2F9U

HCV NS3 protease domain with NS4a peptide and a ketoamide inhibitor with a P2 norborane

Summary for 2F9U

Related1A1R 1JXP 2A4G 2A4Q 2A4R 1N1L
DescriptorNS3 protease/helicase', polyprotein, ZINC ION, ... (5 entities in total)
Functional Keywordshcv, hepatitis c protease, ns3 protease, ketoamide inhibitor, viral protein
Biological sourceHepatitis C virus
More
Total number of polymer chains4
Total molecular weight47861.86
Authors
Venkatraman, S.,Njoroge, F.G.,Wu, W.,Girijavallabhan, V.,Prongay, A.J.,Butkiewicz, N.,Pichardo, J. (deposition date: 2005-12-06, release date: 2006-06-06, Last modification date: 2011-07-13)
Primary citation
Venkatraman, S.,Njoroge, F.G.,Wu, W.,Girijavallabhan, V.,Prongay, A.J.,Butkiewicz, N.,Pichardo, J.
Novel Inhibitors of Hepatitis C NS3-NS4A Serine Protease Derived from 2-Aza-bicyclo[2.2.1]heptane-3-carboxylic acid.
Bioorg.Med.Chem.Lett., 16:1628-1632, 2006
PubMed: 16413182 (PDB entries with the same primary citation)
DOI: 10.1016/j.bmcl.2005.12.046
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.6 Å)
NMR Information
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.203151.1%6.5%2.7%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution