1V7M
| Human Thrombopoietin Functional Domain Complexed To Neutralizing Antibody TN1 Fab | Descriptor: | Monoclonal TN1 Fab Heavy Chain, Monoclonal TN1 Fab Light Chain, Thrombopoietin | Authors: | Feese, M.D, Tamada, T, Kato, Y, Maeda, Y, Hirose, M, Matsukura, Y, Shigematsu, H, Kato, T, Miyazaki, H, Kuroki, R. | Deposit date: | 2003-12-18 | Release date: | 2004-03-02 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.51 Å) | Cite: | Structure of the receptor-binding domain of human thrombopoietin determined by complexation with a neutralizing antibody fragment Proc.Natl.Acad.Sci.USA, 101, 2004
|
|
1YND
| Structure of human cyclophilin A in complex with the novel immunosuppressant sanglifehrin A at 1.6A resolution | Descriptor: | Peptidyl-prolyl cis-trans isomerase A, SANGLIFEHRIN A | Authors: | Kallen, J, Sedrani, R, Zenke, G, Wagner, J. | Deposit date: | 2005-01-24 | Release date: | 2005-04-05 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Structure of human cyclophilin A in complex with the novel immunosuppressant sanglifehrin A at 1.6 A resolution. J.Biol.Chem., 280, 2005
|
|
5VE5
| Crystal structure of persulfide dioxygenase rhodanese fusion protein with rhodanese domain inactivating mutation (C314S) from Burkholderia phytofirmans in complex with glutathione | Descriptor: | BpPRF, CHLORIDE ION, FE (III) ION, ... | Authors: | Motl, N, Skiba, M.A, Smith, J.L, Banerjee, R. | Deposit date: | 2017-04-03 | Release date: | 2017-07-19 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | Structural and biochemical analyses indicate that a bacterial persulfide dioxygenase-rhodanese fusion protein functions in sulfur assimilation. J. Biol. Chem., 292, 2017
|
|
5WUC
| Structural basis for conductance through TRIC cation channels | Descriptor: | SODIUM ION, Uncharacterized protein | Authors: | Su, M, Gao, F, Mao, Y, Li, D.L, Guo, Y.Z, Wang, X.H, Bruni, R, Kloss, B, Hendrickson, W.A, Chen, Y.H, New York Consortium on Membrane Protein Structure (NYCOMPS) | Deposit date: | 2016-12-17 | Release date: | 2017-07-12 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Structural basis for conductance through TRIC cation channels. Nat Commun, 8, 2017
|
|
1Q7G
| Homoserine Dehydrogenase in complex with suicide inhibitor complex NAD-5-hydroxy-4-Oxonorvaline | Descriptor: | Homoserine dehydrogenase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE-5-HYDROXY-4-OXONORVALINE, SODIUM ION | Authors: | Jacques, S.L, Mirza, I.A, Ejim, L, Koteva, K, Hughes, D.W, Green, K, Kinach, R, Honek, J.F, Lai, H.K, Berghuis, A.M, Wright, G.D. | Deposit date: | 2003-08-18 | Release date: | 2003-10-21 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Enzyme assisted suicide: Molecular basis for the antifungal activity of 5-hydroxy-4-oxonorvaline by potent inhibition of homoserine dehydrogenase Chem.Biol., 10, 2003
|
|
1YNY
| Molecular Structure of D-Hydantoinase from a Bacillus sp. AR9: Evidence for mercury inhibition | Descriptor: | D-Hydantoinase, MANGANESE (II) ION | Authors: | Radha Kishan, K.V, Vohra, R.M, Ganeshan, K, Agrawal, V, Sharma, V.M, Sharma, R. | Deposit date: | 2005-01-26 | Release date: | 2005-03-01 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Molecular structure of D-hydantoinase from Bacillus sp. AR9: evidence for mercury inhibition. J.Mol.Biol., 347, 2005
|
|
1Q8V
| Pterocarpus angolensis lectin (PAL) in complex with the trimannoside [Man(Alpha1-3)]Man(alpha1-6)Man | Descriptor: | CALCIUM ION, MANGANESE (II) ION, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose, ... | Authors: | Loris, R, Van Walle, I, De Greve, H, Beeckmans, S, Deboeck, F, Wyns, L, Bouckaert, J. | Deposit date: | 2003-08-22 | Release date: | 2004-02-10 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Structural Basis of Oligomannose Recognition by the Pterocarpus angolensis Seed Lectin J.Mol.Biol., 335, 2004
|
|
5X0G
| Free serine kinase (E30A mutant) in complex with ADP | Descriptor: | 2-hydroxy-3-[4-(2-hydroxy-3-sulfopropyl)piperazin-1-yl]propane-1-sulfonic acid, ADENOSINE MONOPHOSPHATE, ADENOSINE-5'-DIPHOSPHATE, ... | Authors: | Nagata, R, Fujihashi, M, Miki, K. | Deposit date: | 2017-01-20 | Release date: | 2017-04-12 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structural Study on the Reaction Mechanism of a Free Serine Kinase Involved in Cysteine Biosynthesis ACS Chem. Biol., 12, 2017
|
|
1KG5
| Crystal structure of the K142Q mutant of E.coli MutY (core fragment) | Descriptor: | A/G-specific adenine glycosylase, GLYCEROL, IRON/SULFUR CLUSTER, ... | Authors: | Gilboa, R, Kilshtein, A, Zharkov, D.O, Kycia, J.H, Gerchman, S.E, Grollman, A.P, Shoham, G. | Deposit date: | 2001-11-26 | Release date: | 2002-11-26 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (1.35 Å) | Cite: | Analysis of the E.coli MutY DNA glycosylase structure and function by site-directed mutagenesis To be Published
|
|
5X2G
| Crystal structure of Campylobacter jejuni Cas9 in complex with sgRNA and target DNA (AGAAACC PAM) | Descriptor: | 1,2-ETHANEDIOL, CRISPR-associated endonuclease Cas9, Non-target DNA strand, ... | Authors: | Yamada, M, Watanabe, Y, Hirano, H, Nakane, T, Ishitani, R, Nishimasu, H, Nureki, O. | Deposit date: | 2017-01-31 | Release date: | 2017-03-29 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Crystal Structure of the Minimal Cas9 from Campylobacter jejuni Reveals the Molecular Diversity in the CRISPR-Cas9 Systems Mol. Cell, 65, 2017
|
|
1KI3
| CRYSTAL STRUCTURE OF THYMIDINE KINASE FROM HERPES SIMPLEX VIRUS TYPE I COMPLEXED WITH PENCICLOVIR | Descriptor: | 9-(4-HYDROXY-3-(HYDROXYMETHYL)BUT-1-YL)GUANINE, SULFATE ION, THYMIDINE KINASE | Authors: | Champness, J.N, Bennett, M.S, Wien, F, Visse, R, Jarvest, R.L, Summers, W.C, Sanderson, M.R. | Deposit date: | 1998-05-15 | Release date: | 1999-05-18 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.37 Å) | Cite: | Exploring the active site of herpes simplex virus type-1 thymidine kinase by X-ray crystallography of complexes with aciclovir and other ligands. Proteins, 32, 1998
|
|
1QT8
| T26H Mutant of T4 Lysozyme | Descriptor: | 2-HYDROXYETHYL DISULFIDE, PROTEIN (T4 LYSOZYME) | Authors: | Kuroki, R, Weaver, L.H, Matthews, B.W. | Deposit date: | 1999-06-30 | Release date: | 1999-07-08 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structural basis of the conversion of T4 lysozyme into a transglycosidase by reengineering the active site. Proc.Natl.Acad.Sci.USA, 96, 1999
|
|
1QGP
| NMR STRUCTURE OF THE Z-ALPHA DOMAIN OF ADAR1, 15 STRUCTURES | Descriptor: | PROTEIN (DOUBLE STRANDED RNA ADENOSINE DEAMINASE) | Authors: | Schade, M, Turner, C.J, Kuehne, R, Schmieder, P, Lowenhaupt, K, Herbert, A, Rich, A, Oschkinat, H. | Deposit date: | 1999-05-03 | Release date: | 1999-10-19 | Last modified: | 2023-12-27 | Method: | SOLUTION NMR | Cite: | The solution structure of the Zalpha domain of the human RNA editing enzyme ADAR1 reveals a prepositioned binding surface for Z-DNA. Proc.Natl.Acad.Sci.USA, 96, 1999
|
|
5VTG
| |
5WFN
| Revised model of leiomodin 2-mediated actin regulation (alternate refinement of PDB 4RWT) | Descriptor: | Actin-5C, Leiomodin-2, MAGNESIUM ION, ... | Authors: | Yurtsever, Z, Eck, M.J, Dominguez, R. | Deposit date: | 2017-07-12 | Release date: | 2017-08-30 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Crystal structure of leiomodin 2 in complex with actin: a structural and functional reexamination Biophys.J., 113, 2017
|
|
5X2H
| Crystal structure of Campylobacter jejuni Cas9 in complex with sgRNA and target DNA (AGAAACA PAM) | Descriptor: | 1,2-ETHANEDIOL, CRISPR-associated endonuclease Cas9, Non-target DNA strand, ... | Authors: | Yamada, M, Watanabe, Y, Hirano, H, Nakane, T, Ishitani, R, Nishimasu, H, Nureki, O. | Deposit date: | 2017-01-31 | Release date: | 2017-03-29 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Crystal Structure of the Minimal Cas9 from Campylobacter jejuni Reveals the Molecular Diversity in the CRISPR-Cas9 Systems Mol. Cell, 65, 2017
|
|
5W8B
| Carbonic anhydrase II in complex with activating histamine pyridinium derivative | Descriptor: | 1-[2-(1H-imidazol-5-yl)ethyl]-4-methyl-2,6-di(propan-2-yl)pyridin-1-ium, Carbonic anhydrase 2, GLYCEROL, ... | Authors: | Bhatt, A, Ilies, M, McKenna, R. | Deposit date: | 2017-06-21 | Release date: | 2018-05-30 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.601 Å) | Cite: | Crystal Structure of Carbonic Anhydrase II in Complex with an Activating Ligand: Implications in Neuronal Function. Mol. Neurobiol., 55, 2018
|
|
5VYJ
| |
1KI2
| CRYSTAL STRUCTURE OF THYMIDINE KINASE FROM HERPES SIMPLEX VIRUS TYPE I COMPLEXED WITH GANCICLOVIR | Descriptor: | 9-(1,3-DIHYDROXY-PROPOXYMETHANE)GUANINE, SULFATE ION, THYMIDINE KINASE | Authors: | Champness, J.N, Bennett, M.S, Wien, F, Brown, D.G, Visse, R, Sandhu, G, Davies, A, Rizkallah, P.J, Melitz, C, Summers, W.C, Sanderson, M.R. | Deposit date: | 1998-05-15 | Release date: | 1998-12-02 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Exploring the active site of herpes simplex virus type-1 thymidine kinase by X-ray crystallography of complexes with aciclovir and other ligands. Proteins, 32, 1998
|
|
5W91
| Toxoplasma Gondii CDPK1 in complex with inhibitor LZH118 | Descriptor: | 1-tert-butyl-N~3~-(3-chlorophenyl)-1H-pyrazolo[3,4-d]pyrimidine-3,4-diamine, CALCIUM ION, Calmodulin-domain protein kinase 1 | Authors: | El Bakkouri, M, Lovato, D, Loppnau, P, Lin, Y.H, Rutaganaria, F, Lopez, M.S, Shokat, L, Bountra, C, Edwards, A.M, Arrowsmith, C.H, Sibley, D, Hui, R, Walker, J.R, Structural Genomics Consortium (SGC) | Deposit date: | 2017-06-22 | Release date: | 2017-08-30 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Toxoplasma Gondii CDPK1 in complex with inhibitor LZH118 To be published
|
|
5W9R
| Toxoplasma Gondii CDPK1 in complex with inhibitor LJQ138 | Descriptor: | 1-tert-butyl-3-[(1H-indol-3-yl)methyl]-1H-pyrazolo[3,4-d]pyrimidin-4-amine, Calmodulin-domain protein kinase 1 | Authors: | El Bakkouri, M, Lovato, D, Loppnau, P, Lin, Y.H, Rutaganaria, F, Lopez, M.S, Shokat, L, Bountra, C, Edwards, A.M, Arrowsmith, C.H, Sibley, D, Hui, R, Walker, J.R. | Deposit date: | 2017-06-23 | Release date: | 2017-08-02 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Toxoplasma Gondii CDPK1 in complex with inhibitor LJQ138 To be published
|
|
1KT5
| Crystal structure of bovine holo-RBP at pH 4.0 | Descriptor: | Plasma retinol-binding protein, RETINOL | Authors: | Calderone, V, Berni, R, Zanotti, G. | Deposit date: | 2002-01-15 | Release date: | 2003-06-03 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (1.46 Å) | Cite: | High-resolution Structures of Retinol-binding Protein in
Complex with Retinol: pH-induced Protein Structural
Changes in the Crystal State J.Mol.Biol., 329, 2003
|
|
1QT7
| E11N Mutant of T4 Lysozyme | Descriptor: | BETA-MERCAPTOETHANOL, CHLORIDE ION, PROTEIN (T4 LYSOZYME) | Authors: | Kuroki, R, Weaver, L.H, Matthews, B.W. | Deposit date: | 1999-06-30 | Release date: | 1999-07-08 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structural basis of the conversion of T4 lysozyme into a transglycosidase by reengineering the active site. Proc.Natl.Acad.Sci.USA, 96, 1999
|
|
255L
| HYDROLASE | Descriptor: | BETA-MERCAPTOETHANOL, CHLORIDE ION, LYSOZYME | Authors: | Kuroki, R, Shoichet, B, Weaver, L.H, Matthews, B.W. | Deposit date: | 1997-11-10 | Release date: | 1998-01-28 | Last modified: | 2024-05-22 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | A relationship between protein stability and protein function. Proc.Natl.Acad.Sci.USA, 92, 1995
|
|
5XJR
| |