8ILU

Crystal structure of mouse Galectin-3 in complex with small molecule inhibitor

Summary for 8ILU

• Entry DOI: 10.2210/pdb8ilu/pdb
• Descriptor: Galectin-3, (2R,3R,4R,5R,6S)-2-(hydroxymethyl)-6-[2-(2-methyl-1,3-benzothiazol-6-yl)-1,2,4-triazol-3-yl]-4-[4-[3,4,5-tris(fluoranyl)phenyl]-1,2,3-triazol-1-yl]oxane-3,5-diol, THIOCYANATE ION, ... (5 entities in total)
• Functional Keywords: fibrosis, galactose, sugar binding protein
• Biological source: Mus musculus (house mouse)
• Total number of polymer chains: 2
• Total formula weight: 34109.92

Authors

Kumar, A.,Jinal, S.,Raman, S.,Ghosh, K. (deposition date: 2023-03-04, release date: 2024-03-06)

• Primary citation: Ghosh, K.; Identification of Benzothiazole Derived Monosaccharides as Potent, Selective, and Orally Bioavailable Inhibitors of Human and Mouse Galectin-3; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.8 Å)