7JTO
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![BU of 7jto by Molmil](/molmil-images/mine/7jto) | Crystal structure of Protac MS33 in complex with the WD repeat-containing protein 5 and pVHL:ElonginC:ElonginB | Descriptor: | 1,2-ETHANEDIOL, 3-methyl-N-(11-{[2-(4-{[4'-(4-methylpiperazin-1-yl)-3'-{[6-oxo-4-(trifluoromethyl)-5,6-dihydropyridine-3-carbonyl]amino}[1,1'-biphenyl]-3-yl]methyl}piperazin-1-yl)ethyl]amino}-11-oxoundecanoyl)-L-valyl-(4R)-4-hydroxy-N-{[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl}-L-prolinamide, Elongin-B, ... | Authors: | Kottur, J, Jain, R, Aggarwal, A.K. | Deposit date: | 2020-08-18 | Release date: | 2021-10-06 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | A selective WDR5 degrader inhibits acute myeloid leukemia in patient-derived mouse models. Sci Transl Med, 13, 2021
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5AP3
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![BU of 5ap3 by Molmil](/molmil-images/mine/5ap3) | Naturally Occurring Mutations in the MPS1 Gene Predispose Cells to Kinase Inhibitor Drug Resistance. | Descriptor: | 1,2-ETHANEDIOL, 2-(2-(2-(2-(2-(2-ETHOXYETHOXY)ETHOXY)ETHOXY)ETHOXY)ETHOXY)ETHANOL, 9-CYCLOPENTYL-2-[[2-METHOXY-4-[(1-METHYLPIPERIDIN-4-YL)OXY]-PHENYL]AMINO]-7-METHYL-7,9-DIHYDRO-8H-PURIN-8-ONE, ... | Authors: | Gurden, M.D, Westwood, I.M, Faisal, A, Naud, S, Cheung, K.J, McAndrew, C, Wood, A, Schmitt, J, Boxall, K, Mak, G, Workman, P, Burke, R, Hoelder, S, Blagg, J, van Montfort, R.L.M, Linardopoulos, S. | Deposit date: | 2015-09-14 | Release date: | 2015-09-23 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Naturally Occurring Mutations in the Mps1 Gene Predispose Cells to Kinase Inhibitor Drug Resistance. Cancer Res., 75, 2015
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2J8M
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![BU of 2j8m by Molmil](/molmil-images/mine/2j8m) | Structure of P. aeruginosa acetyltransferase PA4866 | Descriptor: | ACETYLTRANSFERASE PA4866 FROM P. AERUGINOSA, AZIDE ION, GLYCEROL, ... | Authors: | Davies, A.M, Tata, R, Beavil, R.L, Sutton, B.J, Brown, P.R. | Deposit date: | 2006-10-26 | Release date: | 2007-02-06 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.44 Å) | Cite: | L-Methionine Sulfoximine, But not Phosphinothricin, is a Substrate for an Acetyltransferase (Gene Pa4866) from Pseudomonas Aeruginosa: Structural and Functional Studies. Biochemistry, 46, 2007
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2J8R
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![BU of 2j8r by Molmil](/molmil-images/mine/2j8r) | Structure of P. aeruginosa acetyltransferase PA4866 solved in complex with L-Methionine sulfoximine | Descriptor: | (2S)-2-AMINO-4-(METHYLSULFONIMIDOYL)BUTANOIC ACID, ACETYLTRANSFERASE PA4866 FROM P. AERUGINOSA, AZIDE ION, ... | Authors: | Davies, A.M, Tata, R, Beavil, R.L, Sutton, B.J, Brown, P.R. | Deposit date: | 2006-10-27 | Release date: | 2007-02-06 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.55 Å) | Cite: | L-Methionine Sulfoximine, But not Phosphinothricin, is a Substrate for an Acetyltransferase (Gene Pa4866) from Pseudomonas Aeruginosa: Structural and Functional Studies. Biochemistry, 46, 2007
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7K05
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![BU of 7k05 by Molmil](/molmil-images/mine/7k05) | |
2J8N
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![BU of 2j8n by Molmil](/molmil-images/mine/2j8n) | Structure of P. aeruginosa acetyltransferase PA4866 solved at room temperature | Descriptor: | ACETYLTRANSFERASE PA4866 FROM P. AERUGINOSA | Authors: | Davies, A.M, Tata, R, Beavil, R.L, Sutton, B.J, Brown, P.R. | Deposit date: | 2006-10-26 | Release date: | 2007-02-06 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | l-Methionine sulfoximine, but not phosphinothricin, is a substrate for an acetyltransferase (gene PA4866) from Pseudomonas aeruginosa: structural and functional studies. Biochemistry, 46, 2007
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4Q70
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![BU of 4q70 by Molmil](/molmil-images/mine/4q70) | Light Harvesting Protein Phycocyanin in high resolution using a femtosecond X-Ray laser | Descriptor: | C-phycocyanin alpha chain, C-phycocyanin beta chain, PHYCOCYANOBILIN | Authors: | Fromme, R, Roy-Chowdhury, S, Basu, S, Yoon, C, Fromme, P. | Deposit date: | 2014-04-23 | Release date: | 2015-05-06 | Last modified: | 2018-02-14 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Observations on the Light Harvesting Protein Phycocyanin structure in high resolution using a femtosecond X-Ray laser TO BE PUBLISHED
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4Q4N
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![BU of 4q4n by Molmil](/molmil-images/mine/4q4n) | Structure of the Resuscitation Promoting Factor Interacting protein RipA mutated at H432 | Descriptor: | Peptidoglycan endopeptidase RipA | Authors: | Squeglia, F, Ruggiero, A, Romano, M, Vitagliano, L, Berisio, R. | Deposit date: | 2014-04-15 | Release date: | 2014-09-10 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.38 Å) | Cite: | Mutational and structural study of RipA, a key enzyme in Mycobacterium tuberculosis cell division: evidence for the L-to-D inversion of configuration of the catalytic cysteine. Acta Crystallogr.,Sect.D, 70, 2014
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4Q4T
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![BU of 4q4t by Molmil](/molmil-images/mine/4q4t) | Structure of the Resuscitation Promoting Factor Interacting protein RipA mutated at E444 | Descriptor: | FORMIC ACID, GLYCEROL, Peptidoglycan endopeptidase RipA | Authors: | Squeglia, F, Ruggiero, A, Romano, M, Vitagliano, L, Berisio, R. | Deposit date: | 2014-04-15 | Release date: | 2014-09-10 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.63 Å) | Cite: | Mutational and structural study of RipA, a key enzyme in Mycobacterium tuberculosis cell division: evidence for the L-to-D inversion of configuration of the catalytic cysteine. Acta Crystallogr.,Sect.D, 70, 2014
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5LI4
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![BU of 5li4 by Molmil](/molmil-images/mine/5li4) | bacteriophage phi812K1-420 tail sheath protein after contraction | Descriptor: | tail sheath protein | Authors: | Novacek, J, Siborova, M, Benesik, M, Pantucek, R, Doskar, J, Plevka, P. | Deposit date: | 2016-07-14 | Release date: | 2017-07-19 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (4.2 Å) | Cite: | Structure and genome release of Twort-like Myoviridae phage with a double-layered baseplate. Proc. Natl. Acad. Sci. U.S.A., 113, 2016
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7JRD
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![BU of 7jrd by Molmil](/molmil-images/mine/7jrd) | |
5LP9
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![BU of 5lp9 by Molmil](/molmil-images/mine/5lp9) | FimA wt from S. flexneri | Descriptor: | Major type 1 subunit fimbrin (Pilin) | Authors: | Zyla, D, Capitani, G, Prota, A, Glockshuber, R. | Deposit date: | 2016-08-12 | Release date: | 2017-12-20 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (0.88626635 Å) | Cite: | Alternative folding to a monomer or homopolymer is a common feature of the type 1 pilus subunit FimA from enteroinvasive bacteria. J.Biol.Chem., 2019
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5B2D
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![BU of 5b2d by Molmil](/molmil-images/mine/5b2d) | Crystal structure of Mumps virus hemagglutinin-neuraminidase bound to 3-sialyllactose | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, HN protein, N-acetyl-alpha-neuraminic acid-(2-3)-beta-D-galactopyranose-(1-4)-alpha-D-glucopyranose, ... | Authors: | Kubota, M, Takeuchi, K, Watanabe, S, Ohno, S, Matsuoka, R, Kohda, D, Hiramatsu, H, Suzuki, Y, Nakayama, T, Terada, T, Shimizu, K, Shimizu, N, Yanagi, Y, Hashiguchi, T. | Deposit date: | 2016-01-14 | Release date: | 2016-09-28 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.177 Å) | Cite: | Trisaccharide containing alpha 2,3-linked sialic acid is a receptor for mumps virus Proc.Natl.Acad.Sci.USA, 113, 2016
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4QG5
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4QCB
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![BU of 4qcb by Molmil](/molmil-images/mine/4qcb) | Protein-DNA complex of Vaccinia virus D4 with double-stranded non-specific DNA | Descriptor: | 5'-D(*GP*CP*AP*AP*AP*CP*GP*TP*TP*TP*GP*C)-3', GLYCEROL, Uracil-DNA glycosylase | Authors: | Schormann, N, Banerjee, S, Ricciardi, R, Chattopadhyay, D. | Deposit date: | 2014-05-09 | Release date: | 2015-06-10 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.89 Å) | Cite: | Binding of undamaged double stranded DNA to vaccinia virus uracil-DNA Glycosylase. BMC Struct. Biol., 15, 2015
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4QIA
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![BU of 4qia by Molmil](/molmil-images/mine/4qia) | Crystal structure of human insulin degrading enzyme (ide) in complex with inhibitor N-benzyl-N-(carboxymethyl)glycyl-L-histidine | Descriptor: | Insulin-degrading enzyme, N-benzyl-N-(carboxymethyl)glycyl-L-histidine, ZINC ION | Authors: | Guo, Q, Deprez-Poulain, R, Deprez, B, Tang, W.J. | Deposit date: | 2014-05-30 | Release date: | 2015-05-13 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (3.202 Å) | Cite: | Structure-activity relationships of imidazole-derived 2-[N-carbamoylmethyl-alkylamino]acetic acids, dual binders of human insulin-degrading enzyme. Eur.J.Med.Chem., 90, 2015
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4PVU
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![BU of 4pvu by Molmil](/molmil-images/mine/4pvu) | Crystal structure of the complex between PPARgamma-LBD and the R enantiomer of Mbx-102 (Metaglidasen) | Descriptor: | (2R)-(4-chlorophenyl)[3-(trifluoromethyl)phenoxy]ethanoic acid, Peroxisome proliferator-activated receptor gamma | Authors: | Pochetti, G, Montanari, R, Capelli, D, Loiodice, F, Laghezza, A, Piemontese, L, Lavecchia, A. | Deposit date: | 2014-03-18 | Release date: | 2015-02-11 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | On the metabolically active form of metaglidasen: improved synthesis and investigation of its peculiar activity on peroxisome proliferator-activated receptors and skeletal muscles. Chemmedchem, 10, 2015
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7JPN
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![BU of 7jpn by Molmil](/molmil-images/mine/7jpn) | Cryo-EM structure of Arpin-bound Arp2/3 complex | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Actin-related protein 2, Actin-related protein 2/3 complex subunit 1B, ... | Authors: | van Eeuwen, T, Fregoso, F.E, Dominguez, R, Zimmet, A, Boczkowska, M, Rebowski, G. | Deposit date: | 2020-08-09 | Release date: | 2022-02-09 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (3.24 Å) | Cite: | Molecular mechanism of Arp2/3 complex inhibition by Arpin. Nat Commun, 13, 2022
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5BP9
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![BU of 5bp9 by Molmil](/molmil-images/mine/5bp9) | Crystal structure of SAM-dependent methyltransferase from Bacteroides fragilis in complex with S-Adenosyl-L-homocysteine | Descriptor: | 2-{2-[2-2-(METHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL, Putative methyltransferase protein, S-ADENOSYL-L-HOMOCYSTEINE, ... | Authors: | Gasiorowska, O.A, Shabalin, I.G, Handing, K.B, Cymborowski, M.T, Mason, D.V, Bonanno, J, Seidel, R, Almo, S.C, Minor, W, New York Structural Genomics Research Consortium (NYSGRC) | Deposit date: | 2015-05-27 | Release date: | 2015-06-10 | Last modified: | 2022-04-13 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Crystal structure of SAM-dependent methyltransferase fromBacteroides fragilis in complex with S-Adenosyl-L-homocysteine to be published
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5LH3
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![BU of 5lh3 by Molmil](/molmil-images/mine/5lh3) | High dose Thaumatin - 0-40 ms. | Descriptor: | L(+)-TARTARIC ACID, Thaumatin-1 | Authors: | Schubert, R, Kapis, S, Heymann, M, Giquel, Y, Bourenkov, G, Schneider, T, Betzel, C, Perbandt, M. | Deposit date: | 2016-07-08 | Release date: | 2016-11-09 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.64 Å) | Cite: | A multicrystal diffraction data-collection approach for studying structural dynamics with millisecond temporal resolution. IUCrJ, 3, 2016
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5B74
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![BU of 5b74 by Molmil](/molmil-images/mine/5b74) | Crystal structure of conjoined Pyrococcus furiosus L-asparaginase with peptide | Descriptor: | CHLORIDE ION, CITRATE ANION, L-asparaginase, ... | Authors: | Sharma, P, Tomar, R, Nath, S.K, Kundu, B, Ashish, F. | Deposit date: | 2016-06-05 | Release date: | 2017-06-14 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.039 Å) | Cite: | Heat induces end to end repetitive association in P. furiosus L-asparaginase which enables its thermophilic property. Sci Rep, 10, 2020
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5LSG
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![BU of 5lsg by Molmil](/molmil-images/mine/5lsg) | PPARgamma complex with the betulinic acid | Descriptor: | Betulinic Acid, Peroxisome proliferator-activated receptor gamma | Authors: | Pochetti, G, Montanari, R, Capelli, D, Loiodice, F, Laghezza, A, Calleri, E, Paiardini, A. | Deposit date: | 2016-08-26 | Release date: | 2017-08-09 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Betulinic acid is a PPAR gamma antagonist that improves glucose uptake, promotes osteogenesis and inhibits adipogenesis. Sci Rep, 7, 2017
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5LTL
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![BU of 5ltl by Molmil](/molmil-images/mine/5ltl) | |
4Q2S
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![BU of 4q2s by Molmil](/molmil-images/mine/4q2s) | |
5LVT
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![BU of 5lvt by Molmil](/molmil-images/mine/5lvt) | |