8A9T
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![BU of 8a9t by Molmil](/molmil-images/mine/8a9t) | Tubulin-[1,2]oxazoloisoindole-1 complex | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, GUANOSINE-5'-DIPHOSPHATE, ... | Authors: | Prota, A.E, Abel, A.-C, Steinmetz, M.O, Barraja, P, Montalbano, A, Spano, V. | Deposit date: | 2022-06-29 | Release date: | 2022-11-09 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.304 Å) | Cite: | Development of [1,2]oxazoloisoindoles tubulin polymerization inhibitors: Further chemical modifications and potential therapeutic effects against lymphomas. Eur.J.Med.Chem., 243, 2022
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8A9Z
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![BU of 8a9z by Molmil](/molmil-images/mine/8a9z) | Tubulin-[1,2]oxazoloisoindole-2e complex | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 7-[(3,5-dimethoxyphenyl)methyl]pyrrolo[3,4-g][1,2]benzoxazole, CALCIUM ION, ... | Authors: | Prota, A.E, Abel, A.-C, Steinmetz, M.O, Barraja, P, Montalbano, A, Spano, V. | Deposit date: | 2022-06-29 | Release date: | 2022-11-09 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.294 Å) | Cite: | Development of [1,2]oxazoloisoindoles tubulin polymerization inhibitors: Further chemical modifications and potential therapeutic effects against lymphomas. Eur.J.Med.Chem., 243, 2022
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5D73
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![BU of 5d73 by Molmil](/molmil-images/mine/5d73) | Structure of Wuchereria bancrofti pi-class glutathione S-transferase | Descriptor: | GLUTATHIONE, Glutathione S-transferase | Authors: | Prince, P.R, Sakthidevi, M, Madhumathi, J, Perbandt, M, Betzel, C, Kaliraj, P. | Deposit date: | 2015-08-13 | Release date: | 2015-11-11 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.33 Å) | Cite: | STRUCTURE OF WUCHERERIA BANCROFTI PI-CLASS GLUTATHIONE S-TRANSFERASE TO BE PUBLISHED
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9EY4
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![BU of 9ey4 by Molmil](/molmil-images/mine/9ey4) | The FK1 domain of FKBP51 in complex with (3S,11S)-12-((3,5-dichlorophenyl)sulfonyl)-5-oxo-11-vinyldecahydro-1H-6,10-epiminopyrrolo[1,2-a]azonine-3-carboxamide | Descriptor: | (1~{S},4~{S},7~{S},8~{S},9~{R})-13-[3,5-bis(chloranyl)phenyl]sulfonyl-8-ethenyl-2-oxidanylidene-3,13-diazatricyclo[7.3.1.0^{3,7}]tridecane-4-carboxamide, Peptidyl-prolyl cis-trans isomerase FKBP5 | Authors: | Meyners, C, Krajczy, P, Hausch, F. | Deposit date: | 2024-04-09 | Release date: | 2024-06-12 | Last modified: | 2024-08-21 | Method: | X-RAY DIFFRACTION (1.16 Å) | Cite: | Structure-Based Design of Ultrapotent Tricyclic Ligands for FK506-Binding Proteins. Chemistry, 30, 2024
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9EY3
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![BU of 9ey3 by Molmil](/molmil-images/mine/9ey3) | The FK1 domain of FKBP51 in complex with (3S,11S,11aS)-12-((3,5-dichlorophenyl)sulfonyl)-5-oxo-11-vinyldecahydro-1H-6,10-epiminopyrrolo[1,2-a]azonine-3-carboxylic acid | Descriptor: | (1~{S},4~{S},7~{S},8~{S},9~{R})-13-[3,5-bis(chloranyl)phenyl]sulfonyl-8-ethenyl-2-oxidanylidene-3,13-diazatricyclo[7.3.1.0^{3,7}]tridecane-4-carboxylic acid, Peptidyl-prolyl cis-trans isomerase FKBP5 | Authors: | Meyners, C, Krajczy, P, Hausch, F. | Deposit date: | 2024-04-09 | Release date: | 2024-06-12 | Last modified: | 2024-08-21 | Method: | X-RAY DIFFRACTION (1.16 Å) | Cite: | Structure-Based Design of Ultrapotent Tricyclic Ligands for FK506-Binding Proteins. Chemistry, 30, 2024
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1BG5
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![BU of 1bg5 by Molmil](/molmil-images/mine/1bg5) | CRYSTAL STRUCTURE OF THE ANKYRIN BINDING DOMAIN OF ALPHA-NA,K-ATPASE AS A FUSION PROTEIN WITH GLUTATHIONE S-TRANSFERASE | Descriptor: | FUSION PROTEIN OF ALPHA-NA,K-ATPASE WITH GLUTATHIONE S-TRANSFERASE | Authors: | Zhang, Z, Devarajan, P, Morrow, J.S. | Deposit date: | 1998-06-05 | Release date: | 1999-01-13 | Last modified: | 2024-05-22 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Structure of the ankyrin-binding domain of alpha-Na,K-ATPase. J.Biol.Chem., 273, 1998
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1JEM
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![BU of 1jem by Molmil](/molmil-images/mine/1jem) | NMR STRUCTURE OF HISTIDINE PHOSPHORYLATED FORM OF THE PHOSPHOCARRIER HISTIDINE CONTAINING PROTEIN FROM BACILLUS SUBTILIS, NMR, 25 STRUCTURES | Descriptor: | HISTIDINE CONTAINING PROTEIN | Authors: | Jones, B.E, Rajagopal, P, Klevit, R.E. | Deposit date: | 1997-04-01 | Release date: | 1997-07-23 | Last modified: | 2021-11-03 | Method: | SOLUTION NMR | Cite: | Phosphorylation on histidine is accompanied by localized structural changes in the phosphocarrier protein, HPr from Bacillus subtilis. Protein Sci., 6, 1997
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3J07
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![BU of 3j07 by Molmil](/molmil-images/mine/3j07) | Model of a 24mer alphaB-crystallin multimer | Descriptor: | Alpha-crystallin B chain | Authors: | Jehle, S, Vollmar, B, Bardiaux, B, Dove, K.K, Rajagopal, P, Gonen, T, Oschkinat, H, Klevit, R.E. | Deposit date: | 2011-04-27 | Release date: | 2016-01-20 | Last modified: | 2024-05-01 | Method: | ELECTRON MICROSCOPY (20 Å), SOLID-STATE NMR, SOLUTION SCATTERING | Cite: | N-terminal domain of {alpha}B-crystallin provides a conformational switch for multimerization and structural heterogeneity. Proc.Natl.Acad.Sci.USA, 108, 2011
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2HID
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2K31
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![BU of 2k31 by Molmil](/molmil-images/mine/2k31) | Solution Structure of cGMP-binding GAF domain of Phosphodiesterase 5 | Descriptor: | GUANOSINE-3',5'-MONOPHOSPHATE, Phosphodiesterase 5A, cGMP-specific | Authors: | Heikaus, C.C, Stout, J.R, Sekharan, M.R, Eakin, C.M, Rajagopal, P, Brzovic, P.S, Beavo, J.A, Klevit, R.E. | Deposit date: | 2008-04-16 | Release date: | 2008-06-03 | Last modified: | 2024-05-08 | Method: | SOLUTION NMR | Cite: | Solution Structure of the cGMP Binding GAF Domain from Phosphodiesterase 5: Insights into Nucleotide Selectivity, Dimerization, and cGMP-Dependent Conformational Change. J.Biol.Chem., 283, 2008
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1JM7
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![BU of 1jm7 by Molmil](/molmil-images/mine/1jm7) | Solution structure of the BRCA1/BARD1 RING-domain heterodimer | Descriptor: | BRCA1-ASSOCIATED RING DOMAIN PROTEIN 1, BREAST CANCER TYPE 1 SUSCEPTIBILITY PROTEIN, ZINC ION | Authors: | Brzovic, P.S, Rajagopal, P, Hoyt, D.W, King, M.-C, Klevit, R.E. | Deposit date: | 2001-07-17 | Release date: | 2001-10-03 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Structure of a BRCA1-BARD1 heterodimeric RING-RING complex. Nat.Struct.Biol., 8, 2001
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2JRF
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![BU of 2jrf by Molmil](/molmil-images/mine/2jrf) | Solution NMR structure of Tubulin polymerization-promoting protein family member 3 from Homo sapiens. Northeast Structural Genomics target HR387. | Descriptor: | Tubulin polymerization-promoting protein family member 3 | Authors: | Aramini, J.M, Rossi, P, Shastry, R, Nwosu, C, Cunningham, K, Xiao, R, Liu, J, Baran, M.C, Rajan, P.K, Acton, T.B, Rost, B, Montelione, G.T, Northeast Structural Genomics Consortium (NESG) | Deposit date: | 2007-06-25 | Release date: | 2007-07-17 | Last modified: | 2023-12-20 | Method: | SOLUTION NMR | Cite: | Solution NMR structure of Tubulin polymerization-promoting protein family member 3 from Homo sapiens. To be Published
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1DFF
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![BU of 1dff by Molmil](/molmil-images/mine/1dff) | PEPTIDE DEFORMYLASE | Descriptor: | PEPTIDE DEFORMYLASE, ZINC ION | Authors: | Chan, M.K, Gong, W, Rajagopalan, P.T.R, Hao, B, Tsai, C.M, Pei, D. | Deposit date: | 1997-08-19 | Release date: | 1998-09-02 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.88 Å) | Cite: | Crystal structure of the Escherichia coli peptide deformylase. Biochemistry, 36, 1997
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1KKG
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![BU of 1kkg by Molmil](/molmil-images/mine/1kkg) | NMR Structure of Ribosome-Binding Factor A (RbfA) | Descriptor: | ribosome-binding factor A | Authors: | Huang, Y.J, Swapna, G.V.T, Rajan, P.K, Ke, H, Xia, B, Shukla, K, Inouye, M, Montelione, G.T, Northeast Structural Genomics Consortium (NESG) | Deposit date: | 2001-12-07 | Release date: | 2003-03-18 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Solution NMR Structure of Ribosome-binding Factor A (RbfA), A Cold-shock
Adaptation Protein from Escherichia coli J.Mol.Biol., 327, 2003
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1LO6
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![BU of 1lo6 by Molmil](/molmil-images/mine/1lo6) | Human Kallikrein 6 (hK6) active form with benzamidine inhibitor at 1.56 A resolution | Descriptor: | BENZAMIDINE, Kallikrein 6, MAGNESIUM ION | Authors: | Bernett, M.J, Blaber, S.I, Scarisbrick, I.A, Dhanarajan, P, Thompson, S.M, Blaber, M. | Deposit date: | 2002-05-06 | Release date: | 2002-05-15 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (1.56 Å) | Cite: | Crystal structure and biochemical characterization of human kallikrein 6 reveals a
trypsin-like kallikrein is expressed in the central nervous system To be Published
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2KLR
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![BU of 2klr by Molmil](/molmil-images/mine/2klr) | Solid-state NMR structure of the alpha-crystallin domain in alphaB-crystallin oligomers | Descriptor: | Alpha-crystallin B chain | Authors: | Jehle, S, Rajagopal, P, Markovic, S, Bardiaux, B, Kuehne, R, Higman, V.A, Klevit, R.E, van Rossum, B, Oschkinat, H. | Deposit date: | 2009-07-08 | Release date: | 2010-07-07 | Last modified: | 2024-05-01 | Method: | SOLID-STATE NMR | Cite: | Solid-state NMR and SAXS studies provide a structural basis for the activation of alphaB-crystallin oligomers. Nat.Struct.Mol.Biol., 17, 2010
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