8ILU
Crystal structure of mouse Galectin-3 in complex with small molecule inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Galectin-3 | polymer | 146 | 16454.9 | 2 | UniProt (P16110) Pfam (PF00337) In PDB | Mus musculus (house mouse) | Gal-3,35 kDa lectin,Carbohydrate-binding protein 35,CBP 35,Galactose-specific lectin 3,IgE-binding protein,L-34 galactoside-binding lectin,Laminin-binding protein,Lectin L-29,Mac-2 antigen |
| 2 | A, B | (2R,3R,4R,5R,6S)-2-(hydroxymethyl)-6-[2-(2-methyl-1,3-benzothiazol-6-yl)-1,2,4-triazol-3-yl]-4-[4-[3,4,5-tris(fluoranyl)phenyl]-1,2,3-triazol-1-yl]oxane-3,5-diol | non-polymer | 559.5 | 2 | Chemie (Q1L) | |||
| 3 | A | THIOCYANATE ION | non-polymer | 58.1 | 1 | Chemie (SCN) | |||
| 4 | A | SODIUM ION | non-polymer | 23.0 | 1 | Chemie (NA) | |||
| 5 | water | water | 18.0 | 193 | Chemie (HOH) |
Sequence modifications
A, B: 122 - 264 (UniProt: P16110)
| PDB | External Database | Details |
|---|---|---|
| Gly 119 | - | expression tag |
| His 120 | - | expression tag |
| Met 121 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 32909.8 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1200.1 | |
| All* | Total formula weight | 34109.9 |
