7LQD
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![BU of 7lqd by Molmil](/molmil-images/mine/7lqd) | Structure of Human MPS1 (TTK) covalently bound to RMS-07 inhibitor | Descriptor: | 2-[2-(2-METHOXY-ETHOXY)-ETHOXY]-ETHOXYL, Dual specificity protein kinase TTK or monopolar spindle 1 kinase, GLYCEROL, ... | Authors: | Santiago, A.S, dos Reis, C.V, Serafim, R.A.M, Massirer, K.B, Arruda, P, Edwards, A.M, Counago, R.M, Structural Genomics Consortium (SGC) | Deposit date: | 2021-02-13 | Release date: | 2022-02-16 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Development of the First Covalent Monopolar Spindle Kinase 1 (MPS1/TTK) Inhibitor. J.Med.Chem., 65, 2022
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2ID7
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![BU of 2id7 by Molmil](/molmil-images/mine/2id7) | 1.75 A Structure of T87I Phosphono-CheY | Descriptor: | Chemotaxis protein cheY | Authors: | Halkides, C.J, Haas, R.M, McAdams, K.A, Casper, E.S, Santarsiero, B.D, Mesecar, A.D. | Deposit date: | 2006-09-14 | Release date: | 2007-09-25 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | The structures of T87I phosphono-CheY and T87I/Y106W phosphono-CheY help to explain their binding affinities to the FliM and CheZ peptides. Arch.Biochem.Biophys., 479, 2008
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2IFI
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![BU of 2ifi by Molmil](/molmil-images/mine/2ifi) | Ala6 Variant of ImI Conotoxin | Descriptor: | Alpha-conotoxin ImI | Authors: | Kini, R.M, Kang, T.S. | Deposit date: | 2006-09-21 | Release date: | 2007-08-14 | Last modified: | 2020-06-24 | Method: | SOLUTION NMR | Cite: | Protein folding determinants: structural features determining alternative disulfide pairing in alpha- and chi/lambda-conotoxins Biochemistry, 46, 2007
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2IFZ
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![BU of 2ifz by Molmil](/molmil-images/mine/2ifz) | Lys6 Variant of ImI Conotoxin | Descriptor: | Alpha-conotoxin ImI | Authors: | Kini, R.M, Kang, T.S. | Deposit date: | 2006-09-22 | Release date: | 2007-08-14 | Last modified: | 2020-06-24 | Method: | SOLUTION NMR | Cite: | Protein folding determinants: structural features determining alternative disulfide pairing in alpha- and chi/lambda-conotoxins Biochemistry, 46, 2007
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2IHW
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![BU of 2ihw by Molmil](/molmil-images/mine/2ihw) | Crystal structure of a cubic core of the dihydrolipoamide acyltransferase (E2b) component in the branched-chain alpha-ketoacid dehydrogenase complex (BCKDC), apo form | Descriptor: | ACETATE ION, CHLORIDE ION, Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex | Authors: | Kato, M, Wynn, R.M, Chuang, J.L, Brautigam, C.A, Custorio, M, Chuang, D.T. | Deposit date: | 2006-09-27 | Release date: | 2006-12-26 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | A synchronized substrate-gating mechanism revealed by cubic-core structure of the bovine branched-chain alpha-ketoacid dehydrogenase complex. Embo J., 25, 2006
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2IS9
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![BU of 2is9 by Molmil](/molmil-images/mine/2is9) | Structure of yeast DCN-1 | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CHLORIDE ION, Defective in cullin neddylation protein 1, ... | Authors: | Yang, X, Zhou, J, Sun, L, Wei, Z, Gao, J, Gong, W, Xu, R.M, Rao, Z, Liu, Y. | Deposit date: | 2006-10-16 | Release date: | 2007-06-26 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.92 Å) | Cite: | Structural basis for the function of DCN-1 in protein Neddylation. J.Biol.Chem., 282, 2007
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8D4F
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![BU of 8d4f by Molmil](/molmil-images/mine/8d4f) | beta-Arf1 mediated dimeric assembly of AP-1, Arf1, Nef complex within lattice on MHC-I lipopeptide incorporated wide(r) membrane tubes | Descriptor: | ADP-ribosylation factor 1, AP-1 complex subunit beta-1, AP-1 complex subunit gamma-1, ... | Authors: | Hooy, R.M, Hurley, J.H. | Deposit date: | 2022-06-01 | Release date: | 2023-06-14 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (9.8 Å) | Cite: | Self-assembly and structure of a clathrin-independent AP-1:Arf1 tubular membrane coat. Sci Adv, 8, 2022
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8D4E
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![BU of 8d4e by Molmil](/molmil-images/mine/8d4e) | Asymmetric unit of AP-1, Arf1, Nef lattice on MHC-I lipopeptide incorporated wide(r) membrane tubes | Descriptor: | ADP-ribosylation factor 1, AP-1 complex subunit beta-1, AP-1 complex subunit gamma-1, ... | Authors: | Hooy, R.M, Hurley, J.H. | Deposit date: | 2022-06-01 | Release date: | 2023-06-14 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (9.2 Å) | Cite: | Self-assembly and structure of a clathrin-independent AP-1:Arf1 tubular membrane coat. Sci Adv, 8, 2022
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8D4G
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![BU of 8d4g by Molmil](/molmil-images/mine/8d4g) | gamma-Arf1 mediated dimeric assembly of AP-1, Arf1, Nef complex within lattice on MHC-I lipopeptide incorporated wide(r) membrane tubes | Descriptor: | ADP-ribosylation factor 1, AP-1 complex subunit beta-1, AP-1 complex subunit gamma-1, ... | Authors: | Hooy, R.M, Hurley, J.H. | Deposit date: | 2022-06-01 | Release date: | 2023-06-14 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (11.6 Å) | Cite: | Self-assembly and structure of a clathrin-independent AP-1:Arf1 tubular membrane coat. Sci Adv, 8, 2022
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1TQY
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![BU of 1tqy by Molmil](/molmil-images/mine/1tqy) | The Actinorhodin Ketosynthase/Chain Length Factor | Descriptor: | ACETYL GROUP, Actinorhodin polyketide putative beta-ketoacyl synthase 1, Actinorhodin polyketide putative beta-ketoacyl synthase 2, ... | Authors: | Keatinge-Clay, A.T, Maltby, D.A, Medzihradszky, K.F, Khosla, C, Stroud, R.M. | Deposit date: | 2004-06-18 | Release date: | 2004-07-27 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | An antibiotic factory caught in action. Nat.Struct.Mol.Biol., 11, 2004
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8D4D
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![BU of 8d4d by Molmil](/molmil-images/mine/8d4d) | gamma-Arf1 mediated dimeric assembly of AP-1, Arf1, Nef complex within lattice on MHC-I lipopeptide incorporated narrow membrane tubes | Descriptor: | ADP-ribosylation factor 1, AP-1 complex subunit beta-1, AP-1 complex subunit gamma-1, ... | Authors: | Hooy, R.M, Hurley, J.H. | Deposit date: | 2022-06-01 | Release date: | 2023-06-14 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (9.6 Å) | Cite: | Self-assembly and structure of a clathrin-independent AP-1:Arf1 tubular membrane coat. Sci Adv, 8, 2022
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2J9F
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![BU of 2j9f by Molmil](/molmil-images/mine/2j9f) | Human branched-chain alpha-ketoacid dehydrogenase-decarboxylase E1b | Descriptor: | 2-OXOISOVALERATE DEHYDROGENASE ALPHA SUBUNIT, 2-OXOISOVALERATE DEHYDROGENASE BETA SUBUNIT, C2-1-HYDROXY-3-METHYL-PROPYL-THIAMIN DIPHOSPHATE, ... | Authors: | Jun, L, Machius, M, Chuang, J.L, Wynn, R.M, Chuang, D.T. | Deposit date: | 2006-11-07 | Release date: | 2007-02-27 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.88 Å) | Cite: | The Two Active Sites in Human Branched-Chain Alpha- Keto Acid Dehydrogenase Operate Independently without an Obligatory Alternating-Site Mechanism. J.Biol.Chem., 282, 2007
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8D4C
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![BU of 8d4c by Molmil](/molmil-images/mine/8d4c) | beta-Arf1 mediated dimeric assembly of AP-1, Arf1, Nef complex within lattice on MHC-I lipopeptide incorporated narrow membrane tubes | Descriptor: | ADP-ribosylation factor 1, AP-1 complex subunit beta-1, AP-1 complex subunit gamma-1, ... | Authors: | Hooy, R.M, Hurley, J.H. | Deposit date: | 2022-06-01 | Release date: | 2023-06-14 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (9.3 Å) | Cite: | Self-assembly and structure of a clathrin-independent AP-1:Arf1 tubular membrane coat. Sci Adv, 8, 2022
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2IH7
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![BU of 2ih7 by Molmil](/molmil-images/mine/2ih7) | Amidated Pro6 Analogue of CMrVIA conotoxin | Descriptor: | Lambda-conotoxin CMrVIA | Authors: | Kini, R.M, Kang, T.S. | Deposit date: | 2006-09-26 | Release date: | 2007-08-14 | Last modified: | 2020-06-24 | Method: | SOLUTION NMR | Cite: | Protein folding determinants: structural features determining alternative disulfide pairing in alpha- and chi/lambda-conotoxins Biochemistry, 46, 2007
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5U3X
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![BU of 5u3x by Molmil](/molmil-images/mine/5u3x) | Human PPARdelta ligand-binding domain in complexed with specific agonist 8 | Descriptor: | 6-[2-({cyclopropyl[4-(pyridin-3-yl)benzene-1-carbonyl]amino}methyl)phenoxy]hexanoic acid, DI(HYDROXYETHYL)ETHER, Peroxisome proliferator-activated receptor delta, ... | Authors: | Wu, C.-C, Baiga, T.J, Downes, M, La Clair, J.J, Atkins, A.R, Richard, S.B, Stockley-Noel, T.A, Bowman, M.E, Evans, R.M, Noel, J.P. | Deposit date: | 2016-12-03 | Release date: | 2017-03-22 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structural basis for specific ligation of the peroxisome proliferator-activated receptor delta. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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1TRG
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![BU of 1trg by Molmil](/molmil-images/mine/1trg) | E. COLI THYMIDYLATE SYNTHASE IN SYMMETRIC COMPLEX WITH CB3717 AND 2'-DEOXYURIDINE 5'-MONOPHOSPHATE (DUMP) | Descriptor: | 10-PROPARGYL-5,8-DIDEAZAFOLIC ACID, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, THYMIDYLATE SYNTHASE | Authors: | Stout, T.J, Sage, C.R, Stroud, R.M. | Deposit date: | 1998-05-21 | Release date: | 1998-08-12 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | The additivity of substrate fragments in enzyme-ligand binding. Structure, 6, 1998
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1TZ7
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![BU of 1tz7 by Molmil](/molmil-images/mine/1tz7) | Aquifex aeolicus amylomaltase | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, 4-alpha-glucanotransferase | Authors: | Barends, T.R.M, Korf, H, Kaper, T, van der Maarel, M.J.E.C, Dijkhuizen, L, Dijkstra, B.W. | Deposit date: | 2004-07-09 | Release date: | 2005-08-02 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | Structural influences on product specificity in amylomaltase from Aquifex aeolicus TO BE PUBLISHED
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7LSO
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![BU of 7lso by Molmil](/molmil-images/mine/7lso) | L-Phenylseptin | Descriptor: | L-Phenylseptin peptide | Authors: | Munhoz, V.H, Verly, R.M. | Deposit date: | 2021-02-18 | Release date: | 2022-11-30 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | NMR structure of L-Phenylseptin in DPC-d38. To Be Published
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7LSP
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![BU of 7lsp by Molmil](/molmil-images/mine/7lsp) | |
2INY
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![BU of 2iny by Molmil](/molmil-images/mine/2iny) | |
1QR0
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![BU of 1qr0 by Molmil](/molmil-images/mine/1qr0) | CRYSTAL STRUCTURE OF THE 4'-PHOSPHOPANTETHEINYL TRANSFERASE SFP-COENZYME A COMPLEX | Descriptor: | 4'-PHOSPHOPANTETHEINYL TRANSFERASE SFP, COENZYME A, MAGNESIUM ION | Authors: | Reuter, K, Mofid, R.M, Marahiel, A.M, Ficner, R. | Deposit date: | 1999-06-17 | Release date: | 1999-12-10 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Crystal structure of the surfactin synthetase-activating enzyme sfp: a prototype of the 4'-phosphopantetheinyl transferase superfamily. EMBO J., 18, 1999
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1TSY
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![BU of 1tsy by Molmil](/molmil-images/mine/1tsy) | THYMIDYLATE SYNTHASE R179K MUTANT | Descriptor: | 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, THYMIDYLATE SYNTHASE | Authors: | Finer-Moore, J, Stroud, R.M. | Deposit date: | 1995-12-05 | Release date: | 1996-03-08 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Contribution of a salt bridge to binding affinity and dUMP orientation to catalytic rate: mutation of a substrate-binding arginine in thymidylate synthase. Protein Eng., 9, 1996
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1TSV
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![BU of 1tsv by Molmil](/molmil-images/mine/1tsv) | THYMIDYLATE SYNTHASE R179A MUTANT | Descriptor: | 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, THYMIDYLATE SYNTHASE | Authors: | Finer-Moore, J, Stroud, R.M. | Deposit date: | 1995-12-05 | Release date: | 1996-03-08 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Contribution of a salt bridge to binding affinity and dUMP orientation to catalytic rate: mutation of a substrate-binding arginine in thymidylate synthase. Protein Eng., 9, 1996
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7MTO
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![BU of 7mto by Molmil](/molmil-images/mine/7mto) | |
2IST
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![BU of 2ist by Molmil](/molmil-images/mine/2ist) | |