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PDB: 27191 件

8RWK
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cryoEM structure of the central Ald4 filament determined by FilamentID
分子名称: NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Potassium-activated aldehyde dehydrogenase, mitochondrial
著者Hugener, J, Xu, J, Wettstein, R, Ioannidi, L, Velikov, D, Wollweber, F, Henggeler, A, Matos, J, Pilhofer, M.
登録日2024-02-05
公開日2024-06-26
最終更新日2024-07-03
実験手法ELECTRON MICROSCOPY (3.8 Å)
主引用文献FilamentID reveals the composition and function of metabolic enzyme polymers during gametogenesis.
Cell, 187, 2024
8S4C
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CdaA-H04 complex
分子名称: DAMINOZIDE, Diadenylate cyclase
著者Neumann, P, Ficner, R.
登録日2024-02-21
公開日2024-06-19
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献CdaA-H04 complex
To Be Published
8SPS
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High resolution structure of ESRRB nucleosome bound OCT4 at site a and site b
分子名称: DNA (168-MER), Histone H2A type 2-C, Histone H2B type 2-E, ...
著者Lian, T, Guan, R, Bai, Y.
登録日2023-05-03
公開日2023-06-28
実験手法ELECTRON MICROSCOPY (3 Å)
主引用文献Structural mechanism of LIN28B nucleosome targeting by OCT4.
Mol.Cell, 83, 2023
8SPU
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Structure of ESRRB nucleosome bound OCT4 at site c
分子名称: DNA (168-MER), Histone H2A type 2-C, Histone H2B type 2-E, ...
著者Lian, T, Guan, R, Bai, Y.
登録日2023-05-03
公開日2023-06-28
最終更新日2024-02-07
実験手法ELECTRON MICROSCOPY (2.8 Å)
主引用文献Structural mechanism of LIN28B nucleosome targeting by OCT4.
Mol.Cell, 83, 2023
8STG
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Discovery and clinical validation of RLY-4008, the first highly selective FGFR2 inhibitor with activity across FGFR2 alterations and resistance mutations
分子名称: Fibroblast growth factor receptor 2, N-{4-[(5P)-4-amino-5-{3-fluoro-4-[(4-methylpyrimidin-2-yl)oxy]phenyl}-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-6-yl]phenyl}-2-methylpropanamide
著者Valverde, R, Foster, L.
登録日2023-05-10
公開日2023-06-07
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (3.79 Å)
主引用文献RLY-4008, the First Highly Selective FGFR2 Inhibitor with Activity across FGFR2 Alterations and Resistance Mutations.
Cancer Discov, 13, 2023
8T8B
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Crystal structure of the Thermus thermophilus 70S ribosome in complex with protein Y, A-site aminoacyl-tRNA analog ACC-PMN, and P-site formyl-MAI-tripeptidyl-tRNA analog ACCA-IAMf at 2.65A resolution
分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, 16S Ribosomal RNA, 23S Ribosomal RNA, ...
著者Thaler, J, Syroegin, E.A, Breuker, K, Polikanov, Y.S, Micura, R.
登録日2023-06-22
公開日2023-07-19
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (2.65 Å)
主引用文献Practical Synthesis of N -Formylmethionylated Peptidyl-tRNA Mimics.
Acs Chem.Biol., 18, 2023
8T8C
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Crystal structure of the Thermus thermophilus 70S ribosome in complex with protein Y, A-site aminoacyl-tRNA analog ACC-PMN, and P-site formyl-MFI-tripeptidyl-tRNA analog ACCA-IFMf at 2.60A resolution
分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, 16S Ribosomal RNA, 23S Ribosomal RNA, ...
著者Thaler, J, Syroegin, E.A, Breuker, K, Polikanov, Y.S, Micura, R.
登録日2023-06-22
公開日2023-07-19
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Practical Synthesis of N -Formylmethionylated Peptidyl-tRNA Mimics.
Acs Chem.Biol., 18, 2023
8FWA
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Phycocyanin structure from a modular droplet injector for serial femtosecond crystallography
分子名称: C-phycocyanin alpha chain, C-phycocyanin beta chain, PHYCOCYANOBILIN, ...
著者Botha, S, Doppler, D.L, Sonker, M, Egatz-Gomez, A, Grieco, A, Zaare, S, Jernigan, R, Meza-Aguilar, J.D, Rabbani, M.T, Manna, A, Alvarez, R, Karpos, K, Cruz Villarreal, J, Nelson, G, Ketawala, G.K, Pey, A.L, Ruiz-Fresneda, M.A, Pacheco-Garcia, J.L, Nazari, R, Sierra, R, Hunter, M.S, Batyuk, A, Kupitz, C.J, Sublett, R.E, Lisova, S, Mariani, V, Boutet, S, Fromme, R, Grant, T.D, Fromme, P, Kirian, R.A, Martin-Garcia, J.M, Ros, A.
登録日2023-01-20
公開日2023-06-28
最終更新日2023-07-12
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Modular droplet injector for sample conservation providing new structural insight for the conformational heterogeneity in the disease-associated NQO1 enzyme.
Lab Chip, 23, 2023
2FU7
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Zinc-beta-lactamase L1 from stenotrophomonas maltophilia (Cu-substituted form)
分子名称: 1,10-PHENANTHROLINE, COPPER (II) ION, GLYCEROL, ...
著者Nauton, L, Garau, G, Kahn, R, Dideberg, O.
登録日2006-01-26
公開日2007-01-30
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Structural insights into the design of inhibitors for the L1 metallo-beta-lactamase from Stenotrophomonas maltophilia.
J.Mol.Biol., 375, 2008
2FWH
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atomic resolution crystal structure of the C-terminal domain of the electron transfer catalyst DsbD (reduced form at pH7)
分子名称: DI(HYDROXYETHYL)ETHER, IODIDE ION, Thiol:disulfide interchange protein dsbD
著者Stirnimann, C.U, Rozhkova, A, Grauschopf, U, Boeckmann, R.A, Glockshuber, R, Capitani, G, Gruetter, M.G.
登録日2006-02-02
公開日2006-06-13
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (0.99 Å)
主引用文献High-resolution structures of Escherichia coli cDsbD in different redox states: A combined crystallographic, biochemical and computational study
J.Mol.Biol., 358, 2006
2FW3
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Crystal structure of rat carnitine palmitoyltransferase 2 in complex with antidiabetic drug ST1326
分子名称: (3R)-3-{[(TETRADECYLAMINO)CARBONYL]AMINO}-4-(TRIMETHYLAMMONIO)BUTANOATE, Carnitine O-palmitoyltransferase II, mitochondrial
著者Rufer, A.C, Thoma, R, Benz, J, Stihle, M, Gsell, B, De Roo, E, Banner, D.W, Mueller, F, Chomienne, O, Hennig, M.
登録日2006-02-01
公開日2007-02-01
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献The crystal structure of carnitine palmitoyltransferase 2 and implications for diabetes treatment
Structure, 14, 2006
2FPY
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Dual binding mode of a novel series of DHODH inhibitors
分子名称: 3-({[3,5-DIFLUORO-3'-(TRIFLUOROMETHOXY)BIPHENYL-4-YL]AMINO}CARBONYL)THIOPHENE-2-CARBOXYLIC ACID, ACETATE ION, Dihydroorotate dehydrogenase, ...
著者Baumgartner, R, Leban, J.
登録日2006-01-17
公開日2007-01-23
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Dual binding mode of a novel series of DHODH inhibitors.
J.Med.Chem., 49, 2006
2FNN
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Activation of human carbonic anhydrase II by exogenous proton donors
分子名称: 4-METHYLIMIDAZOLE, Carbonic Anhydrase 2, ZINC ION
著者Bhatt, D, Fisher, S.Z, Tu, C, McKenna, R, Silverman, D.N.
登録日2006-01-11
公開日2006-11-28
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Location of binding sites in small molecule rescue of human carbonic anhydrase II.
Biophys.J., 92, 2007
2FO3
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Plasmodium vivax ubiquitin conjugating enzyme E2
分子名称: Ubiquitin-conjugating enzyme
著者Dong, A, Zhao, Y, Lew, J, Kozieradski, I, Alam, Z, Melone, M, Wasney, G, Vedadi, M, Edwards, A.M, Arrowsmith, C.H, Weigelt, J, Sundstrom, M, Hui, R, Bochkarev, A, Qiu, W, Structural Genomics Consortium (SGC)
登録日2006-01-12
公開日2006-01-31
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.86 Å)
主引用文献Genome-scale protein expression and structural biology of Plasmodium falciparum and related Apicomplexan organisms.
Mol.Biochem.Parasitol., 151, 2007
2FSO
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mitogen activated protein kinase p38alpha (D176A) activating mutant
分子名称: Mitogen-activated protein kinase 14, octyl beta-D-glucopyranoside
著者Diskin, R, Livnah, O.
登録日2006-01-23
公開日2006-12-05
最終更新日2024-05-29
実験手法X-RAY DIFFRACTION (1.83 Å)
主引用文献Structures of p38alpha Active Mutants Reveal Conformational Changes in L16 Loop that Induce Autophosphorylation and Activation
J.Mol.Biol., 365, 2007
2FWF
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high resolution crystal structure of the C-terminal domain of the electron transfer catalyst DsbD (reduced form)
分子名称: IODIDE ION, SODIUM ION, Thiol:disulfide interchange protein dsbD
著者Stirnimann, C.U, Rozhkova, A, Grauschopf, U, Boeckmann, R.A, Glockshuber, R, Capitani, G, Gruetter, M.G.
登録日2006-02-02
公開日2006-06-13
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (1.3 Å)
主引用文献High-resolution structures of Escherichia coli cDsbD in different redox states: A combined crystallographic, biochemical and computational study
J.Mol.Biol., 358, 2006
2FU8
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Zinc-beta-lactamase L1 from stenotrophomonas maltophilia (d-captopril complex)
分子名称: 1-(3-MERCAPTO-2-METHYL-PROPIONYL)-PYRROLIDINE-2-CARBOXYLIC ACID, GLYCEROL, Metallo-beta-lactamase L1, ...
著者Nauton, L, Garau, G, Kahn, R, Dideberg, O.
登録日2006-01-26
公開日2007-01-30
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Structural insights into the design of inhibitors for the L1 metallo-beta-lactamase from Stenotrophomonas maltophilia.
J.Mol.Biol., 375, 2008
2FXT
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Crystal Structure of Yeast Tim44
分子名称: Import inner membrane translocase subunit TIM44
著者Josyula, R, Sha, B.
登録日2006-02-06
公開日2007-02-06
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献Crystal Structure of Yeast Mitochondrial Peripheral Membrane Protein Tim44p C-terminal Domain.
J.Mol.Biol., 359, 2006
2FQI
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dual binding modes of a novel series of DHODH inhibitors
分子名称: 2-({[2,3,5,6-TETRAFLUORO-3'-(TRIFLUOROMETHOXY)BIPHENYL-4-YL]AMINO}CARBONYL)CYCLOPENTA-1,3-DIENE-1-CARBOXYLIC ACID, ACETATE ION, Dihydroorotate dehydrogenase, ...
著者Baumgartner, R, Leban, J.
登録日2006-01-18
公開日2007-01-23
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Dual binding mode of a novel series of DHODH inhibitors.
J.Med.Chem., 49, 2006
2FQT
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Crystal structure of B.subtilis LuxS in complex with (2S)-2-Amino-4-[(2R,3S)-2,3-dihydroxy-3-N-hydroxycarbamoyl-propylmercapto]butyric acid
分子名称: (2S)-2-AMINO-4-[(2R,3S)-2,3-DIHYDROXY-3-N-HYDROXYCARBAMOYL-PROPYLMERCAPTO]BUTYRIC ACID, COBALT (II) ION, S-ribosylhomocysteine lyase, ...
著者Shen, G, Rajan, R, Zhu, J, Bell, C.E, Pei, D.
登録日2006-01-18
公開日2006-05-30
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.79 Å)
主引用文献Design and Synthesis of Substrate Analogue Inhibitors of S-Ribosylhomocysteinase (LuxS)
J.Med.Chem., 49, 2006
2FP1
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Secreted Chorismate Mutase from Mycobacterium tuberculosis
分子名称: Chorismate mutase, LEAD (II) ION
著者Okvist, M, Dey, R, Sasso, S, Grahn, E, Kast, P, Krengel, U.
登録日2006-01-15
公開日2006-03-28
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.55 Å)
主引用文献1.6A Crystal Structure of the Secreted Chorismate Mutase from Mycobacterium tuberculosis: Novel Fold Topology Revealed
J.Mol.Biol., 357, 2006
2FSL
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mitogen activated protein kinase p38alpha (D176A+F327S) activating mutant form-A
分子名称: Mitogen-activated protein kinase 14, octyl beta-D-glucopyranoside
著者Diskin, R, Livnah, O.
登録日2006-01-23
公開日2006-12-05
最終更新日2024-05-29
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Structures of p38alpha Active Mutants Reveal Conformational Changes in L16 Loop that Induce Autophosphorylation and Activation
J.Mol.Biol., 365, 2007
2FS2
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Structure of the E. coli PaaI protein from the phyenylacetic acid degradation operon
分子名称: Phenylacetic acid degradation protein paaI, SULFATE ION
著者Kniewel, R, Buglino, J.A, Solorzano, V, Wu, J, Lima, C.D, Burley, S.K, New York SGX Research Center for Structural Genomics (NYSGXRC)
登録日2006-01-20
公開日2006-02-07
最終更新日2021-02-03
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structure, Function, and Mechanism of the Phenylacetate Pathway Hot Dog-fold Thioesterase PaaI
J.Biol.Chem., 281, 2006
2FUV
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Phosphoglucomutase from Salmonella typhimurium.
分子名称: MAGNESIUM ION, phosphoglucomutase
著者Osipiuk, J, Wu, R, Holzle, D, Collart, F, Joachimiak, A, Midwest Center for Structural Genomics (MCSG)
登録日2006-01-27
公開日2006-03-07
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献X-ray crystal structure of phosphoglucomutase from Salmonella typhimurium.
To be Published
2FXQ
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Single-stranded DNA-binding protein from Thermus aquaticus
分子名称: Single-strand binding protein
著者Dauter, Z, Jedrzejczak, R, Dauter, M.
登録日2006-02-06
公開日2006-02-14
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Structure of the single-stranded DNA-binding protein SSB from Thermus aquaticus.
Acta Crystallogr.,Sect.D, 62, 2006

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件を2024-07-10に公開中

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