8S,11S)-11-CYCLOHEXYL-N-(1-{[(2-{[(1S)-2-(DIMETHYLAMINO)-2-OXO-1-PHENYLETHYL]AMINO}-2-OXOETHYL)AMINO](OXO)ACETYL}BUTYL)-10,13-DIOXO-2,5-DIOXA-9,12-DIAZATRICYCLO[14.3.1.1~6,9~]HENICOSA-1(20),16,18-TRIENE-8-CARBOXAMIDE, Polyprotein, ZINC ION, ...
Authors:Arasappan, A, Njoroge, F.G, Chen, K.X, Venkatraman, S, Parekh, T.N, Gu, H, Pichardo, J, Butkiewicz, N, Prongay, A, Madison, V, Girijavallabhan, V.
Deposit date:2006-05-02
Release date:2007-01-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:P2-P4 macrocyclic inhibitors of hepatitis C virus NS3-4A serine protease.
Bioorg.Med.Chem.Lett., 16, 2006
4UQ6
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BU of 4uq6 by Molmil
Electron density map of GluA2em in complex with LY451646 and glutamate
Descriptor: GLUTAMATE RECEPTOR 2, GLUTAMIC ACID
Authors:Meyerson, J.R, Kumar, J, Chittori, S, Rao, P, Pierson, J, Bartesaghi, A, Mayer, M.L, Subramaniam, S.
Deposit date:2014-06-20
Release date:2014-08-13
Last modified:2017-08-02
Method:ELECTRON MICROSCOPY (12.8 Å)
Cite:Structural Mechanism of Glutamate Receptor Activation and Desensitization
Nature, 514, 2014
4UQQ
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Electron density map of GluK2 desensitized state in complex with 2S,4R-4-methylglutamate
Descriptor: GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2, GLUTAMIC ACID
Authors:Meyerson, J.R, Kumar, J, Chittori, S, Rao, P, Pierson, J, Bartesaghi, A, Mayer, M.L, Subramaniam, S.
Deposit date:2014-06-24
Release date:2014-08-13
Last modified:2017-08-02
Method:ELECTRON MICROSCOPY (7.6 Å)
Cite:Structural Mechanism of Glutamate Receptor Activation and Desensitization
Nature, 514, 2014
4UQJ
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Cryo-EM density map of GluA2em in complex with ZK200775
Descriptor: GLUTAMATE RECEPTOR 2, {[7-morpholin-4-yl-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2H)-yl]methyl}phosphonic acid
Authors:Meyerson, J.R, Kumar, J, Chittori, S, Rao, P, Pierson, J, Bartesaghi, A, Mayer, M.L, Subramaniam, S.
Deposit date:2014-06-24
Release date:2014-08-13
Last modified:2017-08-02
Method:ELECTRON MICROSCOPY (10.4 Å)
Cite:Structural Mechanism of Glutamate Receptor Activation and Desensitization
Nature, 514, 2014

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