5IN9
| Crystal structure of Grp94 bound to methyl 3-chloro-2-(2-(1-((5-chlorofuran-2-yl)methyl)-1H-imidazol-2-yl)ethyl)-4,6-dihydroxybenzoate, an inhibitor based on the BnIm and Radamide scaffolds. | 分子名称: | Endoplasmin, GLYCEROL, TRIETHYLENE GLYCOL, ... | 著者 | Lieberman, R.L, Huard, D.J.E, Kizziah, J.L. | 登録日 | 2016-03-07 | 公開日 | 2016-05-04 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Development of Glucose Regulated Protein 94-Selective Inhibitors Based on the BnIm and Radamide Scaffold. J.Med.Chem., 59, 2016
|
|
1AE6
| IGG-FAB FRAGMENT OF MOUSE MONOCLONAL ANTIBODY CTM01 | 分子名称: | IGG CTM01 FAB (HEAVY CHAIN), IGG CTM01 FAB (LIGHT CHAIN) | 著者 | Banfield, M.J, Brady, R.L. | 登録日 | 1997-03-06 | 公開日 | 1998-03-18 | 最終更新日 | 2023-08-02 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | VL:VH domain rotations in engineered antibodies: crystal structures of the Fab fragments from two murine antitumor antibodies and their engineered human constructs. Proteins, 29, 1997
|
|
1CDC
| CD2, N-TERMINAL DOMAIN (1-99), TRUNCATED FORM | 分子名称: | CD2 | 著者 | Murray, A.J, Barclay, A.N, Brady, R.L. | 登録日 | 1995-05-23 | 公開日 | 1995-09-15 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | One sequence, two folds: a metastable structure of CD2. Proc.Natl.Acad.Sci.USA, 92, 1995
|
|
1C8T
| HUMAN STROMELYSIN-1 (E202Q) CATALYTIC DOMAIN COMPLEXED WITH RO-26-2812 | 分子名称: | 2-(2-{2-[(BIPHENYL-4-YLMETHYL)-AMINO]-3-MERCAPTO-PENTANOYLAMINO}-ACETYLAMINO)-3-METHYL-BUTYRIC ACID METHYL ESTER, CALCIUM ION, STROMELYSIN-1, ... | 著者 | Steele, D.L, el-Kabbani, O, Dunten, P, Crowther, R.L. | 登録日 | 1999-07-29 | 公開日 | 2000-07-19 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Expression, characterization and structure determination of an active site mutant (Glu202-Gln) of mini-stromelysin-1. Protein Eng., 13, 2000
|
|
6XSS
| CryoEM structure of designed helical fusion protein C4_nat_HFuse-7900 | 分子名称: | C4_nat_HFuse-7900 | 著者 | Redler, R.L, Edman, N.I, Baker, D, Ekiert, D, Bhabha, G. | 登録日 | 2020-07-16 | 公開日 | 2020-12-23 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | 主引用文献 | Design of multi-scale protein complexes by hierarchical building block fusion. Nat Commun, 12, 2021
|
|
5JHB
| Structure of Phosphoinositide 3-kinase gamma (PI3K) bound to the potent inhibitor PIKin3 | 分子名称: | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, SULFATE ION, [1-{4-[6-amino-4-(trifluoromethyl)pyridin-3-yl]-6-(morpholin-4-yl)-1,3,5-triazin-2-yl}-3-(chloromethyl)azetidin-3-yl]methanol | 著者 | Burke, J.E, Inglis, A.J, Williams, R.L. | 登録日 | 2016-04-20 | 公開日 | 2017-03-15 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.48 Å) | 主引用文献 | Deconvolution of Buparlisib's mechanism of action defines specific PI3K and tubulin inhibitors for therapeutic intervention. Nat Commun, 8, 2017
|
|
1CID
| |
5J74
| Fluorogen activating protein AM2.2 in complex with TO1-2p | 分子名称: | 1-(17-amino-5,8-dioxo-12,15-dioxa-4,9-diazaheptadecan-1-yl)-4-{[3-(3-sulfopropyl)-1,3-benzothiazol-3-ium-2-yl]methyl}quinolin-1-ium, PHOSPHATE ION, scFv AM2.2 | 著者 | Stanfield, R.L, Wilson, I.A, Wu, Y. | 登録日 | 2016-04-05 | 公開日 | 2016-05-25 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Discovery of Small-Molecule Nonfluorescent Inhibitors of Fluorogen-Fluorogen Activating Protein Binding Pair. J Biomol Screen, 21, 2016
|
|
5J8D
| Structure of nitroreductase from E. cloacae complexed with nicotinic acid adenine dinucleotide | 分子名称: | FLAVIN MONONUCLEOTIDE, NICOTINIC ACID ADENINE DINUCLEOTIDE, Oxygen-insensitive NAD(P)H nitroreductase | 著者 | Haynes, C.A, Koder, R.L, Miller, A.F, Rodgers, D.W. | 登録日 | 2016-04-07 | 公開日 | 2017-05-17 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Mechanism-Informed Refinement Reveals Altered Substrate-Binding Mode for Catalytically Competent Nitroreductase. Structure, 25, 2017
|
|
1CSJ
| CRYSTAL STRUCTURE OF THE RNA-DEPENDENT RNA POLYMERASE OF HEPATITIS C VIRUS | 分子名称: | HEPATITIS C VIRUS RNA POLYMERASE (NS5B) | 著者 | Bressanelli, S, Tomei, L, Roussel, A, Incitti, I, Vitale, R.L, Mathieu, M, De Francesco, R, Rey, F.A. | 登録日 | 1999-08-18 | 公開日 | 1999-11-08 | 最終更新日 | 2013-02-13 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Crystal structure of the RNA-dependent RNA polymerase of hepatitis C virus. Proc.Natl.Acad.Sci.USA, 96, 1999
|
|
6Y33
| Streptavidin mutant S112R with a biotC5-1 cofactor - an artificial iron hydroxylase | 分子名称: | GLYCEROL, Streptavidin, biotC5-1 cofactor | 著者 | Serrano-Plana, J, Rumo, C, Rebelein, J.G, Peterson, R.L, Barnet, M, Ward, T.R. | 登録日 | 2020-02-17 | 公開日 | 2020-07-01 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.49 Å) | 主引用文献 | Enantioselective Hydroxylation of Benzylic C(sp3)-H Bonds by an Artificial Iron Hydroxylase Based on the Biotin-Streptavidin Technology. J.Am.Chem.Soc., 142, 2020
|
|
7BIM
| A de novo designed nonameric coiled coil, CC-Type2-(GgLaId)4 | 分子名称: | GLYCEROL, ISOPROPYL ALCOHOL, Nonameric de novo coiled coil CC-Type2-(GgLaId)4 | 著者 | Shelley, K.L, Rhys, G.G, Dawson, W.M, Brady, R.L, Woolfson, D.N. | 登録日 | 2021-01-12 | 公開日 | 2021-04-21 | 最終更新日 | 2021-11-17 | 実験手法 | X-RAY DIFFRACTION (1.64 Å) | 主引用文献 | Coiled coils 9-to-5: rational de novo design of alpha-helical barrels with tunable oligomeric states. Chem Sci, 12, 2021
|
|
7BAT
| A hexameric barrel state of a de novo coiled-coil assembly: CC-Type2-(GgIaId)4 | 分子名称: | CC-Type2-(GgIaId)4, N-PROPANOL | 著者 | Martin, F.J.O, Dawson, W.M, Shelley, K, Brady, R.L, Woolfson, D.N. | 登録日 | 2020-12-16 | 公開日 | 2021-04-28 | 最終更新日 | 2021-11-17 | 実験手法 | X-RAY DIFFRACTION (1.77 Å) | 主引用文献 | Coiled coils 9-to-5: rational de novo design of alpha-helical barrels with tunable oligomeric states. Chem Sci, 12, 2021
|
|
7BAS
| A de novo pentameric coiled-coil assembly: CC-Type2-(TgLaId)4-W19BrPhe. | 分子名称: | CC-Type2-(TgLaId)4-W19BrPhe. | 著者 | Martin, F.J.O, Dawson, W.M, Shelley, K, Brady, R.L, Woolfson, D.N. | 登録日 | 2020-12-16 | 公開日 | 2021-04-28 | 最終更新日 | 2021-11-17 | 実験手法 | X-RAY DIFFRACTION (1.1 Å) | 主引用文献 | Coiled coils 9-to-5: rational de novo design of alpha-helical barrels with tunable oligomeric states. Chem Sci, 12, 2021
|
|
7BAU
| A de novo pentameric coiled-coil assembly: CC-Type2-(TgIaId)4-W19BrPhe. | 分子名称: | CC-Type2-(TgLaId)4-W19BrPhe. | 著者 | Martin, F.J.O, Dawson, W.M, Shelley, K, Brady, R.L, Woolfson, D.N. | 登録日 | 2020-12-16 | 公開日 | 2021-04-28 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.42 Å) | 主引用文献 | Coiled coils 9-to-5: rational de novo design of alpha-helical barrels with tunable oligomeric states. Chem Sci, 12, 2021
|
|
7BAV
| A de novo pentameric coiled-coil assembly: CC-Type2-(TgLaId)4-W19BrPhe. | 分子名称: | CC-Type2-(TgLaId)4-W19BrPhe | 著者 | Martin, F.J.O, Dawson, W.M, Shelley, K, Brady, R.L, Woolfson, D.N. | 登録日 | 2020-12-16 | 公開日 | 2021-04-28 | 最終更新日 | 2021-11-17 | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | 主引用文献 | Coiled coils 9-to-5: rational de novo design of alpha-helical barrels with tunable oligomeric states. Chem Sci, 12, 2021
|
|
7BAW
| A heptameric barrel state of a de novo coiled-coil assembly: CC-Type2-(GgIaId)4 | 分子名称: | CC-Type2-(GgIaId)4, GLYCEROL, N-PROPANOL | 著者 | Martin, F.J.O, Dawson, W.M, Brady, R.L, Woolfson, D.N. | 登録日 | 2020-12-16 | 公開日 | 2021-04-28 | 最終更新日 | 2021-11-17 | 実験手法 | X-RAY DIFFRACTION (1.71 Å) | 主引用文献 | Coiled coils 9-to-5: rational de novo design of alpha-helical barrels with tunable oligomeric states. Chem Sci, 12, 2021
|
|
5J75
| Fluorogen Activating Protein AM2.2 in complex with ML342 | 分子名称: | N,4-dimethyl-N-{2-oxo-2-[4-(pyridin-2-yl)piperazin-1-yl]ethyl}benzene-1-sulfonamide, PHOSPHATE ION, scFv AM2.2 | 著者 | Stanfield, R.L, Wilson, I.A, Wu, Y. | 登録日 | 2016-04-05 | 公開日 | 2016-05-04 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Discovery of Small-Molecule Nonfluorescent Inhibitors of Fluorogen-Fluorogen Activating Protein Binding Pair. J Biomol Screen, 21, 2016
|
|
5J8G
| Structure of nitroreductase from E. cloacae complexed with para-nitrobenzoic acid | 分子名称: | 4-NITROBENZOIC ACID, FLAVIN MONONUCLEOTIDE, Oxygen-insensitive NAD(P)H nitroreductase | 著者 | Haynes, C.A, Koder, R.L, Miller, A.-F, Rodgers, D.W. | 登録日 | 2016-04-07 | 公開日 | 2017-05-17 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Mechanism-Informed Refinement Reveals Altered Substrate-Binding Mode for Catalytically Competent Nitroreductase. Structure, 25, 2017
|
|
6WDZ
| Porcine circovirus 2 Rep domain complexed with a single-stranded DNA 10-mer comprising the cleavage site | 分子名称: | 1,2-ETHANEDIOL, ATP-dependent helicase Rep, DNA (5'-D(*TP*AP*GP*TP*AP*TP*TP*AP*CP*C)-3'), ... | 著者 | Litzau, L.A, Tompkins, K, Shi, K, Nelson, A, Evans III, R.L, Gordon, W.R. | 登録日 | 2020-04-01 | 公開日 | 2020-12-16 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.03 Å) | 主引用文献 | Molecular underpinnings of ssDNA specificity by Rep HUH-endonucleases and implications for HUH-tag multiplexing and engineering. Nucleic Acids Res., 49, 2021
|
|
7BO9
| |
7BO8
| A hexameric de novo coiled-coil assembly: CC-Type2-(VaYd)4-Y3F-W19(BrPhe)-Y24F. | 分子名称: | 1,2-ETHANEDIOL, CC-Type2-(VaYd)4-Y3F-W19(BrPhe)-Y24F, OXAMIC ACID | 著者 | Rhys, G.G, Brady, R.L, Woolfson, D.N. | 登録日 | 2021-01-24 | 公開日 | 2021-05-19 | 実験手法 | X-RAY DIFFRACTION (1.84 Å) | 主引用文献 | How Coiled-Coil Assemblies Accommodate Multiple Aromatic Residues. Biomacromolecules, 22, 2021
|
|
7BOA
| |
6YRD
| SFX structure of dye-type peroxidase DtpB in the ferryl state | 分子名称: | MAGNESIUM ION, OXYGEN ATOM, PROTOPORPHYRIN IX CONTAINING FE, ... | 著者 | Lucic, M, Axford, D.A, Owen, R.L, Worrall, J.A.R, Hough, M.A. | 登録日 | 2020-04-20 | 公開日 | 2021-01-13 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | Serial Femtosecond Zero Dose Crystallography Captures a Water-Free Distal Heme Site in a Dye-Decolorising Peroxidase to Reveal a Catalytic Role for an Arginine in Fe IV =O Formation. Angew.Chem.Int.Ed.Engl., 59, 2020
|
|
6Y2M
| Streptavidin mutant S112R with a biotC4-1 cofactor - an artificial iron hydroxylase | 分子名称: | Streptavidin, biotC4-1 cofactor | 著者 | Serrano-Plana, J, Rumo, C, Rebelein, J.G, Peterson, R.L, Barnet, M, Ward, T.R. | 登録日 | 2020-02-17 | 公開日 | 2020-07-01 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Enantioselective Hydroxylation of Benzylic C(sp3)-H Bonds by an Artificial Iron Hydroxylase Based on the Biotin-Streptavidin Technology. J.Am.Chem.Soc., 142, 2020
|
|