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PDB: 127 件

8P1L
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Structure of hantaan orthohantavirus (HTNV) polymerase - Apo full length
分子名称: RNA-directed RNA polymerase L
著者Keown, J.R, Carrique, L, Grimes, J.M.
登録日2023-05-12
公開日2024-05-22
実験手法ELECTRON MICROSCOPY (3.3 Å)
主引用文献Structure of hantaan orthohantavirus (HTNV) polymerase - Apo full length
To Be Published
8P1N
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Structure of hantaan orthohantavirus (HTNV) polymerase bound to 5'vRNA
分子名称: RNA (5'-R(P*AP*GP*UP*AP*G)-3'), RNA-directed RNA polymerase L
著者Keown, J.R, Carrique, L, Grimes, J.M.
登録日2023-05-12
公開日2024-05-22
実験手法ELECTRON MICROSCOPY (2.79 Å)
主引用文献Structure of hantaan orthohantavirus (HTNV) polymerase bound to 5'vRNA
To Be Published
6BNS
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STRUCTURE OF HUMAN PREGNANE X RECEPTOR LIGAND BINDING DOMAIN BOUND TETHERED WITH SRC co-activator peptide and Compound 25a AKA BICYCLIC HEXAFLUOROISOPROPYL 2 ALCOHOL SULFONAMIDES
分子名称: 2-[(2S)-4-[(4-fluorophenyl)sulfonyl]-7-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-3,4-dihydro-2H-1,4-benzothiazin-2-yl]-N-(2-hydroxy-2-methylpropyl)acetamide, Nuclear receptor subfamily 1 group I member 2,Nuclear receptor coactivator 1 Chimera
著者DHAR, T.G, GONG, H, WEINSTEIN, D.S, LU, Z, DUAN, J.J.W, STACHURA, S, HAQUE, L, KARMAKAR, A, HEMAGIRI, H, RAUT, D.K, GUPTA, A.K, KHAN, J.A, SACK, J.S, CAMAC, D.M, PUDZIANOWSKI, A.A, WU, D.R, YARDE, M, SHEN, D.R, BOROWSKI, V, XIE, J.H, SUN, H, ARIENZO, C.D, DABROS, M, GALELLA, M.A, WANG, F, WEIGELT, C.A, ZHAO, Q, FOSTER, W, SOMERVILLE, J.E, SALTER-CID, L.M, BARRISH, J.C, CARTER, P.H.
登録日2017-11-17
公開日2017-12-20
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (2.56 Å)
主引用文献Identification of bicyclic hexafluoroisopropyl alcohol sulfonamides as retinoic acid receptor-related orphan receptor gamma (ROR gamma /RORc) inverse agonists. Employing structure-based drug design to improve pregnane X receptor (PXR) selectivity.
Bioorg. Med. Chem. Lett., 28, 2018
5FRH
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BU of 5frh by Molmil
Solution structure of oxidised RsrA
分子名称: ANTI-SIGMA FACTOR RSRA
著者Zdanowski, K, Pecqueur, L, Werner, J, Potts, J.R, Kleanthous, C.
登録日2015-12-17
公開日2016-08-03
最終更新日2023-06-14
実験手法SOLUTION NMR
主引用文献The Anti-Sigma Factor Rsra Responds to Oxidative Stress by Reburying its Hydrophobic Core.
Nat.Commun., 7, 2016
6ZQI
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BU of 6zqi by Molmil
Cryo-EM structure of Spondweni virus prME
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Genome polyprotein
著者Renner, M, Dejnirattisai, W, Carrique, L, Serna Martin, I, Karia, D, Ilca, S.L, Ho, S.F, Kotecha, A, Keown, J.R, Mongkolsapaya, J, Screaton, G.R, Grimes, J.M.
登録日2020-07-09
公開日2021-01-20
最終更新日2021-08-04
実験手法ELECTRON MICROSCOPY (3.8 Å)
主引用文献Flavivirus maturation leads to the formation of an occupied lipid pocket in the surface glycoproteins.
Nat Commun, 12, 2021
7NDZ
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ThyX reconstituted with N5-carbinolamine flavin
分子名称: DI(HYDROXYETHYL)ETHER, DIHYDROFLAVINE-ADENINE DINUCLEOTIDE, Flavin-dependent thymidylate synthase, ...
著者Bou-Nader, C, Pecqueur, L, Hamdane, D.
登録日2021-02-02
公開日2021-07-21
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献An enzymatic activation of formaldehyde for nucleotide methylation.
Nat Commun, 12, 2021
7NDW
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ThyX-FADH2 soaked with 20 mM Formaldehyde
分子名称: DI(HYDROXYETHYL)ETHER, DIHYDROFLAVINE-ADENINE DINUCLEOTIDE, Flavin-dependent thymidylate synthase, ...
著者Bou-Nader, C, Pecqueur, L, Hamdane, D.
登録日2021-02-02
公開日2021-07-21
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献An enzymatic activation of formaldehyde for nucleotide methylation.
Nat Commun, 12, 2021
7Z3Z
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Locked Wuhan SARS-CoV2 Prefusion Spike ectodomain with lipid bound
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, STEARIC ACID, ...
著者Duyvesteyn, H.M.E, Carrique, L, Ren, J, Stuart, D.I, Fry, E.E.
登録日2022-03-03
公開日2022-05-04
実験手法ELECTRON MICROSCOPY (3.1 Å)
主引用文献The SARS-CoV-2 Spike harbours a lipid binding pocket which modulates stability of the prefusion trimer
bioRxiv, 2020
6XZD
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Influenza C virus polymerase complex without chicken ANP32A - Subclass 2
分子名称: Polymerase acidic protein, Polymerase basic protein 2, RNA (5'-R(*AP*GP*UP*AP*GP*AP*AP*AP*CP*AP*AP*GP*GP*GP*CP*CP*CP*UP*GP*C)-3'), ...
著者Keown, J.R, Carrique, L, Fan, H, Grimes, J.M, Fodor, E.
登録日2020-02-04
公開日2020-12-23
最終更新日2024-05-22
実験手法ELECTRON MICROSCOPY (3.4 Å)
主引用文献Host ANP32A mediates the assembly of the influenza virus replicase.
Nature, 587, 2020
6XZQ
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Influenza C virus polymerase in complex with human ANP32A - Subclass 1
分子名称: Acidic leucine-rich nuclear phosphoprotein 32 family member A, Polymerase acidic protein, Polymerase basic protein 2, ...
著者Fan, H, Carrique, L, Keown, J.R, Grimes, J.M, Fodor, E.
登録日2020-02-05
公開日2020-11-25
最終更新日2024-05-22
実験手法ELECTRON MICROSCOPY (3.6 Å)
主引用文献Host ANP32A mediates the assembly of the influenza virus replicase.
Nature, 587, 2020
6Y0C
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Influenza C virus polymerase in complex with human ANP32A - Subclass 2
分子名称: Polymerase acidic protein, Polymerase basic protein 2, RNA (5'-R(*AP*GP*UP*AP*GP*AP*AP*AP*CP*AP*AP*GP*GP*GP*CP*CP*UP*UP*UP*U)-3'), ...
著者Fan, H, Carrique, L, Keown, J.R, Grimes, J.M, Fodor, E.
登録日2020-02-07
公開日2020-11-25
最終更新日2024-05-22
実験手法ELECTRON MICROSCOPY (3.2 Å)
主引用文献Host ANP32A mediates the assembly of the influenza virus replicase.
Nature, 587, 2020
6EZA
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BU of 6eza by Molmil
Crystal Structure of human tRNA-dihydrouridine(20) synthase catalytic domain E294K mutant
分子名称: CHLORIDE ION, FLAVIN MONONUCLEOTIDE, GLYCEROL, ...
著者Bou-Nader, C, Bregeon, D, Pecqueur, L, Vincent, G, Fontecave, M, Hamdane, D.
登録日2017-11-14
公開日2018-09-26
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Electrostatic Potential in the tRNA Binding Evolution of Dihydrouridine Synthases.
Biochemistry, 57, 2018
2V09
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BU of 2v09 by Molmil
SENS161-164DSSN mutant of Bacillus subtilis Oxalate Decarboxylase OxdC
分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, MANGANESE (II) ION, OXALATE DECARBOXYLASE OXDC
著者Burrell, M.R, Just, V.J, Bowater, L, Fairhurst, S.A, Requena, L, Lawson, D.M, Bornemann, S.
登録日2007-05-10
公開日2007-10-30
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Oxalate Decarboxylase and Oxalate Oxidase Activities Can be Interchanged with a Specificity Switch of Up to 282 000 by Mutating an Active Site Lid.
Biochemistry, 46, 2007
6Z97
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BU of 6z97 by Molmil
Structure of the prefusion SARS-CoV-2 spike glycoprotein
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein,Fibritin
著者Duyvesteyn, H.M.E, Ren, J, Zhao, Y, Zhou, D, Huo, J, Carrique, L, Malinauskas, T, Ruza, R.R, Shah, P.N.M, Fry, E.E, Owens, R, Stuart, D.I.
登録日2020-06-03
公開日2020-07-01
最終更新日2020-09-23
実験手法ELECTRON MICROSCOPY (3.4 Å)
主引用文献Neutralization of SARS-CoV-2 by Destruction of the Prefusion Spike.
Cell Host Microbe, 28, 2020
6Z43
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Cryo-EM Structure of SARS-CoV-2 Spike : H11-D4 Nanobody Complex
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Nanobody, ...
著者Ruza, R.R, Duyvesteyn, H.M.E, Shah, P, Carrique, L, Ren, J, Malinauskas, T, Zhou, D, Stuart, D.I, Naismith, J.H.
登録日2020-05-22
公開日2020-06-03
最終更新日2020-07-29
実験手法ELECTRON MICROSCOPY (3.3 Å)
主引用文献Structural basis for a potent neutralising single-domain antibody that blocks SARS-CoV-2 binding to its receptor ACE2
To Be Published
5KH0
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Crystal Structure of HydF from thermosipho melanesiensis in complex with a [4Fe-4S] cluster
分子名称: IRON/SULFUR CLUSTER, Small GTP-binding protein
著者Caserta, G, Pecqueur, L, Fontecave, M.
登録日2016-06-14
公開日2017-05-03
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Structural and functional characterization of the hydrogenase-maturation HydF protein.
Nat. Chem. Biol., 13, 2017
7NHX
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1918 H1N1 Viral influenza polymerase heterotrimer - full transcriptase (Class1)
分子名称: Polymerase acidic protein, Polymerase basic protein 2,Immunoglobulin G-binding protein A, RNA (5'-R(P*AP*GP*UP*AP*GP*AP*AP*AP*CP*AP*AP*GP*GP*CP*C)-3'), ...
著者Keown, J.R, Carrique, L, Fodor, E, Grimes, J.M.
登録日2021-02-11
公開日2021-12-01
最終更新日2022-02-09
実験手法ELECTRON MICROSCOPY (3.23 Å)
主引用文献Mapping inhibitory sites on the RNA polymerase of the 1918 pandemic influenza virus using nanobodies.
Nat Commun, 13, 2022
7NIS
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1918 H1N1 Viral influenza polymerase heterotrimer with Nb8192 core
分子名称: Nanobody8192 core, Polymerase acidic protein, Polymerase basic protein 2,Immunoglobulin G-binding protein A, ...
著者Keown, J.R, Carrique, L, Fodor, E, Grimes, J.M.
登録日2021-02-13
公開日2021-12-01
最終更新日2022-02-09
実験手法ELECTRON MICROSCOPY (5.96 Å)
主引用文献Mapping inhibitory sites on the RNA polymerase of the 1918 pandemic influenza virus using nanobodies.
Nat Commun, 13, 2022
7NK1
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1918 Influenza virus polymerase heterotirmer in complex with vRNA promoters and Nb8201
分子名称: Nanobody8201, Polymerase acidic protein, Polymerase basic protein 2,Immunoglobulin G-binding protein A, ...
著者Keown, J.R, Carrique, L, Fodor, E, Grimes, J.M.
登録日2021-02-17
公開日2021-12-01
最終更新日2022-02-09
実験手法ELECTRON MICROSCOPY (4.22 Å)
主引用文献Mapping inhibitory sites on the RNA polymerase of the 1918 pandemic influenza virus using nanobodies.
Nat Commun, 13, 2022
7NKI
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BU of 7nki by Molmil
1918 H1N1 Viral influenza polymerase heterotrimer with Nb8209 core
分子名称: Nb8209, Polymerase acidic protein, Polymerase basic protein 2,Polymerase basic protein 2, ...
著者Keown, J.R, Carrique, L, Fodor, E, Grimes, J.M.
登録日2021-02-18
公開日2021-12-01
最終更新日2022-02-09
実験手法ELECTRON MICROSCOPY (4.67 Å)
主引用文献Mapping inhibitory sites on the RNA polymerase of the 1918 pandemic influenza virus using nanobodies.
Nat Commun, 13, 2022
7NKR
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BU of 7nkr by Molmil
1918 H1N1 Viral influenza polymerase heterotrimer with Nb8210
分子名称: Nb8210, Polymerase acidic protein, Polymerase basic protein 2,Polymerase basic protein 2, ...
著者Keown, J.R, Carrique, L, Fodor, E, Grimes, J.M.
登録日2021-02-18
公開日2021-12-01
最終更新日2022-02-09
実験手法ELECTRON MICROSCOPY (5.6 Å)
主引用文献Mapping inhibitory sites on the RNA polymerase of the 1918 pandemic influenza virus using nanobodies.
Nat Commun, 13, 2022
7NK6
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BU of 7nk6 by Molmil
1918 H1N1 Viral influenza polymerase heterotrimer with Nb8204
分子名称: Nb8204, Polymerase acidic protein, Polymerase basic protein 2,Polymerase basic protein 2, ...
著者Keown, J.R, Carrique, L, Fodor, E, Grimes, J.M.
登録日2021-02-17
公開日2021-12-01
最終更新日2022-02-09
実験手法ELECTRON MICROSCOPY (6.72 Å)
主引用文献Mapping inhibitory sites on the RNA polymerase of the 1918 pandemic influenza virus using nanobodies.
Nat Commun, 13, 2022
7NHA
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1918 H1N1 Viral influenza polymerase heterotrimer - Endonuclease and priming loop ordered (Class2a)
分子名称: Polymerase acidic protein, Polymerase basic protein 2,Immunoglobulin G-binding protein A, RNA (5'-R(P*AP*GP*UP*AP*GP*AP*AP*AP*CP*AP*AP*GP*GP*CP*C)-3'), ...
著者Keown, J.R, Carrique, L, Fodor, E, Grimes, J.M.
登録日2021-02-10
公開日2021-12-01
最終更新日2022-02-09
実験手法ELECTRON MICROSCOPY (2.91 Å)
主引用文献Mapping inhibitory sites on the RNA polymerase of the 1918 pandemic influenza virus using nanobodies.
Nat Commun, 13, 2022
7NJ7
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1918 H1N1 Viral influenza polymerase heterotrimer with Nb8200 core
分子名称: Nb8200 core, Polymerase acidic protein, Polymerase basic protein 2,Immunoglobulin G-binding protein A, ...
著者Keown, J.R, Carrique, L, Fodor, E, Grimes, J.M.
登録日2021-02-16
公開日2021-12-01
最終更新日2022-02-09
実験手法ELECTRON MICROSCOPY (4.82 Å)
主引用文献Mapping inhibitory sites on the RNA polymerase of the 1918 pandemic influenza virus using nanobodies.
Nat Commun, 13, 2022
7NIK
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1918 H1N1 Viral influenza polymerase heterotrimer with Nb8189 core
分子名称: Nanobody8189 core, Polymerase acidic protein, Polymerase basic protein 2,Immunoglobulin G-binding protein A, ...
著者Keown, J.R, Carrique, L, Fodor, E, Grimes, J.M.
登録日2021-02-12
公開日2021-12-01
最終更新日2022-02-09
実験手法ELECTRON MICROSCOPY (6.2 Å)
主引用文献Mapping inhibitory sites on the RNA polymerase of the 1918 pandemic influenza virus using nanobodies.
Nat Commun, 13, 2022

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件を2024-06-26に公開中

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