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2F9U

HCV NS3 protease domain with NS4a peptide and a ketoamide inhibitor with a P2 norborane

Functional Information from GO Data
ChainGOidnamespacecontents
A0006508biological_processproteolysis
A0008233molecular_functionpeptidase activity
A0008236molecular_functionserine-type peptidase activity
A0016020cellular_componentmembrane
A0016787molecular_functionhydrolase activity
A0019062biological_processvirion attachment to host cell
A0019087biological_processsymbiont-mediated transformation of host cell
A0033644cellular_componenthost cell membrane
A0043657cellular_componenthost cell
A0044423cellular_componentvirion component
A0046718biological_processsymbiont entry into host cell
A0046872molecular_functionmetal ion binding
A0055036cellular_componentvirion membrane
A0097264biological_processself proteolysis
C0006508biological_processproteolysis
C0008233molecular_functionpeptidase activity
C0008236molecular_functionserine-type peptidase activity
C0016020cellular_componentmembrane
C0016787molecular_functionhydrolase activity
C0019062biological_processvirion attachment to host cell
C0019087biological_processsymbiont-mediated transformation of host cell
C0033644cellular_componenthost cell membrane
C0043657cellular_componenthost cell
C0044423cellular_componentvirion component
C0046718biological_processsymbiont entry into host cell
C0046872molecular_functionmetal ion binding
C0055036cellular_componentvirion membrane
C0097264biological_processself proteolysis
Functional Information from PDB Data
site_idAC1
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN A 901
ChainResidue
ACYS97
ACYS99
ACYS145
AHOH1013

site_idAC2
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN C 901
ChainResidue
CCYS97
CCYS99
CCYS145
CHOH902

site_idAC3
Number of Residues15
DetailsBINDING SITE FOR RESIDUE 5NH A 999
ChainResidue
AGLN41
ATHR42
AHIS57
AILE132
ALYS136
AGLY137
ASER138
ASER139
AARG155
AALA156
AALA157
ACYS159
AASP168
AHOH1009
ATHR40

Catalytic Information from CSA
site_idCSA1
Number of Residues4
DetailsAnnotated By Reference To The Literature 1rgq
ChainResidueDetails
AASP81
ASER139
AGLY137
AHIS57

site_idCSA2
Number of Residues4
DetailsAnnotated By Reference To The Literature 1rgq
ChainResidueDetails
CASP81
CSER139
CGLY137
CHIS57

237735

PDB entries from 2025-06-18

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